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Journal of Investigative Dermatology, ISSN 0022-202X, 12/2018, Volume 138, Issue 12, pp. 2501 - 2504.e1
Chimeric antigen receptor (CAR) and chimeric autoantibody receptor T-cell therapy hold great promise in the treatment of cancer and autoimmune disease,... 
CHIMERIC ANTIGEN RECEPTOR | DERMATOLOGY
Journal Article
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 2, pp. 591 - 594
Phosphatidylinositol-3-kinase p110 delta serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell... 
PHOSPHOINOSITIDE 3-KINASE P110-DELTA | HEMATOLOGY | ANTIGEN RECEPTOR | Lymphoid Neoplasia | Brief Report
Journal Article
BLOOD, ISSN 0006-4971, 05/2019, Volume 133, Issue 21, pp. 2246 - 2247
In this issue of Blood, Sanchez-Martinez and colleagues present a novel approach to the treatment of T-acute lymphoblastic leukemia (T-ALL) using chimeric... 
ADULTS | HEMATOLOGY | CHIMERIC ANTIGEN RECEPTOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2012, Volume 109, Issue 1, pp. E12 - E12
Journal Article
Biotechnology Advances, ISSN 0734-9750, 11/2019, Volume 37, Issue 7, p. 107411
T cells engineered to express a chimeric antigen receptor (CAR) have re-shaped the way hematological malignancies are treated. Despite the overwhelming early... 
Chimeric antigen receptor | Biotechnology | Immunotherapy
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 03/2014, Volume 95, Issue 3, pp. 441 - 450
CD4 Treg cells have quantitative and qualitative differences in the TCR/CD3 complex, particularly concerning CD3ɛ chains; differences may reconcile conflicting... 
Foxp3 | Tconv | antigen receptor
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 04/2017, Volume 18, Issue 4, pp. 393 - 393
To investigate how the human gamma delta T cell pool is shaped during ontogeny and how it is regenerated after transplantation of hematopoietic stem cells... 
POPULATION | MEMORY | BONE-MARROW-TRANSPLANTATION | INNATE | PERIPHERAL-BLOOD | IMMUNOLOGY | CYTOMEGALOVIRUS | ANTIGEN RECEPTOR | SUBSET | RECEPTOR REPERTOIRE | LYMPHOCYTES
Journal Article
IMMUNITY, ISSN 1074-7613, 05/2015, Volume 42, Issue 5, pp. 929 - 941
It has long been thought that clonal deletion efficiently removes almost all self-specific T cells from the peripheral repertoire. We found that self-peptide... 
RECOGNITION | AUTOIMMUNITY | CELL REPERTOIRE | THYMIC SELECTION | TOLERANCE | RECEPTOR TRANSGENIC MICE | INSULIN EPITOPE | NEGATIVE SELECTION | PRECURSOR FREQUENCIES | IMMUNOLOGY | ANTIGEN RECEPTOR
Journal Article
by Zhao, Y and Liu, ZF and Wang, X and Wu, HT and Zhang, JP and Yang, JF and Zhang, FY and Liu, LN and Long, JF and Lu, PH and Chen, ZG
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 09/2019, Volume 25, Issue 18, pp. 5595 - 5607
Purpose: CD19 chimeric antigen receptor (CAR)-T therapy has shown impactful results in treatment of B-cell malignancies. However, immune recognition of the... 
CHIMERIC ANTIGEN RECEPTOR | MODIFIED T-CELLS | ONCOLOGY | CD19
Journal Article
European urology, ISSN 0302-2838, 08/2019
Progress achieved in the treatment of prostate cancer (PCa) with surgical, radiation, and hormonal therapies has drastically reduced mortality from this... 
Journal Article
IMMUNITY, ISSN 1074-7613, 12/2013, Volume 39, Issue 6, pp. 1032 - 1042
The nature of the antigens recognized by gamma delta T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has... 
NKT CELLS | TCR | MULTIPLE-SCLEROSIS | EPITHELIAL-CELLS | SMALL-INTESTINE | IMMUNOLOGY | CLASS-I MOLECULES | ANTIGEN RECEPTOR | EXPRESSION | CELIAC-DISEASE | LYMPHOCYTES
Journal Article
IMMUNITY, ISSN 1074-7613, 12/2013, Volume 39, Issue 6, pp. 994 - 996
In this issue of Immunity, a study by Luoma et al. ( 2013) provides structural evidence for direct interactions of human V delta 1(+) T cell receptors with... 
IMMUNOLOGY | RECOGNITION | SELECTION | CELL ANTIGEN RECEPTOR
Journal Article
The Oncologist, ISSN 1083-7159, 08/2018, Volume 23, Issue 8, pp. 943 - 947
On August 30, 2017, the U.S. Food and Drug Administration approved Actemra (tocilizumab, Genentech, Inc., South San Francisco, CA) for the treatment of severe... 
Cytokine release syndrome | Chimeric antigen receptor | Interleukin‐6 | Tocilizumab | T cell | Immunotherapy | Interleukin-6 | MANAGEMENT | ONCOLOGY | REMISSIONS | LEUKEMIA | FDA | Regulatory Issues
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2018, Volume 36, Issue 11, pp. 1128 - 1139
PurposeTransforming growth factor- (TGF-) production in the tumor microenvironment is a potent and ubiquitous tumor immune evasion mechanism that inhibits the... 
THERAPY | B-CELL | ONCOLOGY | DISEASE | BRENTUXIMAB VEDOTIN | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR-ACTIVITY | BLOCKADE | NIVOLUMAB | HEMATOLOGIC MALIGNANCIES | CANCER | Biology of Neoplasia
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 06/2012, Volume 197, Issue 6, pp. 775 - 787
Activation of T cells by antigen-presenting cells involves assembly of signaling molecules into dynamic microclusters (MCs) within a specialized membrane... 
MICROCLUSTERS | COMPLEX | MYOSIN IIA | IMMUNE SYNAPSE | REORGANIZATION | COSTIMULATION | IMMUNOLOGICAL SYNAPSE FORMATION | ALDRICH-SYNDROME PROTEIN | ANTIGEN RECEPTOR | LYMPHOCYTES | CELL BIOLOGY
Journal Article