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animals (219) 219
antihypertensive agents - pharmacology (193) 193
cromakalim (182) 182
male (163) 163
benzopyrans - pharmacology (137) 137
rats (129) 129
pyrroles - pharmacology (118) 118
potassium channels - drug effects (117) 117
pharmacology & pharmacy (116) 116
in vitro techniques (77) 77
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pinacidil (60) 60
muscle, smooth, vascular - drug effects (59) 59
nicorandil (50) 50
dose-response relationship, drug (48) 48
rats, inbred shr (47) 47
humans (45) 45
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glibenclamide (37) 37
rabbits (36) 36
hypertension - drug therapy (33) 33
potassium channels (33) 33
antihypertensive agents - therapeutic use (32) 32
potassium channels - physiology (30) 30
rats, sprague-dawley (30) 30
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guinea pigs (29) 29
chemistry, medicinal (28) 28
guanidines - pharmacology (28) 28
brl-34915 (27) 27
hemodynamics - drug effects (26) 26
niacinamide - analogs & derivatives (26) 26
pyridines - pharmacology (26) 26
vasodilation - drug effects (26) 26
antihypertensive activity (25) 25
niacinamide - pharmacology (25) 25
structure-activity relationship (25) 25
muscle relaxation - drug effects (24) 24
rats, inbred strains (24) 24
cardiac & cardiovascular systems (21) 21
hypertension (21) 21
hypertension - physiopathology (21) 21
norepinephrine - pharmacology (21) 21
biochemistry & molecular biology (20) 20
membrane potentials - drug effects (20) 20
potassium channels - agonists (20) 20
muscle contraction - drug effects (19) 19
openers (19) 19
vascular resistance - drug effects (19) 19
antihypertensive agent (18) 18
antihypertensive agents - administration & dosage (18) 18
aorta, thoracic - drug effects (18) 18
hypoglycemic agents - pharmacology (18) 18
nifedipine - pharmacology (18) 18
antihypertensive agents - chemical synthesis (17) 17
disease models, animal (17) 17
muscle, smooth, vascular - metabolism (17) 17
nifedipine (17) 17
peripheral vascular disease (17) 17
sensitive k+ channels (17) 17
antihypertensive agents (16) 16
drug interactions (16) 16
k+ channels (16) 16
physiology (16) 16
administration, oral (15) 15
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inhibition (15) 15
potassium - metabolism (15) 15
rats, inbred wky (15) 15
adenosine triphosphate - pharmacology (14) 14
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blood pressure (14) 14
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action potentials - drug effects (13) 13
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potassium channel activator (13) 13
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time factors (13) 13
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Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 11/2017, Volume 58, Issue 13, pp. 5731 - 5742
Journal Article
Experimental Eye Research, ISSN 0014-4835, 01/2019, Volume 178, pp. 223 - 224
Journal Article
Experimental Eye Research, ISSN 0014-4835, 01/2019, Volume 178, pp. 225 - 225
Journal Article
Pharmacological Research, ISSN 1043-6618, 2003, Volume 47, Issue 6, pp. 447 - 461
The roles of cardiomyocyte sarcolemmal ATP-sensitive K + (K ATP) and mitochondrial K ATP channels in the cardioprotection and antiarrhythmic activity induced... 
Reperfusion arrhythmia | Reactive oxygen species | Nicorandil | Cromakalim | Anesthetized rabbit | Myocardial ischemia | Sarcolemmal K ATP channel | Coronary occlusion | HMR 1883 | Mitochondrial K ATP channel | INDUCED ARRHYTHMIAS | cromakalim | REPERFUSION INJURY | coronary occlusion | PROFIBRILLATORY ACTIONS | sarcolemmal K-ATP channel | ACTION-POTENTIAL DURATION | nicorandil | INTRAVENOUS NICORANDIL | reactive oxygen species | mitochondrial K-ATP channel | ACUTE MYOCARDIAL-INFARCTION | NITRIC-OXIDE | reperfusion arrhythmia | PHARMACOLOGY & PHARMACY | myocardial ischemia | RAT-HEART | anesthetized rabbit | DEPENDENT POTASSIUM CHANNELS | ISCHEMIA-REPERFUSION | Sarcolemma - physiology | Myocardial Reperfusion Injury - complications | Antihypertensive Agents - administration & dosage | Male | Arrhythmias, Cardiac - physiopathology | Heart Rate - drug effects | Malondialdehyde - analysis | Glutathione - analysis | Membrane Proteins - physiology | Hydroxy Acids - administration & dosage | Myocardial Infarction - physiopathology | Blood Pressure - drug effects | Myocardial Reperfusion Injury - drug therapy | Disease Models, Animal | Rabbits | Superoxide Dismutase - analysis | Survival Rate | Arrhythmias, Cardiac - etiology | Decanoic Acids - administration & dosage | Nicorandil - administration & dosage | Thiourea - administration & dosage | Anti-Arrhythmia Agents - administration & dosage | Cromakalim - administration & dosage | Potassium Channels | Arrhythmias, Cardiac - drug therapy | Animals | Analysis of Variance | Membrane Proteins - antagonists & inhibitors | Sarcolemma - drug effects | Membrane Proteins - drug effects | Myocardial Infarction - prevention & control | Oxidative Stress - drug effects | Sulfonamides - administration & dosage | Thiourea - analogs & derivatives
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 1989, Volume 248, Issue 3, pp. 1261 - 1268
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 4, pp. 1118 - 1123
ATP-sensitive K⁺ channels ($K_{ATP}$) are an octameric complex of inwardly rectifying K⁺ channels (Kir6.1 and Kir6.2) and sulfonylurea receptors (SUR1 and... 
Reverse transcriptase polymerase chain reaction | Drug interactions | Muscles | Fast twitch muscle fibers | Agonists | Pharmacology | Drug design | Slow twitch muscle fibers | Current density | Skeletal muscle | Physiology | SKELETAL-MUSCLE | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | pharmacology | physiology | HYPOKALEMIC PERIODIC PARALYSIS | NA+ | skeletal muscle | OPENERS | DISUSE | EXPRESSION | MODULATION | Potassium - metabolism | Tolbutamide - pharmacology | Antihypertensive Agents - pharmacology | Diazoxide - pharmacology | Rats, Wistar | Anti-Arrhythmia Agents - pharmacology | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - metabolism | Sulfonylurea Receptors | DNA Primers - chemistry | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Cromakalim - metabolism | Glyburide - pharmacology | ATP-Binding Cassette Transporters - metabolism | Muscles - metabolism | Gene Expression Regulation | Rats | Models, Statistical | Recombinant Fusion Proteins - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Drug - metabolism | Hypoglycemic Agents - pharmacology | Potassium - chemistry | Patch-Clamp Techniques | Phenotype | Animals | KATP Channels | Potassium Channels - chemistry | Kinetics | Adenosine Triphosphate - chemistry | Biophysics - methods | Cromakalim - pharmacology | Potassium Channels, Inwardly Rectifying - metabolism | Biological Sciences
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 7/2015, Volume 24, Issue 7, pp. 3008 - 3020
The present study described the design, synthesis and identification of 3-hydroxy-4[3,4-dihydro-3-oxo-2H-1,4-benzoxazin-4-yl]-2,2-dimethyldihydro-2H-benzopyran... 
Biochemistry, general | Benzoxazine | Biomedicine | Benzopyran | COX-2 | COX-1 | Pharmacology/Toxicology | K channel opener | Anti-inflammatory | Cell Biology | CHEMISTRY, MEDICINAL | SERIES | ANTIHYPERTENSIVE ACTIVITY | THIOPHENE SYSTEMS | CROMAKALIM | POTENT | RING | OPENERS | Drugstores | Potassium channels | Anti-inflammatory drugs | Pharmacy | Resveratrol
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1988, Volume 85, Issue 21, pp. 8360 - 8364
The mechanism by which the antihypertensive agent BRL 34915 (cromakalim) affects action potential duration (APD) and effective refractory period (ERP) in... 
Action potentials | Papillary muscles | Rectifiers | Muscles | Myocardium | Hypoxia | Smooth muscle | Ferrets | Electric current | Muscle tissues
Journal Article