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1. Full Text Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
by Cardoso, Marcos Veríssimo de Oliveira and Moreira, Diogo Rodrigo Magalhães and Filho, Gevanio Bezerra Oliveira and Cavalcanti, Suellen Melo Tiburcio and Coelho, Lucas Cunha Duarte and Espíndola, José Wanderlan Pontes and Gonzalez, Laura Rubio and Rabello, Marcelo Montenegro and Hernandes, Marcelo Zaldini and Ferreira, Paulo Michel Pinheiro and Pessoa, Cláudia and Alberto de Simone, Carlos and Guimarães, Elisalva Teixeira and Soares, Milena Botelho Pereira and Leite, Ana Cristina Lima
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore... 
Antiproliferative | Immunosuppressive | Phthalimide | Thiosemicarbazone | Thiazolidinone | Thiazole | MULTIPLE-MYELOMA | KAPPA-B KINASE | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | TRANSITION-METAL COMPLEXES | CARCINOMA-CELL LINES | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | INTERFERON-GAMMA | THALIDOMIDE ANALOGS | INHIBITORS | Immunomodulation | Antineoplastic Agents - chemical synthesis | Cytokines - analysis | Humans | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Male | Phthalimides - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Lymphocytes - drug effects | Drug Design | Macrophages - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Drug Screening Assays, Antitumor | Prevention | Cancer
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2. Full Text Sideritis spp.: Uses, chemical composition and pharmacological activities—A review
by González-Burgos, E and Carretero, M.E and Gómez-Serranillos, M.P
Journal of Ethnopharmacology, ISSN 0378-8741, 05/2011, Volume 135, Issue 2, pp. 209 - 225
spp. have been traditionally used in Mediterranean area as teas, flavoring agents and for therapeutical purposes because of its anti-inflammatory, digestive,... 
Chemical composition | Traditional uses | Sideritis | Pharmacological activities | ANTIOXIDANT ACTIVITY | SUBSP PERFOLIATA LAMIACEAE | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | BIOLOGICAL-ACTIVITIES | ESSENTIAL OIL COMPOSITION | PLANT SCIENCES | PERFORMANCE LIQUID-CHROMATOGRAPHY | MACROPHAGE EICOSANOID BIOSYNTHESIS | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | FLAVONOID AGLYCONES | ENT-KAURENE DITERPENES | ANTIMICROBIAL ACTIVITY | Plant Extracts - chemistry | Sideritis - chemistry | Animals | Plant Extracts - pharmacology | Humans | Antioxidants
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3. Full Text Monoterpenes with Analgesic Activity—A Systematic Review
by Guimarães, Adriana G and Quintans, Jullyana S. S and Quintans‐Júnior, Lucindo J
Phytotherapy Research, ISSN 0951-418X, 01/2013, Volume 27, Issue 1, pp. 1 - 15
There is still the need for efficacious therapies for pain. In the search for new therapeutic options, plants are a major source of novel biomolecules.... 
pain | monoterpenes | analgesia | KAPPA-B ACTIVATION | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | 1,8-CINEOL EUCALYPTOL | BIOASSAY-GUIDED EVALUATION | ESSENTIAL OIL | ANTINOCICEPTIVE ACTIVITY | IN-VITRO | CHEMICAL-COMPOSITION | PHARMACOLOGY & PHARMACY | INFLAMMATORY RESPONSE | ALPHA-TERPINEOL | Analgesia | Analgesics - therapeutic use | Oils, Volatile - therapeutic use | Animals | Oils, Volatile - chemistry | Pain - drug therapy | Rats | Mice | Monoterpenes - therapeutic use | Analgesics
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4. Full Text Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2‐a]pyrimidine Derivatives with Anti‐inflammatory Activity in Acute Lung Injury
by Chen, Lingfeng and Jin, Yiyi and Fu, Weitao and Xiao, Siyang and Feng, Chen and Fang, Bo and Gu, Yugui and Li, Chenglong and Zhao, Yunjie and Liu, Zhiguo and Liang, Guang
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1022 - 1032
Acute lung injury (ALI) has a high lethality rate, and interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) contribute most to tissue deterioration in... 
anti-inflammatory | thiazolo[3,2-a]pyrimidines | cytokines | acute lung injury | interleukins | MORTALITY | PYRIMIDINE-DERIVATIVES | CHEMISTRY, MEDICINAL | MACROPHAGES | SEPSIS | DISCOVERY | RESPIRATORY-DISTRESS-SYNDROME | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | AGENTS | INHIBITORS | INFLAMMATORY RESPONSE | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Pyrimidines - chemical synthesis | Tumor Necrosis Factor-alpha - genetics | Thiazoles - administration & dosage | Thiazoles - therapeutic use | RNA, Messenger - metabolism | Antigens, CD - metabolism | Sepsis - drug therapy | Sepsis - metabolism | Acute Lung Injury - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Interleukin-6 - metabolism | Macrophages, Peritoneal - drug effects | Quantitative Structure-Activity Relationship | Interleukin-6 - genetics | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Mice, Inbred ICR | Animals | Pneumonia - drug therapy | Thiazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Pyrimidines - therapeutic use | Antigens, Differentiation, Myelomonocytic - metabolism | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Macrophages, Peritoneal - metabolism | Pneumonia - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Acute respiratory distress syndrome | Pyrimidines | Interleukins | Anti-inflammatory drugs | Mitogens | Analysis | Drugs | Ventilators | Antiinflammatory agents | Interleukin | Lethality | Inflammation | Derivatives | Macrophages | Drug development | Lipopolysaccharides | Interleukin 6 | Inhibitors | Synthesis | Lungs | Tumor necrosis factor | Rodents | Attenuation | Tumor necrosis factor-TNF | Peritoneum
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5. Full Text 2-Azetidinone – A new profile of various pharmacological activities
by Mehta, Parul D and Sengar, N.P.S and Pathak, A.K
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 12, pp. 5541 - 5560
2-Azetidinone, a β-lactam four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities.... 
2-Azetidinone | β-Lactam | Biological activity | Four membered heterocyclic ring | 3,4-DISUBSTITUTED AZETIDINONES | CHEMISTRY, MEDICINAL | SOLID-PHASE SYNTHESIS | PROLIFERATOR-ACTIVATED RECEPTORS | beta-Lactam | HUMAN-LEUKOCYTE ELASTASE | HUMAN CYTOMEGALOVIRUS PROTEASE | MONOCYCLIC BETA-LACTAMS | CHOLESTEROL ABSORPTION | ANTIINFLAMMATORY AGENTS | CATHEPSIN-K | SELECTIVE INHIBITORS | Antifungal Agents - pharmacology | Animals | Antiparkinson Agents - pharmacology | Anti-Infective Agents - chemistry | Anti-Infective Agents - pharmacology | Humans | Antiparkinson Agents - chemistry | Antifungal Agents - chemistry | Hypoglycemic Agents - chemistry | Azetidines - pharmacology | Azetidines - chemistry | Hypoglycemic Agents - pharmacology
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6. Full Text Recently reported biological activities of pyrazole compounds
by Faria, Jéssica Venância and Vegi, Percilene Fazolin and Miguita, Ana Gabriella Carvalho and dos Santos, Maurício Silva and Boechat, Nubia and Bernardino, Alice Maria Rolim
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2017, Volume 25, Issue 21, pp. 5891 - 5903
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological... 
ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUBULIN POLYMERIZATION | CHEMISTRY, ORGANIC | MOLECULAR DOCKING | SELECTIVE COX-2 INHIBITORS | ACID-DERIVATIVES | IN-VITRO | ANTIINFLAMMATORY AGENTS | ANTIMICROBIAL EVALUATION | ANTILEISHMANIAL ACTIVITY | Antifungal Agents - pharmacology | Analgesics - pharmacology | Antiviral Agents - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemistry | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Pyrazoles - chemistry | Animals | Analgesics - chemistry | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacology | Nitrogen | Drug approval
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7. Full Text Recent developments in biological activities of chalcones: A mini review
by Singh, Parvesh and Anand, Amit and Kumar, Vipan
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 758 - 777
Chalcones represent key structural motif in the plethora of biologically active molecules including synthetic and natural products. Synthetic manipulations of... 
Antimalarials | Chalcones | Anti-HIV | Anticancer agents | Antiprotozal | Antimicrobials | AGENTS SYNTHESIS | ANTIPROLIFERATIVE ACTIVITY | ANTIINFLAMMATORY ACTIVITY | ALDOL CONDENSATIONS | CHEMISTRY, MEDICINAL | CYTOTOXIC ACTIVITY | ANTICANCER ACTIVITY | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | TNF-ALPHA | DERIVATIVES | Drug Discovery - methods | Animals | Humans | Chalcones - pharmacology | Malaria
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8. Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities
by Fylaktakidou, Konstantina C and Hadjipavlou-Litina, Dimitra J and Litinas, Konstantinos E and Nicolaides, Demetrios N
Current Pharmaceutical Design, ISSN 1381-6128, 2004, Volume 10, Issue 30, pp. 3813 - 3833
Several natural products with a coumarinic moiety have been reported to have multiple biological activities. It is to be expected that, in a similar way to... 
Antioxidants | Antiinflammatories | Natural coumarins | Synthetic coumarins | CONVENIENT SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | SUPEROXIDE | SERIES | antioxidants | CRUDE DRUG | synthetic coumarins | LIPOXYGENASE | INHIBITION | antiinflammatories | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | HEME OXYGENASE-1 | natural coumarins | CONSTITUENTS | Plant Extracts - chemistry | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Plant Extracts - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Coumarins - pharmacology | Inflammation - metabolism | Animals | Inflammation - drug therapy | Coumarins - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Plants, Medicinal
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9. Full Text Cover Picture: Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2‐a]pyrimidine Derivatives with Anti‐inflammatory Activity in Acute Lung Injury (ChemMedChem 13/2017)
by Chen, Lingfeng and Jin, Yiyi and Fu, Weitao and Xiao, Siyang and Feng, Chen and Fang, Bo and Gu, Yugui and Li, Chenglong and Zhao, Yunjie and Liu, Zhiguo and Liang, Guang
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1013 - 1013
The front cover picture shows a series of newly discovered compounds with high inhibitory activities against lipopolysaccharide (LPS)‐induced cytokine... 
anti-inflammatory | thiazolo[3,2-a]pyrimidines | cytokines | acute lung injury | interleukins | Ventilators | Antiinflammatory agents | Cytokines | Bronchus | Inflammation | Derivatives | Bioactive | Lipopolysaccharides | Lungs | Bronchoalveolar lavage | Rodents | Sepsis | Mice | Pretreatment | Alveoli
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10. Full Text Nitric Oxide Donors:  Chemical Activities and Biological Applications
by Wang, Peng George and Xian, Ming and Tang, Xiaoping and Wu, Xuejun and Wen, Zhong and Cai, Tingwei and Janczuk, Adam J
Chemical Reviews, ISSN 0009-2665, 04/2002, Volume 102, Issue 4, pp. 1091 - 1134
SICKLE-CELL HEMOGLOBIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ORGANIC NITRATE ESTERS | LOW-DENSITY-LIPOPROTEIN | UNSYMMETRICALLY SUBSTITUTED FUROXANS | GLUTATHIONE-S-TRANSFERASE | SOLUBLE GUANYLATE-CYCLASE | HYDROXY-L-ARGININE | CHEMISTRY, MULTIDISCIPLINARY | VASCULAR SMOOTH-MUSCLE | METAL NITROSYL COMPLEXES | Nitric Oxide Donors - chemistry | Nitric Oxide - chemistry | Nitric Oxide - pharmacology | Humans | Nitroso Compounds - chemistry | Nitroso Compounds - pharmacology | Animals | Nitroso Compounds - metabolism | Drug Design | Organometallic Compounds - chemistry | Nitric Oxide - classification | Nitric Oxide Donors - classification | Nitric Oxide Donors - pharmacology | Organometallic Compounds - pharmacology | Enzymes | Analysis | Nitric oxide | Nitroglycerin | Chemical research | Physiological aspects | Coordination compounds
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11. Full Text C‐Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities—A Review
by Ninfali, Paolino and Antonini, Elena and Frati, Alessandra and Scarpa, Emanuele‐Salvatore
Phytotherapy Research, ISSN 0951-418X, 06/2017, Volume 31, Issue 6, pp. 871 - 884
The green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. rubra L.) contain phytochemicals that have beneficial effects on human health.... 
betalains | vitexin‐2‐O‐xyloside | antioxidant | antiinflammatory | anticancer | C‐glycosyl flavonoids | vitexin-2-O-xyloside | C-glycosyl flavonoids | Betalains - pharmacology | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Humans | Betacyanins | Antioxidants - pharmacology | Beta vulgaris - chemistry | Animals | Apigenin | Glycosides | Flavonoids - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Phytochemicals - pharmacology | Antioxidants | Care and treatment | Anti-inflammatory drugs | Cancer | Isoflavones | Cell proliferation | Drugs | Biotechnology | Transcription | Toxicity | Liver | Genes | Bladder | Anticancer properties | Liver cancer | β-catenin | Angiogenesis | Antitumor agents | Colon cancer | Pathways | Urinary bladder | Colon | Vascular endothelial growth factor | Beetroot | Cell survival | Berries | Health | Tumor cells | Multidrug resistance | Tumor cell lines | Survival | Flavonoids | Phytochemicals | Reviews | Molecular modelling | Inhibitors | Diet | Breast | Hypoxia | Antitumor activity | Apoptosis
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12. Full Text 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4 H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities
by Salgın-Gökşen, Umut and Gökhan-Kelekçi, Nesrin and Göktaş, Özgür and Köysal, Yavuz and Kılıç, Ekrem and Işık, Şamil and Aktay, Göknur and Özalp, Meral
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 17, pp. 5738 - 5751
A novel series of 1-acylthiosemicarbazides, 1,2,4-triazole-5-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones was synthesized... 
Thiosemicarbazide | Triazol | Hydrazone | Analgesic-anti-inflammatory and antimicrobial activities | Thiadiazole | 2-Benzoxazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | hydrazone | 2-benzoxazolinone | CYCLOOXYGENASE | analgesic-anti-inflammatory and antimicrobial | ACYLARYLHYDRAZONES | triazol | ACID-DERIVATIVES | IN-VITRO | thiosemicarbazide | ANTITUBERCULOSIS ACTIVITY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | activities | thiadiazole | NITRIC-OXIDE | 2-BENZOXAZOLINONE DERIVATIVES | AGENTS | ANTIFUNGAL | Analgesics - pharmacology | Triazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Anti-Bacterial Agents - chemistry | Hydrazones - therapeutic use | Semicarbazides - pharmacology | Semicarbazides - chemistry | Anti-Inflammatory Agents - therapeutic use | Triazoles - chemical synthesis | Molecular Structure | Thiadiazoles - pharmacology | Triazoles - therapeutic use | Microbial Viability - drug effects | Anti-Inflammatory Agents - pharmacology | Models, Molecular | Edema - drug therapy | Hydrazones - chemical synthesis | Semicarbazides - therapeutic use | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Semicarbazides - chemical synthesis | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzoxazoles - chemistry | Thiadiazoles - chemical synthesis | Analgesics - chemistry | Hindlimb - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Mice | Methylation | Edema - pathology
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