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European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1022 - 1032
Acute lung injury (ALI) has a high lethality rate, and interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) contribute most to tissue deterioration in... 
anti-inflammatory | thiazolo[3,2-a]pyrimidines | cytokines | acute lung injury | interleukins | MORTALITY | PYRIMIDINE-DERIVATIVES | CHEMISTRY, MEDICINAL | MACROPHAGES | SEPSIS | DISCOVERY | RESPIRATORY-DISTRESS-SYNDROME | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | AGENTS | INHIBITORS | INFLAMMATORY RESPONSE | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Pyrimidines - chemical synthesis | Tumor Necrosis Factor-alpha - genetics | Thiazoles - administration & dosage | Thiazoles - therapeutic use | RNA, Messenger - metabolism | Antigens, CD - metabolism | Sepsis - drug therapy | Sepsis - metabolism | Acute Lung Injury - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Interleukin-6 - metabolism | Macrophages, Peritoneal - drug effects | Quantitative Structure-Activity Relationship | Interleukin-6 - genetics | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Mice, Inbred ICR | Animals | Pneumonia - drug therapy | Thiazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Pyrimidines - therapeutic use | Antigens, Differentiation, Myelomonocytic - metabolism | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Macrophages, Peritoneal - metabolism | Pneumonia - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Acute respiratory distress syndrome | Pyrimidines | Interleukins | Anti-inflammatory drugs | Mitogens | Analysis | Drugs | Ventilators | Antiinflammatory agents | Interleukin | Lethality | Inflammation | Derivatives | Macrophages | Drug development | Lipopolysaccharides | Interleukin 6 | Inhibitors | Synthesis | Lungs | Tumor necrosis factor | Rodents | Attenuation | Tumor necrosis factor-TNF | Peritoneum
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 758 - 777
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1013 - 1013
The front cover picture shows a series of newly discovered compounds with high inhibitory activities against lipopolysaccharide (LPS)‐induced cytokine... 
anti-inflammatory | thiazolo[3,2-a]pyrimidines | cytokines | acute lung injury | interleukins | Ventilators | Antiinflammatory agents | Cytokines | Bronchus | Inflammation | Derivatives | Bioactive | Lipopolysaccharides | Lungs | Bronchoalveolar lavage | Rodents | Sepsis | Mice | Pretreatment | Alveoli
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 17, pp. 5738 - 5751
A novel series of 1-acylthiosemicarbazides, 1,2,4-triazole-5-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones was synthesized... 
Thiosemicarbazide | Triazol | Hydrazone | Analgesic-anti-inflammatory and antimicrobial activities | Thiadiazole | 2-Benzoxazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | hydrazone | 2-benzoxazolinone | CYCLOOXYGENASE | analgesic-anti-inflammatory and antimicrobial | ACYLARYLHYDRAZONES | triazol | ACID-DERIVATIVES | IN-VITRO | thiosemicarbazide | ANTITUBERCULOSIS ACTIVITY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | activities | thiadiazole | NITRIC-OXIDE | 2-BENZOXAZOLINONE DERIVATIVES | AGENTS | ANTIFUNGAL | Analgesics - pharmacology | Triazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Anti-Bacterial Agents - chemistry | Hydrazones - therapeutic use | Semicarbazides - pharmacology | Semicarbazides - chemistry | Anti-Inflammatory Agents - therapeutic use | Triazoles - chemical synthesis | Molecular Structure | Thiadiazoles - pharmacology | Triazoles - therapeutic use | Microbial Viability - drug effects | Anti-Inflammatory Agents - pharmacology | Models, Molecular | Edema - drug therapy | Hydrazones - chemical synthesis | Semicarbazides - therapeutic use | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Semicarbazides - chemical synthesis | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzoxazoles - chemistry | Thiadiazoles - chemical synthesis | Analgesics - chemistry | Hindlimb - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Mice | Methylation | Edema - pathology
Journal Article