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1. Full Text Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases
by Gul, Waseem and Hamann, Mark T
Life Sciences, ISSN 0024-3205, 2005, Volume 78, Issue 5, pp. 442 - 453
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine... 
Indole alkaloids | Bioactive marine natural products | New drug leads | TUNICATE EUDISTOMA-OLIVACEUM | MISCELLANEOUS MECHANISMS | MEDICINE, RESEARCH & EXPERIMENTAL | indole alkaloids | BETA-CARBOLINES | BIS-INDOLE | BRYOZOAN FLUSTRA-FOLIACEA | NERVOUS SYSTEMS | ANTIVIRAL ACTIVITIES | new drug leads | ORINA SP | SPONGE | PHARMACOLOGY & PHARMACY | DEEP-WATER | bioactive marine natural products | Anti-Infective Agents - isolation & purification | Serotonin Agents - isolation & purification | Anti-Infective Agents - pharmacology | Humans | Parasitic Diseases - drug therapy | Neoplasms - prevention & control | Neuroprotective Agents - pharmacology | Antineoplastic Agents - isolation & purification | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antiparasitic Agents - isolation & purification | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Enzyme Inhibitors - pharmacology | Nervous System Diseases - drug therapy | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Biological Products - chemistry | Nervous System Diseases - prevention & control | Animals | Serotonin Agents - chemistry | Serotonin Agents - pharmacology | Neuroprotective Agents - isolation & purification | Antiparasitic Agents - pharmacology | Alkaloids - therapeutic use | Indoles - therapeutic use | Indoles - chemistry | Alkaloids - chemistry | Antiparasitic Agents - chemistry | Antimitotic agents | Alkaloids | Care and treatment | Antineoplastic agents | Cancer
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2. Full Text Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N‑(4-Methoxyphenyl)‑N,2,6-trimethyl-6,7-dihydro‑5H‑cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents
by Gangjee, Aleem and Zhao, Ying and Raghavan, Sudhir and Rohena, Cristina C and Mooberry, Susan L and Hamel, Ernest
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 17, pp. 6829 - 6844
A series of 21 substituted cyclopenta[d]pyrimidines were synthesized as an extension of our discovery of the parent compound (±)-1·HCl as an anti-microtubule... 
CELL LUNG-CANCER | COMBRETASTATIN-A4 | CHEMISTRY, MEDICINAL | VASCULAR DISRUPTING AGENTS | COLCHICINE SITE | TARGETING AGENTS | MECHANISMS | POLYMERIZATION | MULTIDRUG-RESISTANCE | EXPRESSION | III BETA-TUBULIN | Aniline Compounds - pharmacology | Humans | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Structure-Activity Relationship | Aniline Compounds - chemistry | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Pyrimidines - chemistry | Drug Screening Assays, Antitumor | tubulin | cyclopenta[d]pyrimidines | antimitotic | colchicine site
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3. Full Text Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents
by Pavana, Roheeth Kumar and Choudhary, Shruti and Bastian, Anja and Ihnat, Michael A and Bai, Ruoli and Hamel, Ernest and Gangjee, Aleem
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 2, pp. 545 - 556
The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical... 
Receptor tyrosine kinase inhibitors | Microtubule targeting agents | Combination chemotherapy | Antiangiogenic | Multitargeted agents | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DRUG-RESISTANCE | TUMOR HETEROGENEITY | CELL LUNG-CANCER | BREAST-CANCER | COLCHICINE SITE | BIOLOGICAL EVALUATION | ANGIOGENESIS INHIBITOR | ANTIANGIOGENIC AGENTS | RECEPTOR TYROSINE KINASE | ENDOTHELIAL GROWTH-FACTOR | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Microtubules - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Angiogenesis Inhibitors - chemical synthesis | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Angiogenesis Inhibitors - pharmacology | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Neovascularization, Pathologic - drug therapy | Pyrroles - chemistry | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Antimitotic agents | Amines | Antineoplastic agents | Analysis | receptor tyrosine kinase inhibitors | multitargeted agents | microtubule targeting agents | antiangiogenic | combination chemotherapy
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4. Full Text Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity—state of the art
by Grunberg, Steven M and Warr, David and Gralla, Richard J and Rapoport, Bernardo L and Hesketh, Paul J and Jordan, Karin and Espersen, Birgitte T
Supportive Care in Cancer, ISSN 0941-4355, 3/2011, Volume 19, Issue S1, pp. 43 - 47
Antiemetic drug development can follow the same logical path as antineoplastic drug development from appropriate preclinical models through Phase I, Phase II,... 
Pain Medicine | Rehabilitation Medicine | Nursing | Medicine & Public Health | Vomiting | Emetogenicity | Classification | Oncology | Nausea | Nursing Management/Nursing Research | ONCOLOGY | HEALTH CARE SCIENCES & SERVICES | REHABILITATION | Drug Administration Routes | Serotonin Antagonists - administration & dosage | Dexamethasone - administration & dosage | Drug Administration Schedule | Nausea - chemically induced | Humans | Antiemetics - administration & dosage | Clinical Trials as Topic | Vomiting - drug therapy | Nausea - prevention & control | Vomiting - chemically induced | Antineoplastic Agents - adverse effects | Antiemetics - therapeutic use | Nausea - drug therapy | Vomiting - prevention & control | Neurokinin-1 Receptor Antagonists | Practice Guidelines as Topic | Antimitotic agents | Chemotherapy | Antineoplastic agents | Analysis | Cancer | Side effects | Preventive medicine | Research & development--R&D
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5. Full Text Advances in Copper Complexes as Anticancer Agents
by Santini, Carlo and Pellei, Maura and Gandin, Valentina and Porchia, Marina and Tisato, Francesco and Marzano, Cristina
Chemical Reviews, ISSN 0009-2665, 01/2014, Volume 114, Issue 1, pp. 815 - 862
APOPTOSIS-INDUCING ACTIVITIES | MIXED-LIGAND COMPLEXES | METAL ION COMPLEXES | TOPOISOMERASE-II-ALPHA | EHRLICH ASCITES-CARCINOMA | DNA-BINDING PROPERTIES | CELL-CYCLE ARREST | SELECTIVE ANTITUMOR-ACTIVITY | IN-VITRO CYTOTOXICITY | PHOSPHATASE-LIKE ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | Neoplasms - metabolism | Quinones - chemistry | Proteasome Endopeptidase Complex - chemistry | Coordination Complexes - metabolism | Antineoplastic Agents - therapeutic use | DNA Topoisomerases - metabolism | DNA Topoisomerases - chemistry | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Coordination Complexes - therapeutic use | Pyrazoles - chemistry | Animals | Copper - chemistry | Carboxylic Acids - chemistry | Schiff Bases - chemistry | Sulfhydryl Compounds - chemistry | Proteasome Endopeptidase Complex - metabolism | Neoplasms - pathology | Indoles - chemistry | Antimitotic agents | Copper compounds | Research | Chemical properties | Antineoplastic agents | Health aspects | Schiff bases | Copper
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6. Full Text Spirooxindoles: Promising scaffolds for anticancer agents
by Yu, De-Quan and Yu, Bin and Liu, Hong-Min
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, Issue 1, pp. 673 - 698
The search for novel anticancer agents with more selectivity and lower toxicity continues to be an area of intensive investigation. The unique structural... 
Oxindole | Spirooxindoles | Synthesis | Cancer therapy | CHEMISTRY, MEDICINAL | ENANTIOSELECTIVE SYNTHESIS | SMALL-MOLECULE | CRUCIFEROUS PHYTOALEXINS | CYTOTOXIC ACTIVITY | DIVERSITY-ORIENTED SYNTHESIS | REGIOSELECTIVE SYNTHESIS | UNCARIA-TOMENTOSA | EFFICIENT CONSTRUCTION | MODIFIED STEROIDAL DIENAMIDES | STRUCTURE-BASED DESIGN | Animals | Humans | Drug Discovery - methods | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Antineoplastic Agents - chemistry | Indoles - chemistry | Spiro Compounds - chemistry | Antimitotic agents | Care and treatment | Analysis | Drug discovery | Tumor proteins | Antineoplastic agents | Cancer
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7. Full Text Sponging off nature for new drug leads
by Andersen, Raymond J
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
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8. Full Text Caffeine-Based Gold(I) N‑Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties
by Bertrand, Benoît and Stefan, Loic and Pirrotta, Marc and Monchaud, David and Bodio, Ewen and Richard, Philippe and Le Gendre, Pierre and Warmerdam, Elena and de Jager, Marina H and Groothuis, Geny M.M and Picquet, Michel and Casini, Angela
Inorganic Chemistry, ISSN 0020-1669, 02/2014, Volume 53, Issue 4, pp. 2296 - 2303
A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, and... 
DNA STRUCTURES | RNA G-QUADRUPLEXES | LIGANDS | CHEMISTRY | STRUCTURAL-CHARACTERIZATION | SILVER(I) | INHIBITORS | CANCER | METAL-COMPLEXES | MOLECULAR-MECHANISMS | CHEMISTRY, INORGANIC & NUCLEAR | Gold - chemistry | Cell Line | Methane - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Xanthine - chemistry | Antineoplastic Agents - chemistry | Animals | Heterocyclic Compounds - chemistry | Caffeine - chemistry | Cell Line, Tumor | Inhibitory Concentration 50 | Ligands | Methane - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Antimitotic agents | Gold compounds | Antineoplastic agents | Carbenes | Analysis | Electric properties | Index Medicus | Inorganic chemistry | Chemical Sciences
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9. Full Text Apoptins: selective anticancer agents
by Rollano Peñaloza, Oscar M and Lewandowska, Magdalena and Stetefeld, Joerg and Ossysek, Karolina and Madej, Mariusz and Bereta, Joanna and Sobczak, Mateusz and Shojaei, Shahla and Ghavami, Saeid and Łos, Marek J and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Hälsouniversitetet and Avdelningen för cellbiologi
Trends in Molecular Medicine, ISSN 1471-4914, 2014, Volume 20, Issue 9, pp. 519 - 528
Highlights • Apoptins are viral proteins that trigger cell death. • Apoptins show cancer-selective toxicity. • Potential delivery methods are being assayed for... 
Pathology | anaphase-promoting complex | protein phosphatase 2A | protein kinase C | CDK2 | anticancer agents | Protein kinase C | Anticancer agents | Anaphase-promoting complex | Protein phosphatase 2A | NEWCASTLE-DISEASE-VIRUS | MEDICINE, RESEARCH & EXPERIMENTAL | CHICKEN ANEMIA VIRUS | ATTENUATED SALMONELLA-TYPHIMURIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONCOLYTIC VIRUS | CELL-DEATH | CELL BIOLOGY | NUCLEAR-LOCALIZATION | IN-VITRO | HEPATOCELLULAR-CARCINOMA | HUMAN GYROVIRUS | ADENOVIRUS EXPRESSING APOPTIN | Apoptosis - drug effects | Humans | Chicken anemia virus - chemistry | Antineoplastic Agents - administration & dosage | Gyrovirus - chemistry | Animals | Capsid Proteins - physiology | Viral Proteins - isolation & purification | Viral Proteins - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Drug Delivery Systems - methods | Capsid Proteins - pharmacology | Proteins | Antimitotic agents | Medical colleges | Care and treatment | Antineoplastic agents | Cells | Cancer | Basic Medicine | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cancer and Oncology | Klinisk medicin | Cell- och molekylärbiologi | anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A | Cancer och onkologi
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10. Full Text In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents
by Denoyelle, Séverine and Chen, Limo and Chen, Ting and Wang, Yibo and Klosi, Edvin and Halperin, José A and Aktas, Bertal H and Chorev, Michael
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 1, pp. 402 - 409
Structure–activity relationship study on , ′-diarylureas, potential anti-cancer drugs capable of inhibiting the translation initiation of mRNA in cancer cells... 
Phosphorylation of eIF2α | SAR study | N,N′-Diarylureas | Ternary complex | Inhibition of translation initiation | Anti-cancer drugs | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | KINASE INHIBITORS | CELL-GROWTH | CXCR2 CHEMOKINE RECEPTOR | DISCOVERY | POTENT | N,N '-Diarylureas | BIOLOGICAL EVALUATION | ANTAGONISTS | DERIVATIVES | EXPRESSION | Phosphorylation of eIF2 alpha | STRUCTURE-BASED DESIGN | Phosphorylation | Cell Proliferation | Chemistry, Pharmaceutical - methods | Models, Chemical | Eukaryotic Initiation Factor-2 - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Transcription Factor CHOP - chemistry | RNA, Messenger - metabolism | Urea - chemistry | Animals | RNA, Transfer, Met - chemistry | Transfection | Drug Design | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Mice | In Vitro Techniques | Genes, Reporter | Prevention | Antimitotic agents | Care and treatment | Antineoplastic agents | Cancer | Transfer RNA | Index Medicus | N,N’-diarylureas | anti-cancer drugs | inhibition of translation initiation | ternary complex | phosphorylation of eIF2α
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11. Full Text Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure–activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents
by Wei, Linyi and Brossi, Arnold and Kendall, Ross and Bastow, Kenneth F and Morris-Natschke, Susan L and Shi, Qian and Lee, Kuo-Hsiung
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2006, Volume 14, Issue 19, pp. 6560 - 6569
In a series of polar phenanthrene-based tylophorine derivatives (PBTs), -(2,3-methylenedioxy-6-methoxy-phenanthr-9-ylmethyl)- -2-piperidinemethanol ( ) and... 
Cytotoxicity | Antitumor agents | Phenanthrene-based tylophorine derivatives | Tylophora | PHENANTHROINDOLIZIDINE ALKALOIDS PERGULARININE | CHEMISTRY, MEDICINAL | CYNANCHUM-VINCETOXICUM | CRYPTOPLEURINE | phenanthrene-based tylophorine derivatives | THYMIDYLATE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODE | CHEMISTRY, ORGANIC | CELL-GROWTH | PROTEIN-SYNTHESIS | TYLOCREBRINE | antitumor agents | RESISTANT | INHIBITION | cytotoxicity | Lung Neoplasms - drug therapy | Alkaloids - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Magnetic Resonance Spectroscopy | Humans | Alkaloids - chemical synthesis | Indolizines - chemical synthesis | Structure-Activity Relationship | Dose-Response Relationship, Drug | Phenanthrenes - pharmacology | Phenanthrenes - chemical synthesis | Spectrometry, Mass, Electrospray Ionization | Drug Design | Cell Line, Tumor | Indicators and Reagents | Antineoplastic Agents, Phytogenic - pharmacology | Indolizines - pharmacology | Drug Screening Assays, Antitumor | Antimitotic agents | Care and treatment | Antineoplastic agents | Cancer
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12. Full Text Selective inhibitors of nuclear export (SINE)-A novel class of anti-cancer agents
by Parikh, Kaushal and Parikh, Kaushal and Cang, Shundong and Cang, Shundong and Sekhri, Arunabh and Sekhri, Arunabh and Liu, Delong and Liu, Delong
Journal of hematology & oncology, ISSN 1756-8722, 2014, Volume 7, Issue 1, pp. 78 - 78
Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity... 
KPT-330 | Sine | Selinexor | Nuclear export | MULTIPLE-MYELOMA | MANTLE-CELL LYMPHOMA | IMPROVED SURVIVAL | SINE | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | LUNG-CANCER | ONCOLOGY | RECEPTOR SIGNALING PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | NUCLEOCYTOPLASMIC TRANSPORT | Antineoplastic Agents - pharmacology | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Humans | Neoplasms - drug therapy | Antimitotic agents | Carrier proteins | Antineoplastic agents | Exports | Leukemia | Clinical trials | Breast cancer | Kinases | Proteins | Cell growth | Hospitals | Medical prognosis | Pancreatic cancer | Cell cycle | Pancreas | Drug dosages | Cytoplasm | Apoptosis | Index Medicus
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