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Life Sciences, ISSN 0024-3205, 2005, Volume 78, Issue 5, pp. 442 - 453
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine... 
Indole alkaloids | Bioactive marine natural products | New drug leads | TUNICATE EUDISTOMA-OLIVACEUM | MISCELLANEOUS MECHANISMS | MEDICINE, RESEARCH & EXPERIMENTAL | indole alkaloids | BETA-CARBOLINES | BIS-INDOLE | BRYOZOAN FLUSTRA-FOLIACEA | NERVOUS SYSTEMS | ANTIVIRAL ACTIVITIES | new drug leads | ORINA SP | SPONGE | PHARMACOLOGY & PHARMACY | DEEP-WATER | bioactive marine natural products | Anti-Infective Agents - isolation & purification | Serotonin Agents - isolation & purification | Anti-Infective Agents - pharmacology | Humans | Parasitic Diseases - drug therapy | Neoplasms - prevention & control | Neuroprotective Agents - pharmacology | Antineoplastic Agents - isolation & purification | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antiparasitic Agents - isolation & purification | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Enzyme Inhibitors - pharmacology | Nervous System Diseases - drug therapy | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Biological Products - chemistry | Nervous System Diseases - prevention & control | Animals | Serotonin Agents - chemistry | Serotonin Agents - pharmacology | Neuroprotective Agents - isolation & purification | Antiparasitic Agents - pharmacology | Alkaloids - therapeutic use | Indoles - therapeutic use | Indoles - chemistry | Alkaloids - chemistry | Antiparasitic Agents - chemistry | Antimitotic agents | Alkaloids | Care and treatment | Antineoplastic agents | Cancer
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 2, pp. 545 - 556
The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical... 
Receptor tyrosine kinase inhibitors | Microtubule targeting agents | Combination chemotherapy | Antiangiogenic | Multitargeted agents | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DRUG-RESISTANCE | TUMOR HETEROGENEITY | CELL LUNG-CANCER | BREAST-CANCER | COLCHICINE SITE | BIOLOGICAL EVALUATION | ANGIOGENESIS INHIBITOR | ANTIANGIOGENIC AGENTS | RECEPTOR TYROSINE KINASE | ENDOTHELIAL GROWTH-FACTOR | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Microtubules - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Angiogenesis Inhibitors - chemical synthesis | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Angiogenesis Inhibitors - pharmacology | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Neovascularization, Pathologic - drug therapy | Pyrroles - chemistry | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Antimitotic agents | Amines | Antineoplastic agents | Analysis | receptor tyrosine kinase inhibitors | multitargeted agents | microtubule targeting agents | antiangiogenic | combination chemotherapy
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
Journal Article
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2014, Volume 20, Issue 9, pp. 519 - 528
Highlights • Apoptins are viral proteins that trigger cell death. • Apoptins show cancer-selective toxicity. • Potential delivery methods are being assayed for... 
Pathology | anaphase-promoting complex | protein phosphatase 2A | protein kinase C | CDK2 | anticancer agents | Protein kinase C | Anticancer agents | Anaphase-promoting complex | Protein phosphatase 2A | NEWCASTLE-DISEASE-VIRUS | MEDICINE, RESEARCH & EXPERIMENTAL | CHICKEN ANEMIA VIRUS | ATTENUATED SALMONELLA-TYPHIMURIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONCOLYTIC VIRUS | CELL-DEATH | CELL BIOLOGY | NUCLEAR-LOCALIZATION | IN-VITRO | HEPATOCELLULAR-CARCINOMA | HUMAN GYROVIRUS | ADENOVIRUS EXPRESSING APOPTIN | Apoptosis - drug effects | Humans | Chicken anemia virus - chemistry | Antineoplastic Agents - administration & dosage | Gyrovirus - chemistry | Animals | Capsid Proteins - physiology | Viral Proteins - isolation & purification | Viral Proteins - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Drug Delivery Systems - methods | Capsid Proteins - pharmacology | Proteins | Antimitotic agents | Medical colleges | Care and treatment | Antineoplastic agents | Cells | Cancer | Basic Medicine | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cancer and Oncology | Klinisk medicin | Cell- och molekylärbiologi | anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A | Cancer och onkologi
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 1, pp. 402 - 409
Journal Article
Journal Article