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Journal of Clinical Investigation, ISSN 0021-9738, 02/2014, Volume 124, Issue 2, pp. 592 - 603
Journal Article
PHARMACOLOGICAL REVIEWS, ISSN 0031-6997, 01/2013, Volume 65, Issue 1, pp. 223 - 254
Morphine and related m-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating... 
BETA-ARRESTIN 2 | PERIAQUEDUCTAL GRAY NEURONS | TERMINAL SPLICE VARIANTS | AGONIST-SELECTIVE MECHANISMS | MORPHINE ANTINOCICEPTIVE TOLERANCE | BASAL SIGNALING ACTIVITY | PHARMACOLOGY & PHARMACY | RAT LOCUS-COERULEUS | SINGLE-NUCLEOTIDE POLYMORPHISM | PROTEIN-COUPLED-RECEPTOR | PHOSPHOLIPASE-D ACTIVATION
Journal Article
Medical Clinics of North America, ISSN 0025-7125, 03/2007, Volume 91, Issue 2, pp. 199 - 211
Journal Article
PHARMACOLOGICAL REVIEWS, ISSN 0031-6997, 12/2011, Volume 63, Issue 4, pp. 1001 - 1019
Opioids are the most effective analgesic drugs for the management of moderate or severe pain, yet their clinical use is often limited because of the onset of... 
BETA-ARRESTIN 2 | CLATHRIN-MEDIATED ENDOCYTOSIS | PROTEIN-KINASE-C | TERMINAL SPLICE VARIANTS | MORPHINE ANTINOCICEPTIVE TOLERANCE | IN-VIVO | COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | RAT LOCUS-COERULEUS | AGONIST-SPECIFIC REGULATION | SEROTONIN 2A RECEPTOR
Journal Article
Journal Article
Pain, ISSN 0304-3959, 2010, Volume 151, Issue 1, pp. 194 - 205
Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive... 
Calcitonin gene-related peptide | Morphine tolerance | Astrocyte | Transcription factor | N-methyl- d-aspartate receptor | Microglia | N-methyl-d-aspartate receptor | NMDA RECEPTOR | ACTIVATED PROTEIN-KINASE | INTRATHECAL MORPHINE | PRIMARY AFFERENT-FIBERS | SERINE PHOSPHORYLATION | NEUROSCIENCES | CLINICAL NEUROLOGY | GLUTAMATE TRANSPORTERS | INDUCED HYPERALGESIA | N-methyl-D-aspartate receptor | ANESTHESIOLOGY | SPINAL-CORD-INJURY | NF-KAPPA-B | ANTINOCICEPTIVE TOLERANCE | Spinal Cord - drug effects | Spinal Cord - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Drug Tolerance - physiology | Male | Dose-Response Relationship, Drug | CREB-Binding Protein - metabolism | Drug Interactions | Calcitonin Gene-Related Peptide - antagonists & inhibitors | Calcitonin Gene-Related Peptide - agonists | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Spinal Cord - cytology | Calcitonin Gene-Related Peptide - metabolism | Protein-Serine-Threonine Kinases - metabolism | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Enzyme Inhibitors - pharmacology | Rats | Receptor Activity-Modifying Protein 1 - metabolism | Pain Measurement - drug effects | Calcitonin Receptor-Like Protein - metabolism | Piperazines - pharmacology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Analysis of Variance | Signal Transduction - drug effects | Analgesics, Opioid - administration & dosage | Signal Transduction - physiology | Physical Stimulation - adverse effects | Quinazolines - pharmacology | Morphine - administration & dosage
Journal Article