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1. Full Text Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship
by Boumendjel, Ahcène and Boccard, Julien and Carrupt, Pierre-Alain and Nicolle, Edwige and Blanc, Madeleine and Geze, Annabelle and Choisnard, Luc and Wouessidjewe, Denis and Matera, Eva-Laure and Dumontet, Charles
Journal of medicinal chemistry, ISSN 0022-2623, 04/2008, Volume 51, Issue 7, pp. 2307 - 2310
Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Cell Survival - drug effects | Chalcones - chemistry | Antimitotic Agents - toxicity | Stereoisomerism | Humans | Survival Rate | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Antineoplastic Agents - toxicity | Animals | Chalcones - toxicity | Drug-Related Side Effects and Adverse Reactions | Chalcones - pharmacology | Cell Line, Tumor | Antimitotic Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Structure | Cell Cycle - drug effects | Antimitotic Agents - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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2. Full Text Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: Structure-activity relationship
by Shenvi, Suvarna and Kumar, Krishna and Hatti, Kaushik S and Rijesh, K and Diwakar, Latha and Reddy, G. Chandrasekara
European journal of medicinal chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 435 - 442
Flavonols | Chalcones | In-silico | Flavones | Anticancer | Antioxidant | Cell Survival - drug effects | Chalcones - chemistry | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Chalcones - chemical synthesis | MCF-7 Cells | Chalcones - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | HeLa Cells | Aldehydes - chemistry | Drug Screening Assays, Antitumor | Antioxidants | Care and treatment | Hydrazine | Analysis | Cancer | Flavonoids | Bioflavonoids | Index Medicus
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3. Full Text Cytotoxic Activity and Structure–Activity Relationship of Triazole‐Containing Bis(Aryl Ether) Macrocycles
by Hernández‐Vázquez, Eduardo and Chávez‐Riveros, Alejandra and Romo‐Pérez, Adriana and Ramírez‐Apán, María Teresa and Chávez‐Blanco, Alma D and Morales‐Bárcenas, Rocío and Dueñas‐González, Alfonso and Miranda, Luis D
ChemMedChem, ISSN 1860-7179, 06/2018, Volume 13, Issue 12, pp. 1193 - 1209
multicomponent reactions | apoptosis | cancer | macrocycles | cytotoxicity | Ethers - chemical synthesis | Macrocyclic Compounds - chemistry | Apoptosis - drug effects | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Ethers - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Macrocyclic Compounds - chemical synthesis | Macrocyclic Compounds - pharmacology | Dose-Response Relationship, Drug | Ethers - pharmacology | Triazoles - pharmacology | Cell Line, Tumor | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Drug Screening Assays, Antitumor | Triazoles | Aromatic compounds | Toxicity | Cytotoxicity | Breast cancer | Substrates | Aliphatic compounds | Molecular chains | Apoptosis | Cancer | Index Medicus
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4. Full Text Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids
by Kraljević, Tatjana Gazivoda and Harej, Anja and Sedić, Mirela and Pavelić, Sandra Kraljević and Stepanić, Višnja and Drenjančević, Domagoj and Talapko, Jasminka and Raić-Malić, Silvana
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 794 - 808
Antibacterial activity | Acid ceramidase (ASAH) | Click chemistry | 1,2,3-triazole–coumarin hybrids | Cytostatic activity | 5-Lipoxygenase (5-LO) | Chemistry Techniques, Synthetic | Apoptosis - drug effects | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Coumarins - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Coumarins - pharmacology | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Computer Simulation | Coumarins - chemical synthesis | Drug Design | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Triazoles | Cell death | Antibacterial agents | Analysis | Index Medicus
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5. Full Text Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
by Cardoso, Marcos Veríssimo de Oliveira and Moreira, Diogo Rodrigo Magalhães and Filho, Gevanio Bezerra Oliveira and Cavalcanti, Suellen Melo Tiburcio and Coelho, Lucas Cunha Duarte and Espíndola, José Wanderlan Pontes and Gonzalez, Laura Rubio and Rabello, Marcelo Montenegro and Hernandes, Marcelo Zaldini and Ferreira, Paulo Michel Pinheiro and Pessoa, Cláudia and Alberto de Simone, Carlos and Guimarães, Elisalva Teixeira and Soares, Milena Botelho Pereira and Leite, Ana Cristina Lima
European journal of medicinal chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
Antiproliferative | Immunosuppressive | Phthalimide | Thiosemicarbazone | Thiazolidinone | Thiazole | Immunomodulation | Antineoplastic Agents - chemical synthesis | Cytokines - analysis | Humans | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Male | Phthalimides - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Lymphocytes - drug effects | Drug Design | Macrophages - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Drug Screening Assays, Antitumor | Prevention | Cancer | Index Medicus
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6. Full Text Biological activities of chitosan and chitooligosaccharides
by Xia, Wenshui and Liu, Ping and Zhang, Jiali and Chen, Jie
Food hydrocolloids, ISSN 0268-005X, 2011, Volume 25, Issue 2, pp. 170 - 179
Antimicrobial | Hypocholesterolemic | Biological activities | Chitosan | Chitooligosaccharides | Antitumor | Food Science & Technology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Science & Technology | Biomedical materials | Calcium | Iron | Biological | Derivatives | Foods | Oligosaccharides
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7. Full Text Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
by Topalian, Suzanne L and Hodi, F. Stephen and Brahmer, Julie R and Gettinger, Scott N and Smith, David C and McDermott, David F and Powderly, John D and Carvajal, Richard D and Sosman, Jeffrey A and Atkins, Michael B and Leming, Philip D and Spigel, David R and Antonia, Scott J and Horn, Leora and Drake, Charles G and Pardoll, Drew M and Chen, Lieping and Sharfman, William H and Anders, Robert A and Taube, Janis M and McMiller, Tracee L and Xu, Haiying and Korman, Alan J and Jure-Kunkel, Maria and Agrawal, Shruti and McDonald, Daniel and Kollia, Georgia D and Gupta, Ashok and Wigginton, Jon M and Sznol, Mario
The New England journal of medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2443 - 2454
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Melanoma - drug therapy | Adult | Female | Ligands | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Carcinoma, Renal Cell - drug therapy | Prostatic Neoplasms - drug therapy | Drugs | Dose-response relationship (Biochemistry) | Immune response | Anti-antibodies | Dosage and administration | Product/Service Evaluations | Regulation | Research | Drug therapy | Cancer | Fees & charges | Kidneys | Stock options | PD-1 protein | Laboratories | Toxicity | Tumor cells | Body weight | Lung cancer | Colorectal carcinoma | Colorectal cancer | Melanoma | Licenses | Lymphocytes T | Patients | Castration | PD-L1 protein | Antitumor activity | Prostate cancer | Drug dosages | Prostate | Clear cell-type renal cell carcinoma | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus
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8. Full Text Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
by Brahmer, Julie R and Tykodi, Scott S and Chow, Laura Q.M and Hwu, Wen-Jen and Hwu, Patrick and Topalian, Suzanne L and Drake, Charles G and Camacho, Luis H and Kauh, John and Odunsi, Kunle and Pitot, Henry C and Hamid, Omid and Bhatia, Shailender and Martins, Renato and Eaton, Keith and Chen, Shuming and Salay, Theresa M and Alaparthy, Suresh and Grosso, Joseph F and Korman, Alan J and Parker, Susan M and Agrawal, Shruti and Goldberg, Stacie M and Pardoll, Drew M and Gupta, Ashok and Wigginton, Jon M
The New England journal of medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2455 - 2465
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Neoplasms - metabolism | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Female | Carcinoma, Renal Cell - drug therapy | Ovarian Neoplasms - drug therapy | Programmed Cell Death 1 Receptor - metabolism | Stomach Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Antibodies, Monoclonal - administration & dosage | Melanoma - drug therapy | Nivolumab | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Intravenous administration | Kidneys | Immune response | Disease | PD-1 protein | Tumor cells | Colorectal carcinoma | Body weight | Melanoma | Lymphocytes T | Breast cancer | Stomach cancer | Patients | Ovarian cancer | Lungs | Pancreatic cancer | PD-L1 protein | Antitumor activity | Ligands | Autoimmune diseases | Gastric cancer | Clear cell-type renal cell carcinoma | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
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9. Full Text Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1‐6 hepatocellular carcinoma model
by Kimura, Takayuki and Kato, Yu and Ozawa, Yoichi and Kodama, Kotaro and Ito, Junichi and Ichikawa, Kenji and Yamada, Kazuhiko and Hori, Yusaku and Tabata, Kimiyo and Takase, Kazuma and Matsui, Junji and Funahashi, Yasuhiro and Nomoto, Kenichi
Cancer science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 3993 - 4002
lenvatinib | sorafenib | immunomodulatory activity | anti‐PD‐1 antibody | hepatocellular carcinoma | anti-PD-1 antibody | Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Agents, Immunological - administration & dosage | CD8-Positive T-Lymphocytes - cytology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - administration & dosage | Quinolines - administration & dosage | Quinolines - pharmacology | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - immunology | Immunocompetence | Single-Cell Analysis | Cell Survival - drug effects | Sorafenib - administration & dosage | Liver Neoplasms - genetics | Immunomodulation | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Sorafenib - pharmacology | Antineoplastic Agents, Immunological - pharmacology | Xenograft Model Antitumor Assays | Animals | Sequence Analysis, RNA | Phenylurea Compounds - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Viral antibodies | Antimitotic agents | RNA sequencing | Cell death | Analysis | Antibodies | Hepatoma | Antineoplastic agents | T cells | Growth factors | Fibroblast growth factor | Laboratories | CD8 antigen | Clinical trials | Hepatocellular carcinoma | Lymphocytes T | Metastasis | Kinases | Macrophages | Cancer therapies | Liver cancer | Ret protein | Lymphocytes | Protein-tyrosine kinase receptors | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Protein-tyrosine kinase | Tyrosine | Mortality | Immunodeficiency | Ribonucleic acid--RNA | Monocytes | Thyroid cancer | Immune checkpoint | Response rates | Antitumor activity | Angiogenesis inhibitors | Apoptosis | Tumors | Index Medicus | Original
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