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Journal of medicinal chemistry, ISSN 0022-2623, 04/2008, Volume 51, Issue 7, pp. 2307 - 2310
Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Cell Survival - drug effects | Chalcones - chemistry | Antimitotic Agents - toxicity | Stereoisomerism | Humans | Survival Rate | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Antineoplastic Agents - toxicity | Animals | Chalcones - toxicity | Drug-Related Side Effects and Adverse Reactions | Chalcones - pharmacology | Cell Line, Tumor | Antimitotic Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Structure | Cell Cycle - drug effects | Antimitotic Agents - chemistry | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 435 - 442
Flavonols | Chalcones | In-silico | Flavones | Anticancer | Antioxidant | Cell Survival - drug effects | Chalcones - chemistry | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Chalcones - chemical synthesis | MCF-7 Cells | Chalcones - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | HeLa Cells | Aldehydes - chemistry | Drug Screening Assays, Antitumor | Antioxidants | Care and treatment | Hydrazine | Analysis | Cancer | Flavonoids | Bioflavonoids | Index Medicus
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2018, Volume 13, Issue 12, pp. 1193 - 1209
multicomponent reactions | apoptosis | cancer | macrocycles | cytotoxicity | Ethers - chemical synthesis | Macrocyclic Compounds - chemistry | Apoptosis - drug effects | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Ethers - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Macrocyclic Compounds - chemical synthesis | Macrocyclic Compounds - pharmacology | Dose-Response Relationship, Drug | Ethers - pharmacology | Triazoles - pharmacology | Cell Line, Tumor | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Drug Screening Assays, Antitumor | Triazoles | Aromatic compounds | Toxicity | Cytotoxicity | Breast cancer | Substrates | Aliphatic compounds | Molecular chains | Apoptosis | Cancer | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 794 - 808
Antibacterial activity | Acid ceramidase (ASAH) | Click chemistry | 1,2,3-triazole–coumarin hybrids | Cytostatic activity | 5-Lipoxygenase (5-LO) | Chemistry Techniques, Synthetic | Apoptosis - drug effects | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Coumarins - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Coumarins - pharmacology | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Computer Simulation | Coumarins - chemical synthesis | Drug Design | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Triazoles | Cell death | Antibacterial agents | Analysis | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
Antiproliferative | Immunosuppressive | Phthalimide | Thiosemicarbazone | Thiazolidinone | Thiazole | Immunomodulation | Antineoplastic Agents - chemical synthesis | Cytokines - analysis | Humans | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Male | Phthalimides - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Lymphocytes - drug effects | Drug Design | Macrophages - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Drug Screening Assays, Antitumor | Prevention | Cancer | Index Medicus
Journal Article
Food hydrocolloids, ISSN 0268-005X, 2011, Volume 25, Issue 2, pp. 170 - 179
Antimicrobial | Hypocholesterolemic | Biological activities | Chitosan | Chitooligosaccharides | Antitumor | Food Science & Technology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Science & Technology | Biomedical materials | Calcium | Iron | Biological | Derivatives | Foods | Oligosaccharides
Journal Article
The New England journal of medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2443 - 2454
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Melanoma - drug therapy | Adult | Female | Ligands | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Carcinoma, Renal Cell - drug therapy | Prostatic Neoplasms - drug therapy | Drugs | Dose-response relationship (Biochemistry) | Immune response | Anti-antibodies | Dosage and administration | Product/Service Evaluations | Regulation | Research | Drug therapy | Cancer | Fees & charges | Kidneys | Stock options | PD-1 protein | Laboratories | Toxicity | Tumor cells | Body weight | Lung cancer | Colorectal carcinoma | Colorectal cancer | Melanoma | Licenses | Lymphocytes T | Patients | Castration | PD-L1 protein | Antitumor activity | Prostate cancer | Drug dosages | Prostate | Clear cell-type renal cell carcinoma | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2455 - 2465
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Neoplasms - metabolism | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Female | Carcinoma, Renal Cell - drug therapy | Ovarian Neoplasms - drug therapy | Programmed Cell Death 1 Receptor - metabolism | Stomach Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Antibodies, Monoclonal - administration & dosage | Melanoma - drug therapy | Nivolumab | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Intravenous administration | Kidneys | Immune response | Disease | PD-1 protein | Tumor cells | Colorectal carcinoma | Body weight | Melanoma | Lymphocytes T | Breast cancer | Stomach cancer | Patients | Ovarian cancer | Lungs | Pancreatic cancer | PD-L1 protein | Antitumor activity | Ligands | Autoimmune diseases | Gastric cancer | Clear cell-type renal cell carcinoma | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 3993 - 4002
lenvatinib | sorafenib | immunomodulatory activity | anti‐PD‐1 antibody | hepatocellular carcinoma | anti-PD-1 antibody | Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Agents, Immunological - administration & dosage | CD8-Positive T-Lymphocytes - cytology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - administration & dosage | Quinolines - administration & dosage | Quinolines - pharmacology | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - immunology | Immunocompetence | Single-Cell Analysis | Cell Survival - drug effects | Sorafenib - administration & dosage | Liver Neoplasms - genetics | Immunomodulation | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Sorafenib - pharmacology | Antineoplastic Agents, Immunological - pharmacology | Xenograft Model Antitumor Assays | Animals | Sequence Analysis, RNA | Phenylurea Compounds - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Viral antibodies | Antimitotic agents | RNA sequencing | Cell death | Analysis | Antibodies | Hepatoma | Antineoplastic agents | T cells | Growth factors | Fibroblast growth factor | Laboratories | CD8 antigen | Clinical trials | Hepatocellular carcinoma | Lymphocytes T | Metastasis | Kinases | Macrophages | Cancer therapies | Liver cancer | Ret protein | Lymphocytes | Protein-tyrosine kinase receptors | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Protein-tyrosine kinase | Tyrosine | Mortality | Immunodeficiency | Ribonucleic acid--RNA | Monocytes | Thyroid cancer | Immune checkpoint | Response rates | Antitumor activity | Angiogenesis inhibitors | Apoptosis | Tumors | Index Medicus | Original
Journal Article