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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2019, Volume 29, Issue 21, p. 126679
Searching for CNS active cyclic amines derivatives containing heterocyclic xanthone core we designed and synthesized a set of fourteen novel 2- or... 
Antidepressant-like activity | Anxiolytic-like activity | Xanthone | Piperazine derivatives
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 07/2019, Volume 367, pp. 28 - 34
Neuropeptide S (NPS) has shown anxiolytic-like effects in rodents after acute administration, but its long-term effects remain unknown. Gene therapy enables... 
Depression | Adeno-associated virus | Anxiety | Neuropeptide S | AROUSAL | DISORDERS | NEUROSCIENCES | ANXIOLYTIC-LIKE | NEURONS | BEHAVIORAL SCIENCES | EXPRESSION | VECTORS | BRAIN
Journal Article
AMERICAN JOURNAL OF PSYCHIATRY, ISSN 0002-953X, 02/2004, Volume 161, Issue 2, pp. 195 - 216
Objective: Most research on the effects of severe psychological stress has focused on stress-related psychopathology. Here, the author develops... 
CORTICOTROPIN-RELEASING HORMONE | PITUITARY-ADRENAL REGULATION | MESSENGER-RNA EXPRESSION | PSYCHIATRY | MEDIAL PREFRONTAL CORTEX | OVEREXPRESSING TRANSGENIC MICE | FEAR-POTENTIATED STARTLE | SOCIAL-INTERACTION TEST | LONG-TERM POTENTIATION | ANXIETY-LIKE BEHAVIOR | ANXIOLYTIC-LIKE ACTION
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 06/2012, Volume 141, Issue 3, pp. 872 - 877
Ethnopharmacological relevance: Medicinal applications of Pimenta pseudocaryophyllus infusion as a diuretic and aphrodisiac agent as well as tranquilizer in... 
(E)-methyl-isoeugenol | Anxiolytic-like effect | Pimenta pseudocaryophyllus | Oleanolic acid
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 117 - 124
The work describes a discovery of new chemical family of potent ligands for the 5-HT serotonin receptors. During the search for new histamine H receptor... 
5-HT6 ligands | Docking | CNS drugability | 1,3,5-Triazine | Serotonin receptors | ligands | 5-HT | ADRENOCEPTOR | ANTIDEPRESSANT | CHEMISTRY, MEDICINAL | RATS | FORCED SWIMMING TEST | AGONISTS | POTENT | AFFINITY | ANXIOLYTIC-LIKE | SB-399885 | ANTAGONISTS
Journal Article
Journal Article
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 12/2012, Volume 367, Issue 1607, pp. 3364 - 3378
Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main... 
Receptors | Animal models | Cannabis | Serotonin receptors | Rats | Schizophrenia | Antipsychotic agents | Agonists | Dosage | Antianxiety agents | Psychosis | Cannabidiol | Depression | Anxiety | Serotonin | Anandamide | CARDIOVASCULAR-RESPONSES | PREPULSE INHIBITION | ENDOCANNABINOID SYSTEM | ADULT HIPPOCAMPAL NEUROGENESIS | psychosis | cannabidiol | anxiety | serotonin | DORSOLATERAL PERIAQUEDUCTAL GRAY | CANNABINOID RECEPTOR | NEURAL-BASIS | STRIA TERMINALIS | ANXIOLYTIC-LIKE | BIOLOGY | depression | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER | anandamide | Endocannabinoids - metabolism | Humans | Anti-Anxiety Agents - pharmacology | Cannabidiol - pharmacology | Clinical Trials as Topic | Polyunsaturated Alkamides - metabolism | Neurogenesis | Synaptic Transmission | Dose-Response Relationship, Drug | Psychotic Disorders - metabolism | Depression - drug therapy | Receptor, Cannabinoid, CB1 - metabolism | TRPV Cation Channels - metabolism | Arachidonic Acids - metabolism | Animals | Antidepressive Agents - pharmacology | Anxiety Disorders - metabolism | Psychotic Disorders - drug therapy | Anxiety Disorders - drug therapy | Phytotherapy | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorders | Neurotransmitters | Literature Review | Anxiety Disorders | Neuroanatomy | Drug Therapy | Hallucinogenic Drugs | Psychotic Disorders | Psychiatric Disorders | Animal Models | 133 | Review
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2018, Volume 819, pp. 270 - 280
In patients with epilepsy, anxiety and depression are the most frequent psychiatric comorbidities but they often remain unrecognized and untreated. We report... 
Anticonvulsant | Antidepressant-like | Voltage-gated sodium channels | N-propyl-2,2-diphenyl-2-hydroxyacetamide | Anxiolytic-like | DEPRESSION | TRIMETHADIONE | ANXIETY | RATS | PHENYTOIN | DRUG DEVELOPMENT | TARGETS | PHARMACOLOGY & PHARMACY | EPILEPSY | NEUROBIOLOGY | BEHAVIORS
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2014, Volume 111, Issue 19, pp. 7138 - 7143
The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems. It is a modulator of various physiological and pathological... 
ECCRINE SWEAT GLAND | MULTIDISCIPLINARY SCIENCES | BRAIN GALANIN SYSTEM | KNOCKOUT MICE | ELEVATED PLUS-MAZE | Gcat variant 2 | galanin receptor | NEUROPEPTIDE-Y | serotonin | DEPRESSION-LIKE BEHAVIOR | ANXIOLYTIC-LIKE | OVEREXPRESSING MICE | STRESS | TRANSGENIC MICE
Journal Article
Journal of Neuroendocrinology, ISSN 0953-8194, 04/2012, Volume 24, Issue 4, pp. 609 - 628
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 09/2019, Volume 370, pp. 111961 - 111961
The immunologic modulation of glutamate (Glu) neurotransmission is a topic of great interest. Neuroinflammation is an intrinsic component of neurodegenerative... 
Mice | Social interactions | Modified Barnes maze | TST | COX-2 | mGluR5 | INDUCIBLE CYCLOOXYGENASE | PROTEIN-KINASE | HIPPOCAMPAL | METABOTROPIC GLUTAMATE RECEPTORS | NEUROSCIENCES | MEMORY | ANXIOLYTIC-LIKE | BEHAVIORAL SCIENCES | LONG-TERM POTENTIATION | ANTAGONISTS | STRESS-INDUCED HYPERTHERMIA
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4
Improper neuroimmune responses following chronic stress exposure have been reported to cause neuronal dysfunctions leading to memory impairment, anxiety and... 
INDUCED MEMORY IMPAIRMENT | ANTIDEPRESSANT-LIKE | INHIBITION | RAT | MICROGLIA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | ANXIOLYTIC-LIKE | MAJOR DEPRESSION | PLUS-MAZE | PARKINSONS-DISEASE
Journal Article