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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2017, Volume 37, Issue 2, pp. 258 - 263
Objective-To create a model of atherosclerosis using green fluorescent protein (GFP)-targeted monocytes/macrophages, allowing analysis of both endogenous... 
atherosclerosis | GFP | mouse | macrophage | monocyte | model | trafficking | CELLS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | CCR2 | Macrophages - transplantation | Aortic Aneurysm - metabolism | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Cell Tracking - methods | Galectin 3 - metabolism | Male | Monocytes - metabolism | Green Fluorescent Proteins - genetics | Adoptive Transfer | Aorta - metabolism | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Aortic Diseases - metabolism | Receptors, IgG - metabolism | Antigens, CD - metabolism | Aortic Aneurysm - chemically induced | CD11c Antigen - metabolism | Monocytes - transplantation | Monocytes - pathology | Antigens, Differentiation - metabolism | Aortic Aneurysm - pathology | Angiotensin II | Aortic Diseases - pathology | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Plaque, Atherosclerotic | Antigens, Differentiation, Myelomonocytic - genetics | Atherosclerosis - metabolism | Disease Progression | Aorta - pathology | Aortic Diseases - genetics | Macrophages - metabolism | Phenotype | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Apolipoproteins E - genetics | CD11b Antigen - metabolism | Aortic Aneurysm - genetics | 10030 | 10012 | 10188 | 10014 | Basic Sciences
Journal Article
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2016, Volume 36, Issue 4, pp. 673 - 681
Journal Article
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2016, Volume 36, Issue 2, pp. 236 - 244
Journal Article
Circulation, ISSN 0009-7322, 04/2018, Volume 138, Issue 15, pp. 1551 - 1568
Journal Article
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 03/2019, Volume 69, Issue 3, pp. 710 - 716.e3
Identification of a safe and effective medical therapy for abdominal aortic aneurysm (AAA) disease remains a significant unmet medical need. Recent small... 
Veterans Affairs | Abdominal aortic aneurysm | Metformin | SURGERY | DIAMETER | ULTRASOUND | EXPANSION | RISK | PERIPHERAL VASCULAR DISEASE | COMPUTED-TOMOGRAPHY | SOCIETY | Development and progression | Diagnostic imaging | Abdominal aneurysm
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 911 - 917
Objective-Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of... 
aortic aneurysm | receptor, angiotensin, type 1 | losartan | transforming growth factor β | Marfan syndrome | PATHOGENESIS | TGF-BETA | type 1 | transforming growth factor beta | MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | receptor, angiotensin | Aortic Aneurysm, Thoracic - genetics | Phosphorylation | Aortic Aneurysm, Thoracic - prevention & control | Humans | Aortic Rupture - metabolism | Mice, 129 Strain | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Aortic Rupture - prevention & control | Transforming Growth Factor beta - antagonists & inhibitors | Aorta, Thoracic - drug effects | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Disease Models, Animal | Transforming Growth Factor beta - immunology | Fibrillin-1 | Mice, Inbred C57BL | Losartan - pharmacology | Smad2 Protein - metabolism | Aorta, Thoracic - metabolism | Antibodies, Neutralizing - pharmacology | Aortic Rupture - pathology | Fibrillins | Disease Progression | Marfan Syndrome - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Aortic Rupture - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Mutation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article