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by Qiu, L and Wang, M and Hu, SF and Ru, XF and Ren, YG and Zhang, ZW and Yu, SW and Zhang, YG
CANCERS, ISSN 2072-6694, 12/2018, Volume 10, Issue 12, p. 520
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of nonalcoholic steatohepatitis with dyslipidemia, and then its deterioration... 
proteasome | hepatoma | PTEN | ELEMENT-BINDING PROTEIN | AP-1 | Nrf2 | tumor repressor | PROSTATE-CANCER | GENE-EXPRESSION | COX2 | COX1 | miR-22 | tumor promoter | regulatory networks | LIPID-METABOLISM | SUPPRESSOR PTEN | COX-2 GENE | Nrf1 alpha | CELL-SURVIVAL | ONCOLOGY | LIVER | Keap1 | EMBRYONIC LETHALITY | ENDOPLASMIC-RETICULUM | oxidative stress | non-alcoholic steatohepatitis | Nrf1α
Journal Article
International Immunology, ISSN 0953-8178, 3/2009, Volume 21, Issue 3, pp. 227 - 235
Activation of T cells leads to the induction of many cytokine genes that are required for appropriate immune responses, including IL-2, a key cytokine for T... 
Cytokines | T cells | Transcriptional regulation | DELTA-EF1 | transcriptional regulation | MYOGENESIS | ZINC-FINGER | INTERLEUKIN-2 PROMOTER | IMMUNOLOGY | IDENTIFICATION | AP-1 | COREPRESSORS | cytokines | PROTEINS | NF-KAPPA-B | EXPRESSION | Phosphoproteins - immunology | Protein Interaction Domains and Motifs - immunology | Transcriptional Activation - genetics | Homeodomain Proteins - metabolism | Homeodomain Proteins - immunology | Histone Deacetylases - immunology | Transcriptional Activation - immunology | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Feedback, Physiological - immunology | Interleukin-2 - immunology | Transfection | T-Lymphocytes - metabolism | Kruppel-Like Transcription Factors - metabolism | Binding Sites - immunology | Transgenes | Repressor Proteins - metabolism | Interleukin-2 - metabolism | DNA-Binding Proteins - immunology | Mice, Inbred C57BL | Homeostasis - immunology | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Histone Deacetylase 1 | Homeodomain Proteins - genetics | Interleukin-2 - genetics | Animals | Repressor Proteins - immunology | Feedback, Physiological - genetics | Cell Line, Tumor | Protein Binding | T-Lymphocytes - immunology | Mice | Promoter Regions, Genetic - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9678, pp. 1905 - 1917
Summary Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases—including chronic obstructive... 
Internal Medicine | RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | HISTONE DEACETYLASE ACTIVITY | MIGRATION INHIBITORY FACTOR | ULCERATIVE-COLITIS | REGULATORY T-CELLS | RECEPTOR-BETA | RELATIVE CORTICOSTEROID INSENSITIVITY | BLOOD MONONUCLEAR-CELLS | RESPIRATORY-DISTRESS-SYNDROME | Transcription Factor AP-1 - drug effects | Glucocorticoids - therapeutic use | Transcriptional Activation - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Transcriptional Activation - drug effects | Transcription Factor AP-1 - immunology | Histone Deacetylases - immunology | Transcriptional Activation - immunology | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Calcineurin Inhibitors | Macrophage Migration-Inhibitory Factors - genetics | Inflammation - drug therapy | Phosphodiesterase 4 Inhibitors | Anti-Inflammatory Agents - therapeutic use | Mitogen-Activated Protein Kinases - immunology | Genetic Predisposition to Disease - genetics | NF-kappa B - antagonists & inhibitors | Histone Deacetylases - genetics | Macrophage Migration-Inhibitory Factors - drug effects | Repressor Proteins - genetics | Histone Deacetylase 2 | Drug Resistance - drug effects | Inflammation - immunology | Asthma - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - immunology | Drug Resistance - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Drug Resistance - immunology | Repressor Proteins - immunology | Histone Deacetylases - drug effects | Mitogen-Activated Protein Kinases - genetics | Repressor Proteins - drug effects | Mitogen-Activated Protein Kinases - drug effects | Pulmonary Disease, Chronic Obstructive - drug therapy | Corticosteroids | Dosage and administration | Inflammation | Research | Drug resistance | Drug therapy | Health aspects | Complications and side effects | Risk factors | Inflammatory bowel disease | Proteins | Respiratory distress syndrome | Asthma | Steroids
Journal Article
Journal Article