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1. TiO sub(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells
by Shukla, RK and Kumar, A and Gurbani, D and Pandey, AK and Singh, S and Dhawan, A
Nanotoxicology, ISSN 1743-5390, 02/2013, Volume 7, Issue 1, pp. 48 - 60
Titanium dioxide nanoparticles (TiO sub(2) NPs), widely used in consumer products, paints, pharmaceutical preparations and so on, have been shown to induce... 
Apaf-1 protein
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2. Full Text Cdc6: A trifunctional AAA+ ATPase that plays a central role in controlling the G1-S transition and cell survival
by Okayama, Hiroto
Journal of Biochemistry, ISSN 0021-924X, 10/2012, Volume 152, Issue 4, pp. 297 - 303
Apaf-1 | ROCK | Cdc6 | p27 | Cdk2
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3. Full Text The Apaf-1 center dot Kprocaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
by Malladi, S and Challa-Malladi, M and Fearnhead, HO and Bratton, SB
EMBO JOURNAL, ISSN 0261-4189, 07/2009, Volume 28, Issue 13, pp. 1916 - 1925
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity.... 
NUCLEOTIDE EXCHANGE | CANCER CELLS | caspase-9 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | DEPENDENT FORMATION | molecular timer | CELL BIOLOGY | CYTOCHROME-C | PROCASPASE-9 | INHIBITION | APAF-1 APOPTOSOME | CASPASE-ACTIVATING COMPLEX | Apaf-1 | apoptosome | BINDING
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4. Full Text The Apoptosome: Physiological, Developmental, and Pathological Modes of Regulation
by Schafer, Zachary T and Kornbluth, Sally
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 5, pp. 549 - 561
Apoptosis, a form of programmed cell death, is executed by a family of zymogenic proteases known as caspases, which cleave an array of intracellular substrates... 
PROGRAMMED CELL-DEATH | CAENORHABDITIS-ELEGANS | ACTIVATING FACTOR-I | APAF-1 EXPRESSION | APAF-1/CASPASE-9 APOPTOSOME | STRESS-INDUCED APOPTOSIS | DROSOPHILA CELLS | APAF-1-INTERACTING PROTEIN | DEVELOPMENTAL BIOLOGY | DEPENDENT CASPASE ACTIVATION | CYTOCHROME-C RELEASE | CELL BIOLOGY | Biological Evolution | Animals | Disease | Gene Expression Regulation, Developmental | Humans | Apoptosis - genetics | Apoptosis - physiology
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5. Full Text BIOCHEMICAL PATHWAYS OF CASPASE ACTIVATION DURING APOPTOSIS
by Budihardjo, Imawati and Oliver, Holt and Lutter, Michael and Luo, Xu and Wang, Xiaodong
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 11/1999, Volume 15, Issue 1, pp. 269 - 290
Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase activation have been recently... 
Bcl-2 | cytochrome | cell surface death receptor | Apaf-1 | mitochondria | Cell surface death receptor | Cytochrome c | Mitochondria | PERMEABILITY TRANSITION PORE | BCL-X-L | HUMAN-LYMPHOCYTES | DOMAIN-CONTAINING PROTEIN | DEVELOPMENTAL BIOLOGY | MITOCHONDRIAL CONTROL | INTERLEUKIN-1-BETA CONVERTING-ENZYME | SIGNALING COMPLEX | CELL BIOLOGY | PROGRAMMED CELL-DEATH | cytochrome c | CYTOCHROME-C RELEASE | ADENOSINE-DEAMINASE DEFICIENCY | Animals | Caspases - metabolism | Humans | Receptors, Cell Surface - metabolism | Mitochondria - metabolism | Enzyme Activation | Apoptosis | inhibitor of apoptosis protein | caspase-8 | Apaf-1 protein | caspase-9
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6. Full Text Unrestrained caspase-dependent cell death caused by loss of Diap 1 function requires the Drosophila Apaf-1 homolog, Dark
by Rodriguez, Antony and Rodriguez, Antony and Chen, Po and Chen, Po and Oliver, Holt and Oliver, Holt and Abrams, John M
EMBO Journal, ISSN 0261-4189, 05/2002, Volume 21, Issue 9, pp. 2189 - 2197
PCD | Drosophila | IAP | Apaf-1 | Apoptosis
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7. Full Text Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells
by Park, Yoo Hoi and Seo, Ji Hae and Park, Ji-Hyeon and Lee, Hye Shin and Kim, Kyu-Won
International Journal of Oncology, ISSN 1019-6439, 08/2017, Volume 51, Issue 2, pp. 573 - 578
Cancer cells are continuously challenged by adverse environmental factors including hypoxia, metabolite restriction, and immune reactions, and must adopt... 
acetylation | ARD1 | Hsp70 | autophagy | apoptosis | Apaf-1 | apoptosis-inducing factor | Apoptosis-inducing factor | Acetylation | Autophagy | Apoptosis | SYSTEM | PROTEIN | MECHANISM | FAMILY | INHIBITS APOPTOSIS | MICROENVIRONMENT | ONCOLOGY | APAF-1 APOPTOSOME | DEGRADATION | STRESS | AIF | Care and treatment | Cell death | Oncology, Experimental | Heat shock proteins | Genetic aspects | Research | Health aspects | Cancer | Proteins | Chromatin | Plasmids | Homeostasis | Regulation
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8. Full Text Over‐expression of HSP70 attenuates caspase‐dependent and caspase‐independent pathways and inhibits neuronal apoptosis
by Sabirzhanov, Boris and Stoica, Bogdan A and Hanscom, Marie and Piao, Chun‐Shu and Faden, Alan I
Journal of Neurochemistry, ISSN 0022-3042, 11/2012, Volume 123, Issue 4, pp. 542 - 554
HSP70 is a member of the family of heat‐shock proteins that are known to be up‐regulated in neurons following injury and/or stress. HSP70 over‐expression has... 
apoptosis | Apaf‐1 | HSP70 | neurons | neuroprotection | AIF | Apaf-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CULTURED NEURONS | STRESS-INDUCED APOPTOSIS | HEAT-SHOCK | GLUCOSE DEPRIVATION | NEUROSCIENCES | PROGRAMMED CELL-DEATH | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | SHOCK-PROTEIN HSP70 | APAF-1 APOPTOSOME | THERMAL-STRESS | Immunoprecipitation | Apoptosis - drug effects | Embryo, Mammalian | Amyloid beta-Peptides - pharmacology | Humans | Peptide Fragments - pharmacology | Green Fluorescent Proteins - genetics | Cerebral Cortex - cytology | Caspases - metabolism | Transfection | Protein Binding - drug effects | Neurons - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Cells, Cultured | Etoposide - pharmacology | Gene Expression Regulation - physiology | Rats | HSP70 Heat-Shock Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | HSP70 Heat-Shock Proteins - metabolism | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Apoptosis - physiology | Poly (ADP-Ribose) Polymerase-1 | Neural Inhibition - drug effects | Staurosporine - pharmacology | Neurochemistry | Gene expression | Neurons | Proteases | Apoptosis | Indexing in process
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9. Full Text Apoptotic protease activating factor‐1 negatively regulates Wnt signaling in hepatocellular carcinoma
by Han, Rui and Chen, Xin‐Yi
The Kaohsiung Journal of Medical Sciences, ISSN 1607-551X, 08/2019, Volume 35, Issue 8, pp. 459 - 466
The current study aims to evaluate the mechanism of apoptotic protease activating factor‐1 (Apaf‐1) in hepatocellular carcinoma (HCC) cells by verifying the... 
tumor suppressor | Wnt signaling | Apaf‐1 | hepatocellular carcinoma | Apaf-1 | MIR-122 | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | PATHWAY | APAF-1 EXPRESSION | CATENIN | PROGRESSION
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10. Full Text Rola apoptosomu w aktywacji prokaspazy 9
by Marek, Łukasz
Postepy Higieny i Medycyny Doswiadczalnej, ISSN 0032-5449, 2013, Volume 67, pp. 54 - 64
Mitochondrion | Apoptosome | Apaf-1 | Caspases | Apoptosis
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11. Full Text The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome
by Würstle, Maximilian L and Laussmann, Maike A and Rehm, Markus
Experimental Cell Research, ISSN 0014-4827, 07/2012, Volume 318, Issue 11, pp. 1213 - 1220
Key structural and catalytic features are conserved across the entire family of cysteine-dependent aspartate-specific proteases (caspases). Of the caspases... 
Apoptosome | Protease | Caspase-3 | Caspase-9 | Apoptosis | COMPLEX | PHOSPHORYLATION | APAF-1 | ENDOGENOUS XIAP | DEATH | OVARIAN-CANCER | CELL BIOLOGY | PROCASPASE-9 | INHIBITION | POLYMORPHISMS | ONCOLOGY | BINDING | Animals | Signal Transduction | Caspase 9 - physiology | Humans | Caspases, Initiator | Apoptosomes | Proteases | Signal transduction | Cellular biology
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12. Full Text Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
by Halle, Annett and Rock, Kenneth L and Latz, Eicke and Fitzgerald, Katherine A and Bauernfeind, Franz and Hornung, Veit and Samstad, Eivind O and Kono, Hajime
Nature Immunology, ISSN 1529-2908, 08/2008, Volume 9, Issue 8, pp. 847 - 856
Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development of silicosis, an... 
INTRACELLULAR K | CASPASE-1 | MACROPHAGES | TOLL-LIKE RECEPTORS | APAF-1 APOPTOSOME | INTERLEUKIN-1-BETA RELEASE | IMMUNOLOGY | LEUCINE METHYL-ESTER | URIC-ACID | CATHEPSIN-B | CELL-DEATH | Inflammation - chemically induced | Inflammation - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Mice, Inbred C57BL | Inflammation - immunology | Aluminum Compounds - metabolism | Macrophages - enzymology | Inflammation - metabolism | Macrophages - metabolism | Silicon Dioxide - metabolism | Animals | Macrophages - drug effects | Mice | Silicosis - pathology | Inflammation Mediators - physiology | Silicosis - immunology | Carrier Proteins | Cell receptors | Aluminum compounds | Physiological aspects | Causes of | Development and progression | Inflammation | Research | Health aspects | Silica | Index Medicus
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