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Nanotoxicology, ISSN 1743-5390, 02/2013, Volume 7, Issue 1, pp. 48 - 60
Titanium dioxide nanoparticles (TiO sub(2) NPs), widely used in consumer products, paints, pharmaceutical preparations and so on, have been shown to induce... 
Apaf-1 protein
Journal Article
Journal of Biochemistry, ISSN 0021-924X, 10/2012, Volume 152, Issue 4, pp. 297 - 303
Apaf-1 | ROCK | Cdc6 | p27 | Cdk2
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 07/2009, Volume 28, Issue 13, pp. 1916 - 1925
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity.... 
NUCLEOTIDE EXCHANGE | CANCER CELLS | caspase-9 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | DEPENDENT FORMATION | molecular timer | CELL BIOLOGY | CYTOCHROME-C | PROCASPASE-9 | INHIBITION | APAF-1 APOPTOSOME | CASPASE-ACTIVATING COMPLEX | Apaf-1 | apoptosome | BINDING
Journal Article
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 5, pp. 549 - 561
Journal Article
EMBO Journal, ISSN 0261-4189, 05/2002, Volume 21, Issue 9, pp. 2189 - 2197
Journal Article
International Journal of Oncology, ISSN 1019-6439, 08/2017, Volume 51, Issue 2, pp. 573 - 578
Cancer cells are continuously challenged by adverse environmental factors including hypoxia, metabolite restriction, and immune reactions, and must adopt... 
acetylation | ARD1 | Hsp70 | autophagy | apoptosis | Apaf-1 | apoptosis-inducing factor | Apoptosis-inducing factor | Acetylation | Autophagy | Apoptosis | SYSTEM | PROTEIN | MECHANISM | FAMILY | INHIBITS APOPTOSIS | MICROENVIRONMENT | ONCOLOGY | APAF-1 APOPTOSOME | DEGRADATION | STRESS | AIF | Care and treatment | Cell death | Oncology, Experimental | Heat shock proteins | Genetic aspects | Research | Health aspects | Cancer | Proteins | Chromatin | Plasmids | Homeostasis | Regulation
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2012, Volume 123, Issue 4, pp. 542 - 554
HSP70 is a member of the family of heat‐shock proteins that are known to be up‐regulated in neurons following injury and/or stress. HSP70 over‐expression has... 
apoptosis | Apaf‐1 | HSP70 | neurons | neuroprotection | AIF | Apaf-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CULTURED NEURONS | STRESS-INDUCED APOPTOSIS | HEAT-SHOCK | GLUCOSE DEPRIVATION | NEUROSCIENCES | PROGRAMMED CELL-DEATH | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | SHOCK-PROTEIN HSP70 | APAF-1 APOPTOSOME | THERMAL-STRESS | Immunoprecipitation | Apoptosis - drug effects | Embryo, Mammalian | Amyloid beta-Peptides - pharmacology | Humans | Peptide Fragments - pharmacology | Green Fluorescent Proteins - genetics | Cerebral Cortex - cytology | Caspases - metabolism | Transfection | Protein Binding - drug effects | Neurons - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Cells, Cultured | Etoposide - pharmacology | Gene Expression Regulation - physiology | Rats | HSP70 Heat-Shock Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | HSP70 Heat-Shock Proteins - metabolism | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Apoptosis - physiology | Poly (ADP-Ribose) Polymerase-1 | Neural Inhibition - drug effects | Staurosporine - pharmacology | Neurochemistry | Gene expression | Neurons | Proteases | Apoptosis | Indexing in process
Journal Article
The Kaohsiung Journal of Medical Sciences, ISSN 1607-551X, 08/2019, Volume 35, Issue 8, pp. 459 - 466
The current study aims to evaluate the mechanism of apoptotic protease activating factor‐1 (Apaf‐1) in hepatocellular carcinoma (HCC) cells by verifying the... 
tumor suppressor | Wnt signaling | Apaf‐1 | hepatocellular carcinoma | Apaf-1 | MIR-122 | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | PATHWAY | APAF-1 EXPRESSION | CATENIN | PROGRESSION
Journal Article
Postepy Higieny i Medycyny Doswiadczalnej, ISSN 0032-5449, 2013, Volume 67, pp. 54 - 64
Journal Article
Experimental Cell Research, ISSN 0014-4827, 07/2012, Volume 318, Issue 11, pp. 1213 - 1220
Key structural and catalytic features are conserved across the entire family of cysteine-dependent aspartate-specific proteases (caspases). Of the caspases... 
Apoptosome | Protease | Caspase-3 | Caspase-9 | Apoptosis | COMPLEX | PHOSPHORYLATION | APAF-1 | ENDOGENOUS XIAP | DEATH | OVARIAN-CANCER | CELL BIOLOGY | PROCASPASE-9 | INHIBITION | POLYMORPHISMS | ONCOLOGY | BINDING | Animals | Signal Transduction | Caspase 9 - physiology | Humans | Caspases, Initiator | Apoptosomes | Proteases | Signal transduction | Cellular biology
Journal Article