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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1422 - 1432.e11
Background The initiation and regulation of pulmonary fibrosis are not well understood. IL-33, an important cytokine for respiratory diseases, is overexpressed... 
Allergy and Immunology | type 2 innate lymphoid cells | alternatively activated macrophages | IL-33 | lung fibrosis | IMMUNITY | RECRUITMENT | NEUTROPHIL | MOUSE | AIRWAY INFLAMMATION | BLEOMYCIN | CYTOKINE | MECHANISMS | IMMUNOLOGY | ALLERGY | IN-VIVO | PULMONARY-FIBROSIS | Interleukin-1 Receptor-Like 1 Protein | Lung - pathology | Receptors, Interleukin - immunology | Interleukin-33 | Mice, Inbred C57BL | Interleukin-13 - immunology | Transforming Growth Factor beta1 - genetics | Receptors, Interleukin - genetics | Mice, Knockout | Interleukins - genetics | Transforming Growth Factor beta1 - immunology | Interleukin-13 - genetics | Animals | Lymphocytes - immunology | Interleukins - immunology | Fibrosis | Lung - immunology | Macrophages, Alveolar - immunology | Macrophages | Transforming growth factors | Studies | Pulmonary fibrosis | Cytokines | Transgenic animals | Lymphocytes | Rodents | Collagen | Extracellular matrix | Software | CT, Computed tomography | flIL-33, Full-length IL-33 | ICOS, Inducible costimulator | M2 macrophage, Alternatively activated macrophage | BAL, Bronchoalveolar lavage | Nos2, Inducible nitric oxide synthase 2 gene | WT, Wild-type | APC, Allophycocyanin | Arg1, Arginase 1 | IPF, Idiopathic pulmonary fibrosis | qPCR, Quantitative PCR | M1 macrophage, Classically activated macrophage | PE, Phycoerythrin | FITC, Fluorescein isothiocyanate | ILC2, Type 2 innate lymphoid cell | mIL-33, Mature IL-33 | BMDM, Bone marrow–derived macrophage | Mechanisms of Allergy and Clinical Immunology
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1161 - 1178
Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance... 
proteasome | multiple myeloma | autophagy | proteasome inhibitors | bortezomib | plasma cells | proteostasis | p62 | SQSTM1 | endoplasmic reticulum | ubiquitin | aggregate | Ubiquitin | Bortezomib | Proteostasis | Multiple myeloma | Plasma cells | Aggregate | Autophagy | Endoplasmic reticulum | P62 | Proteasome inhibitors | Proteasome | SURVIVAL | bafilomycin A | phosphate-buffered saline | CANCER | CELL BIOLOGY | gene ontology | hydroxychloroquine | UPR | immunoprecipitation | UPS | plasma cell | PBS | antibody | ERGIC | Rapa | STRESS-RESPONSE | allophycocyanin | pAb | unfolded protein response | EXTENDED FOLLOW-UP | amc | HCQ | DISEASE | Btz | DEFICIENT MICE | Baf A1 | proteasome inhibitor | polyclonal antibody | immunoglobulin | IMMUNOGLOBULIN PRODUCTION | stable isotope labeling in cell culture | SILAC | 7-amino-4-methylcoumarin | bone marrow | PLASMA-CELLS | LC-MS | ubiquitin-proteasome system | APC | liquid chromatography-tandem mass spectrometry | DIFFERENTIATION | ER-Golgi intermediate compartment | rapamycin | Cell Survival - drug effects | Proteasome Inhibitors - pharmacology | Sequestosome-1 Protein | Humans | Endoplasmic Reticulum - metabolism | Multiple Myeloma - metabolism | Autophagy - drug effects | Endoplasmic Reticulum - ultrastructure | Proteolysis - drug effects | Multiple Myeloma - pathology | Protein Binding - drug effects | Cytoprotection - drug effects | Cell Line, Tumor | Homeostasis - drug effects | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitinated Proteins - metabolism | Protein Aggregates - drug effects
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 5, pp. 1159 - 1166.e6
Background The IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in allergic patients and after viral infection. Several cell... 
Allergy and Immunology | mammalian target of rapamycin | asthma | innate lymphoid cells | IL-33 | TH2 | rapamycin | HYPERREACTIVITY | PHOSPHATIDYLINOSITOL 3-KINASE | CYTOKINE | IMMUNOLOGY | MTOR | T(H)2 | ST2 | EFFECTOR | ALLERGY | DIFFERENTIATION | INHIBITORS | SELECTIVITY | EXPRESSION | Interleukin-1 Receptor-Like 1 Protein | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunity, Innate - genetics | Th2 Cells - immunology | Th2 Cells - drug effects | Immunity, Cellular - drug effects | Pneumonia - chemically induced | Pneumonia - immunology | Immunity, Cellular - genetics | Immunity, Innate - drug effects | Interleukin-33 | Interleukin-5 - metabolism | Cells, Cultured | Interleukin-13 - metabolism | Receptors, Interleukin - genetics | Mice, Knockout | Animals | Pneumonia - drug therapy | Interleukins - administration & dosage | Signal Transduction - drug effects | Mice | Mice, Inbred BALB C | Th2 Cells - transplantation | Virus diseases | T cells | Inflammation | Flow cytometry | Cell growth | Phosphorylation | Lungs | Rodents | Kinases | Viral infections | Methods | rpS6, Ribosomal protein S6 | S6K1, Ribosomal protein S6 kinase 1 | TCR, T-cell receptor | 2), Mammalian target of rapamycin (complex 1 | Lin, Lineage-specific marker | ICOS, Inducible costimulator | BAL, Bronchoalveolar lavage | WT, Wild-type | APC, Allophycocyanin | TSLP, Thymic stromal lymphopoietin | mTOR(C1 | PE, Phycoerythrin | PI3K, Phosphoinositide 3-kinase | ILC, Innate lymphoid cell | AHR, Airway hyperresponsiveness | Mechanisms of Allergy and Clinical Immunology
Journal Article
Neoplasia, ISSN 1476-5586, 05/2019, Volume 21, Issue 5, pp. 469 - 481
Leukemogenic potential of MLL fusion with the coiled-coil domain-containing partner genes and the downstream target genes of this type of MLL fusion have not... 
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 153, Issue 1, pp. 233 - 248.e16
Background & Aims There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy... 
Gastroenterology and Hepatology | Sphingolipid | Immune Cell Localization | Mouse Model | CCR2 | SURVIVAL | REGRESSION | HEPATOCYTES | MACROPHAGES | RESOLUTION | TRANSPLANT | TRAFFICKING | BONE-MARROW-CELLS | SPHINGOSINE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Lysophospholipids - metabolism | Liver - pathology | Humans | Immunosuppressive Agents - therapeutic use | Actins - metabolism | Male | Macrophages | Lymph - metabolism | Hematopoietic Stem Cells - physiology | Female | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Liver Cirrhosis - genetics | Chemical and Drug Induced Liver Injury, Chronic - complications | Fingolimod Hydrochloride - therapeutic use | Cell Line | Liver Cirrhosis - etiology | Gene Expression | Phosphoric Monoester Hydrolases - genetics | Collagen Type I - metabolism | Liver Cirrhosis - prevention & control | Lysophospholipids - antagonists & inhibitors | Membrane Proteins - genetics | Sphingosine - antagonists & inhibitors | Liver - metabolism | Neutrophils | Hematopoietic Stem Cell Transplantation | Phosphotransferases (Alcohol Group Acceptor) - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Cell Movement - drug effects | Monocytes | Sphingosine - analogs & derivatives | Animals | Liver Cirrhosis - pathology | Mice | Prevention | Phosphates | Medical research | Liver diseases | Immunotherapy | Liver | Fibrosis | Sphingosine | Medicine, Experimental | Research institutes | Hematopoietic stem cells | Analysis | Bone marrow | Lipids | Transplantation | Liver cirrhosis | APC, allophycocyanin | Original Research | CFSE, carboxyfluorescein succinimidyl ester | α-SMA, α-smooth muscle actin | CCL, chemokine (C-C motif) ligand | HPC-7, hematopoietic progenitor cell line | DiR, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide | CMP, common myeloid progenitors | BM, bone marrow | CLP, common lymphoid progenitors | KSL, c-kit+ sca-1+ and lineageneg | HSC, hematopoietic stem cell | PSR, picrosirius red | S1P, sphingosine 1-phosphate | SGPL1, sphingosine-1-phosphate lyase | SGPP1, sphingosine-1-phosphate phosphatase | MMP, matrix metalloproteinase | SphK1, sphingosine kinase 1
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 607 - 620.e15
Background Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid... 
Allergy and Immunology | PHTS | autoimmunity | immunologic synapse | PTEN | Regulatory T cells | phosphatases | phosphoinositide 3-kinase | PH domain leucine-rich repeat protein phosphatase | HOMEOSTASIS | PROTEIN | KINASE | PROMOTER MUTATIONS | RILEY-RUVALCABA-SYNDROME | IMMUNOLOGY | ALLERGY | RESOLUTION MELTING ANALYSIS | AKT-MTOR | LYMPHOID HYPERPLASIA | EXPRESSION | Autoimmunity | Humans | Hyperplasia | Middle Aged | Phosphoprotein Phosphatases - metabolism | Male | Immunological Synapses - metabolism | Young Adult | Forkhead Transcription Factors - metabolism | Membrane Potential, Mitochondrial | Adult | Child | Hamartoma Syndrome, Multiple - immunology | Lymphocyte Subsets - physiology | T-Lymphocytes, Regulatory - physiology | PTEN Phosphohydrolase - genetics | Hamartoma Syndrome, Multiple - genetics | Signal Transduction | Cells, Cultured | B-Lymphocytes - physiology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Mutation - genetics | Protein Transport | Adolescent | Protein Binding | Aged | Medical colleges | Care and treatment | Phosphatases | Gene mutations | Analysis | Children's hospitals | Genomics | Medical genetics | Genetic research | T cells | Tumors | Hamartoma | Proteins | Blood & organ donations | Hematology | Biopsy | Lymphocytes | T cell receptors | Mutation | Kinases | Metabolism | Phosphatase | FACS, Fluorescence-activated cell sorting | TCR, T-cell receptor | mTOR complex 1 | NHERF1, Na+ | H+-exchanger 3 regulatory factor | MALT, Mucosa-associated lymphoid tissue | APC, Allophycocyanin | SHIP, Src homology domain 2–containing inositol phosphatase | HRM, High Resolution DNA Melting | FITC, Fluorescein isothiocyanate | PP2A, Protein phosphatase 2A | mTORC1, PTEN | PHTS, PTEN hamartoma tumor syndrome | PerCP, Peridinin-chlorophyll-protein complex | CS, Cowden syndrome | POD, Peroxidase | Tmem, Memory T | TMRE, Tetramethylrhodamine-ethylester | Immune Deficiencies, Infection, and Systemic Immune Disorders | IC50, Inhibitory concentration of 50 | CTLA-4, Cytotoxic T lymphocyte–associated antigen 4 | PHLPP, PH domain leucine-rich repeat protein phosphatase | AKT | DLG1, Scaffold protein discs, large homolog 1 | FOXP3, Forkhead box P3 | ICAM-1, Intercellular adhesion molecule 1 | iTreg, In vitro induced regulatory T | PE, Phycoerythrin | PI3K, Phosphoinositide 3-kinase | mTOR, Mammalian target of rapamycin | PTEN, Phosphatase and tensin homologue deleted on chromosome 10
Journal Article
Journal Article
Clinical Nutrition, ISSN 0261-5614, 2016, Volume 36, Issue 2, pp. 407 - 415
Journal Article
Journal Article