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Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2018, Volume 20, Issue 1, pp. 157 - 164
AimsApelin is a recently identified adipokine known to improve glucose tolerance and insulin sensitivity in murine models. This study was dedicated to the... 
system | type 2 diabetes | apelin | adipokine | hyperinsulinaemic‐euglycaemic clamp | APJ | insulin resistance | apelin/APJ system | hyperinsulinaemic-euglycaemic clamp | APJ system | HEART-FAILURE | ENDOCRINOLOGY & METABOLISM | RESISTANT MICE | AGONIST | Apelin - analogs & derivatives | Overweight - drug therapy | Humans | Anti-Obesity Agents - adverse effects | Male | Apelin Receptors - agonists | Anti-Obesity Agents - therapeutic use | Apelin - blood | Dose-Response Relationship, Drug | Young Adult | Overweight - metabolism | Intercellular Signaling Peptides and Proteins - pharmacokinetics | Hypoglycemic Agents - administration & dosage | Adult | Intercellular Signaling Peptides and Proteins - administration & dosage | Body Mass Index | Hypoglycemic Agents - therapeutic use | Anti-Obesity Agents - administration & dosage | Double-Blind Method | Apelin - adverse effects | Peptide Fragments - administration & dosage | Insulin Resistance | Peptide Fragments - pharmacokinetics | Apelin - therapeutic use | Proof of Concept Study | Cross-Over Studies | Apelin Receptors - metabolism | Overweight - blood | Adolescent | Intercellular Signaling Peptides and Proteins - therapeutic use | Peptide Fragments - adverse effects | Peptide Fragments - therapeutic use | Glucose Clamp Technique | Infusions, Intravenous | Hypoglycemic Agents - adverse effects | Intercellular Signaling Peptides and Proteins - adverse effects | Type 2 diabetes | Obesity | Diabetics | Analysis | Insulin resistance | Glucose | Insulin | Dextrose | Glucose tolerance | Animal models | Intravenous administration | Diabetes mellitus | Rodents | Body weight | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 04/2018, Volume 71, Issue 4, pp. 223 - 232
Journal Article
Cardiovascular Research, ISSN 0008-6363, 2017, Volume 113, Issue 7, pp. 760 - 769
Aims Elabela/Toddler/Apela (ELA) has been identified as a novel endogenous peptide ligand for APJ/Apelin receptor/ Aplnr. ELA plays a crucial role in early... 
ACE2 | ACE | APJ | Elabela | Angiotensin | Apelin | CONVERTING ENZYME 2 | ENDOGENOUS LIGAND | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPOTENSIVE ACTION | CONTRACTILITY | APELIN RECEPTOR | FAILING HEARTS | HYPERTROPHY | PATHWAY | IN-VIVO | Humans | Heart Failure - physiopathology | Apelin Receptors - deficiency | Myocardial Contraction - drug effects | Male | Heart Failure - prevention & control | Ventricular Dysfunction, Left - genetics | Myocardium - metabolism | Peptidyl-Dipeptidase A - metabolism | Hypertension - genetics | Heart Failure - etiology | Disease Models, Animal | Constriction | Hypertrophy, Left Ventricular - prevention & control | Ventricular Function, Left - drug effects | Heart Failure - genetics | Cardiotonic Agents - pharmacology | Hypertension - metabolism | Mice, Knockout | Ventricular Dysfunction, Left - metabolism | Cardiotonic Agents - administration & dosage | Signal Transduction - drug effects | Aorta - surgery | Fibrosis | Forkhead Box Protein M1 - genetics | Ligands | Hypertrophy, Left Ventricular - physiopathology | Peptide Hormones - pharmacology | Peptidyl-Dipeptidase A - genetics | Arterial Pressure | Transfection | Apelin Receptors - genetics | HEK293 Cells | Hypertension - prevention & control | Aorta - physiopathology | Angiotensin II | Peptide Hormones - administration & dosage | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Myocardium - pathology | Hypertension - physiopathology | Ventricular Dysfunction, Left - physiopathology | Ventricular Dysfunction, Left - prevention & control | Infusions, Subcutaneous | Apelin Receptors - metabolism | Animals | Forkhead Box Protein M1 - metabolism | Index Medicus
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 02/2017, Volume 16, Issue 2, pp. 1223 - 1231
Apelin is hypothesized to serve a dual function in pain processing. Spinal administration of apelin induces hyperalgesia, while opioid receptors are implicated... 
chronic constriction injury | neuropathic pain | spinal cord | apelin | apelin receptor | dorsal horn | Spinal cord | Apelin receptor | Chronic constriction injury | Apelin | Dorsal horn | Neuropathic pain | ENDOGENOUS LIGAND APELIN | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | HEART-FAILURE | PEPTIDE | MESSENGER-RNA | ONCOLOGY | OPIOID RECEPTOR | TISSUE DISTRIBUTION | GENE-EXPRESSION | NEURONS | BRAIN | Phosphorylation | Sciatic Nerve - injuries | Spinal Cord - metabolism | Spinal Cord Dorsal Horn - metabolism | Neuralgia - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Apelin - metabolism | Apelin Receptors - genetics | Neuralgia - etiology | Neuralgia - physiopathology | Disease Models, Animal | Injections, Spinal | Peripheral Nerve Injuries - complications | Gene Expression | RNA, Messenger - genetics | Rats | Neuralgia - drug therapy | Apelin - genetics | Apelin Receptors - metabolism | Animals | Nitrobenzoates - administration & dosage | Pyrans - administration & dosage | Chronic Disease | Genetic aspects | Pain | Gene expression | Health aspects | Animal models | Pain perception | Opioid receptors | Narcotics | Hypersensitivity | Extracellular signal-regulated kinase | Immunoblotting | Neuropathy | Kinases | Catheters | Studies | Signal transduction | Surgery | Rodents | Ligands | Horns | Immunofluorescence | Sciatic nerve
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 12/2016, Volume 1864, Issue 12, pp. 1748 - 1756