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EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 06/2019, Volume 379, Issue 2, pp. 172 - 181
The neurotoxin beta-N-methylamino-L-alanine replaces L-serine in proteins and produces Alzheimer-like pathology. In proteoglycans, e.g. glypican-1, this should... 
Heparan sulfate | TG2576 | APLP2 | RELEASE | PROTEOGLYCAN | Amyloid precursor protein | CELL BIOLOGY | Neuronal cells | AMINO-ACID | Glypican-1 | BMAA | ONCOLOGY | Neurotoxin | DISEASE | DEGRADATION | ACCUMULATION | Alzheimer's disease
Journal Article
FEBS Journal, ISSN 1742-464X, 03/2010, Volume 277, Issue 6, pp. 1503 - 1518
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 04/2019, Volume 33, Issue 4, pp. 5076 - 5081
The amyloid precursor-like protein 2 (APLP2) molecule is a type I transmembrane protein that is crucial for survival, cell-cell adhesion, neuronal development,... 
dimerization | copper | zinc | APLP2 | X-ray macromolecule structure | APP | SITE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COPPER-BINDING DOMAIN | HOMOLOG | HEPARIN | REVEAL | BETA | CELL BIOLOGY | BIOLOGY | MICE
Journal Article
GLYCOBIOLOGY, ISSN 0959-6658, 05/2015, Volume 25, Issue 5, pp. 548 - 556
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced... 
autophagy | glypican-1 | ALZHEIMERS-DISEASE | APLP2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IONS | nuclear transit | amyloid beta | ENDOSOMES | BINDS | heparan sulfate | OLIGOMER | A-BETA | BETA PRECURSOR PROTEIN | DEPENDENT AUTOCLEAVAGE | DEAMINATIVE CLEAVAGE
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18609 - 18620
Journal Article
Glia, ISSN 0894-1491, 03/2019, Volume 67, Issue 3, pp. 525 - 538
The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and... 
knockout | myelin | cuprizone | amyloid precursor protein | amyloid precursor‐like protein | amyloid precursor-like protein | BETA-SECRETASE | APLP2 | NEUREGULIN-1 | NEUROSCIENCES | BACE1 | MULTIPLE-SCLEROSIS | DAMAGED AXONS | CENTRAL-NERVOUS-SYSTEM | MICE | BRAIN | Amyloid Precursor Protein Secretases - genetics | Oligodendroglia - metabolism | Corpus Callosum - metabolism | Axons - metabolism | Male | Aspartic Acid Endopeptidases - genetics | Demyelinating Diseases - metabolism | Mice, Knockout | Myelin Sheath - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Cuprizone | Aspartic Acid Endopeptidases - metabolism | Remyelination - physiology | Amyloid beta-Protein Precursor - metabolism | Demyelinating Diseases - chemically induced | Mice | Disease Models, Animal | Optic Nerve - metabolism | Neurosciences | Analysis | Myelin proteins | Amyloid beta-protein | Blood proteins | Brain | Oligodendrocyte-myelin glycoprotein | Central nervous system | Nervous system | Modulators | Proteins | Clonal deletion | Sheaths | Demyelination | Precursors | Rodents | Nerves | Deletion | Alzheimer's disease | Peripheral nervous system | b-Site APP cleaving enzyme 1 | Biochemical analysis | Myelin | Glycoprotein | Substrates | Amyloid precursor protein | Corpus callosum | Regeneration | Axons | Myelination | Molecular modelling | Proteolipid protein
Journal Article
Folia Neuropathologica, ISSN 1641-4640, 2018, Volume 56, Issue 1, pp. 30 - 38
The purpose of this study was to investigate the expression status of amyloid precursor-like protein 2 (APLP2) and its clinical relevance in patients with... 
Project betastasis | Prognosis | APLP2 | Glioblastoma | GLIOMAS | CANCER CELLS | INCREASES | MICRORNA-153 | PATHOLOGY | prognosis | NEUROSCIENCES | GROWTH-FACTOR RECEPTOR | glioblastoma | RETINOIC ACID | project betastasis | GENE-EXPRESSION | STEM-CELL | DIFFERENTIATION | MICROARRAYS
Journal Article
Experimental Cell Research, ISSN 0014-4827, 05/2017, Volume 354, Issue 1, pp. 31 - 39
The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed... 
Heparan sulfate | Histones | Anhydromannose | Glypican | RNA | Nucleolin | VITAMIN-C | CELLS | LOCALIZATION | HEPATOCYTES | GLYCOSAMINOGLYCANS | APLP2 | CELL BIOLOGY | ONCOLOGY | ROLES | DEGRADATION | TUMOR-GROWTH | Mannose - genetics | Humans | Cell Nucleus - ultrastructure | Phosphoproteins - metabolism | Glypicans - metabolism | Heparitin Sulfate - metabolism | Phosphoproteins - ultrastructure | Endosomes - metabolism | Alzheimer Disease - pathology | RNA-Binding Proteins - ultrastructure | Mannose - metabolism | Microscopy, Confocal | Animals | Cell Nucleus - metabolism | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Endosomes - ultrastructure | Mice | Alzheimer Disease - genetics | Nitric Oxide - metabolism | RNA-Binding Proteins - metabolism | Disease Models, Animal | Monoclonal antibodies | Sulfates | Gliomas | Alzheimer's disease | Nitric oxide | Genetic engineering | DNA binding proteins | GLIOMAS | RECYCLING | SULFATES | MONOCLONAL ANTIBODIES | NITRIC OXIDE | NUCLEOLI | URIDINE | MICROSCOPY | 60 APPLIED LIFE SCIENCES | HISTONES | FIBROBLASTS | THIOLS | ANOXIA | DNA | SYNTHESIS | MICE | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
Current Alzheimer Research, ISSN 1567-2050, 12/2014, Volume 11, Issue 10, pp. 971 - 980
The amyloid precursor protein (APP) has previously been allocated to an organellar pool residing in the Golgi apparatus and in endosomal compartments, and in... 
Synaptophysin | Synaptotagmin-1 | Presynaptic active zone | Amyloid precursor protein APP | APLP2 | APLP1 | Docked synaptic vesicles | SV2 | synaptophysin | APP | ALZHEIMERS-DISEASE | FAMILY-MEMBERS | TRAFFICKING | NEUROSCIENCES | CLINICAL NEUROLOGY | synaptotagmin-1 | TRANSPORT | SYNAPSES | presynaptic active zone | docked synaptic vesicles | MICE | GENERATION | HOMOLOGS | EXPRESSION
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 1/2019, Volume 56, Issue 1, pp. 13 - 28
Journal Article