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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2010, Volume 30, Issue 2, pp. 253 - 259
PURPOSE—This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage... 
ApoE/CCR2 | Magnetic Resonance Imaging | Inflammation | USPIO | Atherosclerosis | HYPERLIPIDEMIC RABBITS | ATHEROSCLEROTIC PLAQUES | ApoE(-/-) CCR2 | LESION FORMATION | CCR2 ANTAGONIST | ANGIOTENSIN-II | ULTRASMALL SUPERPARAMAGNETIC PARTICLES | REDUCES ATHEROSCLEROSIS | IRON-OXIDE PARTICLES | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | Immunohistochemistry | Receptors, CCR2 - genetics | Angiotensin II - administration & dosage | Apolipoproteins E - deficiency | Humans | Receptors, CCR2 - antagonists & inhibitors | Ferrosoferric Oxide | Dextrans | Time Factors | Peritonitis - prevention & control | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Macrophages - immunology | Magnetite Nanoparticles | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Infusion Pumps, Implantable | Macrophages - pathology | Anti-Inflammatory Agents - pharmacology | Aortic Diseases - immunology | Mice, Transgenic | Peritonitis - immunology | Mice, Knockout | Receptors, CCR2 - metabolism | Animals | Contrast Media | Naphthyridines - pharmacokinetics | Aortic Diseases - diet therapy | Apolipoproteins E - genetics | Macrophages - drug effects | Mice | Naphthyridines - pharmacology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3751 - 3759
Activation of very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (apoER2) results in either pro- or anti-atherogenic effects... 
ABCA1 | AORTIC ENDOTHELIAL-CELLS | TANGIER-DISEASE | PROTEIN-KINASE-C | LDL RECEPTOR | RECEPTOR/RETINOID-X-RECEPTOR | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOLESTEROL EFFLUX | INDUCTION | VLDL RECEPTOR | LDL-Receptor Related Proteins - metabolism | Humans | Sp1 Transcription Factor - metabolism | Cholesterol - genetics | LDL-Receptor Related Proteins - genetics | Gene Knockdown Techniques | ATP-Binding Cassette Transporters - genetics | Up-Regulation - physiology | Serine Endopeptidases - genetics | Cell Adhesion Molecules, Neuronal - metabolism | ATP Binding Cassette Transporter 1 | Extracellular Matrix Proteins - metabolism | Cell Line | Receptors, LDL - genetics | Extracellular Matrix Proteins - genetics | Protein Kinase C-epsilon - genetics | Receptors, LDL - metabolism | Apolipoprotein E3 - metabolism | Cholesterol - metabolism | Nerve Tissue Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | ATP-Binding Cassette Transporters - biosynthesis | Nerve Tissue Proteins - metabolism | Apolipoprotein E3 - genetics | Macrophages - metabolism | Animals | Sp1 Transcription Factor - genetics | Protein Kinase C-epsilon - metabolism | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Mice | Serine Endopeptidases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Reelin | Signal Transduction | ABC Transporter | Lipids | ApoE | ApoE Receptor2 | VLDL Receptor | Macrophages | Cholesterol
Journal Article
by Zhang, MA and Song, P and Xu, JA and Zou, MH
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 01/2011, Volume 31, Issue 1, pp. 125 - 125
Objective-The thromboxane receptor (TPr) and multiple TPr ligands, including thromboxane A(2) (TxA(2)) and prostaglandin H-2, are elevated during vascular and... 
OXIDATIVE STRESS | peroxynitrite | prostacyclin | signal transduction | PROSTACYCLIN SYNTHASE | PROTEIN-KINASE | SUPEROXIDE ANION | CARDIOVASCULAR INJURY | thromboxanes | APOE-DEFICIENT MICE | TETRAHYDROBIOPTERIN | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | nitric oxide synthase | HEMATOLOGY | TYROSINE NITRATION
Journal Article
INTERNATIONAL JOURNAL OF CARDIOLOGY, ISSN 0167-5273, 11/2013, Volume 169, Issue 4, pp. 281 - 287
Background: The angiotensin II type 2 receptor (AT(2)R) has been suggested to have an athero-protective role, however no studies have investigated the effect... 
ATHEROSCLEROTIC LESIONS | SYSTEM | Plaque rupture | ATHEROGENESIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | CGP42112 | KNOCKOUT MICE | AT receptor | ANGIOTENSIN TYPE-2 RECEPTOR | Atherosclerosis | Endothelial dysfunction | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | EXPRESSION
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2002, Volume 21, Issue 22, pp. 5996 - 6004
Specialized neurons throughout the developing central nervous system secrete Reelin, which binds to ApoE receptor 2 (ApoER2) and very low density lipoprotein... 
ApoE receptor 2 | furin processing | Reelin signaling | Furin processing | NEURONAL MIGRATION | LIGAND-BINDING | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOSOLIC ADAPTER | MICE LACKING | ALPHA-2-MACROGLOBULIN RECEPTOR | VLDL RECEPTOR | CELL BIOLOGY | APOLIPOPROTEIN-E RECEPTOR-2 | GENE FAMILY | DENSITY-LIPOPROTEIN RECEPTOR | Brain - embryology | Phosphorylation | Alternative Splicing | Heymann Nephritis Antigenic Complex - metabolism | LDL-Receptor Related Proteins | Receptors, Lipoprotein - physiology | Recombinant Fusion Proteins - physiology | Nerve Tissue Proteins - chemistry | Genes, Dominant | Protein Isoforms - chemistry | Nerve Tissue Proteins - biosynthesis | Furin | Cell Adhesion Molecules, Neuronal - metabolism | Neurons - metabolism | Subtilisins - metabolism | Serine Endopeptidases | Binding Sites | Extracellular Matrix Proteins - metabolism | Protein Structure, Tertiary | Nerve Tissue Proteins - antagonists & inhibitors | Cell Adhesion Molecules, Neuronal - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Extracellular Matrix Proteins - antagonists & inhibitors | Extracellular Matrix Proteins - genetics | Receptors, Lipoprotein - biosynthesis | Receptors, Lipoprotein - genetics | Solubility | Receptors, LDL - metabolism | Exons - genetics | Glycosylation | Cell Adhesion Molecules, Neuronal - genetics | Protein Isoforms - physiology | Protein Interaction Mapping | Receptors, Lipoprotein - chemistry | Animals | Protein Isoforms - biosynthesis | Signal Transduction - physiology | Mice | Protein Processing, Post-Translational | Fungal Proteins - metabolism | Index Medicus | ApoE receptor 2
Journal Article
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2017, Volume 47, pp. 31 - 43
Abstract Introduction Endarterectomized human atherosclerotic plaques are a valuable basis for gene expression studies to disclose novel imaging biomarkers and... 
Radiology | ApoE KO | Shear stress | Cannabinoid receptor type 2 | Gene expression | Positron emission tomography | Plaque inflammation | MICE DEFICIENT | ENDOCANNABINOID SYSTEM | COSTIMULATORY MOLECULES | IN-VIVO | SHEAR-STRESS | MOUSE MODEL | BIOLOGICAL EVALUATION | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | DENSITY-LIPOPROTEIN RECEPTOR | Biomarkers - metabolism | Plaque, Atherosclerotic - diagnostic imaging | Radioactive Tracers | Plaque, Atherosclerotic - genetics | Plaque, Atherosclerotic - metabolism | Adamantane - metabolism | Humans | Gene Expression Regulation | Quinolones - metabolism | Male | Receptor, Cannabinoid, CB2 - genetics | Antigens, CD - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carotid Artery Diseases - diagnostic imaging | Antigens, Differentiation, Myelomonocytic - metabolism | Carotid Artery Diseases - genetics | Mice | Carotid Artery Diseases - metabolism | Adamantane - analogs & derivatives | Carbon Radioisotopes | Positron Emission Tomography Computed Tomography - methods | Genetic research | Genes | Atherosclerosis | PET imaging | Lymphocytes | Apolipoproteins | Target recognition | Addition polymerization | CD86 antigen | Emission analysis | Lymphocytes T | Matrix metalloproteinase | Arteries | Cell activation | Histopathology | Apolipoprotein E | Imaging | Tomography | Bioindicators | Metalloproteinase | Lesions | Plaques | Antigens | Positron emission | CD80 antigen | Inflammation | Cells | Polymerase chain reaction | Immune systems | Autoradiography | Arteriosclerosis | Biomarkers | Mechanical stimuli | Index Medicus
Journal Article
Journal of the Renin-Angiotensin-Aldosterone System, ISSN 1470-3203, 03/2008, Volume 9, Issue 1, pp. 17 - 21
Journal Article
Journal Article
Journal of Hypertension, ISSN 0263-6352, 08/2005, Volume 23, Issue 8, pp. 1541 - 1549
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 04/2017, Volume 47, pp. 31 - 43
Introduction Endarterectomized human atherosclerotic plaques are a valuable basis for gene expression studies to disclose novel imaging biomarkers and... 
ApoE KO | Cannabinoid receptor type 2 | Shear stress | Gene expression | Positron emission tomography | Plaque inflammation
Journal Article
NEURON, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 353 - 369
Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the... 
APOE RECEPTOR 2 | LAMINAR ORGANIZATION | CORTICAL-NEURONS | DEVELOPING NEOCORTEX | BRAIN-DEVELOPMENT | ALPHA-3-BETA-1 INTEGRIN | GENE-EXPRESSION | RADIAL MIGRATION | DEVELOPING CEREBRAL-CORTEX | NEUROSCIENCES | VLDL RECEPTOR
Journal Article