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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 44, pp. 30538 - 30555
Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and insoluble amyloid-beta (A beta) in Alzheimer disease... 
BEXAROTENE THERAPY | ABCA1 | ALZHEIMERS-DISEASE | DEPOSITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | A-BETA | TRANSGENIC MOUSE MODEL | MILD COGNITIVE IMPAIRMENT | BRAIN | APOLIPOPROTEIN-E | Disks Large Homolog 4 Protein | Liver - pathology | Nicotinic Acids - pharmacokinetics | Humans | Male | Tetrahydronaphthalenes - adverse effects | ATP Binding Cassette Transporter 1 - metabolism | Liver - drug effects | Tetrahydronaphthalenes - administration & dosage | Amyloid beta-Peptides - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Membrane Proteins - metabolism | Nicotinic Acids - administration & dosage | Drug Evaluation, Preclinical | Nicotinic Acids - adverse effects | Retinoid X Receptors - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Bexarotene | Peptide Fragments - metabolism | Administration, Oral | Mice, Inbred C57BL | Solubility | Alzheimer Disease - drug therapy | Tetrahydronaphthalenes - pharmacokinetics | Genotype | Mice, Transgenic | Organ Size - drug effects | Animals | Retinoid X Receptors - agonists | Apolipoproteins E - genetics | Guanylate Kinases - metabolism | Index Medicus | Molecular Bases of Disease | Oligomeric Aβ | Alzheimer Disease | Drug Delivery | Aβ Complex | Apolipoprotein E (ApoE) | Amyloid-β (AB) | RXR Agonists | Hepatomegaly | ABCG1 Lipid Transporters | Drug Action | ApoE
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2016, Volume 51, pp. 104 - 112
Abstract Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in... 
Neurology | Internal Medicine | APOE ε4 | Amyloid | Diabetes | Blood-brain barrier | Vascular pathology | Dementia | ALZHEIMERS-DISEASE | COGNITIVE IMPAIRMENT | APOE epsilon 4 | FRONTOTEMPORAL LOBAR DEGENERATION | CEREBROSPINAL-FLUID | DEPENDENT MANNER | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | TIGHT JUNCTIONS | VASCULAR DEMENTIA | DYSFUNCTION | DIAGNOSTIC-CRITERIA | LEWY BODIES | Diabetes Mellitus - blood | Capillary Permeability | Humans | Middle Aged | Blood-Brain Barrier - physiopathology | Immunoglobulins - cerebrospinal fluid | Vascular Endothelial Growth Factor A - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | Genotype | Male | Diabetes Mellitus - cerebrospinal fluid | Dementia - etiology | Serum Albumin | Cell Adhesion Molecule-1 | Apolipoproteins E - genetics | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Albumins - cerebrospinal fluid | Diabetes Mellitus - etiology | Female | Aged | Cohort Studies | Nervous system diseases | Neurosciences | PET imaging | Endothelial growth factors | Physiological aspects | Brain damage | Genetic aspects | Permeability | Apolipoproteins | Alzheimer's disease | Endothelium | Medical research | Medicine, Experimental | lewy bodies | vascular dementia | Geriatrics & Gerontology | Neurosciences & Neurology | dependent manner | dysfunction | cerebrospinal-fluid | Endokrinologi och diabetes | diagnostic-criteria | cognitive impairment | tight junctions | Geriatrik | frontotemporal lobar degeneration | Neurovetenskaper | Endocrinology and Diabetes | Geriatrics | alzheimers-disease
Journal Article
Journal of the American Geriatrics Society, ISSN 0002-8614, 12/2016, Volume 64, Issue 12, pp. 2479 - 2486
To investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ε4, and risk of incident mild cognitive impairment (MCI). Prospective... 
mild cognitive impairment | APOE | physical activity | APOE e4 | Apolipoprotein E4 - genetics | Prospective Studies | Humans | Genotype | Male | Risk | Motor Activity | Cognitive Dysfunction - prevention & control | Incidence | Aged, 80 and over | Cognitive Dysfunction - genetics | Female | Surveys and Questionnaires | Aged | Mild Cognitive Impairment | Physical Activity
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