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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2016, Volume 36, Issue 7, pp. 1305 - 1315
Journal Article
Nature reviews. Neurology, ISSN 1759-4766, 2013, Volume 9, Issue 2, pp. 106 - 118
Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main... 
E GENOTYPE | CEREBRAL AMYLOID ANGIOPATHY | A-BETA DEPOSITION | GENETIC RISK | APOE EPSILON-4 ALLELE | E TYPE-4 ALLELE | MILD COGNITIVE IMPAIRMENT | HIPPOCAMPAL NEUROGENESIS | CLINICAL NEUROLOGY | DENSITY-LIPOPROTEIN RECEPTOR | GENOME-WIDE ASSOCIATION | Inflammation - pathology | Predictive Value of Tests | Humans | tau Proteins - metabolism | Dementia - physiopathology | Risk | Brain Injuries - physiopathology | Dementia - genetics | Apolipoproteins E - metabolism | Neurogenesis - genetics | Neuronal Plasticity - genetics | Neuronal Plasticity - physiology | Apolipoproteins E - antagonists & inhibitors | Immunotherapy | Amyloid beta-Peptides - metabolism | Cognitive Dysfunction - psychology | Alzheimer Disease - epidemiology | Lipid Metabolism - genetics | Alzheimer Disease - psychology | Alzheimer Disease - therapy | Dendritic Spines - physiology | Vascular Diseases - genetics | Vascular Diseases - physiopathology | Brain Injuries - genetics | Cognitive Dysfunction - pathology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Neurogenesis - physiology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Apolipoproteins E - physiology | Brain - pathology | Inflammation - genetics | Alzheimer Disease - genetics | Lipid Metabolism - physiology | Allelomorphism | Physiological aspects | Genetic aspects | Research | Apolipoproteins | Alzheimer's disease | Risk factors | Index Medicus
Journal Article
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2012, Volume 33, Issue 3, pp. 437 - 456
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2013, Volume 127, Issue 25, pp. 2523 - 2534
Journal Article