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Autophagy, ISSN 1554-8627, 11/2015, Volume 11, Issue 11, pp. 1956 - 1977
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads to stress conditions. To mitigate such circumstances, stressed cells... 
ER stress | unfolded protein response | protein aggregates | autophagy | lysosome | Autophagy | Protein aggregates | Lysosome | Unfolded protein response | TRANSCRIPTION FACTORS | MEDIATED AUTOPHAGY | INDUCED APOPTOSIS | INTRACELLULAR CALCIUM | XBP1 MESSENGER-RNA | ENDOPLASMIC-RETICULUM STRESS | QUALITY-CONTROL | CELL-DEATH | CELL BIOLOGY | NF-KAPPA-B
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 397, pp. 72 - 82
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. To identify potential effective therapeutic drugs for PDAC, we... 
Hematology, Oncology and Palliative Medicine | Epithelial–stromal interaction | Microenvironment | Indirubin 3′-oximes | Pancreatic ductal adenocarcinoma | APOPTOSIS | Epithelial-stromal interaction | ACTIVATION | CHINESE ANTILEUKEMIA MEDICINE | Indirubin 3 '-oximes | HUMAN CANCER-CELLS | INHIBITS TUMOR-GROWTH | HUMAN NEUROBLASTOMA | CYCLIN-DEPENDENT KINASES | LUNG-CANCER | ONCOLOGY | ENDOTHELIAL-CELL | DERIVATIVES | CDC2 Protein Kinase | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Cyclin B1 - metabolism | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | G2 Phase Cell Cycle Checkpoints - drug effects | Time Factors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Oximes - pharmacology | Mice, Inbred BALB C | Adenocarcinoma | Medical colleges | Microbiology | Cell death | Analysis | Pancreatic cancer | Biochemistry | Biotechnology | Immunoglobulins | Lung cancer | Leukemia | Kinases | Cancer therapies | Studies | Cell growth | Chemotherapy | Medical prognosis | Rodents | Cell cycle | Fibroblasts | Software | Apoptosis | Cancer
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2009, Volume 11, Issue 11, pp. 1305 - 1314
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | 309
Journal Article
Diabetologia, ISSN 0012-186X, 6/2009, Volume 52, Issue 6, pp. 1092 - 1101
The destruction of pancreatic beta cells leading to type 1 diabetes in humans is thought to occur mainly through apoptosis and necrosis induced by activated... 
NF-κB | Medicine & Public Health | Human Physiology | Cytokines | Type 1 diabetes | Metabolic Diseases | Internal Medicine | Human islets | Microarray | Apoptosis | BIRC3 | ACTIVATION | NOD MICE | NECROSIS-FACTOR-ALPHA | ELEMENT-BINDING PROTEIN | DEATH | FACTOR-I | DIABETES-MELLITUS | PATHOGENESIS | NF-kappa B | ENDOCRINOLOGY & METABOLISM | TRANSCRIPTION FACTOR | EXPRESSION | Islets of Langerhans - drug effects | Interleukin-1beta - pharmacology | Oligonucleotide Array Sequence Analysis | Inhibitor of Apoptosis Proteins - genetics | Minor Histocompatibility Antigens | Humans | NF-kappa B - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Insulin-Secreting Cells - metabolism | Islets of Langerhans - metabolism | Cell Line | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Cells, Cultured | TNF Receptor-Associated Factor 1 - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Ubiquitin-Protein Ligases | Tumor Necrosis Factor-alpha - pharmacology | Animals | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cytokines - pharmacology | Interferon-gamma - pharmacology | Pancreatic beta cells | Anopheles | Analysis | Luciferase | Physiological aspects | Genetic research | Genetic aspects | Universities and colleges | Gene expression | T cells | Macrophages | Genes
Journal Article
Phytomedicine, ISSN 0944-7113, 05/2016, Volume 23, Issue 5, pp. 566 - 577
Journal Article