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JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 03/2019, Volume 84, Issue 6, pp. 3388 - 3404
We designed and synthesized (R)-5'-C-aminopropyl-2'-O-methyluridine and (S)-5'-C-aminopropy1-2'-O-methyluridine, which are applicable to small interfering RNAs... 
SYSTEM | MOLECULAR-DYNAMICS | POTENT | HUMAN ARGONAUTE-2 | STABILITY | CHEMISTRY, ORGANIC | INTERFERENCE | DUPLEXES | SIRNA | STRAND | OLIGONUCLEOTIDES
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2018, Volume 61, Issue 3, pp. 734 - 744
(E)-Vinylphosphonate ((E)-VP), a metabolically stable phosphate mimic at the 5'-end of the antisense strand, enhances the in vivo potency of siRNA. Here we... 
PHOSPHATE | THERAPEUTICS | BISPHOSPHONATE PRODRUGS | HEPATOCYTES | CHEMISTRY, MEDICINAL | AMYLOIDOSIS | LOOP RT-PCR | HUMAN ARGONAUTE-2 | QUANTIFICATION | SMALL INTERFERING RNAS | OLIGONUCLEOTIDES
Journal Article
Basic Research in Cardiology, ISSN 0300-8428, 9/2014, Volume 109, Issue 5, pp. 1 - 15
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2018, Volume 74, Issue 42, pp. 6182 - 6186
5′-( )-Vinylphosphonate (VP) is an effective bioisostere of the natural 5′-monophosphate in small interfering RNAs (siRNAs). Solid-phase synthesis of VP-siRNAs... 
Small interfering RNAs | Solid-phase synthesis | 5′-monophosphate | Oligonucleotides | Deprotection | IMPROVE | ACRYLONITRILE | CHEMISTRY, ORGANIC | GUIDE | PHOSPHOROTHIOATE | HUMAN ARGONAUTE-2 | IN-VIVO | DRUGS | SIRNA | 5'-VINYLPHOSPHONATE | 5 '-monophosphate | INTERFERING RNAS
Journal Article
Cell reports, 08/2018, Volume 24, Issue 6, p. 1397
Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the... 
Journal Article
International journal of physiology, pathophysiology and pharmacology, ISSN 1944-8171, 2018, Volume 10, Issue 6, p. 172
Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of the microtubule-associated protein tau. These include... 
Journal Article
Chemical Science, ISSN 2041-6520, 2018, Volume 9, Issue 8, pp. 2074 - 2086
The understanding of the dynamical and mechanistic aspects that lie behind siRNA-based gene regulation is a requisite to boost the performance of siRNA... 
PAZ DOMAIN | 3'-OVERHANG | MOLECULAR-DYNAMICS | IN-VITRO | COMPLEX | HUMAN ARGONAUTE-2 | DUPLEXES | RNA INTERFERENCE ACTIVITY | INHIBITORS | BINDING FREE-ENERGIES | CHEMISTRY, MULTIDISCIPLINARY | Steric hindrance | Overhang | Computer simulation | Gene expression | Free energy
Journal Article
Current Opinion in Microbiology, ISSN 1369-5274, 2016, Volume 32, pp. 71 - 76
Journal Article
Journal of Cancer, ISSN 1837-9664, 2015, Volume 6, Issue 9, pp. 877 - 882
AGO2 (Argonaute 2, EIF2C2) is the only member in AGO family with catalytic activity and of extreme importance during small RNAs guided gene silencing... 
Carcinomas | Angiogenesis | Argonaute-2 | MicroRNAs | microRNAs | angiogenesis | CRYSTAL-STRUCTURE | SELF-RENEWAL | PAZ DOMAIN | HEPATOCELLULAR-CARCINOMA | TRANSLATIONAL REPRESSION | ONCOLOGY | IMMUNOHISTOCHEMICAL ANALYSIS | carcinomas | ENDOTHELIAL-CELLS | AGO2 EXPRESSION | RNA RECOGNITION | PROTEINS
Journal Article
Journal Article