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Journal Article
Journal Article
PLoS Biology, ISSN 1544-9173, 02/2007, Volume 5, Issue 2, pp. 0179 - 0189
The mammalian circadian timing system consists of a master pacemaker in neurons of the suprachiasmatic nucleus (SCN) and clocks of a similar molecular makeup... 
RAT-LIVER | REVEALS PERSISTENT | SUPRACHIASMATIC NUCLEUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK RESPONSE | MOUSE | BIOLOGY | GENE-EXPRESSION | TIME | PERIPHERAL-TISSUES | BINDING | INDIVIDUAL FIBROBLASTS | Male | Biological Clocks - drug effects | DNA-Binding Proteins - metabolism | Hepatocytes - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver - drug effects | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Hepatocytes - drug effects | Hepatocytes - physiology | Nuclear Receptor Subfamily 1, Group D, Member 1 | ARNTL Transcription Factors | Basic Helix-Loop-Helix Transcription Factors - genetics | Cell Cycle Proteins - metabolism | Circadian Rhythm - genetics | Mice, Transgenic | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Period Circadian Proteins | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Biological Clocks - genetics | Chronobiology Phenomena | Liver - physiology | Protein Array Analysis | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Liver - cytology | Mice | Circadian Rhythm - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Neuroscience | Molecular Biology | Computational Biology | Genetics and Genomics | Mus (Mouse) | Biochemistry | Physiology | Mammals | Cell Biology | Circadian rhythm | Kinases | Experiments | Liver | Binding sites
Journal Article
Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7306, pp. 627 - 631
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5927, pp. 651 - 654
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report... 
RNA | Hepatocytes | Liver | Genes | Oscillation | Control loops | Reports | Biosynthesis | Gene expression regulation | Metabolism | Research universities | LIFE-SPAN | CELLS | GLUCOSE-HOMEOSTASIS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | EXTENSION | COMPONENT | SIRT1 | BINDING | CALORIE RESTRICTION | Humans | Adipose Tissue, White - metabolism | Hepatocytes - metabolism | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | Sirtuin 1 | NAD - biosynthesis | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Transcription, Genetic | Biological Clocks | Nuclear Proteins - genetics | Acrylamides - pharmacology | Cytokines - genetics | ARNTL Transcription Factors | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Liver - metabolism | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Transcription Factors - genetics | Circadian Rhythm | Period Circadian Proteins | Feedback, Physiological | Nicotinamide Phosphoribosyltransferase - genetics | Animals | CLOCK Proteins | Cell Line, Tumor | Protein Binding | Trans-Activators - metabolism | Mice | Cytokines - antagonists & inhibitors | Sirtuins - metabolism | Enzymes | Circadian rhythm | Cellular biology | Animal behavior | Rodents | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 04/2017, Volume 15, Issue 4, pp. e2001069 - e2001069
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by... 
HEPATIC GLUCONEOGENESIS | HUMAN GENOME | CHROMATIN LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COORDINATE DESCENT | IN-VIVO | BIOLOGY | DNA-BINDING PROTEINS | REV-ERB-ALPHA | HISTONE MODIFICATIONS | CIRCADIAN GENE-EXPRESSION | STRUCTURE PREDICTION | Promoter Regions, Genetic | ARNTL Transcription Factors - genetics | Fasting | Deoxyribonuclease I - genetics | Mice, Inbred C57BL | Circadian Rhythm - genetics | Gene Expression Regulation | ARNTL Transcription Factors - metabolism | Male | CLOCK Proteins - genetics | Circadian Clocks - genetics | Transcription Factors - genetics | Mice, Knockout | CLOCK Proteins - metabolism | Deoxyribonuclease I - metabolism | Multiprotein Complexes - metabolism | Animals | Chromatin Immunoprecipitation | Liver - physiology | RNA Polymerase II - genetics | Transcription, Genetic | Bioengineering | High resolution | Transcription factors | Genomics | Liver | Modules | Biochemistry | Assaying | Loads (forces) | Proteins | Eukaryotes | Life sciences | Bioinformatics | Deoxyribonucleic acid--DNA | Circadian rhythms | Nucleic acids | Gene expression | Mammals | Metabolism | Diurnal | Generalized linear models | Computer applications | Mice | Protein structure | Binding sites | DNA sequencing | Health sciences | Visualization | Chromatin | Animal models | Gene regulation | Genomes | Biology | DNA-directed RNA polymerase | Nanoparticles | Rodents | Dimensional analysis | Hepatocyte nuclear factor 4 | Mathematical models | Adrenal gland | Hepatocyte nuclear factor 1 | Deoxyribonuclease | Data analysis | Hypersensitivity | Diabetes mellitus | Data processing | Circadian rhythm | Ribonucleic acid--RNA | Computer programs | Feeding | Medicine | BMAL1 protein | Diabetes | Control theory | Molecular biology | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Cell, ISSN 0092-8674, 05/2006, Volume 125, Issue 3, pp. 497 - 508
The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of... 
ACTIVATION | CHROMATIN | MECHANISM | ACETYLATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | MOUSE | PERIPHERAL CLOCK | GENE-EXPRESSION | PROTEIN SIR2 | CELL BIOLOGY | Oncogene Proteins - genetics | Trans-Activators - classification | Acetyltransferases - metabolism | Humans | Histone Acetyltransferases - genetics | Chromatin Assembly and Disassembly - genetics | Oncogene Proteins - classification | Acetyltransferases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Mice, Mutant Strains | Histone Acetyltransferases - metabolism | Acetyltransferases - classification | Binding Sites - physiology | Trans-Activators - genetics | Acetylation | ARNTL Transcription Factors | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Circadian Rhythm - genetics | Oncogene Proteins - metabolism | Mice, Transgenic | Transcription Factors - genetics | Transcription Factors - classification | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Amino Acid Motifs - physiology | Animals | CLOCK Proteins | Cell Line, Tumor | Nuclear Receptor Coactivator 1 | Trans-Activators - metabolism | Mice | Nuclear Receptor Coactivator 3 | Histones - metabolism | Histones | Chromatin | Pacemaker, Artificial (Heart) | Research | Enzymes | DNA binding proteins | Index Medicus | Histone Acetyltransferases | Trans-Activators | Biochemistry, Molecular Biology | Oncogene Proteins | Chromatin Assembly and Disassembly | Circadian Rhythm | Amino Acid Motifs | Life Sciences | Transcription Factors | Molecular biology | Binding Sites | Acetyltransferases | Basic Helix-Loop-Helix Transcription Factors
Journal Article
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7376, pp. 209 - 214
Journal Article