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1. Full Text Shaojun Guo
Angewandte Chemie, ISSN 0044-8249, 09/2020, Volume 132, Issue 37, pp. 15924 - 15924
Artemisinin
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2. Full Text Wanbin Zhang
Angewandte Chemie, ISSN 0044-8249, 05/2020, Volume 132, Issue 20, pp. 7718 - 7718
Artemisinin
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3. Full Text High-level semi-synthetic production of the potent antimalarial artemisinin
by Paddon, C.J and Westfall, P.J and Pitera, D.J and Benjamin, K and Fisher, K and McPhee, D and Leavell, M.D and Tai, A and Main, A and Eng, D and Polichuk, D.R and Teoh, K.H and Reed, D.W and Treynor, T and Lenihan, J and Jiang, H and Fleck, M and Bajad, S and Dang, G and Dengrove, D and Diola, D and Dorin, G and Ellens, K.W and Fickes, S and Galazzo, J and Gaucher, S.P and Geistlinger, T and Henry, R and Hepp, M and Horning, T and Iqbal, T and Kizer, L and Lieu, B and Melis, D and Moss, N and Regentin, R and Secrest, S and Tsuruta, H and Vazquez, R and Westblade, L.F and Xu, L and Yu, M and Zhang, Y and Zhao, L and Lievense, J and Covello, P.S and Keasling, J.D and Reiling, K.K and Renninger, N.S and Newman, J.D
Nature (London), ISSN 0028-0836, 04/2013, Volume 496, Issue 7446, pp. 528 - 532
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Artemisinins - isolation & purification | Biotechnology | Malaria, Falciparum - drug therapy | Antimalarials - metabolism | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Saccharomyces cerevisiae - classification | Biosynthetic Pathways | Fermentation | Artemisinins - supply & distribution | Saccharomyces cerevisiae - metabolism | Singlet Oxygen - metabolism | Antimalarials - isolation & purification | Genetic Engineering | Antimalarials - economics | Artemisinins - metabolism | Artemisinins - economics | Antimalarials - supply & distribution | Artemisinins - chemistry | Saccharomyces cerevisiae - growth & development | Pharmaceutical research | Antimalarials | Product development | Biosynthesis | Research | Enzymes | Immunization | Microbiology | Deoxyribonucleic acid--DNA | Index Medicus
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4. Full Text Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities
by Reiter, Christoph and Fröhlich, Tony and Gruber, Lisa and Hutterer, Corina and Marschall, Manfred and Voigtländer, Cornelia and Friedrich, Oliver and Kappes, Barbara and Efferth, Thomas and Tsogoeva, Svetlana B
Bioorganic & medicinal chemistry, ISSN 0968-0896, 09/2015, Volume 23, Issue 17, pp. 5452 - 5458
Artemisinin-derived hybrids | Artemisinin-derived dimers | Antimalarial activity | Artemisinin-derived trimers | Anticancer activity | Antiviral activity | Antiviral Agents - pharmacology | Artemisinins - pharmacology | Artemisinins - therapeutic use | Humans | Artemisinins - administration & dosage | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Antimalarials - pharmacology | Antiviral agents | Analysis | Drug resistance in microorganisms | Anthracyclines | Malaria | Pharmacy | Leukemia | Drugstores | College teachers | Index Medicus
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5. Full Text A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
by Ménard, Sandie and Ménard, Didier and Khim, Nimol and Beghain, Johann and Adegnika, Ayola A and Shafiul-Alam, Mohammad and Amodu, Olukemi and Rahim-Awab, Ghulam and Barnadas, Céline and Berry, Antoine and Boum, Yap and Bustos, Maria D and Cao, Jun and Chen, Jun-Hu and Collet, Louis and Cui, Liwang and Thakur, Garib-Das and Dieye, Alioune and Djallé, Djibrine and Dorkenoo, Monique A and Eboumbou-Moukoko, Carole E and Espino, Fe-Esperanza-Caridad J and Fandeur, Thierry and Ferreira-da-Cruz, Maria-Fatima and Fola, Abebe A and Fuehrer, Hans-Peter and Hassan, Abdillahi M and Herrera, Socrates and Hongvanthong, Bouasy and Houzé, Sandrine and Ibrahim, Maman L and Jahirul-Karim, Mohammad and Jiang, Lubin and Kano, Shigeyuki and Ali-Khan, Wasif and Khanthavong, Maniphone and Kremsner, Peter G and Lacerda, Marcus and Leang, Rithea and Leelawong, Mindy and Li, Mei and Lin, Khin and Mazarati, Jean-Baptiste and Morlais, Isabelle and Muhindo-Mavoko, Hypolite and Musset, Lise and Na-Bangchang, Kesara and Nambozi, Michael and Niaré, Karamoko and Noedl, Harald and Ouédraogo, Jean-Bosco and Pillai, Dylan R and Pradines, Bruno and Quang-Phuc, Bui and Ramharter, Michael and Randrianarivelojosia, Milijaona and Sattabongkot, Jetsumon and Sheikh-Omar, Abdiqani and Silué, Kigbafori D and Sirima, Sodiomon B and Sutherland, Colin and Syafruddin, Din and Tahar, Rachida and Tang, Lin-Hua and Touré, Offianan A and Tshibangu-wa-Tshibangu, Patrick and Vigan-Womas, Inès and Warsame, Marian and Wini, Lyndes and Zakeri, Sedigheh and Kim, Saorin and Eam, Rotha and Berne, Laura and Khean, Chanra and Chy, Sophy and Ken, Malen and Loch, Kaknika and Canier, Lydie and Duru, Valentine and Legrand, Eric and Barale, Jean-Christophe and Stokes, Barbara and Straimer, Judith and Witkowski, Benoit and Fidock, David A and Rogier, Christophe and Ringwald, Pascal and Ariey, Frederic and Mercereau-Puijalon, Odile and KARMA Consortium
The New England journal of medicine, ISSN 0028-4793, 06/2016, Volume 374, Issue 25, pp. 2453 - 2464
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Malaria, Falciparum - drug therapy | Humans | Genotype | Plasmodium falciparum - drug effects | Protozoan Proteins - genetics | Sequence Analysis, DNA | Lactones - pharmacology | Lactones - therapeutic use | Polymorphism, Genetic | Asia, Southeastern | Endemic Diseases | Drug Resistance - genetics | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Algorithms | Artemisinins - therapeutic use | China | Plasmodium falciparum - genetics | Mutation | Malaria | Artemisinin | Alleles | Parasites | Drug resistance | Polymorphism | Index Medicus | Abridged Index Medicus | Malaria, Falciparum | Protozoan Proteins | Lactones | Life Sciences | Plasmodium falciparum | Human health and pathology | Infectious diseases | Artemisinins | Drug Resistance
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6. Full Text Hemolysis after oral artemisinin combination therapy for uncomplicated Plasmodium falciparum Malaria
by Kurth, Florian and Lingscheid, Tilman and Steiner, Florian and Stegemann, Miriam S and Bélard, Sabine and Menner, Nikolai and Pongratz, Peter and Kim, Johanna and von Bernuth, Horst and Mayer, Beate and Damm, Georg and Seehofer, Daniel and Salama, Abdulgabar and Suttorp, Norbert and Zoller, Thomas
Emerging infectious diseases, ISSN 1080-6040, 08/2016, Volume 22, Issue 8, pp. 1381 - 1386
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Hemolysis - drug effects | Antimalarials - adverse effects | Malaria, Falciparum - drug therapy | Prospective Studies | Administration, Oral | Humans | Fluorenes - therapeutic use | Anemia - chemically induced | Artemisinins - administration & dosage | Male | Antimalarials - therapeutic use | Quinolines - administration & dosage | Ethanolamines - administration & dosage | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Adolescent | Adult | Ethanolamines - therapeutic use | Female | Fluorenes - administration & dosage | Quinolines - therapeutic use | Drug Therapy, Combination | Artemisinins - adverse effects | Child | Plasmodium falciparum | Care and treatment | Malaria | Haptoglobin | Anemia | Hemoglobin | Hemolysis and hemolysins | Index Medicus | clinical study | oral artemisinin combination therapy | lactate dehydrogenase | Research | hemolysis | hemoglobin | anemia | artemisinin | uncomplicated malaria | parasites | haptoglobin | Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated | malaria
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7. Full Text Artemisinins Target GABA(A) Receptor Signaling and Impair alpha Cell Identity
by Li, Jin and Casteels, Tamara and Frogne, Thomas and Ingvorsen, Camilla and Honore, Christian and Courtney, Monica and Huber, Kilian V. M and Schmitner, Nicole and Kimmel, Robin A and Romanov, Roman A and Sturtzel, Caterina and Lardeau, Charles-Hugues and Klughammer, Johanna and Farlik, Matthias and Sdelci, Sara and Vieira, Andhira and Avolio, Fabio and Briand, Francois and Baburin, Igor and Majek, Peter and Pauler, Florian M and Penz, Thomas and Stukalov, Alexey and Gridling, Manuela and Parapatics, Katja and Barbieux, Charlotte and Berishvili, Ekaterine and Spittler, Andreas and Colinge, Jacques and Bennett, Keiryn L and Hering, Steffen and Sulpice, Thierry and Bock, Christoph and Distel, Martin and Harkany, Tibor and Meyer, Dirk and Superti-Furga, Giulio and Collombat, Patrick and Hecksher-Sorensen, Jacob and Kubicek, Stefan
Cell (Cambridge), ISSN 0092-8674, 01/2017, Volume 168, Issue 1-2, pp. 86 - 100.e15
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Islets of Langerhans - drug effects | gamma-Aminobutyric Acid - metabolism | Homeodomain Proteins - metabolism | Humans | Gene Expression Profiling | Artemisinins - pharmacology | Cell Transdifferentiation - drug effects | Membrane Proteins - metabolism | Insulin - genetics | Single-Cell Analysis | Disease Models, Animal | Signal Transduction | Cells, Cultured | Diabetes Mellitus - drug therapy | Diabetes Mellitus, Type 1 - pathology | Artemisinins - administration & dosage | Rats | Zebrafish | Diabetes Mellitus, Type 1 - drug therapy | Transcription Factors - metabolism | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Protein Stability - drug effects | Mice | Receptors, GABA-A - metabolism | Life Sciences | Signal transduction | Artemisinins/Pharmacology | Insulin/Genetics | Disease models, animal | Cancer
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8. Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones
by Ren, Yulin and Yu, Jianhua and Kinghorn, A. Douglas
Current medicinal chemistry, ISSN 0929-8673, 01/2016, Volume 23, Issue 23, pp. 2397 - 2420
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Plants, Medicinal - chemistry | Antineoplastic Agents, Phytogenic - chemical synthesis | Sesquiterpenes - chemistry | Apoptosis - drug effects | Humans | Structure-Activity Relationship | Lactones - pharmacology | Lactones - therapeutic use | Neoplasms - drug therapy | Artemisinins - pharmacology | Animals | Artemisinins - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Neoplasms - pathology | Plants, Medicinal - metabolism | Artemisinins - chemistry | Lactones - chemistry | Toxicity | Artemisinin | Clinical trials | Cytotoxicity | Lead compounds | Plants | Structure-activity relationships | Lactones | Anticancer properties | Thapsigargin | Sesquiterpene lactones | Antitumor agents | Natural products | Artesunate | Antitumor activity | Biocompatibility | In vivo methods and tests | Cancer | Structural analysis
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9. Full Text Artemisinin-resistant plasmodium falciparum with high survival rates, uganda, 2014-2016
by Ikeda, Mie and Kaneko, Megumi and Tachibana, Shin-Ichiro and Balikagala, Betty and Sakurai-Yatsushiro, Miki and Yatsushiro, Shouki and Takahashi, Nobuyuki and Yamauchi, Masato and Sekihara, Makoto and Hashimoto, Muneaki and Katuro, Osbert T and Olia, Alex and Obwoya, Paul S and Auma, Mary A and Anywar, Denis A and Odongo-Aginya, Emmanuel I and Okello-Onen, Joseph and Hirai, Makoto and Ohashi, Jun and Palacpac, Nirianne M. Q and Kataoka, Masatoshi and Tsuboi, Takafumi and Kimura, Eisaku and Horii, Toshihiro and Mita, Toshihiro
Emerging infectious diseases, ISSN 1080-6040, 04/2018, Volume 24, Issue 4, pp. 718 - 726
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Cross-Sectional Studies | History, 21st Century | Humans | Malaria, Falciparum - history | Child, Preschool | Uganda - epidemiology | Genotype | Male | Survival Rate | Antimalarials - therapeutic use | Plasmodium falciparum - drug effects | Antimalarials - pharmacology | Whole Genome Sequencing | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Malaria, Falciparum - mortality | Phenotype | Artemisinins - therapeutic use | Plasmodium falciparum - genetics | Malaria, Falciparum - epidemiology | Female | Mutation | Drug Resistance | Surveys | Plasmodium falciparum | Malaria | Population genetics | Patient outcomes | Pyrimethamine | Index Medicus | with High Survival Rates, Uganda, 2014–2016 | antimicrobial resistance | Artemisinin | Uganda | parasites | Research | Resistant | drug resistance | malaria
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10. Full Text Artemisinin-resistant Plasmodium falciparum K13 mutant alleles, Thailand-Myanmar border
by Boullé, Mikael and Witkowski, Benoit and Duru, Valentine and Sriprawat, Kanlaya and Nair, Shalini K and McDew-White, Marina and Anderson, Tim J.C and Phyo, Aung Pyae and Menard, Didier and Nosten, François
Emerging infectious diseases, ISSN 1080-6040, 08/2016, Volume 22, Issue 8, pp. 1503 - 1505
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Malaria, Falciparum - drug therapy | Humans | Thailand - epidemiology | Antimalarials - therapeutic use | Plasmodium falciparum - drug effects | Antimalarials - pharmacology | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Artemisinins - therapeutic use | Plasmodium falciparum - genetics | Alleles | Malaria, Falciparum - epidemiology | Myanmar - epidemiology | Mutation | Drug Resistance | Physiological aspects | Plasmodium falciparum | Demographic aspects | Drug resistance | Distribution | Index Medicus | Myanmar | Malaria, Falciparum | Parasitology | Antimalarials | Thailand | Life Sciences | Human health and pathology | Microbiology and Parasitology | Infectious diseases | Artemisinins | ring-stage survival assay | Malaria | artemisinin resistance | parasite clearance half-life | genotype | Letter | K13 mutant alleles | antimicrobial resistance | Artemisinin-Resistant | K13 Mutant Alleles, Thailand–Myanmar Border | parasites | Letters to the Editor
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11. Full Text Semi-synthetic artemisinin: A model for the use of synthetic biology in pharmaceutical development
by Paddon, Chris J and Keasling, Jay D
Nature reviews. Microbiology, ISSN 1740-1526, 2014, Volume 12, Issue 5, pp. 355 - 367
Life Sciences & Biomedicine | Microbiology | Science & Technology | Genetic Engineering - methods | Artemisinins - isolation & purification | Biotechnology | Artemisinins - chemical synthesis | Metabolic Engineering - methods | Antimalarials - metabolism | Saccharomyces cerevisiae - genetics | Systems Biology | Antimalarials - pharmacology | Saccharomyces cerevisiae - metabolism | Antimalarials - isolation & purification | Artemisinins - pharmacology | Synthetic Biology | Escherichia coli - genetics | Drug Design | Escherichia coli - metabolism | Artemisinins - metabolism | Plants - chemistry | Antimalarials - chemical synthesis | Antiparasitic agents | Pharmacology, Experimental | Synthetic biology | Research | Properties | Index Medicus
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