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1. Full Text A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
by Ménard, Sandie and Ménard, Didier and Khim, Nimol and Beghain, Johann and Adegnika, Ayola A and Shafiul-Alam, Mohammad and Amodu, Olukemi and Rahim-Awab, Ghulam and Barnadas, Céline and Berry, Antoine and Boum, Yap and Bustos, Maria D and Cao, Jun and Chen, Jun-Hu and Collet, Louis and Cui, Liwang and Thakur, Garib-Das and Dieye, Alioune and Djallé, Djibrine and Dorkenoo, Monique A and Eboumbou-Moukoko, Carole E and Espino, Fe-Esperanza-Caridad J and Fandeur, Thierry and Ferreira-da-Cruz, Maria-Fatima and Fola, Abebe A and Fuehrer, Hans-Peter and Hassan, Abdillahi M and Herrera, Socrates and Hongvanthong, Bouasy and Houzé, Sandrine and Ibrahim, Maman L and Jahirul-Karim, Mohammad and Jiang, Lubin and Kano, Shigeyuki and Ali-Khan, Wasif and Khanthavong, Maniphone and Kremsner, Peter G and Lacerda, Marcus and Leang, Rithea and Leelawong, Mindy and Li, Mei and Lin, Khin and Mazarati, Jean-Baptiste and Morlais, Isabelle and Muhindo-Mavoko, Hypolite and Musset, Lise and Na-Bangchang, Kesara and Nambozi, Michael and Niaré, Karamoko and Noedl, Harald and Ouédraogo, Jean-Bosco and Pillai, Dylan R and Pradines, Bruno and Quang-Phuc, Bui and Ramharter, Michael and Randrianarivelojosia, Milijaona and Sattabongkot, Jetsumon and Sheikh-Omar, Abdiqani and Silué, Kigbafori D and Sirima, Sodiomon B and Sutherland, Colin and Syafruddin, Din and Tahar, Rachida and Tang, Lin-Hua and Touré, Offianan A and Tshibangu-wa-Tshibangu, Patrick and Vigan-Womas, Inès and Warsame, Marian and Wini, Lyndes and Zakeri, Sedigheh and Kim, Saorin and Eam, Rotha and Berne, Laura and Khean, Chanra and Chy, Sophy and Ken, Malen and Loch, Kaknika and Canier, Lydie and Duru, Valentine and Legrand, Eric and Barale, Jean-Christophe and Stokes, Barbara and Straimer, Judith and Witkowski, Benoit and Fidock, David A and Rogier, Christophe and Ringwald, Pascal and Ariey, Frederic and Mercereau-Puijalon, Odile and KARMA Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2016, Volume 374, Issue 25, pp. 2453 - 2464
The emergence of Plasmodium falciparum resistance to artemisinin-based therapy is a major global health challenge. In this report, investigators describe the... 
CLEARANCE | MEDICINE, GENERAL & INTERNAL | IN-VITRO | WESTERN CAMBODIA | SUB-SAHARAN AFRICA | ARTEMISININ RESISTANCE MUTATIONS | MALARIA | CHINA-MYANMAR BORDER | K13 PROPELLER GENE | MOLECULAR MARKER | DRUG-RESISTANCE | Malaria, Falciparum - drug therapy | Humans | Genotype | Plasmodium falciparum - drug effects | Protozoan Proteins - genetics | Sequence Analysis, DNA | Lactones - pharmacology | Lactones - therapeutic use | Polymorphism, Genetic | Asia, Southeastern | Endemic Diseases | Drug Resistance - genetics | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Algorithms | Artemisinins - therapeutic use | China | Plasmodium falciparum - genetics | Mutation | Malaria | Artemisinin | Alleles | Parasites | Drug resistance | Polymorphism | Malaria, Falciparum | Parasitology | Protozoan Proteins | Lactones | Life Sciences | Plasmodium falciparum | Microbiology and Parasitology | Artemisinins | Drug Resistance
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2. Full Text Semi-synthetic artemisinin: A model for the use of synthetic biology in pharmaceutical development
by Paddon, Chris J and Keasling, Jay D
Nature Reviews Microbiology, ISSN 1740-1526, 2014, Volume 12, Issue 5, pp. 355 - 367
Recent developments in synthetic biology, combined with continued progress in systems biology and metabolic engineering, have enabled the engineering of... 
CRISPR-CAS SYSTEMS | ENGINEERED ESCHERICHIA-COLI | ANTIMALARIAL AGENT ARTEMISININ | ISOPRENOID BIOSYNTHESIS | PLASMODIUM-FALCIPARUM | QINGHAOSU ARTEMISININ | BENZYLISOQUINOLINE ALKALOIDS | MICROBIOLOGY | MEVALONATE PATHWAY | SACCHAROMYCES-CEREVISIAE | HIGH-LEVEL PRODUCTION | Genetic Engineering - methods | Artemisinins - isolation & purification | Biotechnology | Artemisinins - chemical synthesis | Metabolic Engineering - methods | Antimalarials - metabolism | Saccharomyces cerevisiae - genetics | Systems Biology | Antimalarials - pharmacology | Saccharomyces cerevisiae - metabolism | Antimalarials - isolation & purification | Artemisinins - pharmacology | Synthetic Biology | Escherichia coli - genetics | Drug Design | Escherichia coli - metabolism | Artemisinins - metabolism | Plants - chemistry | Antimalarials - chemical synthesis | Antiparasitic agents | Pharmacology, Experimental | Synthetic biology | Research | Properties
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3. Full Text High-level semi-synthetic production of the potent antimalarial artemisinin
by Paddon, C.J and Westfall, P.J and Pitera, D.J and Benjamin, K and Fisher, K and McPhee, D and Leavell, M.D and Tai, A and Main, A and Eng, D and Polichuk, D.R and Teoh, K.H and Reed, D.W and Treynor, T and Lenihan, J and Jiang, H and Fleck, M and Bajad, S and Dang, G and Dengrove, D and Diola, D and Dorin, G and Ellens, K.W and Fickes, S and Galazzo, J and Gaucher, S.P and Geistlinger, T and Henry, R and Hepp, M and Horning, T and Iqbal, T and Kizer, L and Lieu, B and Melis, D and Moss, N and Regentin, R and Secrest, S and Tsuruta, H and Vazquez, R and Westblade, L.F and Xu, L and Yu, M and Zhang, Y and Zhao, L and Lievense, J and Covello, P.S and Keasling, J.D and Reiling, K.K and Renninger, N.S and Newman, J.D
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7446, pp. 528 - 532
In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths(1). The World Health Organization has recommended artemisinin-based... 
YEAST | ANNUA | DRUG ARTEMISININ | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GENE DISRUPTION | REDUCTASE | MOLECULAR-CLONING | CYTOCHROME B | SACCHAROMYCES-CEREVISIAE | DIHYDROARTEMISINIC ACID | Artemisinins - isolation & purification | Biotechnology | Malaria, Falciparum - drug therapy | Antimalarials - metabolism | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Saccharomyces cerevisiae - classification | Biosynthetic Pathways | Fermentation | Artemisinins - supply & distribution | Saccharomyces cerevisiae - metabolism | Singlet Oxygen - metabolism | Antimalarials - isolation & purification | Genetic Engineering | Antimalarials - economics | Artemisinins - metabolism | Artemisinins - economics | Antimalarials - supply & distribution | Artemisinins - chemistry | Saccharomyces cerevisiae - growth & development | Pharmaceutical research | Antimalarials | Product development | Biosynthesis | Research | Enzymes | Immunization | Microbiology | Deoxyribonucleic acid--DNA
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4. Full Text Continuous-flow synthesis of the anti-malaria drug artemisinin
by Lévesque, François and Seeberger, Peter H
Angewandte Chemie - International Edition, ISSN 1433-7851, 02/2012, Volume 51, Issue 7, pp. 1706 - 1709
Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained... 
artemisinin | drug research | malaria | photochemistry | flow chemistry | ANTIMALARIAL-DRUG | ACID | QINGHAOSU ARTEMISININ | SINGLET OXYGEN | (+)-ARTEMISININ | CHEMISTRY, MULTIDISCIPLINARY | Artemisinins - chemical synthesis | Molecular Conformation | Antimalarials - chemistry | Chromatography, High Pressure Liquid - instrumentation | Photochemistry - instrumentation | Antimalarials - chemical synthesis | Artemisinins - chemistry | Drugs | Extraction | Synthesis | Malaria | Health
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5. Full Text A continuous-flow process for the synthesis of artemisinin
by Kopetzki, Daniel and Lévesque, François and Seeberger, Peter H
Chemistry - A European Journal, ISSN 0947-6539, 04/2013, Volume 19, Issue 17, pp. 5450 - 5456
Isolation of the most effective antimalarial drug, artemisinin, from the plant sweet wormwood, does not yield sufficient quantities to provide the more than... 
artemisinin | antimalarial agents | singlet oxygen | photochemistry | flow chemistry | ANTIMALARIAL-DRUG | CONVERSION | DIHYDROARTEMISINIC ACID | CHEMISTRY, MULTIDISCIPLINARY | BIOSYNTHESIS | QINGHAOSU ARTEMISININ | ANNUA L | CHEMISTRY | MALARIA | (+)-ARTEMISININ | Artemisinins - chemical synthesis | Artemisinins - pharmacology | Artemisia - chemistry | Africa | Antimalarials - chemistry | Singlet Oxygen | Antimalarials - chemical synthesis | Artemisinins - chemistry | Antimalarials - pharmacology | Active oxygen | Manufacturing | Availability | Drugs | Precursors | Photochemical | Plants (organisms) | Wastes | Conversion | Optimization
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6. Full Text Synthetic strategies for peroxide ring construction in artemisinin
by Vil, Vera A and Yaremenko, Ivan A and Ilovaisky, Alexey I and Terent'ev, Alexander O
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, p. 117
The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the... 
Organic Peroxide | Cycles | Artemisinic Acid | Artemisinin | Peroxidation | ARTEANNUIC ACID | ANTIMALARIAL AGENT ARTEMISININ | CHEMISTRY, ORGANIC | cycles | STEREOSELECTIVE TOTAL-SYNTHESIS | DIHYDROARTEMISINIC ACID | SEMISYNTHETIC ARTEMISININ | artemisinin | MEDICINAL CHEMISTRY | SPONTANEOUS AUTOXIDATION | artemisinic acid | peroxidation | ANNUA | QINGHAOSU ARTEMISININ | (+)-ARTEMISININ | organic peroxide | Artemisinins - chemical synthesis | History, 21st Century | Oxidation-Reduction | Stereoisomerism | History, 20th Century | Humans | Ozone - chemistry | Peroxides - chemistry | Chemistry Techniques, Synthetic - methods | Artemisinins - history | Singlet Oxygen - chemistry | Chemistry Techniques, Synthetic - history | Antimalarials - history | Antimalarials - chemical synthesis | Artemisinins - chemistry
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7. Full Text Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin
by Corsello, Michael A and Garg, Neil K
Natural Product Reports, ISSN 0265-0568, 2/2015, Volume 32, Issue 3, pp. 359 - 366
Covering: up to 2014 In the developing world, multi-drug resistant malaria caused by the parasite Plasmodium falciparum is an epidemic that claims the lives of... 
CHEMISTRY, MEDICINAL | ANTIMALARIAL AGENT ARTEMISININ | AMORPHA-4,11-DIENE SYNTHASE | DRUG ARTEMISININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CHEMISTRY, ORGANIC | STEREOSELECTIVE TOTAL-SYNTHESIS | DIHYDROARTEMISINIC ACID | SEMISYNTHETIC ARTEMISININ | QINGHAOSU ARTEMISININ | SINGLET OXYGEN | MOLECULAR-CLONING | Artemisinins - chemical synthesis | Artemisinins - pharmacology | Drug Resistance, Microbial - drug effects | Antimalarials - chemistry | Molecular Structure | Malaria - drug therapy | Plasmodium falciparum - drug effects | Antimalarials - chemical synthesis | Artemisinins - chemistry | Antimalarials - pharmacology
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8. Full Text Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities
by Reiter, Christoph and Fröhlich, Tony and Gruber, Lisa and Hutterer, Corina and Marschall, Manfred and Voigtländer, Cornelia and Friedrich, Oliver and Kappes, Barbara and Efferth, Thomas and Tsogoeva, Svetlana B
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2015, Volume 23, Issue 17, pp. 5452 - 5458
New pharmaceutically active compounds can be obtained by modification of existing drugs to access more effective agents in the wake of drug resistance amongst... 
Artemisinin-derived hybrids | Artemisinin-derived dimers | Antimalarial activity | Artemisinin-derived trimers | Anticancer activity | Antiviral activity | CANCER-CELLS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NATURAL-PRODUCT HYBRIDS | MEDICINAL CHEMISTRY | IN-VITRO | MALARIA-INFECTED MICE | PLASMODIUM-FALCIPARUM | QINGHAOSU ARTEMISININ | LEUKEMIA-CELLS | TRIOXANE DIMERS | MULTIDRUG-RESISTANCE | Antiviral Agents - pharmacology | Artemisinins - pharmacology | Artemisinins - therapeutic use | Humans | Artemisinins - administration & dosage | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Antimalarials - pharmacology | Antiviral agents | Analysis | Drug resistance in microorganisms | Anthracyclines | Malaria | Pharmacy | Leukemia | Drugstores | College teachers
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9. Artemisia annua
: prospects, applications and therapeutic uses
by Aftab, Tariq
2018, ISBN 9781138632103
Artemisia annua | Artemisinin | Therapeutic use
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10. Full Text Hemolysis after oral artemisinin combination therapy for uncomplicated Plasmodium falciparum Malaria
by Kurth, Florian and Lingscheid, Tilman and Steiner, Florian and Stegemann, Miriam S and Bélard, Sabine and Menner, Nikolai and Pongratz, Peter and Kim, Johanna and von Bernuth, Horst and Mayer, Beate and Damm, Georg and Seehofer, Daniel and Salama, Abdulgabar and Suttorp, Norbert and Zoller, Thomas
Emerging Infectious Diseases, ISSN 1080-6040, 08/2016, Volume 22, Issue 8, pp. 1381 - 1386
Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective... 
INFECTIOUS DISEASES | DELAYED HEMOLYSIS | INTRAVENOUS ARTESUNATE | ARTEMETHER-LUMEFANTRINE | PATIENT | ANEMIA | IMMUNOLOGY | CHILDREN | Hemolysis - drug effects | Antimalarials - adverse effects | Malaria, Falciparum - drug therapy | Prospective Studies | Administration, Oral | Humans | Fluorenes - therapeutic use | Anemia - chemically induced | Artemisinins - administration & dosage | Male | Antimalarials - therapeutic use | Quinolines - administration & dosage | Ethanolamines - administration & dosage | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Adolescent | Adult | Ethanolamines - therapeutic use | Female | Fluorenes - administration & dosage | Quinolines - therapeutic use | Drug Therapy, Combination | Artemisinins - adverse effects | Child | Plasmodium falciparum | Care and treatment | Malaria | Haptoglobin | Anemia | Hemoglobin | Hemolysis and hemolysins | clinical study | oral artemisinin combination therapy | lactate dehydrogenase | Research | hemolysis | hemoglobin | anemia | artemisinin | uncomplicated malaria | parasites | haptoglobin | Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated | malaria
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11. Full Text Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmissionblocking activity by methylene blue
by Adjalley, Sophie H and Johnston, Geoffrey L and Li, Tao and Eastman, Richard T and Ekland, Eric H and Eappen, Abraham G and Richman, Adam and Sim, B. Kim Lee and Lee, Marcus C. S and Hoffman, Stephen L and Fidock, David A
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 47, pp. E1214 - E1223
Artemisinin-based combination therapies | Transfection
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12. Full Text A Temporizing Solution to “Artemisinin Resistance”
by Chan, Xin-Hui S and White, Nicholas J and Hien, Tran T and Wang, Jigang and Krishna, Sanjeev and Xu, Chengchao
The New England Journal of Medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 989 - 990
To the Editor: We agree with Wang et al. (May 30 issue) 1 that artemisinins are a precious weapon against malaria that must be preserved through intelligent... 
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13. Full Text Current perspectives on the mechanism of action of artemisinins
by Golenser, Jacob and Waknine, Judith H and Krugliak, Miriam and Hunt, Nicholas H and Grau, Georges E
International Journal for Parasitology, ISSN 0020-7519, 2006, Volume 36, Issue 14, pp. 1427 - 1441
Artemisinin derivatives are the most recent single drugs approved and introduced for public antimalarial treatment. Although their recommended use is for... 
Resistance | Free radicals | Cytokines | SERCA | Malaria treatment | Artemisinin | free radicals | ANTIMALARIAL AGENT ARTEMISININ | RODENT MALARIA | DRUG ARTEMISININ | PLASMODIUM-FALCIPARUM MALARIA | malaria treatment | resistance | artemisinin | SOUTHEAST-ASIA | LABORATORY-ANIMALS | IN-VITRO SENSITIVITY | cytokines | PFMDR1 GENE | PARASITOLOGY | CEREBRAL MALARIA | Antimalarials - adverse effects | Malaria, Falciparum - drug therapy | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Antimalarials - metabolism | Electron Transport - drug effects | Reactive Oxygen Species - metabolism | Humans | Antimalarials - therapeutic use | Drug Resistance - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Plasmodium falciparum - drug effects | Animals | Artemisinins - therapeutic use | Immune System - drug effects | Artemisinins - metabolism | Malaria - drug therapy | Artemisinins - adverse effects | Plasmodium falciparum | Carrier proteins | Malaria | Drug resistance | Radicals (Chemistry) | Drug approval
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