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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Artemisinins | Malaria | Half lives | Antimalarials | Peroxides | Parasites | Dosage | Ozonides | Blood | Blood plasma | 1,2,4-trioxolane | Antimalarial drug discovery | OZ277 | PHARMACODYNAMIC PROPERTIES | MULTIDISCIPLINARY SCIENCES | ARTEROLANE | TRIOXOLANE | 1-AMINOBENZOTRIAZOLE | antimalarial drug discovery | PEROXIDES | IN-VITRO ASSESSMENT | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | ARTEMISININ | Peroxides - administration & dosage | Plasmodium berghei - physiology | Male | Peroxides - therapeutic use | Peroxides - pharmacokinetics | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Heterocyclic Compounds - chemistry | Time Factors | Adamantane - therapeutic use | Adamantane - administration & dosage | Adamantane - pharmacokinetics | Artemisinins - chemistry | Adamantane - analogs & derivatives | Antimalarials - pharmacokinetics | Heterocyclic Compounds - administration & dosage | Drug Stability | Peroxides - chemistry | Rats | Treatment Outcome | Antimalarials - therapeutic use | Iron - metabolism | Rats, Sprague-Dawley | Animals | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Antimalarials - chemistry | Malaria - parasitology | Heterocyclic Compounds - pharmacokinetics | Mice | Adamantane - chemistry | Heterocyclic Compounds - therapeutic use | Malaria - drug therapy | Care and treatment | Composition | Health aspects | Malaria vaccine | Biological Sciences
Journal Article
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 07/2016, Volume 17, Issue 10, pp. 1303 - 1307
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2016, Volume 16, Issue 1, pp. 61 - 69
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2016, Volume 57, Issue 47, pp. 5286 - 5289
Mycangimycin is a eicosa-heptenic acid containing an unprecedented 3,5-disubstituted-1,2-dioxolane ring with promising anti-fungal and antimalarial activity.... 
Kulinkovich reaction | Natural product | Anti-malarial | Peroxide | Fatty acid | ACIDS | OXYGENATION | ARTEROLANE | QINGHAOSU | CHEMISTRY, ORGANIC | ALKENES | ORGANIC PEROXIDES | PLASMODIUM-FALCIPARUM | ESTERS | 1,2-DIOXOLANES | ARTEMISININ
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2016, Volume 60, Issue 8, pp. 4501 - 4510
Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been approved for marketing or are... 
MULTICENTER | MECHANISM | PEROXIDES | ARTEMISININ RESISTANCE | ARTEROLANE | SENSITIVITY | MALARIA | TRIOXOLANE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MALEATE | CAMBODIA | Artemisinins - pharmacology | Parasitic Sensitivity Tests | Plasmodium falciparum - drug effects | Heterocyclic Compounds - pharmacology | Antimalarials - pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2017, Volume 60, Issue 7, pp. 2654 - 2668
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 04/2016, Volume 62, Issue 8, pp. 964 - 971
Background. Artemisinins, which are derived from plants, are subject to risk of supply interruption due to climatic changes. Consequently, an effort to... 
artemisinin combination therapy | arterolane maleate | malaria | once-daily dose | fixed-dose combination | INFECTIOUS DISEASES | MULTICENTER | CLINICAL-TRIAL | EFFICACY | SAFETY EVALUATION | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | CHILDREN | PHARMACOKINETICS | DIHYDROARTEMISININ-PIPERAQUINE | PLASMODIUM-FALCIPARUM | Africa - epidemiology | Peroxides - administration & dosage | Humans | Middle Aged | Fluorenes - therapeutic use | Half-Life | Spiro Compounds - administration & dosage | Male | Spiro Compounds - therapeutic use | Peroxides - therapeutic use | Plasmodium falciparum - drug effects | Quinolines - administration & dosage | Ethanolamines - administration & dosage | Heterocyclic Compounds, 1-Ring - administration & dosage | Young Adult | Malaria, Falciparum - epidemiology | Adult | Female | Fluorenes - administration & dosage | Drug Therapy, Combination | Child | Malaria, Falciparum - drug therapy | Double-Blind Method | Artemisinins - administration & dosage | India - epidemiology | Antimalarials - therapeutic use | Malaria, Falciparum - parasitology | Asia - epidemiology | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Adolescent | Heterocyclic Compounds, 1-Ring - therapeutic use | Ethanolamines - therapeutic use | Aged | Quinolines - therapeutic use | Plasmodium falciparum | Youth | Adults | Teenagers | Research | Health aspects | and Commentaries
Journal Article
Acta Tropica, ISSN 0001-706X, 08/2016, Volume 160, pp. 35 - 38
Primaquine has been the drug of choice for the prevention of relapse for more than 60 years. Primaquine tolerant strain of was identified in 1944. Significant... 
P. vivax | Resistance | Treatment | Therapeutic failure | Primaquine | EFFICACY | SAFETY | TAFENOQUINE | REGIMENS | TROPICAL MEDICINE | RELAPSE | PIPERAQUINE PHOSPHATE | MALARIA | FIXED-DOSE COMBINATION | ARTEROLANE MALEATE | TROOPS | PARASITOLOGY | Plasmodium vivax | Antimalarials - therapeutic use | Malaria, Vivax - drug therapy | Primaquine - therapeutic use | Humans | Treatment Failure | Health aspects
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 11/2017, Volume 65, Issue 10, pp. 1711 - 1720
Background. Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose and... 
dispersible tablet | arterolane maleate | P. falciparum | pediatric | INFECTIOUS DISEASES | ADULTS | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | ANTIMALARIAL | CHILDREN | PHARMACOKINETICS | DIHYDROARTEMISININ-PIPERAQUINE | ARTESUNATE PLUS AMODIAQUINE | Quinolines - blood | Ethanolamines - adverse effects | Artemisinins - pharmacokinetics | Tablets | Humans | Fluorenes - therapeutic use | Antimalarials - blood | Child, Preschool | Infant | Male | Spiro Compounds - therapeutic use | Peroxides - therapeutic use | Spiro Compounds - adverse effects | Peroxides - pharmacokinetics | Peroxides - adverse effects | Quinolines - pharmacokinetics | Ethanolamines - pharmacokinetics | Malaria, Falciparum - mortality | Artemisinins - blood | Female | Fluorenes - adverse effects | Fluorenes - blood | Child | Antimalarials - adverse effects | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Africa | Antimalarials - therapeutic use | Spiro Compounds - pharmacokinetics | India | Ethanolamines - blood | Peroxides - blood | Artemisinins - therapeutic use | Spiro Compounds - blood | Heterocyclic Compounds, 1-Ring - adverse effects | Survival Analysis | Heterocyclic Compounds, 1-Ring - therapeutic use | Ethanolamines - therapeutic use | Quinolines - therapeutic use | Heterocyclic Compounds, 1-Ring - blood | Artemisinins - adverse effects | Drug Combinations | Quinolines - adverse effects
Journal Article
JOURNAL OF VECTOR BORNE DISEASES, ISSN 0972-9062, 01/2019, Volume 56, Issue 1, pp. 15 - 24
The global fight against malaria requires continual development of new tools. Collaborations in India have played a key role in MMV's partnerships to discover,... 
INFECTIOUS DISEASES | EFFICACY | vaccines | SAFETY | Access | PHASE-II | malaria | PLASMODIUM-FALCIPARUM MALARIA | TROPICAL MEDICINE | VIVAX MALARIA | drug discovery | ARTEMISININ RESISTANCE | PIPERAQUINE PHOSPHATE | FIXED-DOSE COMBINATION | ARTEROLANE MALEATE | PARASITOLOGY | Medicine, Experimental | Medical research | Control | Malaria | Access; drug discovery; malaria; vaccines
Journal Article