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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 223 - 232
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2009, Volume 237, Issue 1, pp. 119 - 126
Human and rodent cytochrome P450 (CYP) enzymes sometimes exhibit striking species-specific differences in substrate preference and rate of metabolism. Human... 
hCYP1A1_1A2_Cyp1a1/1a2(−/−) BAC-transgenic mouse line | Western immunoblot | Cytochrome P450 1 (CYP1) genes | Human HepG2 cell culture | uPA/SCID chimeric mouse line carrying human hepatocytes | Benzo[a]pyrene hydroxylase, ethoxyresorufin O-deethylase, acetanilide 4-hydroxylase and methoxyresorufin O-demethylase as CYP1A1 and CYP1A2 substrates | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) as P450 inducer | Human risk assessment | Mouse Hepa-1c1c7 cell culture | Bacterial artificial chromosome (BAC) | hCYP1A1_1A2_Cyp1a1/1a2(-/-) BAC-transgenic mouse line | ENZYME-ACTIVITY | TOXICITY | KNOCKOUT MICE | SUBSTRATE-SPECIFICITY | CARCINOGENESIS | METABOLISM | ARYL-HYDROCARBON RECEPTOR | LIVER | GENE-EXPRESSION | EMBRYONIC LETHALITY | PHARMACOLOGY & PHARMACY | as CYP1A1 and CYP1A2 Substrates | TOXICOLOGY | Benzo[a]pyrene hydroxylase, ethoxyresorufin O-deethylase, acetanilide 4-hydroxylase and methoxyresorufin O-demethylase | Cell Line | Cytochrome P-450 CYP1A1 - genetics | Species Specificity | Humans | Liver - metabolism | Mice, Inbred C57BL | Dioxins - pharmacology | Environmental Pollutants - pharmacology | Gene Expression Regulation - physiology | RNA, Messenger - analysis | Mice, Transgenic | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Animals | Cytochrome P-450 CYP1A1 - drug effects | Cytochrome P-450 CYP1A2 - genetics | Models, Animal | Cytochrome P-450 CYP1A2 - drug effects | Liver - cytology | Mice | Enzyme Induction - physiology | Chimera | Hepatocytes - enzymology | Herbicides | Messenger RNA | Dioxin | Cytochrome P-450 | Physiological aspects | Gene expression | Index Medicus | DIOXIN | HUMAN POPULATIONS | HEPATOMAS | CELL CULTURES | CHROMOSOMES | 60 APPLIED LIFE SCIENCES | PLASMINOGEN | HYDROXYLASES | ENZYME ACTIVITY | BENZOPYRENE | RISK ASSESSMENT | GENES | LIVER CELLS | TRANSGENIC MICE | UROKINASE | 1a2 | uPA | BAC-transgenic mouse line | hCYP1A1_1A2_Cyp1a1 | SCID chimeric mouse line carrying human hepatocytes
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 80, pp. 106 - 120
Journal Article
Journal Article
Journal Article
The international journal of biochemistry & cell biology, ISSN 1357-2725, 2011, Volume 43, Issue 10, pp. 1483 - 1489
Journal Article