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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2014, Volume 111, Issue 2, pp. 775 - 780
Journal Article
International journal of cancer, ISSN 0020-7136, 10/2015, Volume 137, Issue 7, pp. 1587 - 1597
Journal Article
The Journal of pathology, ISSN 0022-3417, 07/2015, Volume 236, Issue 3, pp. 278 - 289
Journal Article
International journal of cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 5, pp. 1060 - 1071
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each... 
LAT1 | melanoma | ASCT2 | mTORC1 | amino acid transport | Life Sciences & Biomedicine | Oncology | Science & Technology | RNA, Small Interfering - genetics | Minor Histocompatibility Antigens | Humans | Glutamine - metabolism | Multiprotein Complexes - genetics | CDC2 Protein Kinase - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Biological Transport | RNA Interference | Amino Acid Transport System ASC - genetics | Tumor Cells, Cultured | Spheroids, Cellular | Melanoma - metabolism | Skin Neoplasms - pathology | Leucine - metabolism | Amino Acids, Cyclic - pharmacology | Signal Transduction | Cell Survival | Serine - analogs & derivatives | Carrier Proteins - biosynthesis | Carrier Proteins - antagonists & inhibitors | Amino Acid Transport System ASC - antagonists & inhibitors | Melanoma - pathology | Skin Neoplasms - metabolism | Carrier Proteins - genetics | Large Neutral Amino Acid-Transporter 1 - biosynthesis | Benzyl Compounds - pharmacology | Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins B-raf - genetics | Serine - pharmacology | Cell Proliferation - drug effects | Ubiquitin-Conjugating Enzymes - biosynthesis | Amino Acid Transport System ASC - biosynthesis | Physiological aspects | Melanoma | Glutamine | Amino acids | Cell growth | Cell cycle | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 06/2013, Volume 110, Issue 24, pp. 9862 - 9867
Journal Article
Oncogene, ISSN 1476-5594, 01/2013, Volume 33, Issue 5, pp. 556 - 566
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancers. Rb functions to inhibit cell cycle progression in part... 
Metabolism | Cancer | Glutamine | Retinoblastoma Protein | Tumor Suppressor | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Reactive Oxygen Species - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Minor Histocompatibility Antigens | Glutamine - metabolism | Retinoblastoma-Like Protein p107 - genetics | Adenosine Triphosphate - biosynthesis | Oxygen - metabolism | Glutathione - biosynthesis | RNA Interference | Retinoblastoma-Like Protein p130 - metabolism | Fibroblasts | Biological Transport - genetics | Amino Acid Transport System ASC - genetics | Ketoglutaric Acids - metabolism | Glutaminase - biosynthesis | Promoter Regions, Genetic | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | Cells, Cultured | Amino Acid Transport System ASC - metabolism | Glutaminase - metabolism | Mice, Knockout | Animals | E2F3 Transcription Factor - biosynthesis | Cell Cycle | Retinoblastoma Protein - genetics | E2F3 Transcription Factor - metabolism | Mice | RNA, Small Interfering | Retinoblastoma-Like Protein p130 - genetics | Amino Acid Transport System ASC - biosynthesis | Glutaminase - genetics | Oncology, Experimental | Physiological aspects | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Studies | Tumors | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2877 - 2887
The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1 member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5),... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Adenocarcinoma - pathology | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Glutamine - metabolism | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | Gene Deletion | Membrane Transport Modulators - pharmacology | Minor Histocompatibility Antigens - genetics | Female | Antineoplastic Agents - pharmacology | Clone Cells | Amino Acid Transport System ASC - genetics | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Absorption, Physiological - drug effects | Amino Acid Transport System ASC - antagonists & inhibitors | Recombinant Proteins - chemistry | Amino Acid Transport System ASC - metabolism | Large Neutral Amino Acid-Transporter 1 - genetics | Gene Knockout Techniques | Adenocarcinoma - drug therapy | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mechanistic Target of Rapamycin Complex 1 - agonists | Minor Histocompatibility Antigens - metabolism | Animals | Mice, Nude | Colonic Neoplasms - pathology | CRISPR-Cas Systems | Cell Line, Tumor | Large Neutral Amino Acid-Transporter 1 - chemistry | Index Medicus | LAT1 | amino acid | ASCT2 | mammalian target of rapamycin (mTOR) | cancer | cell metabolism | amino acid transport | Cell Biology
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 01/2015, Volume 25, Issue 1, pp. 113 - 116
Journal Article
Cancer cell, ISSN 1535-6108, 03/2015, Volume 27, Issue 3, pp. 354 - 369
Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5... 
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Paclitaxel - pharmacology | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Minor Histocompatibility Antigens | Humans | Antineoplastic Agents - therapeutic use | Endoplasmic Reticulum Stress - genetics | Ubiquitin-Protein Ligases - physiology | Autophagy - drug effects | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Ubiquitination | Endoplasmic Reticulum - drug effects | Female | Antineoplastic Agents - pharmacology | Amino Acid Transport System ASC - genetics | Amino Acid Transport System A - genetics | DNA-Binding Proteins - physiology | Endoplasmic Reticulum Stress - drug effects | Mice, Inbred C57BL | Citric Acid Cycle - drug effects | Ubiquitin-Protein Ligases - metabolism | Amino Acid Transport System ASC - metabolism | DNA-Binding Proteins - genetics | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Mice, Nude | Amino Acid Transport System A - metabolism | Mice, Inbred BALB C | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Chemotherapy | Carrier proteins | Ligases | Paclitaxel | Physiological aspects | Breast cancer | Stress (Physiology) | Glutamine | Cancer | Index Medicus
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 692 - 705
Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have... 
Life Sciences & Biomedicine | Immunology | Science & Technology | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Glutamine - metabolism | Adoptive Transfer | Neoplasm Proteins - metabolism | Th1 Cells - immunology | Enzyme Activation - immunology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Caspases - metabolism | Biological Transport | Receptors, Antigen, T-Cell - immunology | Amino Acid Transport System ASC - genetics | Leucine - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Amino Acid Transport System ASC - immunology | Jurkat Cells | Mice, Inbred C57BL | Amino Acid Transport System ASC - metabolism | CD28 Antigens - immunology | Inflammation - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Cell CLL-Lymphoma 10 Protein | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-2 - biosynthesis | Autoimmunity | T cells | Analysis | Glutamine | Cytokines | Sucrose | Colleges & universities | Homeostasis | Amino acids | T cell receptors | Glucose | Kinases | Proteins | Cell growth | Lymphocytes | Immune system | Cancer | Index Medicus | ASCT2 | CARMA1 | TCR signaling | EAE | T-cell differentiation | mTORC1 | Glutamine uptake
Journal Article