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STEM CELLS, ISSN 1066-5099, 02/2017, Volume 35, Issue 2, pp. 374 - 385
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a leading cause of autism. FXS is due to the silencing of the Fragile... 
Therapeutic window | Autism | Intellectual disability | Fragile X syndrome | Embryonic stem cells | Neurogenesis | TRANSCRIPTION FACTORS | KNOCK-OUT MICE | FMR1 KNOCK | BRAIN-DEVELOPMENT | NEURONAL DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | DENDRITIC SPINES | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | NEURAL PROGENITOR CELLS | ACTIN CYTOSKELETON | HEMATOLOGY | EXPRESSION | Gene Expression Regulation | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | Signal Transduction - genetics | Cell Shape - genetics | Mouse Embryonic Stem Cells - metabolism | Gene Knockdown Techniques | Mice, Knockout | Neurogenesis - genetics | Cell Differentiation - genetics | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Kinetics | RNA, Small Interfering - metabolism | Neurons | Analysis | Amyloid beta-protein | Mental illness | Mental retardation | Protein binding | Proteins | Intellectual disabilities | Stem cells | ASCL1 protein | Brain | Spine | Embryo cells | Stem cell transplantation | Dendritic spines | Alterations | Fragile X mental retardation protein | Tubulin | Allografts | Plasticity | Alzheimer's disease | Plasticity (dendritic) | Repressing | Translation | Pharmacology | Ribonucleic acid--RNA | Embryos | Amyloid precursor protein | Beta2 protein | Pathology | RNA-binding protein | Plasticity (synaptic) | Cyclin-dependent kinase inhibitor p27 | Differentiation | FMR1 protein | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2012, Volume 443, Issue 3, pp. 821 - 828
RNAa (RNA activation) is a mechanism by which small dsRNA (double-stranded RNA), termed saRNA (small activating RNA), target promoter sequences to induce gene... 
Induced pluripotent stem cell (iPS cell) | NANOG | Cell fate | Differentiation | RNA activation (RNAa) | induced pluripotent stem cell (iPS cell) | DEFINED FACTORS | differentiation | cell fate | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIRECT CONVERSION | PLURIPOTENCY | MAMMALIAN-CELLS | FIBROBLASTS | COMPLEMENTARY | FEATURES | EMBRYONIC STEM-CELLS | UP-REGULATION | ES CELLS | Promoter Regions, Genetic | Nanog Homeobox Protein | Cell Differentiation - drug effects | Humans | Homeodomain Proteins - genetics | RNA - genetics | Tretinoin - pharmacology | Index Medicus | ASCL1 protein | Transcription factors | Nucleotide sequence | Oct-4 protein | Double-stranded RNA | Gene expression | Embryos | Promoters | Beta2 protein | Pax6 protein | DNA | Transcription activation | Forkhead protein | Mutation | Retinoic acid | OCT4, octamer-binding protein 4 | dsRNA, double-stranded RNA | REST, RE1-silencing transcription factor | saRNA, small activating RNA | HEK, human embryonic kidney | RT, reverse transcription | MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium | ES, embryonic stem | ASCL1, achaete-scute complex homologue 1 | iPS, induced pluripotent stem | RA, retinoic acid | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | GFP, green fluorescent protein | SSEA, stage-specific embryonic antigen | FOXH1, forkhead box H1 | NEUROD1, neuronal differentiation 1 | PAX6, paired box 6 | Hsp70, heat-shock protein 70 | RNAa, RNA activation | REX1, reduced expression protein 1 | TSS, transcription start site
Journal Article
Development (Cambridge), ISSN 0950-1991, 05/2018, Volume 145, Issue 9, pp. dev159970 - dev159970
Journal Article
Developmental Dynamics, ISSN 1058-8388, 2009, Volume 238, Issue 9, pp. 2163 - 2178
Delta gene expression in Drosophila is regulated by proneural basic helix-loop-helix (bHLH) transcription factors, such as acheate-scute. In vertebrates,... 
Hes6 | Mutual and lateral inhibition | Neurog2 | Molecular circuit | Delta-like | Dll1 | Dll3 | Dll4 | Notch activity | Retinal development | Hes1 | Hes5 | Ascl1 | CELL FATE SPECIFICATION | DEVELOPMENTAL BIOLOGY | notch activity | PROMOTES NEURONAL DIFFERENTIATION | molecular circuit | PROGENITOR CELLS | NERVOUS-SYSTEM | STEM-CELLS | ANATOMY & MORPHOLOGY | mutual and lateral inhibition | retinal development | BHLH GENES | CORTICAL NEUROGENESIS | delta-like | MOUSE RETINA | MAMMALIAN ACHAETE-SCUTE | LOOP-HELIX GENES | Retina - metabolism | Receptors, Notch - metabolism | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Repressor Proteins - physiology | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Eye - embryology | In Situ Hybridization | Basic Helix-Loop-Helix Transcription Factors - metabolism | Retina - cytology | Serrate-Jagged Proteins | Polymerase Chain Reaction | Jagged-2 Protein | Membrane Proteins - metabolism | Neurons - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Eye - metabolism | Drosophila Proteins | Basic Helix-Loop-Helix Transcription Factors - physiology | Nerve Tissue Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
International Journal of Developmental Neuroscience, ISSN 0736-5748, 10/2017, Volume 61, pp. 1 - 11
White matter injury (WMI) of prematurity is associated with a spectrum of neurological disorders ranging from mild cognitive and behavioral deficits to... 
Neurodevelopment | Hypoxia | Transcription factors | White matter | Oligodendrocytes | MOUSE-BRAIN | PREMATURE-INFANTS | SPINAL-CORD | PRETERM INFANTS | DEVELOPMENTAL BIOLOGY | ASCL1 | MATURATION | NEUROSCIENCES | WHITE-MATTER INJURY | LINEAGE CELLS CONTRIBUTE | BIRTH | ISCHEMIC BRAIN-DAMAGE | Oligodendroglia - metabolism | Age Factors | White Matter - metabolism | Gene Expression Regulation, Developmental - genetics | Green Fluorescent Proteins - genetics | Hypoxia-Ischemia, Brain - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Oligodendrocyte Transcription Factor 2 - metabolism | Cell Differentiation | Hypoxia-Ischemia, Brain - metabolism | Disease Models, Animal | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Mice, Inbred C57BL | Mice, Transgenic | Hypoxia - complications | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | White Matter - pathology | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Mice | Myelin Proteins - metabolism | Infants (Newborn) | Nervous system diseases | DNA binding proteins | Analysis | Myelin proteins | ASCL1 protein | Neonates | Brain | Regulators | Anterior commissure | Cognitive ability | Olig2 protein | Infants | Glial stem cells | Myelin basic protein | Proteins | Alterations | Rodents | Paralysis | Neurological disorders | Neurons | Myelin | Glycoprotein | Nkx2.2 protein | Substantia alba | Myelin-associated glycoprotein | Corpus callosum | Neurological diseases | Myelination | Cells (biology) | Comparative analysis | Differentiation | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2012, Volume 120, Issue 5, pp. 667 - 683
cAMP-dependent protein kinase (PKA) plays a critical role in nervous system development by modulating sonic hedgehog and bone morphogenetic protein signaling.... 
shRNA | cyclic AMP | differentiation | CATALYTIC SUBUNIT | REGULATORY SUBUNIT | TERATOCARCINOMA STEM-CELLS | ALKALINE-PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOSINE | ALPHA-SUBUNIT GENE | BHLH PROTEINS | HORMONAL-REGULATION | CAMP INDUCTION | NEUROSCIENCES | RETINOIC ACID | Humans | RNA, Messenger - metabolism | CREB-Binding Protein - metabolism | Cell Differentiation - genetics | Tubulin - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cyclic AMP - analogs & derivatives | Neurons - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | Neurons - drug effects | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Thionucleotides - pharmacology | Cyclic AMP - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice | Cell Line, Transformed | Bone morphogenetic proteins | Neurosciences | Messenger RNA | Tubulins | Neurons | Protein kinases | Neurochemistry | Proteins | Brain | Cellular biology | Gene expression | Index Medicus | ASCL1 protein | Protein kinase A | Transcription factors | protein kinase inhibitors | Nervous system | Embryos | Tubulin | Hedgehog protein | Microtubules | Helix-loop-helix proteins | Differentiation | Expression vectors
Journal Article
Science Translational Medicine, ISSN 1946-6234, 2019, Volume 11, Issue 484, p. eaav0891
Histologic transformation to small cell neuroendocrine prostate cancer occurs in a subset of patients with advanced prostate cancer as a mechanism of treatment... 
HETEROGENEITY | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | INHIBITION | CIRCULATING TUMOR-CELLS | GENE | LINEAGE PLASTICITY | NOTCH | SEGMENTATION | RECEPTOR | ASCL1 | CELL BIOLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0118918 - e0118918
Unlike CNS neurons in adult mammals, neurons in fish and embryonic mammals can regenerate their axons after injury. These divergent regenerative responses are... 
LOOP-HELIX PROTEINS | HAIR-CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH | GENE-EXPRESSION | DIRECT CONVERSION | SPINAL-CORD | NEURONAL DIFFERENTIATION | HUMAN FIBROBLASTS | CENTRAL-NERVOUS-SYSTEM | DOPAMINERGIC-NEURONS | Dependovirus - genetics | Genetic Therapy | Basic Helix-Loop-Helix Transcription Factors - genetics | Dependovirus - metabolism | Animals, Genetically Modified | GAP-43 Protein - metabolism | Zebrafish Proteins - metabolism | Brain Stem - metabolism | Rats | Axons - physiology | Nerve Regeneration | GAP-43 Protein - genetics | Brain Stem - cytology | Gene Knockdown Techniques | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Central Nervous System - cytology | Zebrafish - metabolism | Optic Nerve Injuries - metabolism | Optic Nerve Injuries - pathology | Zebrafish Proteins - genetics | Spinal Cord Injuries - therapy | Transcription factors | Genetic engineering | Research | Gene expression | ASCL1 protein | Spinal cord | Brain stem | Central nervous system | Transgenic | Fluorescence | Retina | Spinal cord injury | Experiments | Neurogenesis | Proteins | Cell fate | Rodents | Cell cycle | Helix-loop-helix proteins | Paralysis | Ganglion cells | Optic nerve | Neurons | Zebrafish | Implantation | Thorax | Mammals | Embryos | Medicine | Regeneration | Retinal ganglion cells | Axons | Vertebrates | Injury prevention | Green fluorescent protein | Norepinephrine | Laboratory animals | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e19297 - e19297
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2018, Volume 38, Issue 5, pp. 1100 - 1113
Many Preterm-born children suffer from neurobehavioral disorders. Premature birth terminates the hypoxic in utero environment and supply of maternal hormones.... 
Medial ganglionic eminence | Premature rabbits | Neurogenesis | Estrogen | Interneuron | Nkx2.1 | CORTICAL INTERNEURONS | estrogen | GERMINAL MATRIX HEMORRHAGE | WHITE-MATTER | LOW-BIRTH-WEIGHT | medial ganglionic eminence | VENTRAL TELENCEPHALON | premature rabbits | NEUROSCIENCES | BEHAVIORAL-PROBLEMS | INTRAVENTRICULAR HEMORRHAGE | neurogenesis | EXTREMELY PRETERM INFANTS | interneuron | CELL-CYCLE | 17-BETA-ESTRADIOL PROTECTS | Ganglia - growth & development | Rabbits | Premature Birth | Ganglia - metabolism | Homeodomain Proteins - metabolism | Interneurons - drug effects | Ki-67 Antigen - metabolism | Thyroid Nuclear Factor 1 - metabolism | Estrogens - therapeutic use | Hypoxia, Brain - pathology | SOXB1 Transcription Factors - metabolism | Pregnancy | Ganglia - cytology | Proto-Oncogene Proteins c-myc - biosynthesis | Animals | Animals, Newborn - physiology | Female | Neurogenesis - drug effects | Proto-Oncogene Proteins c-myc - genetics | Neural Stem Cells - metabolism | Hypoxia, Brain - chemically induced | ASCL1 protein | Neonates | Phosphorylation | Interneurons | Premature birth | Estrogens | c-Myc protein | Infants | Hormones | Myc protein | Proteins | Restoration | Inhibition | Children | Phase transformations | Retinoblastoma protein | Embryos | Childbirth & labor | S phase | Hypoxia | Hormone replacement therapy | Disruption | Retinoblastoma | Thyroid transcription factor 1 | Phase transition | Index Medicus | s
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 25, pp. 10343 - 10348
Journal Article