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FEBS Letters, ISSN 0014-5793, 07/2015, Volume 589, Issue 16, pp. 2100 - 2109
•ULK1 interacts with ATG9 in mammalian cells.•ULK1-VN/ATG9-VC BiFC assay isolated a new autophagy modulator.•G6PT regulates autophagic flux independent of its... 
Screening | G6PT | ULK1 | ATG9 | Autophagy modulator | glucose-6-phosphate transporter | N-terminus of Venus vector | chlorogenic acid | BiFC | bimolecular fluorescence complementation | CHA | C-terminus of Venus vector | NEURODEGENERATIVE DISEASE | DISEASE TYPE-IB | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | MACROAUTOPHAGY | MTOR | CELL BIOLOGY | MAMMALIAN ATG PROTEINS | FORMATION SITE | BIOPHYSICS | SIGNALING PATHWAY | AMINO-ACIDS | ANTIPORTER DEFICIENT | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Vesicular Transport Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Intracellular Signaling Peptides and Proteins - genetics | Monosaccharide Transport Proteins - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Monosaccharide Transport Proteins - genetics | Membrane Proteins - genetics | Phagosomes - metabolism | Recombinant Proteins - chemistry | Antiporters - metabolism | Recombinant Fusion Proteins - chemistry | Huntingtin Protein | Peptide Fragments - chemistry | Models, Biological | Protein-Serine-Threonine Kinases - chemistry | Antiporters - antagonists & inhibitors | Hepatocytes - enzymology | Autophagy-Related Proteins | Phagosomes - enzymology | Cricetulus | Hepatocytes - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Hepatocytes - cytology | Nerve Tissue Proteins - chemistry | Antiporters - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Monosaccharide Transport Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Mutant Proteins - metabolism | Vesicular Transport Proteins - chemistry | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Amino Acid Substitution | Phosphates | Enzymes | Glucose | Analysis | Dextrose
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 184 - 192
Cancer formation is a complex and highly regulated multi-step process which is highly dependent of its environment, from the tissue to the patient. This... 
Mitochondria | Antioxidant | Mitophagy | Autophagy | ROS | Cancer | KAPPA-B ACTIVATION | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | HYPOXIA | FIBROBLASTS | METABOLISM | STROMA COEVOLUTION | GROWTH | Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Proteins | Reactive Oxygen Species - metabolism | Humans | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Antineoplastic Agents - therapeutic use | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Mitochondrial Degradation - genetics | Cysteine Endopeptidases - metabolism | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Signal Transduction | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Lymphatic Metastasis | Mitochondria - metabolism | Mitochondria - pathology | Cell Transformation, Neoplastic - metabolism | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Cysteine Endopeptidases - genetics | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | AMP-Activated Protein Kinases - genetics
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2251 - 2268
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants... 
Socs36E, suppressor of cytokine signaling at 36E | Vps25, vacuolar protein sorting 25 | dome | ESCRT, endosomal sorting complex required for transport | Syb, Synaptobrevin | hop-Stat92E, hopscotch-signal transducer and activator of transcription protein at 92E | SNARE | EM, electron microscopy | FE, follicular epithelium | usnp | CEDNIK, cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma | V-ATPase, vacuolar H | dome, domeless | NECD, N extracellular domain | Vamp, vesicle-associated membrane protein | trafficking | N, Notch | CFP, cyan fluorescent protein | Atg, autophagy-related | GFP, green fluorescent protein | autophagy | MENE, mutant eye no eclosion | ATPase | Notch | WT, wild type | refP, refractory to sigma P | MVB, multivesicular body | + | Snap29 | NPF, asparagine-proline-phenylalanine | SNARE, soluble NSF attachment protein receptor | os, outstretched | E(spl)mβ-HLH, enhancer of split mβ, helix-loop-helix | Syx, syntaxin | histone H3, His3 | Snap29, synaptosomal-associated protein 29 kDa | Dome | Trafficking | Usnp | Autophagy | ACTIVATION | FUSION | ATPASE | COMPLEX GENES | CELL BIOLOGY | GENETIC SCREEN | SNAP-29 | PATHWAY | NOTCH RECEPTOR | UNCONVENTIONAL SECRETION | MELANOGASTER | Exosomes - metabolism | Vesicular Transport Proteins - metabolism | Humans | Phagosomes - metabolism | Qb-SNARE Proteins - metabolism | Protein Transport - physiology | Autophagy - physiology | Drosophila Proteins - metabolism | Cell Movement - physiology | Endosomes - metabolism | Drosophila melanogaster - metabolism | Animals | Qc-SNARE Proteins - metabolism | SNARE Proteins - metabolism | Protein Binding - physiology
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2015, Volume 589, Issue 22, pp. 3343 - 3353
Autophagy is an intracellular degradation system that, as a basic mechanism it delivers cytoplasmic components to the lysosomes in order to maintain adequate... 
Autophagosome biogenesis | Rab GTPase | Autophagosome–lysosome fusion | Autophagy | SNAP receptor | GTP | PAS | PtdIns3P | sequestosome 1 | TRAPP | LRRK1 | mechanistic target of rapamycin | 200 kD focal adhesion kinase family-interacting protein | unc-51 like autophagy activating kinase 1 | GAS-containing autophagosome-like vacuoles | FYCO1 | guanosine diphosphate | GDP | WD-repeat-interacting phosphoinositide proteins | CMA | guanosine nucleotide exchange factor | STX | AMD | mTOR | Group A Streptococcus | LC3 | GTPase activating protein | N-ethyl-maleimide-sensitive factor | NSF | endoplasmic reticulum exit sites | chaperone-mediated autophagy | autophagy-related protein | phosphatidylinositol 3-phosphate | light chain 3 | coat protein complex II | phagophore assembly site | Huntington disease | PKA | GEF | cAMP-dependent protein kinase | transport protein particle | GAP | NS4B | soluble N-ethyl-maleimide attachment proteins | FIP200 | GAS | MVB | AMPK | HCV | PIK3C3 | ULK1 | ERES | epidermal growth factor | SQSTM1 | class III phosphatidylinositol 3 kinase | AMP-activated protein kinase | FYVE and coiled-coil domain-containing 1 | SNARE | vacuolar protein sorting | COPII | non-structural protein 4B | age-related macular degeneration of the eye | multivesicular body | VPS | leucine-rich repeat kinase 1 | recycling endosome | WIPI | EGF | guanosine triphosphate | molecular weight | SNAP | Syntaxin | phosphatidylethanolamine | ATG | GcAVs | Hepatitis C virus | DFCP1 | endoplasmic reticulum | double FYVE domain-containing protein 1 | Autophagosome-lysosome fusion | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA-MEMBRANE | RAB24 GTPASE | SMALL GTPASE | NEGATIVE REGULATOR | CELL BIOLOGY | MEMBRANE-FUSION | PROMOTES AUTOPHAGY | LONGIN DOMAIN | BIOPHYSICS | MULTIVESICULAR BODIES | WIPI PROTEINS | rab GTP-Binding Proteins - metabolism | Animals | Proteins - metabolism | Biological Transport | Humans | Intracellular Space - metabolism | SNARE Proteins - metabolism | Proteins
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 7, pp. 1287 - 1295
Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as... 
Autophagy-related gene 1 | UNC-51-like kinase 1 | UNC-51-like kinase 2 | Mammalian target of rapamycin | Autophagy-related gene 13 | raptor | mTOR complex 2 | mTOR complex 1 | tuberous sclerosis complex | human ortholog of yeast vacuolar protein sorting 34 | GABARAP | focal adhesion kinase (FAK) family interacting protein of 200 kDa | mammalian target of rapamycin | γ-aminobutyric acid (GABA) receptor associated protein | Rheb | mTOR | regulatory associated protein of mTOR | GAP1 | rapamycin insensitive companion of mTOR | protein kinase B | GATE-16 | TSC | PKB | general amino acid permease 1 | Autophagy-related gene | trans-Golgi network | Golgi-associated ATPase enhancer of 16 kDa | rictor | Atg | 5′-AMP-activated protein kinase | FIP200 | AMPK | ULK2 | ras homolog enriched in brain | hVps34 | ULK1 | TGN | mTORC2 | mTORC1 | BINDING PARTNER | SIGNALING PATHWAYS | RAG GTPASES | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | P70 S6 KINASE | CELL BIOLOGY | BIOPHYSICS | PROTEIN-KINASE COMPLEX | INHIBITS CELL-GROWTH | ENDOPLASMIC-RETICULUM | C-ELEGANS | Saccharomyces cerevisiae - cytology | Animals | Models, Biological | Stress, Physiological | Saccharomyces cerevisiae - enzymology | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Serine-Threonine Kinases - chemistry | TOR Serine-Threonine Kinases | Autophagy | Protein-Serine-Threonine Kinases - metabolism | Tuberous sclerosis | GABA | Protein kinases | Atg1 | Atg13
Journal Article