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FEBS Letters, ISSN 0014-5793, 01/2016, Volume 590, Issue 1, pp. 161 - 173
Macroautophagy is a major intracellular degradation system. We previously reported that overexpression of phosphatase‐deficient MTMR3, a member of the... 
mTOR | autophagy | MTMR3 | PI3P | Ptdlns3P phosphatase | mTOR complex1 | ATG PROTEINS | COMPLEX | ACTIVATION | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNAL INTEGRATION | IDENTIFICATION | HVPS34 | CELL BIOLOGY | BIOPHYSICS | AMINO-ACIDS | GROWTH | AUTOPHAGOSOME FORMATION | Adaptor Proteins, Signal Transducing - chemistry | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | Protein Transport - drug effects | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | TOR Serine-Threonine Kinases - genetics | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Gene Deletion | Protein Tyrosine Phosphatases, Non-Receptor - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Catalytic Domain | Peptide Fragments - metabolism | MTOR Associated Protein, LST8 Homolog | Cells, Cultured | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Multiprotein Complexes - chemistry | Peptide Fragments - chemistry | Animals | TOR Serine-Threonine Kinases - chemistry | Embryo, Mammalian - cytology | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Research Letters | Research Letter
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 740 - 747
BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells.... 
BECN1 | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | BCL2L1/Bcl | PtdIns3K | BECN1, Beclin 1, autophagy related | BafA1, bafilomycin A | BECN1P1/BECN2, Beclin 1, autophagy related, pseudogene 1 | EM, electron microscopy | UVRAG, UV radiation resistance associated | MAP1LC3-II/LC3-II, proteolytically processed and lipid-modified microtubule-associated protein 1 light chain 3 | LC3 | ZFYVE1/DFCP1, zinc finger, FYVE domain containing 1 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | TALEN, transcription activator-like effector nuclease | GFP, green fluorescent protein | autophagy | SQSTM1/p62, sequestosome 1 | xL, BCL2-like 1 | PtdIns3K, phosphatidylinositol 3-kinase | - | PIK3R4/VPS15, phosphoinositide-3-kinase, regulatory subunit 4 | 1 | TUBB, tubulin, β class I | KO, knockout | MAP1LC3-I/LC3-I, soluble, proteolytically processed microtubule-associated protein 1 light chain 3 | ATG, autophagy related | autophagosome | PIK3C3/VPS34, phosphatidylinositol 3-kinase, catalytic subunit type 3 | Autophagosome | Autophagy | CANCER-CELLS | ATG PROTEINS | COMPLEX | PHOSPHATIDYLINOSITOL 3-KINASE | BECLIN 1-INDEPENDENT AUTOPHAGY | MACROAUTOPHAGY | ARSENIC TRIOXIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | PATHWAY | RUBICON | Beclin-1 | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Molecular Sequence Data | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - deficiency | Lipids - chemistry | Apoptosis Regulatory Proteins - deficiency | Base Sequence | Phagosomes - ultrastructure | Membrane Proteins - metabolism | HeLa Cells
Journal Article
Autophagy, ISSN 1554-8627, 02/2015, Volume 11, Issue 2, pp. 239 - 252
PTEN (phosphatase and tensin homolog), a tumor suppressor frequently mutated in human cancer, has various cytoplasmic and nuclear functions. PTEN translocates... 
SESN2, sestrin 2 | CASP3, caspase 3, apoptosis-related cysteine peptidase | PPase, protein phosphatase | YFP, yellow fluorescent protein | bafilomycin A | PTEN | ATG, autophagy-related | CITED1/p300/CBP, Cbp/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 1 | member X | RAD51, RAD51 recombinase | topotecan | TPT, topotecan | DSBs, DNA double-strand breaks | autophagy | GST, glutathione S-transferase | TUBA4A, tubulin, α, 4a | H2AFX | MVP, major vault protein | TP53, tumor protein p53 | 1 | 3 | NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | Baf.A | CCND1, cyclin D1 | ATM, ATM serine/threonine kinase | AKT/PKB, v-akt murine thymoma viral oncogene homolog | PtdIns(3, 4, 5)P | CDDP, cisplatin | NC, normal control | PMSF, phenylmethanesulfonyl fluoride | PI3K, phosphoinositide 3-kinase | DNA damage | PARP, poly (ADP-ribose) polymerase 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | SDS, sodium dodecyl sulfate | H2A histone family | GLTSCR2/PICT-1, glioma tumor suppressor candidate region gene 2 | MTORC1, mechanistic target of rapamycin complex 1 | PAGE, polyacrylamide gel electrophoresis | CENPC/CENP-C, centromere protein C | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | AMPK, protein kinase, AMP-activated | GFP, green fluorescent protein | JUN | SQSTM1/p62, sequestosome 1 | phosphatidylinositol (3, 4, 5)-trisphosphate | WT, wild type | ribosomal protein S6 kinase, 70kDa | RPS6KB/p70S6K | siRNA, small interfering RNA | CSNK2/CK2, casein kinase 2 | GSK3B, glycogen synthase kinase 3 β | ATM | jun proto-oncogene | PTEN, phosphatase and tensin homolog | Topotecan | Autophagy | LOCALIZATION | PROTEIN | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | PHOSPHATASE | CYCLE ARREST | CHROMOSOME-10 PTEN | CELL BIOLOGY | HISTONE H2AX PHOSPHORYLATION | PROSTATE-CANCER | TUMOR-SUPPRESSOR | EXPRESSION | Tumor Suppressor Proteins - metabolism | Topotecan - pharmacology | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | PTEN Phosphohydrolase - metabolism | Autophagy - physiology | Signal Transduction - genetics | Cisplatin - pharmacology | Autophagy - drug effects | Topoisomerase I Inhibitors - pharmacology | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Antineoplastic Agents - pharmacology | DNA Damage | Phosphorylation - drug effects
Journal Article
Traffic, ISSN 1398-9219, 10/2013, Volume 14, Issue 10, pp. 1029 - 1041
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 06/2004, Volume 117, Issue 13, pp. 2805 - 2812
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 10/2014, Volume 128, Issue 4, pp. 505 - 524
The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of... 
Pathology | Neurosciences | Medicine & Public Health | Expanded repeat | Repeat-associated non-ATG translation | ER stress | Amyotrophic lateral sclerosis | Frontotemporal dementia | C9ORF72 | Poly(GA) proteins | Proteasome activity | UBIQUITIN-PROTEASOME SYSTEM | CHEMICAL CHAPERONES | COGNITIVE IMPAIRMENT | ENDOPLASMIC-RETICULUM STRESS | AMYOTROPHIC-LATERAL-SCLEROSIS | PATHOLOGY | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CLINICAL NEUROLOGY | CELL-DEATH | C9ORF72 HEXANUCLEOTIDE REPEAT | RNA FOCI | Cholagogues and Choleretics - pharmacology | DNA Repeat Expansion - genetics | Embryo, Mammalian | Humans | Middle Aged | Male | DNA Repeat Expansion - immunology | Endoplasmic Reticulum Stress - genetics | Brain - metabolism | Frontotemporal Dementia - metabolism | Cell Nucleolus - metabolism | Cell Nucleolus - ultrastructure | Brain - ultrastructure | HEK293 Cells | Aged, 80 and over | Adult | Female | C9orf72 Protein | Frontotemporal Dementia - pathology | Frontotemporal Dementia - genetics | Endoplasmic Reticulum Stress - drug effects | Protein Structure, Secondary | Amyotrophic Lateral Sclerosis - genetics | Cells, Cultured | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Proteins - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Brain - pathology | Gene Expression Regulation - radiation effects | Aged | Mice | Proteins - chemistry | Endoplasmic Reticulum Stress - physiology | Proteins | Health aspects | Dementia | Index Medicus | Original Paper
Journal Article
Autophagy, ISSN 1554-8627, 02/2015, Volume 11, Issue 2, pp. 200 - 213
Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single... 
TSC, tuberous sclerosis complex | exercise | ATG, autophagy-related | BECN1, Beclin 1, autophagy related | MTMR14/hJumpy, myotubularin related protein 14 | protein breakdown | ULK1, unc-51 like autophagy activating kinase 1 | HSF1, heat shock transcription factor 1 | heat shock response | PBMC, peripheral blood mononuclear cell | FOXO, forkhead box O | EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1 | MTOR, mechanistic target of rapamycin | autophagy | HSP70 | SQSTM1/p62, sequestosome 1 | HSPA8/HSC70, heat shock 70kDa protein 8 | protein synthesis | SOD, superoxide dismutase | TPR, translocated promoter region, nuclear basket protein | PPARGC1A/PGC-1α, peroxisome proliferator-activated receptor, gamma, coactivator 1 α | LC3, MAP1LC3, microtubule-associated protein 1 light chain 3 | NR1D1/Rev-Erb-α, nuclear receptor subfamily 1, group D, member 1 | AMPK, adenosine monophosphate-activated protein kinase | AKT, v-akt murine thymoma viral oncogene homolog 1 | RHEB, Ras homolog enriched in brain | IL, interleukin | HSP, heat shock protein | humans | ER, endoplasmic reticulum | Protein breakdown | Exercise | Protein synthesis | Humans | Heat shock response | Autophagy | MAMMALIAN TARGET | CHAPERONE-MEDIATED AUTOPHAGY | MOLECULAR CHAPERONES | ESSENTIAL AMINO-ACID | EXERCISE-INDUCED INCREASE | HUMAN SKELETAL-MUSCLE | CELL BIOLOGY | MUSCLE PROTEIN-SYNTHESIS | RESISTANCE EXERCISE | ECCENTRIC EXERCISE | NF-KAPPA-B | Animals | Lysosomes - metabolism | Heat-Shock Proteins - metabolism | Metabolic Networks and Pathways - physiology | Signal Transduction - physiology | Autophagy - physiology | Heat-Shock Response - physiology
Journal Article