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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 11, pp. 9107 - 9119
The recognition and signaling of DNA double strand breaks involves the participation of multiple proteins, including the protein kinase ATM (mutated in... 
REPAIR PROTEINS | MRE11-RAD50-NBS1 COMPLEX | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHROMATIN RETENTION | IN-VIVO | DOUBLE-STRAND BREAKS | NUCLEAR FOCI | MRN COMPLEX | N-TERMINUS | ATAXIA-TELANGIECTASIA | Humans | DNA Repair Enzymes - genetics | Multiprotein Complexes - genetics | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Phosphorylation - genetics | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | S Phase - genetics | Phosphorylation - radiation effects | S Phase - radiation effects | Animals | Ataxia Telangiectasia - genetics | Mice | Protein Kinase Inhibitors - pharmacology | S Phase - drug effects | Enzyme Activation - genetics | Cell Line, Transformed | Index Medicus | Ataxia-telangiectasia | Signal Transduction | Post-translational Modification | Mass Spectrometry (MS) | DNA Damage | Protein Phosphorylation | Serine Threonine Protein Kinase | ATM Kinase
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2011, Volume 30, Issue 18, pp. 3741 - 3753
The transcription factor nuclear factor κB (NF‐κB) regulates various cellular processes such as inflammation and apoptosis. The NF‐κB essential modulator... 
genotoxic stress | NF‐κB | ubiquitination | LUBAC | NEMO | NF-κB | DOMAIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | IKK | CHAIN ASSEMBLY COMPLEX | CELL BIOLOGY | NF-kappa B | STRUCTURAL BASIS | POLYUBIQUITIN CHAINS | TAB2 | ATM | BINDING | Cell Line | Ubiquitination | I-kappa B Kinase - metabolism | NF-kappa B - biosynthesis | Humans | Ubiquitin-Protein Ligases - metabolism | DNA Damage | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 63 - 74
As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus
Journal Article
CELL, ISSN 0092-8674, 11/2003, Volume 115, Issue 5, pp. 565 - 576
The transcription factor NF-kappaB is critical for setting the cellular sensitivities to apoptotic stimuli, including DNA damaging anticancer agents. Central... 
KINASE COMPLEX | TRANSCRIPTIONAL ACTIVATION | ECTODERMAL DYSPLASIA | PORE COMPLEX | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | NUCLEAR EXPORT SIGNAL | GENE-EXPRESSION | IKK ACTIVATION | IONIZING-RADIATION | CELL BIOLOGY | NEMO protein | SUMO-1 protein | IKK^g protein | ATM protein
Journal Article
Cell Reports, ISSN 2211-1247, 12/2014, Volume 9, Issue 5, pp. 1703 - 1717
Journal Article
Oncogene, ISSN 0950-9232, 02/2007, Volume 26, Issue 5, pp. 641 - 651
The inactive transcription factor NF-kappa B is localized in the cytoplasm and rapidly responds to a variety of extracellular factors and intracellular stress... 
H | ATM | SUMOylation | NEMO | O | OXIDATIVE STRESS | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVABLE COMPLEXES | DOUBLE-STRAND BREAKS | TOPOISOMERASE-I | PROTEIN-TYROSINE KINASE | H2O2 | CELL BIOLOGY | ONCOLOGY | HAMSTER OVARY CELLS | SIGNALING PATHWAY | GENETICS & HEREDITY | TRANSCRIPTION FACTOR | FIELD GEL-ELECTROPHORESIS
Journal Article
Journal Article