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Arthritis & Rheumatology, ISSN 2326-5191, 07/2017, Volume 69, Issue 7, pp. 1461 - 1469
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 24 - 35
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated adaptive response play important roles in the development of... 
HepG2 cells | Rifampicin | Bile acid transporters | Nrf2 | TUDCA | Adaptive response | DRUG | SALT EXPORT PUMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | RIFAMYCIN SV | INDUCED LIVER-INJURY | CHOLESTATIC RAT-LIVER | INHIBITION | ENDOCRINOLOGY & METABOLISM | CANALICULAR MEMBRANES | INDUCED HEPATOTOXICITY | Adaptation, Physiological | Aspartate Aminotransferases - genetics | L-Lactate Dehydrogenase - metabolism | RNA, Small Interfering - genetics | ATP Binding Cassette Subfamily B Member 11 - antagonists & inhibitors | Humans | Alkaline Phosphatase - metabolism | Stress, Physiological | Rifampin - antagonists & inhibitors | NF-E2-Related Factor 2 - agonists | Adenosine Triphosphate | Bilirubin | Organic Anion Transporters, Sodium-Dependent - genetics | Taurochenodeoxycholic Acid - pharmacology | Alanine Transaminase - genetics | ATP Binding Cassette Subfamily B Member 11 - metabolism | ATP Binding Cassette Transporter, Sub-Family B - agonists | Membrane Transport Proteins - genetics | ATP Binding Cassette Subfamily B Member 11 - agonists | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | NF-E2-Related Factor 2 - genetics | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics | Alkaline Phosphatase - genetics | Signal Transduction | Gene Expression Regulation | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | gamma-Glutamyltransferase - metabolism | Antibiotics, Antitubercular - pharmacology | Symporters - metabolism | Aspartate Aminotransferases - metabolism | Hep G2 Cells | gamma-Glutamyltransferase - genetics | L-Lactate Dehydrogenase - genetics | NF-E2-Related Factor 2 - metabolism | Solute Carrier Organic Anion Transporter Family Member 1b1 - metabolism | Symporters - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Multidrug Resistance-Associated Proteins - agonists | Alanine Transaminase - metabolism | Rifampin - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP Binding Cassette Subfamily B Member 11 - genetics | RNA, Small Interfering - metabolism | Drug resistance in microorganisms | Phosphatases | Liver | Muscle proteins | Rifampin | Adenosine triphosphate | Deoxycholic acid | Proteins | Liver diseases
Journal Article
Cancer Research, ISSN 0008-5472, 10/2008, Volume 68, Issue 19, pp. 7905 - 7914
Lapatinib is active at the ATP-binding site of Lyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2.... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 525 - 528
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical... 
VISUALIZATION | TAP | TRANSPORTERS | TAPASIN | CALRETICULIN | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | ERP57 | PURIFICATION | MAJOR HISTOCOMPATIBILITY COMPLEX | BINDING | ATP Binding Cassette Transporter, Subfamily B, Member 2 - chemistry | Protein Disulfide-Isomerases - metabolism | Protein Disulfide-Isomerases - ultrastructure | ATP Binding Cassette Transporter, Subfamily B, Member 3 - chemistry | Cytosol - immunology | Humans | Endoplasmic Reticulum - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 2 - ultrastructure | Histocompatibility Antigens Class I - metabolism | Multiprotein Complexes - metabolism | Endoplasmic Reticulum - chemistry | Antigen Presentation | ATP Binding Cassette Transporter, Subfamily B, Member 3 - ultrastructure | Calreticulin - metabolism | Protein Domains | Membrane Transport Proteins - metabolism | Binding Sites | Histocompatibility Antigens Class I - immunology | Models, Molecular | Histocompatibility Antigens Class I - chemistry | Burkitt Lymphoma - chemistry | Disease Progression | Membrane Transport Proteins - chemistry | Calreticulin - chemistry | Calreticulin - ultrastructure | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 3 - metabolism | Histocompatibility Antigens Class I - ultrastructure | Membrane Transport Proteins - ultrastructure | Models, Biological | ATP Binding Cassette Transporter, Subfamily B, Member 2 - metabolism | Cytosol - metabolism | Protein Disulfide-Isomerases - chemistry | Multiprotein Complexes - immunology | Peptides | Physiological aspects | Major histocompatibility complex | Oxidoreductase | Antigen processing | Lymphocytes T | Cell surface | Proteins | Calreticulin | Immune system | Binding | Symbiosis | Translocation | Antigens | Immune response | Macromolecules | TAP protein | Lymphoma | Glycan | Burkitt's lymphoma | Tapasin | Microscopy | Lymphomas | Endoplasmic reticulum | Histocompatibility | ABC transporter
Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 216 - 241
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile... 
Multidrug resistance- associated protein | Drug-induced liver injury | ATP-binding cassette transporter | Transporter | Bile acid | Bile salt export pump | drug-induced liver injury | BSEP | MRP2 | bile acid | SALT EXPORT PUMP | multidrug resistance- associated protein | CHOLESTASIS | INDUCED LIVER-INJURY | IN-VITRO | INHIBITION | transporter | DRUG DEVELOPMENT | bile salt export pump | TOXICOLOGY | HEPATOTOXICITY | BILE-ACIDS | Humans | Drug-Related Side Effects and Adverse Reactions - metabolism | Male | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Toxicity Tests - methods | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Recombinant Proteins - metabolism | Risk Assessment | Liver - metabolism | Risk Factors | Rats | Drug-Related Side Effects and Adverse Reactions - etiology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cluster Analysis | Index Medicus
Journal Article
Journal Article
Cancer Science, ISSN 1347-9032, 04/2018, Volume 109, Issue 4, pp. 1135 - 1146
Journal Article