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Lipids in health and disease, ISSN 1476-511X, 2019, Volume 18, Issue 1, pp. 2 - 7
Background: ATP-binding cassette (ABC) transporters are involved in a huge range of physiological processes... 
ATP-binding cassette transporters | NUTRITION & DIETETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Abcc6 | MOUSE | Pseudoxanthoma elasticum | Mice | MUTATIONS | SECRETION | Gene expression | PCR | Liver - pathology | Kidney - pathology | Lipoproteins - genetics | Adipose Tissue, White - metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | ATP-Binding Cassette Transporters - deficiency | Kidney - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Transporter, Subfamily G, Member 8 - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 5 - metabolism | Disease Models, Animal | ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics | Adipose Tissue, White - pathology | Pseudoxanthoma Elasticum - metabolism | Liver - metabolism | Gene Expression Regulation | Bile Acids and Salts - metabolism | Pseudoxanthoma Elasticum - pathology | Cholesterol - metabolism | ATP Binding Cassette Transporter, Subfamily B - metabolism | Disease Progression | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 11 - genetics | ATP Binding Cassette Transporter, Subfamily D - genetics | Animals | ATP Binding Cassette Transporter, Subfamily D - metabolism | Pseudoxanthoma Elasticum - genetics | Research | Tissues | Adenosine triphosphate | Calcification (ectopic) | Adipose tissue | Disease | Gene regulation | Liver | Homeostasis | Lipids | Phospholipids | ABCA1 protein | Sterols | Metabolites | Mineralization | Rodents | Fibroblasts | Physiology | ABC transporters | Lipid metabolism | Age | Kidneys | Metabolism | Cholesterol | Lipoproteins | Calcification | ATP-binding protein | Mutation | ABC transporter | Bile
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
.... The ATP binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux to lipid-free apolipoprotein A-I, but the majority of apolipoprotein A-I in the circulation is transported in a lipidated state and ABCA1-dependent efflux to individual... 
foam cells | HDL | ATP-binding cassette transporters | macrophages | cholesterol, HDL | ATP binding cassette transporter 1 | Cholesterol | cholesterol-efflux regulatory protein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | APOA-I | HIGH-DENSITY-LIPOPROTEIN | TANGIER DISEASE | EFFLUX | MESSENGER-RNA | CASSETTE TRANSPORTER A1 | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ABCG1 | APOLIPOPROTEIN-A-I | Lipoproteins - deficiency | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Lipoproteins, HDL - metabolism | ATP-Binding Cassette Transporters - physiology | Recombinant Fusion Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP Binding Cassette Transporter 1 - physiology | Biological Transport | Foam Cells - metabolism | Lipoproteins, HDL2 - metabolism | CHO Cells | Cell Line | Cricetinae | Tangier Disease - enzymology | Tangier Disease - genetics | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Gene Silencing | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Lipoproteins - physiology | Mice, Knockout | Particle Size | Macrophages - metabolism | Animals | ATP Binding Cassette Transporter 1 - deficiency | ATP Binding Cassette Transporter 1 - antagonists & inhibitors | Mice | ATP Binding Cassette Transporter 1 - genetics
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 49, pp. 19719 - 19724
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 05/2013, Volume 112, Issue 10, pp. 1345 - 1354
RATIONALE:Macrophage accumulation in adipose tissue associates with insulin resistance and increased cardiovascular disease risk. We previously have shown that... 
Apolipoprotein AI | HDL | ABC transporters | Adipocytes | Cholesterol | CARDIAC & CARDIOVASCULAR SYSTEMS | apolipoprotein AI | CELLULAR CHOLESTEROL | DEFICIENT MICE | MACROPHAGE ACCUMULATION | OBESITY | INSULIN-RESISTANCE | ADIPOSE-TISSUE INFLAMMATION | ENDOTHELIAL-CELLS | LIPID RAFTS | TOLL-LIKE RECEPTORS | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | adipocytes | TRANSGENIC MICE | Apolipoprotein A-I - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Reactive Oxygen Species - metabolism | Humans | Lipoproteins, HDL - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Lipoproteins, HDL - pharmacology | Apolipoprotein A-I - genetics | Inflammation - metabolism | Lipoproteins - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Scavenger Receptors, Class B - drug effects | Disease Models, Animal | Receptors, LDL - genetics | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Receptors, LDL - metabolism | Mice, Transgenic | Apolipoprotein A-I - metabolism | 3T3-L1 Cells | Cholesterol - metabolism | Mice, Knockout | Animals | ATP-Binding Cassette Transporters - drug effects | Membrane Microdomains - drug effects | Adipocytes - metabolism | Biological Transport - physiology | Mice | Lipoproteins - drug effects | Scavenger Receptors, Class B - metabolism | In Vitro Techniques
Journal Article
Biochemical journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these proteins is often hampered by their large size and membrane location... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
Journal Article
American journal of physiology. Renal physiology, ISSN 1522-1466, 2017, Volume 313, Issue 3, pp. F826 - F834
.... In the membrane fraction of the kidney, the expression of urate transporter 1 (URAT1) was significantly decreased, whereas that of ATP-binding cassette subfamily G member 2 (ABCG2... 
Hyperinsulinemia | Urate transporters | Hypouricosuria | Kidney proximal tubule | PHYSIOLOGY | hyperinsulinemia | SGLT2 INHIBITOR | GOUT | RISK | LEVEL | EXCRETION | IDENTIFICATION | hypouricosuria | DIABETES-MELLITUS | RENAL HYPOURICEMIA | urate transporters | RESISTANCE | UROLOGY & NEPHROLOGY | kidney proximal tubule | HYPERTENSION | Kidney Tubules - physiopathology | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Diabetes Mellitus, Type 1 - metabolism | Male | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Uric Acid - urine | Renal Reabsorption - drug effects | Time Factors | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Kidney Tubules - metabolism | Diabetes Mellitus, Experimental - physiopathology | Cell Line | Insulin - pharmacology | Glucosides - pharmacology | Uric Acid - metabolism | Kidney Tubules - drug effects | Sodium-Glucose Transporter 2 - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Thiophenes - pharmacology | Renal Elimination - drug effects | Anion Transport Proteins - metabolism | Rats, Sprague-Dawley | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Animals | Blood Glucose - metabolism | Carrier proteins | Physiological aspects | Physiological research | Uric acid | Research | G proteins | Insulin | Absorption (Physiology)
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3900 - 3908
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 2014, Volume 34, Issue 2, pp. 279 - 284
... and (2) exert anti-inflammatory effects mediated by transrepression of nuclear factor-κB target genes. We investigated whether myeloid cell deficiency of ATP-binding cassette transporters A1 and G1... 
atherosclerosis | ATP-binding cassette transporters | macrophages | liver X receptor | inflammation | ANTIINFLAMMATORY ACTIVITY | MYELOPROLIFERATIVE DISORDERS | LDL RECEPTOR | TERTIARY-AMINES | ACCELERATES ATHEROSCLEROSIS | KNOCKOUT MICE | NUCLEAR RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MACROPHAGE ABCA1 | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Lipoproteins - deficiency | Macrophages - transplantation | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Hydrocarbons, Fluorinated - pharmacology | Male | Aorta - metabolism | Orphan Nuclear Receptors - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver X Receptors | Myocardium - metabolism | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Female | Cytokines - genetics | Macrophages - immunology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Aorta - drug effects | Mice, Inbred C57BL | Orphan Nuclear Receptors - agonists | Gene Expression Regulation | Myocardium - pathology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | ATP Binding Cassette Transporter 1 - deficiency | Benzoates - pharmacology | Macrophages - drug effects | Mice | Benzylamines - pharmacology | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter 1 - genetics
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2005, Volume 204, Issue 3, pp. 216 - 237
In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease in cellular drug accumulation which is attributed to the overexpression of certain ATP-binding cassette (ABC... 
P-glycoprotein | BCRP | ATP-binding cassette transporters | Chemical toxicity | Carcinogen transport | MRP | Tissue defense | Heavy metal transport | CONJUGATE EXPORT PUMP | ORGANIC ANION TRANSPORTER | KIDNEY PROXIMAL TUBULES | FOOD-DERIVED CARCINOGEN | HUMAN LUNG-CANCER | carcinogen transport | chemical toxicity | BLOOD-BRAIN-BARRIER | AMINO-ACID RESIDUE | heavy metal transport | ATP-BINDING CASSETTE | FUNCTIONAL EXPRESSION | tissue defense | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SINGLE-NUCLEOTIDE POLYMORPHISMS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasm Proteins - biosynthesis | Humans | Neoplasm Proteins - physiology | ATP Binding Cassette Transporter, Sub-Family B - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Multidrug Resistance-Associated Proteins - biosynthesis | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Transport Proteins - physiology | ATP-Binding Cassette Transporters - biosynthesis | Pregnancy | Tissue Distribution | Membrane Transport Proteins - biosynthesis | Animals | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Drug-Related Side Effects and Adverse Reactions | Multidrug Resistance-Associated Proteins - physiology | Female | ANIONS | MAMMARY GLANDS | NEOPLASMS | LUNGS | PLACENTA | CARCINOGENS | GLYCOPROTEINS | TOXINS | BLOOD-BRAIN BARRIER | TOXICITY | TUMOR CELLS | EXCRETION | 60 APPLIED LIFE SCIENCES | KIDNEYS | METABOLISM | TISSUE DISTRIBUTION | DRUGS | GENES | LIVER | BLOOD | LIPIDS
Journal Article