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The Journal of clinical investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3900 - 3908
Journal Article
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2005, Volume 204, Issue 3, pp. 216 - 237
In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease in cellular drug accumulation which is attributed to the overexpression of certain ATP-binding cassette (ABC... 
P-glycoprotein | BCRP | ATP-binding cassette transporters | Chemical toxicity | Carcinogen transport | MRP | Tissue defense | Heavy metal transport | CONJUGATE EXPORT PUMP | ORGANIC ANION TRANSPORTER | KIDNEY PROXIMAL TUBULES | FOOD-DERIVED CARCINOGEN | HUMAN LUNG-CANCER | carcinogen transport | chemical toxicity | BLOOD-BRAIN-BARRIER | AMINO-ACID RESIDUE | heavy metal transport | ATP-BINDING CASSETTE | FUNCTIONAL EXPRESSION | tissue defense | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SINGLE-NUCLEOTIDE POLYMORPHISMS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasm Proteins - biosynthesis | Humans | Neoplasm Proteins - physiology | ATP Binding Cassette Transporter, Sub-Family B - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Multidrug Resistance-Associated Proteins - biosynthesis | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Transport Proteins - physiology | ATP-Binding Cassette Transporters - biosynthesis | Pregnancy | Tissue Distribution | Membrane Transport Proteins - biosynthesis | Animals | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Drug-Related Side Effects and Adverse Reactions | Multidrug Resistance-Associated Proteins - physiology | Female | ANIONS | MAMMARY GLANDS | NEOPLASMS | LUNGS | PLACENTA | CARCINOGENS | GLYCOPROTEINS | TOXINS | BLOOD-BRAIN BARRIER | TOXICITY | TUMOR CELLS | EXCRETION | 60 APPLIED LIFE SCIENCES | KIDNEYS | METABOLISM | TISSUE DISTRIBUTION | DRUGS | GENES | LIVER | BLOOD | LIPIDS
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7659, pp. 504 - 509
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2008, Volume 68, Issue 19, pp. 7905 - 7914
.... It is conceivable that lapatinib may inhibit the function of ATP-binding cassette (ABC) transporters by binding to their ATP-binding sites... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2010, Volume 70, Issue 20, pp. 7981 - 7991
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 1532-6535, 2007, Volume 83, Issue 2, pp. 258 - 264
... (human organic cation transporter 1; hOCT1) and efflux transporters (ATP‐binding cassette transporters ABCB1, ABCG2, and ABCC1) using real... 
CHRONIC MYELOGENOUS LEUKEMIA | ORGANIC CATION TRANSPORTER-1 | TYROSINE KINASE INHIBITORS | INTERFERON-ALPHA | ABCG2 BCRP | BCR-ABL | BLAST CRISIS | RESISTANCE | FOLLOW-UP | PHARMACOLOGY & PHARMACY | LOW-DOSE CYTARABINE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myeloid - genetics | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | Piperazines - metabolism | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Pyrimidines - metabolism | Patient Selection | Antineoplastic Agents - metabolism | Protein-Tyrosine Kinases - genetics | Transfection | ATP-Binding Cassette Transporters - genetics | Fusion Proteins, bcr-abl | Time Factors | ATP-Binding Cassette Transporters - metabolism | Aged, 80 and over | Adult | Neoplasm Proteins - genetics | Treatment Outcome | Octamer Transcription Factor-1 - genetics | Piperazines - therapeutic use | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Disease-Free Survival | Leukemia, Myeloid - drug therapy | Regression Analysis | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Leukemia, Myeloid - metabolism | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Aged | Benzamides | Mutation | Octamer Transcription Factor-1 - metabolism | Protein Kinase Inhibitors - metabolism
Journal Article
The FASEB Journal, ISSN 0892-6638, 12/2007, Volume 21, Issue 14, pp. 3937 - 3948
...) of this ATP binding cassette (ABC) transporter contact both transmembrane domains (TMDs). Such a domain arrangement is particularly unexpected because it is... 
ABC protein | drug efflux | MDR1 | ABCB1 | ATP binding cassette transporter | Drug efflux | DRUG-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NUCLEOTIDE-BINDING DOMAIN | ATP-BINDING | CELL BIOLOGY | ABC-TRANSPORTER | BIOLOGY | RESISTANCE | TRANSMEMBRANE DOMAINS | CYSTIC-FIBROSIS | HEMOLYSIN-B | CATALYTIC CYCLE | Protein Binding - genetics | Humans | Bacterial Proteins - chemistry | Escherichia coli Proteins - physiology | ATP-Binding Cassette Transporters - physiology | Cysteine - genetics | Nucleotides - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Membrane Proteins - physiology | Haemophilus influenzae - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cell Line | Mutagenesis, Site-Directed | Membrane Proteins - genetics | Bacterial Proteins - genetics | Haemophilus influenzae - genetics | Protein Structure, Tertiary - genetics | Bacterial Proteins - physiology | Nucleotides - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Proteins - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Haemophilus influenzae - physiology | Escherichia coli Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B | Structural Homology, Protein | Drug Resistance, Multiple, Bacterial - genetics | Escherichia coli Proteins - chemistry
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2016, Volume 101, pp. 40 - 53
[Display omitted] P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter superfamily... 
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | ABCB1 | TURNOVER | PHARMACOLOGY & PHARMACY | BINDING | TARIQUIDAR | RESIDUES | CATALYTIC CYCLE | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | multidrug resistance | structural motifs | modulators | drug-binding site
Journal Article