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Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 216 - 241
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile... 
Multidrug resistance- associated protein | Drug-induced liver injury | ATP-binding cassette transporter | Transporter | Bile acid | Bile salt export pump | drug-induced liver injury | BSEP | MRP2 | bile acid | SALT EXPORT PUMP | multidrug resistance- associated protein | CHOLESTASIS | INDUCED LIVER-INJURY | IN-VITRO | INHIBITION | transporter | DRUG DEVELOPMENT | bile salt export pump | TOXICOLOGY | HEPATOTOXICITY | BILE-ACIDS | Humans | Drug-Related Side Effects and Adverse Reactions - metabolism | Male | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Toxicity Tests - methods | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Recombinant Proteins - metabolism | Risk Assessment | Liver - metabolism | Risk Factors | Rats | Drug-Related Side Effects and Adverse Reactions - etiology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cluster Analysis | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7981 - 7991
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2011, Volume 8, Issue 4, pp. 1332 - 1341
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette... 
blood-brain barrier | quantitative LC-MS/MS | transporters | drug-metabolizing enzymes | human | PREGNANE-X RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | BARRIER | P-GLYCOPROTEIN | UDP-GLUCURONOSYLTRANSFERASE | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | GLUTATHIONE-S-TRANSFERASE | RAT-BRAIN | PROTEINS | UP-REGULATION | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glutamate Plasma Membrane Transport Proteins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Microvessels - metabolism | Glucose Transporter Type 1 - metabolism | Glutamate Plasma Membrane Transport Proteins - genetics | Excitatory Amino Acid Transporter 1 - genetics | Neoplasm Proteins - metabolism | Brain - metabolism | Brain - blood supply | Tandem Mass Spectrometry | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Chromatography, Liquid | Proteomics - methods | Neoplasm Proteins - genetics | Transcriptome - physiology | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Glutathione Transferase - metabolism | Excitatory Amino Acid Transporter 1 - metabolism | Transcriptome - genetics | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | In Vitro Techniques | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Journal Article
The Plant Cell, ISSN 1040-4651, 1/2007, Volume 19, Issue 1, pp. 131 - 147
Directional transport of the phytohormone auxin is established primarily at the point of cellular efflux and is required for the establishment and maintenance... 
Proteins | Yeasts | Hypocotyls | Plant roots | HeLa cells | Auxins | Cell membranes | Plants | Seedlings | Plant cells | ABC TRANSPORTER | ROOT GRAVITROPISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT DEVELOPMENT | POLAR TRANSPORT | DRUG-RESISTANCE | PLASMA-MEMBRANE | PLANT SCIENCES | CELL BIOLOGY | GENE-EXPRESSION | TWISTED DWARF1 | EFFLUX CARRIER | RNA-POLYMERASE | Hypocotyl - genetics | ATP Binding Cassette Transporter, Sub-Family B - analysis | Plant Roots - genetics | RNA, Messenger - metabolism | ATP-Binding Cassette Transporters - physiology | Arabidopsis Proteins - metabolism | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Hypocotyl - metabolism | Arabidopsis Proteins - analysis | Arabidopsis Proteins - genetics | Arabidopsis Proteins - physiology | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Membrane Transport Proteins - analysis | ATP-Binding Cassette Transporters - analysis | Arabidopsis - metabolism | Arabidopsis - genetics | Two-Hybrid System Techniques | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Biological Transport - physiology | Mutation | ATP Binding Cassette Transporter, Sub-Family B - genetics | Plant translocation | Physiological aspects | Glycoproteins | Research | Arabidopsis | Index Medicus
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 12/2012, Volume 464, Issue 6, pp. 601 - 611
Acquiring a mechanistic understanding of the processes underlying the renal clearance of drug molecules in man has been hampered by a lack of robust in vitro... 
Biomedicine | Proximal tubule cells | Human Physiology | Drug transporters | PHYSIOLOGY | MEMBRANE | INTESTINE | ORGANIC ANION TRANSPORTERS | HUMAN KIDNEY | P-CRESYL SULFATE | UREMIC TOXIN | PROTEIN MRP | MOLECULAR-CLONING | GLYCOPROTEIN | MULTIDRUG-RESISTANCE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Epithelial Cells - metabolism | Kidney Cortex - metabolism | Humans | Neoplasm Proteins - metabolism | Monocarboxylic Acid Transporters - metabolism | ATP-Binding Cassette Transporters - genetics | Biological Transport | Monocarboxylic Acid Transporters - biosynthesis | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Neoplasm Proteins - genetics | Cell Line | Kidney Cortex - cytology | Kidney Tubules, Proximal - cytology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Symporters - metabolism | ATP-Binding Cassette Transporters - biosynthesis | Membrane Transport Proteins - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Symporters - genetics | Kidney Tubules, Proximal - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Monocarboxylic Acid Transporters - genetics | Symporters - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - genetics | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2008, Volume 68, Issue 19, pp. 7905 - 7914
Lapatinib is active at the ATP-binding site of Lyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2.... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
International Journal of Cancer, ISSN 0020-7136, 2014, Volume 134, Issue 6, pp. 1484 - 1494
Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase... 
brain accumulation | crizotinib | P‐glycoprotein | ALK inhibitor | elacridar | P-glycoprotein | EML4-ALK FUSION GENE | METASTASES | MOUSE | PENETRATION | GF120918 | BIOAVAILABILITY | CELL LUNG-CANCER | ANAPLASTIC LYMPHOMA KINASE | ONCOLOGY | MULTIDRUG-RESISTANCE | PHASE-I | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pyridines - pharmacokinetics | Biological Availability | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - physiology | Brain - metabolism | Tissue Distribution | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Drug Therapy, Combination | Neoplasm Proteins - genetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Administration, Oral | Cells, Cultured | Mice, Knockout | Brain - drug effects | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Acridines - pharmacology | ATP Binding Cassette Transporter, Sub-Family B | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Plasma | Chemotherapy | Brain cancer | Rodents | Lymphomas | Glycoproteins | Metastasis | Index Medicus
Journal Article