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Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
RATIONALE:High-density lipoprotein (HDL) is a heterogeneous population of particles. Differences in the capacities of HDL subfractions to remove cellular... 
foam cells | HDL | ATP-binding cassette transporters | macrophages | cholesterol, HDL | ATP binding cassette transporter 1 | Cholesterol | cholesterol-efflux regulatory protein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | APOA-I | HIGH-DENSITY-LIPOPROTEIN | TANGIER DISEASE | EFFLUX | MESSENGER-RNA | CASSETTE TRANSPORTER A1 | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ABCG1 | APOLIPOPROTEIN-A-I | Lipoproteins - deficiency | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Lipoproteins, HDL - metabolism | ATP-Binding Cassette Transporters - physiology | Recombinant Fusion Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP Binding Cassette Transporter 1 - physiology | Biological Transport | Foam Cells - metabolism | Lipoproteins, HDL2 - metabolism | CHO Cells | Cell Line | Cricetinae | Tangier Disease - enzymology | Tangier Disease - genetics | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Gene Silencing | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Lipoproteins - physiology | Mice, Knockout | Particle Size | Macrophages - metabolism | Animals | ATP Binding Cassette Transporter 1 - deficiency | ATP Binding Cassette Transporter 1 - antagonists & inhibitors | Mice | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3900 - 3908
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19719 - 19724
Four members of the mammalian ATP binding cassette (ABC) transporter G subfamily are thought to be involved in transmembrane (TM) transport of sterols. The... 
ATP binding cassette transporters | COS cells | Sterols | Plasmids | HDL lipoproteins | Amino acids | Cell membranes | Repression | Cholesterols | Endosomes | 27-hydroxycholesterol | 25-hydroxycholesterol | Cholesterol | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | ATHEROSCLEROSIS | MEMBRANE-PROTEIN | PLASMA-MEMBRANE | HIGH-DENSITY-LIPOPROTEIN | SENSING DOMAIN | cholesterol | SCAP | CELLULAR CHOLESTEROL EFFLUX | ENDOPLASMIC-RETICULUM | ACCUMULATION | Sterols - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Lipoproteins - genetics | Humans | Cercopithecus aethiops | Molecular Sequence Data | Macrophages, Peritoneal - cytology | Endosomes - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | HEK293 Cells | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - metabolism | Macrophages, Peritoneal - drug effects | CHO Cells | Amino Acid Sequence | Cricetinae | Cells, Cultured | Blotting, Western | Sequence Homology, Amino Acid | Animals | Intracellular Space - metabolism | Benzoates - pharmacology | Mutation | Macrophages, Peritoneal - metabolism | Benzylamines - pharmacology | COS Cells | Research | Properties | Adenosine triphosphate | Protein binding | Proteins | Membranes | ABC transporters | Cells | Steroids | Index Medicus | Biological Sciences
Journal Article
Circulation Research, ISSN 0009-7330, 05/2013, Volume 112, Issue 10, pp. 1345 - 1354
RATIONALE:Macrophage accumulation in adipose tissue associates with insulin resistance and increased cardiovascular disease risk. We previously have shown that... 
Apolipoprotein AI | HDL | ABC transporters | Adipocytes | Cholesterol | CARDIAC & CARDIOVASCULAR SYSTEMS | apolipoprotein AI | CELLULAR CHOLESTEROL | DEFICIENT MICE | MACROPHAGE ACCUMULATION | OBESITY | INSULIN-RESISTANCE | ADIPOSE-TISSUE INFLAMMATION | ENDOTHELIAL-CELLS | LIPID RAFTS | TOLL-LIKE RECEPTORS | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | adipocytes | TRANSGENIC MICE | Apolipoprotein A-I - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Reactive Oxygen Species - metabolism | Humans | Lipoproteins, HDL - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Lipoproteins, HDL - pharmacology | Apolipoprotein A-I - genetics | Inflammation - metabolism | Lipoproteins - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Scavenger Receptors, Class B - drug effects | Disease Models, Animal | Receptors, LDL - genetics | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Receptors, LDL - metabolism | Mice, Transgenic | Apolipoprotein A-I - metabolism | 3T3-L1 Cells | Cholesterol - metabolism | Mice, Knockout | Animals | ATP-Binding Cassette Transporters - drug effects | Membrane Microdomains - drug effects | Adipocytes - metabolism | Biological Transport - physiology | Mice | Lipoproteins - drug effects | Scavenger Receptors, Class B - metabolism | In Vitro Techniques | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 2014, Volume 34, Issue 2, pp. 279 - 284
Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR activators (1) directly upregulate genes involved in reverse cholesterol transport and... 
atherosclerosis | ATP-binding cassette transporters | macrophages | liver X receptor | inflammation | ANTIINFLAMMATORY ACTIVITY | MYELOPROLIFERATIVE DISORDERS | LDL RECEPTOR | TERTIARY-AMINES | ACCELERATES ATHEROSCLEROSIS | KNOCKOUT MICE | NUCLEAR RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MACROPHAGE ABCA1 | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Lipoproteins - deficiency | Macrophages - transplantation | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Hydrocarbons, Fluorinated - pharmacology | Male | Aorta - metabolism | Orphan Nuclear Receptors - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver X Receptors | Myocardium - metabolism | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Female | Cytokines - genetics | Macrophages - immunology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Aorta - drug effects | Mice, Inbred C57BL | Orphan Nuclear Receptors - agonists | Gene Expression Regulation | Myocardium - pathology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | ATP Binding Cassette Transporter 1 - deficiency | Benzoates - pharmacology | Macrophages - drug effects | Mice | Benzylamines - pharmacology | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2008, Volume 118, Issue 18, pp. 1837 - 1847
Background-Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages... 
Lipoproteins | ABC transporters | Inflammation | Cholesterol | Atherosclerosis | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | INDUCED APOPTOSIS | CELLULAR CHOLESTEROL | NECROSIS-FACTOR-ALPHA | ABCG1(-/-) BONE-MARROW | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-E | LIPID-ACCUMULATION | EFFLUX | inflammation | ABCA1-DEFICIENT MACROPHAGES | cholesterol | PERIPHERAL VASCULAR DISEASE | MICE | lipoproteins | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Membrane Microdomains - immunology | Signal Transduction - immunology | ATP-Binding Cassette Transporters - genetics | Mice, Mutant Strains | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Macrophages - immunology | Receptors, LDL - genetics | Atherosclerosis - immunology | Atherosclerosis - physiopathology | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Receptors, LDL - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Cholesterol - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | Ligands | Macrophages - drug effects | Mice | ATP-Binding Cassette Transporters - immunology | Lipoproteins - immunology | Physiological aspects | Research | Macrophages | Gene expression | Index Medicus | Abridged Index Medicus | Toll-receptors
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 2013, Volume 112, Issue 11, pp. 1456 - 1465
Rationale: Plasma high-density lipoprotein levels are inversely correlated with atherosclerosis. Although it is widely assumed that this is attributable to the... 
atherosclerosis | monocytes | macrophages | inflammation | high-density lipoprotein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | STEM-CELL PROLIFERATION | APOA-I | LESIONS | HIGH-DENSITY-LIPOPROTEIN | TANGIER-DISEASE | LIPID-ACCUMULATION | EFFLUX | GENE | REVERSE CHOLESTEROL TRANSPORT | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Cholesterol, Dietary - metabolism | Vasculitis - pathology | Monocytes - metabolism | Monocytes - immunology | Vasculitis - immunology | Vasculitis - genetics | ATP-Binding Cassette Transporters - genetics | Bone Marrow Transplantation | Lipoproteins - metabolism | Monocytes - pathology | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Spleen - pathology | Foam Cells - pathology | Neutrophils - metabolism | Foam Cells - metabolism | Macrophages - immunology | Neutrophils - pathology | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Macrophages - pathology | Neutrophils - immunology | Receptors, LDL - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Foam Cells - immunology | Mice | ATP-Binding Cassette Transporters - immunology | Lipoproteins - immunology | Animal Feed | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 27, pp. 12228 - 12232
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptional programs that stimulate cellular... 
MicroRNA | Messenger RNA | HEK293 cells | Sterols | Adenoviruses | HDL lipoproteins | Mice | Repression | Macrophages | Cholesterols | ABCA1 | miRNA | High-density lipoprotein | ABCG1 | Cholesterol | LDL RECEPTOR | high-density lipoprotein | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | MICRORNAS | STATINS | HIGH-DENSITY-LIPOPROTEIN | CHOLESTEROL-METABOLISM | EFFLUX | cholesterol | MICE | BINDING | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cholesterol - blood | Humans | Transcriptional Activation | Molecular Sequence Data | Male | 5' Untranslated Regions - genetics | RNA, Messenger - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Base Sequence | ATP-Binding Cassette Transporters - metabolism | Lipoproteins, LDL - metabolism | Response Elements - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Receptors, LDL - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Receptors, LDL - metabolism | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Animals | Cholesterol, HDL - blood | MicroRNAs - genetics | Lipoproteins, LDL - blood | High density lipoproteins | Research | Properties | Binding proteins | Genetic regulation | Proteins | Plasma | Gene expression | Ribonucleic acid--RNA | Low density lipoprotein | Statins | Index Medicus | Biological Sciences
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 2014, Volume 34, Issue 8, pp. 1731 - 1738
OBJECTIVE: Although the role of monocytes in the pathogenesis of atherosclerosis is well established, the persistent vascular inflammation remains largely... 
Monocytes | Inflammation | Epigenomics | Oxidized low-density lipoprotein | Atherosclerosis | atherosclerosis | monocytes | ACTIVATION | STERILE INFLAMMATION | MYOCARDIAL-INFARCTION | MACROPHAGES | epigenomics | HUMAN ENDOTHELIAL-CELLS | MEDIATED HISTONE MODIFICATIONS | RECEPTOR-DEFICIENT MICE | inflammation | TRAINED IMMUNITY | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | oxidized low-density lipoprotein | HEMATOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | CD36 Antigens - genetics | Atherosclerosis - genetics | Humans | Monocytes - metabolism | Monocytes - immunology | RNA, Messenger - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Foam Cells - drug effects | DNA Methylation | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | ATP-Binding Cassette Transporters - genetics | CD36 Antigens - metabolism | Time Factors | Inflammation Mediators - metabolism | ATP-Binding Cassette Transporters - metabolism | Scavenger Receptors, Class A - genetics | Epigenesis, Genetic - drug effects | Lipoproteins, LDL - metabolism | Cytokines - genetics | Foam Cells - metabolism | Promoter Regions, Genetic | Atherosclerosis - immunology | Cytokines - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Atherosclerosis - metabolism | Cellular Reprogramming - drug effects | Monocytes - drug effects | Phenotype | Histone-Lysine N-Methyltransferase - metabolism | Foam Cells - immunology | Histones - metabolism | Scavenger Receptors, Class A - metabolism | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2013, Volume 17, Issue 4, pp. 549 - 561
Journal Article