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Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7659, pp. 504 - 509
ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the... 
BINDING CASSETTE TRANSPORTER | PHOSPHOLIPID-BILAYER NANODISCS | STEROL TRANSPORTER | PARTICLE ELECTRON CRYOMICROSCOPY | RESISTANCE PROTEIN BCRP/ABCG2 | MULTIDISCIPLINARY SCIENCES | EM STRUCTURE DETERMINATION | CRYO-EM | MONOCLONAL-ANTIBODY | MEMBRANE-PROTEINS | P-GLYCOPROTEIN | Immunoglobulin Fab Fragments - ultrastructure | Antibodies - chemistry | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Cholesterol - chemistry | Biological Transport | Antibodies - immunology | Protein Domains | Adenosine Triphosphatases - ultrastructure | Binding Sites | Amino Acid Sequence | Neoplasm Proteins - ultrastructure | Adenosine Triphosphatases - metabolism | Antibodies - ultrastructure | Models, Molecular | Neoplasm Proteins - chemistry | Cholesterol - metabolism | Cryoelectron Microscopy | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - antagonists & inhibitors | Immunoglobulin Fab Fragments - chemistry | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - chemistry | Polymorphism, Single Nucleotide - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - ultrastructure | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Immunoglobulin Fab Fragments - immunology | Physiological aspects | Binding proteins | Observations | Drug interactions | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2008, Volume 68, Issue 19, pp. 7905 - 7914
Lapatinib is active at the ATP-binding site of Lyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2.... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2011, Volume 8, Issue 4, pp. 1332 - 1341
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette... 
blood-brain barrier | quantitative LC-MS/MS | transporters | drug-metabolizing enzymes | human | PREGNANE-X RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | BARRIER | P-GLYCOPROTEIN | UDP-GLUCURONOSYLTRANSFERASE | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | GLUTATHIONE-S-TRANSFERASE | RAT-BRAIN | PROTEINS | UP-REGULATION | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glutamate Plasma Membrane Transport Proteins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Microvessels - metabolism | Glucose Transporter Type 1 - metabolism | Glutamate Plasma Membrane Transport Proteins - genetics | Excitatory Amino Acid Transporter 1 - genetics | Neoplasm Proteins - metabolism | Brain - metabolism | Brain - blood supply | Tandem Mass Spectrometry | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Chromatography, Liquid | Proteomics - methods | Neoplasm Proteins - genetics | Transcriptome - physiology | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Glutathione Transferase - metabolism | Excitatory Amino Acid Transporter 1 - metabolism | Transcriptome - genetics | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | In Vitro Techniques | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 05/2018, Volume 9, Issue MAY, pp. 463 - 463
The ATP-binding cassette transporter ABCG2 (BCRP and MXR) is involved in the absorption, distribution, and elimination of numerous drugs. Thus, drugs that are... 
Pharmacogenetics | AT1 receptor antagonists | ATP-binding cassette (ABC) transporter | F489L polymorphism | ABCG2 | MIGRATION | BCRP | TUBE FORMATION | P-GLYCOPROTEIN | TELMISARTAN | IN-VITRO | POLYMORPHISMS | GENE | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | EXPRESSION | pharmacogenetics | Cell receptors | Genetic aspects | Carrier proteins | Health aspects | Drug interactions
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 09/2017, Volume 313, Issue 3, pp. F826 - F834
Accumulating data indicate that renal uric acid (UA) handling is altered in diabetes and by hypoglycemic agents. In addition, hyperinsulinemia is associated... 
Hyperinsulinemia | Urate transporters | Hypouricosuria | Kidney proximal tubule | PHYSIOLOGY | hyperinsulinemia | SGLT2 INHIBITOR | GOUT | RISK | LEVEL | EXCRETION | IDENTIFICATION | hypouricosuria | DIABETES-MELLITUS | RENAL HYPOURICEMIA | urate transporters | RESISTANCE | UROLOGY & NEPHROLOGY | kidney proximal tubule | HYPERTENSION | Kidney Tubules - physiopathology | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Diabetes Mellitus, Type 1 - metabolism | Male | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Uric Acid - urine | Renal Reabsorption - drug effects | Time Factors | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Kidney Tubules - metabolism | Diabetes Mellitus, Experimental - physiopathology | Cell Line | Insulin - pharmacology | Glucosides - pharmacology | Uric Acid - metabolism | Kidney Tubules - drug effects | Sodium-Glucose Transporter 2 - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Thiophenes - pharmacology | Renal Elimination - drug effects | Anion Transport Proteins - metabolism | Rats, Sprague-Dawley | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Animals | Blood Glucose - metabolism | Carrier proteins | Physiological aspects | Physiological research | Uric acid | Research | G proteins | Insulin | Absorption (Physiology) | Excretion | Kidneys | Renal function | Syngeneic grafts | Epithelial cells | Diabetes mellitus | Reabsorption | Proteins | Hyperuricemia | Sodium | Hypoglycemic agents | Diabetes | Adenosine triphosphatase | Binding sites | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 2014, Volume 134, Issue 6, pp. 1484 - 1494
Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase... 
brain accumulation | crizotinib | P‐glycoprotein | ALK inhibitor | elacridar | P-glycoprotein | EML4-ALK FUSION GENE | METASTASES | MOUSE | PENETRATION | GF120918 | BIOAVAILABILITY | CELL LUNG-CANCER | ANAPLASTIC LYMPHOMA KINASE | ONCOLOGY | MULTIDRUG-RESISTANCE | PHASE-I | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pyridines - pharmacokinetics | Biological Availability | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - physiology | Brain - metabolism | Tissue Distribution | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Drug Therapy, Combination | Neoplasm Proteins - genetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Administration, Oral | Cells, Cultured | Mice, Knockout | Brain - drug effects | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Acridines - pharmacology | ATP Binding Cassette Transporter, Sub-Family B | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Plasma | Chemotherapy | Brain cancer | Rodents | Lymphomas | Glycoproteins | Metastasis | Index Medicus
Journal Article
Journal Article