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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1484 - 1493
OBJECTIVE—Transintestinal cholesterol excretion (TICE) is an alternate pathway to hepatobiliary secretion. Our study aimed at identifying molecular mechanisms... 
PCSK9 | ATP-binding cassette transporter B1 | Lipoprotein | Low-density lipoprotein receptor | Transintestinal cholesterol excretion | MULTIDRUG TRANSPORTER | low-density lipoprotein receptor | lipoprotein | DENSITY-LIPOPROTEIN RECEPTORS | KNOCKOUT MICE | COMPLETE BILE DIVERSION | P-GLYCOPROTEIN | BILIARY STEROL SECRETION | PLASMA | LIVER | CONVERTASE SUBTILISIN/KEXIN TYPE-9 | PERIPHERAL VASCULAR DISEASE | transintestinal cholesterol excretion | ABSORPTION | HEMATOLOGY | Lovastatin - pharmacology | Humans | Male | Proprotein Convertases - genetics | Jejunum - drug effects | Time Factors | Serine Endopeptidases - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Recombinant Proteins - metabolism | Receptors, LDL - genetics | Jejunum - enzymology | Serine Endopeptidases - deficiency | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Proprotein Convertases - metabolism | ATP Binding Cassette Transporter, Subfamily B - deficiency | Receptors, LDL - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - deficiency | Cholesterol - metabolism | Proprotein Convertases - deficiency | ATP Binding Cassette Transporter, Subfamily B - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Biopsy | Cholesterol, LDL - metabolism | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus
Journal Article
Journal Article
The Plant Cell, ISSN 1040-4651, 12/2007, Volume 19, Issue 12, pp. 3930 - 3943
ATP binding cassette (ABC) transporters transport diverse substrates across membranes in various organisms. However, plant ABC transporters have only been... 
ATP binding cassette transporters | Yeasts | Hair cells | Epidermal cells | HeLa cells | Auxins | Root hairs | Cell membranes | Plants | Plant cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | PIN PROTEINS | P-GLYCOPROTEIN | PLANT SCIENCES | CELL BIOLOGY | PATHWAY | GROWTH | TWISTED DWARF1 | MULTIDRUG-RESISTANCE | EXPRESSION | PLANT ABC TRANSPORTERS | GNOM ARF-GEF | Plant Roots - genetics | Brefeldin A - pharmacology | Arabidopsis Proteins - metabolism | ATP-Binding Cassette Transporters - genetics | Plants, Genetically Modified | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter, Subfamily B - genetics | Biological Transport - drug effects | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Tobacco - metabolism | Cells, Cultured | Plant Roots - cytology | Reverse Transcriptase Polymerase Chain Reaction | ATP Binding Cassette Transporter, Subfamily B - metabolism | Arabidopsis - metabolism | Tobacco - cytology | Arabidopsis - genetics | Microscopy, Confocal | Gene Expression Regulation, Plant - drug effects | Indoleacetic Acids - pharmacology | Tobacco - genetics | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Staurosporine - pharmacology | Auxin | Carrier proteins | Arabidopsis | Physiological aspects | Glycoproteins | Chemical properties | Adenosine triphosphate | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 525 - 528
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical... 
TAP | TRANSPORTER | PARTICLE ELECTRON CRYOMICROSCOPY | TAPASIN | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | ERP57 | EM STRUCTURE DETERMINATION | CALRETICULIN P-DOMAIN | MAJOR HISTOCOMPATIBILITY COMPLEX | BINDING | ATP Binding Cassette Transporter, Subfamily B, Member 2 - chemistry | Protein Disulfide-Isomerases - metabolism | Protein Disulfide-Isomerases - ultrastructure | ATP Binding Cassette Transporter, Subfamily B, Member 3 - chemistry | Cytosol - immunology | Humans | Endoplasmic Reticulum - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 2 - ultrastructure | Histocompatibility Antigens Class I - metabolism | Multiprotein Complexes - metabolism | Endoplasmic Reticulum - chemistry | Antigen Presentation | ATP Binding Cassette Transporter, Subfamily B, Member 3 - ultrastructure | Calreticulin - metabolism | Protein Domains | Membrane Transport Proteins - metabolism | Binding Sites | Histocompatibility Antigens Class I - immunology | Models, Molecular | Histocompatibility Antigens Class I - chemistry | Burkitt Lymphoma - chemistry | Disease Progression | Membrane Transport Proteins - chemistry | Calreticulin - chemistry | Calreticulin - ultrastructure | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 3 - metabolism | Histocompatibility Antigens Class I - ultrastructure | Membrane Transport Proteins - ultrastructure | Models, Biological | ATP Binding Cassette Transporter, Subfamily B, Member 2 - metabolism | Cytosol - metabolism | Protein Disulfide-Isomerases - chemistry | Multiprotein Complexes - immunology | Peptides | Physiological aspects | Major histocompatibility complex | Oxidoreductase | Antigen processing | Lymphocytes T | Cell surface | Proteins | Calreticulin | Binding | Symbiosis | Translocation | Antigens | Immune response | Macromolecules | TAP protein | Lymphoma | Glycan | Burkitt's lymphoma | Immune systems | Tapasin | Microscopy | Lymphomas | Endoplasmic reticulum | Histocompatibility | ABC transporter | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 03/2018, Volume 45, Issue 4, pp. 1515 - 1528
Background/Aims: The overexpression of ATP-Binding Cassette (ABC) transporters has known to be one of the major obstacles impeding the success of chemotherapy... 
Voruciclib | ATP-binding cassette transporters | ABCB1 | Multidrug resistance | ABCG2 | PHYSIOLOGY | TRANSPORTER | VIVO | SPECIFICITY | MEDIATED DRUG-RESISTANCE | MODULATORS | CELL BIOLOGY | TYROSINE KINASE INHIBITORS | BREAST-CANCER | IN-VITRO | REVERSAL AGENTS | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Paclitaxel - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Apoptosis - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Benzopyrans - chemistry | Protein Kinase Inhibitors - chemistry | HEK293 Cells | ATP Binding Cassette Transporter, Subfamily B - genetics | Antineoplastic Agents - pharmacology | Benzopyrans - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Binding Sites | Protein Structure, Tertiary | Cell Survival - drug effects | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Imino Furanoses - pharmacology | Antineoplastic Agents - chemistry | Cyclin-Dependent Kinase 4 - metabolism | ATP Binding Cassette Transporter, Subfamily B - metabolism | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Imino Furanoses - chemistry | Cell Line, Tumor | Mitoxantrone - pharmacology | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Mutation | Multidrug Resistance-Associated Proteins - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Cytotoxicity | Breast cancer | Kinases | Drug resistance | Cancer therapies | Penicillin | Index Medicus
Journal Article
Journal Article
BMC Biology, ISSN 1741-7007, 06/2013, Volume 11, Issue 1, pp. 69 - 69
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2014, Volume 20, Issue 10, pp. 2703 - 2713
PURPOSE: Little is known about the optimal clinical use of ABT-888 (veliparib) for treatment of glioblastoma. ABT-888 is a PARP inhibitor undergoing extensive... 
MALIGNANT GLIOMA | POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITOR | REPAIR | ONCOLOGY | TRANSPORTERS | TUMOR STEM-CELLS | ENDOTHELIAL-CELLS | MULTIDRUG-RESISTANCE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | BRAIN-TUMORS | Immunohistochemistry | Area Under Curve | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Metabolic Clearance Rate | Brain - metabolism | LLC-PK1 Cells | ATP-Binding Cassette Transporters - genetics | Benzimidazoles - administration & dosage | Glioblastoma - genetics | Swine | Dacarbazine - analogs & derivatives | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Acridines - administration & dosage | Acridines - pharmacokinetics | Dacarbazine - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily B - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | PTEN Phosphohydrolase - genetics | Dacarbazine - administration & dosage | Kaplan-Meier Estimate | Benzimidazoles - pharmacokinetics | PTEN Phosphohydrolase - metabolism | Treatment Outcome | Tetrahydroisoquinolines - administration & dosage | Blood-Brain Barrier - drug effects | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Glioblastoma - pathology | Dogs | Tetrahydroisoquinolines - pharmacokinetics | Cell Line, Tumor | Temozolomide | Glioblastoma - drug therapy | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 5, pp. 1304 - 1316
Central nervous system (CNS) chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs... 
blood brain barrier | toxicology | drug transporters | endobiotics | steroid hormones | drug side effect mechanisms | behavior | central nervous system | MUSHROOM BODIES | MANDUCA-SEXTA | CYCLOSPORINE-A | ECDYSONE-INDUCIBLE GENE | DROSOPHILA-MELANOGASTER | RECEPTOR SUPERFAMILY | P-GLYCOPROTEIN EXPRESSION | DRUG-RESISTANCE | MULTIDRUG-RESISTANCE | EARLY PUFF | CELL BIOLOGY | Central Nervous System - metabolism | Cyclosporine - pharmacology | Substrate Specificity | Male | Drosophila Proteins - metabolism | Xenobiotics - chemistry | Brain - metabolism | Aldosterone - metabolism | Behavior, Animal - drug effects | ATP Binding Cassette Transporter, Subfamily B - genetics | Xenobiotics - metabolism | Aldosterone - chemistry | Ecdysterone - chemistry | Binding Sites | ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry | Ecdysterone - metabolism | Gonadal Steroid Hormones - metabolism | Drosophila | ATP Binding Cassette Transporter, Subfamily B - chemistry | Rats | Drosophila Proteins - chemistry | Blood-Brain Barrier - drug effects | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Gonadal Steroid Hormones - analysis | Biological Evolution | Brain - drug effects | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Databases, Chemical | Molecular Docking Simulation | Drosophila Proteins - genetics | Index Medicus
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 01/2015, Volume 32, Issue 7, pp. 2205 - 2216
Purpose: Regorafenib is a novel multikinase inhibitor, currently approved for the treatment of metastasized colorectal cancer and advanced gastrointestinal... 
Biochemistry, general | Biomedical Engineering | brain accumulation | Biomedicine | ABCB1 | testis accumulation | Pharmacy | Medical Law | regorafenib | Pharmacology/Toxicology | ABCG2 | MULTICENTER | TRANSPORTER | BARRIER | PENETRATION | SORAFENIB | CHEMISTRY, MULTIDISCIPLINARY | PHARMACOKINETICS | SUNITINIB | PHARMACOLOGY & PHARMACY | INHIBITOR | Testis - metabolism | Humans | Pyridines - pharmacokinetics | Male | Neoplasm Proteins - metabolism | Antineoplastic Agents - metabolism | Brain - metabolism | Tissue Distribution | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter, Subfamily B - genetics | Antineoplastic Agents - pharmacokinetics | Phenylurea Compounds - metabolism | Phenylurea Compounds - pharmacokinetics | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Administration, Oral | Phenylurea Compounds - blood | ATP Binding Cassette Transporter, Subfamily B - metabolism | Mice, Knockout | Pyridines - blood | Animals | Pyridines - metabolism | Dogs | Antineoplastic Agents - blood | Mice | Brain | Breast cancer | Metabolites | Colorectal cancer | Inhibitor drugs | Kinases | Rodents | Pharmaceutical sciences | Index Medicus
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 324 - 335
Poor antiretroviral drug (ARV) penetration in the testes could be due, in part, to the presence of ATP-binding cassette (ABC) membrane-associated drug efflux... 
Testis - metabolism | Receptors, Steroid - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Male | Receptors, Steroid - antagonists & inhibitors | Neoplasm Proteins - metabolism | Receptors, Steroid - agonists | Sertoli Cells - drug effects | Testis - drug effects | RNA Interference | Seminiferous Tubules - metabolism | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Sertoli Cells - metabolism | Cell Line | Blood-Testis Barrier - metabolism | Mice, Inbred C57BL | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Anti-Retroviral Agents - pharmacology | Recombinant Proteins - chemistry | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | ATP Binding Cassette Transporter, Subfamily B - metabolism | Anti-Retroviral Agents - metabolism | Orchiectomy | Gene Expression Regulation - drug effects | Animals | Receptors, Steroid - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Ligands | Blood-Testis Barrier - drug effects | Mice | Pregnane X Receptor | Seminiferous Tubules - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20412 - 20424
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2018, Volume 233, Issue 4, pp. 3066 - 3079
Journal Article