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Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7981 - 7991
Journal Article
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5986, pp. 1689 - 1693
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood.... 
Myeloid cells | Leukocytosis | Transgenic animals | HDL lipoproteins | REPORTS | Atherosclerosis | Transgenes | Macrophages | Lesions | Cholesterols | Progenitor cells | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | MACROPHAGE ABCA1 | LIPID RAFTS | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | ACCUMULATION | ABCG1 | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Cell Proliferation | Lipoproteins - genetics | Lipoproteins, HDL - metabolism | Apolipoprotein A-I - genetics | Leukocytosis - metabolism | ATP-Binding Cassette Transporters - genetics | Atherosclerosis - therapy | Leukocytosis - therapy | Myeloproliferative Disorders - metabolism | Bone Marrow Transplantation | Leukocytosis - physiopathology | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Hematopoietic Stem Cells - physiology | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Multipotent Stem Cells - physiology | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Myeloproliferative Disorders - therapy | Signal Transduction | Atherosclerosis - physiopathology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Receptors, Interleukin-3 - metabolism | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Phenotype | Animals | Myeloid Progenitor Cells - physiology | Myeloproliferative Disorders - physiopathology | Mice | Hypercholesterolemia - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Cell proliferation | High density lipoproteins | Physiological aspects | Development and progression | Research | Health aspects | Hematopoietic stem cells | Adenosine triphosphate
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 525 - 528
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical... 
VISUALIZATION | TAP | TRANSPORTERS | TAPASIN | CALRETICULIN | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | ERP57 | PURIFICATION | MAJOR HISTOCOMPATIBILITY COMPLEX | BINDING | ATP Binding Cassette Transporter, Subfamily B, Member 2 - chemistry | Protein Disulfide-Isomerases - metabolism | Protein Disulfide-Isomerases - ultrastructure | ATP Binding Cassette Transporter, Subfamily B, Member 3 - chemistry | Cytosol - immunology | Humans | Endoplasmic Reticulum - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 2 - ultrastructure | Histocompatibility Antigens Class I - metabolism | Multiprotein Complexes - metabolism | Endoplasmic Reticulum - chemistry | Antigen Presentation | ATP Binding Cassette Transporter, Subfamily B, Member 3 - ultrastructure | Calreticulin - metabolism | Protein Domains | Membrane Transport Proteins - metabolism | Binding Sites | Histocompatibility Antigens Class I - immunology | Models, Molecular | Histocompatibility Antigens Class I - chemistry | Burkitt Lymphoma - chemistry | Disease Progression | Membrane Transport Proteins - chemistry | Calreticulin - chemistry | Calreticulin - ultrastructure | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 3 - metabolism | Histocompatibility Antigens Class I - ultrastructure | Membrane Transport Proteins - ultrastructure | Models, Biological | ATP Binding Cassette Transporter, Subfamily B, Member 2 - metabolism | Cytosol - metabolism | Protein Disulfide-Isomerases - chemistry | Multiprotein Complexes - immunology | Peptides | Physiological aspects | Major histocompatibility complex | Oxidoreductase | Antigen processing | Lymphocytes T | Cell surface | Proteins | Calreticulin | Immune system | Binding | Symbiosis | Translocation | Antigens | Immune response | Macromolecules | TAP protein | Lymphoma | Glycan | Burkitt's lymphoma | Tapasin | Microscopy | Lymphomas | Endoplasmic reticulum | Histocompatibility | ABC transporter
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1484 - 1493
OBJECTIVE—Transintestinal cholesterol excretion (TICE) is an alternate pathway to hepatobiliary secretion. Our study aimed at identifying molecular mechanisms... 
PCSK9 | ATP-binding cassette transporter B1 | Lipoprotein | Low-density lipoprotein receptor | Transintestinal cholesterol excretion | MULTIDRUG TRANSPORTER | low-density lipoprotein receptor | lipoprotein | DENSITY-LIPOPROTEIN RECEPTORS | KNOCKOUT MICE | COMPLETE BILE DIVERSION | P-GLYCOPROTEIN | BILIARY STEROL SECRETION | PLASMA | LIVER | CONVERTASE SUBTILISIN/KEXIN TYPE-9 | PERIPHERAL VASCULAR DISEASE | transintestinal cholesterol excretion | ABSORPTION | HEMATOLOGY | Lovastatin - pharmacology | Humans | Male | Proprotein Convertases - genetics | Jejunum - drug effects | Time Factors | Serine Endopeptidases - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Recombinant Proteins - metabolism | Receptors, LDL - genetics | Jejunum - enzymology | Serine Endopeptidases - deficiency | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Proprotein Convertases - metabolism | ATP Binding Cassette Transporter, Subfamily B - deficiency | Receptors, LDL - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - deficiency | Cholesterol - metabolism | Proprotein Convertases - deficiency | ATP Binding Cassette Transporter, Subfamily B - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Biopsy | Cholesterol, LDL - metabolism | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9
Journal Article
Cancer Research, ISSN 0008-5472, 10/2008, Volume 68, Issue 19, pp. 7905 - 7914
Lapatinib is active at the ATP-binding site of Lyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2.... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article