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Lipids in health and disease, ISSN 1476-511X, 2019, Volume 18, Issue 1, pp. 2 - 7
Background: ATP-binding cassette (ABC) transporters are involved in a huge range of physiological processes. Mutations in the ABCC6 gene cause pseudoxanthoma... 
ATP-binding cassette transporters | NUTRITION & DIETETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Abcc6 | MOUSE | Pseudoxanthoma elasticum | Mice | MUTATIONS | SECRETION | Gene expression | PCR | Liver - pathology | Kidney - pathology | Lipoproteins - genetics | Adipose Tissue, White - metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | ATP-Binding Cassette Transporters - deficiency | Kidney - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Transporter, Subfamily G, Member 8 - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 5 - metabolism | Disease Models, Animal | ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics | Adipose Tissue, White - pathology | Pseudoxanthoma Elasticum - metabolism | Liver - metabolism | Gene Expression Regulation | Bile Acids and Salts - metabolism | Pseudoxanthoma Elasticum - pathology | Cholesterol - metabolism | ATP Binding Cassette Transporter, Subfamily B - metabolism | Disease Progression | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 11 - genetics | ATP Binding Cassette Transporter, Subfamily D - genetics | Animals | ATP Binding Cassette Transporter, Subfamily D - metabolism | Pseudoxanthoma Elasticum - genetics | Research | Tissues | Adenosine triphosphate | Calcification (ectopic) | Adipose tissue | Disease | Gene regulation | Liver | Homeostasis | Lipids | Phospholipids | ABCA1 protein | Sterols | Metabolites | Mineralization | Rodents | Fibroblasts | Physiology | ABC transporters | Lipid metabolism | Age | Kidneys | Metabolism | Cholesterol | Lipoproteins | Calcification | ATP-binding protein | Mutation | ABC transporter | Bile
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2005, Volume 204, Issue 3, pp. 216 - 237
In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease in cellular drug accumulation which is attributed to the... 
P-glycoprotein | BCRP | ATP-binding cassette transporters | Chemical toxicity | Carcinogen transport | MRP | Tissue defense | Heavy metal transport | CONJUGATE EXPORT PUMP | ORGANIC ANION TRANSPORTER | KIDNEY PROXIMAL TUBULES | FOOD-DERIVED CARCINOGEN | HUMAN LUNG-CANCER | carcinogen transport | chemical toxicity | BLOOD-BRAIN-BARRIER | AMINO-ACID RESIDUE | heavy metal transport | ATP-BINDING CASSETTE | FUNCTIONAL EXPRESSION | tissue defense | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SINGLE-NUCLEOTIDE POLYMORPHISMS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasm Proteins - biosynthesis | Humans | Neoplasm Proteins - physiology | ATP Binding Cassette Transporter, Sub-Family B - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Multidrug Resistance-Associated Proteins - biosynthesis | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Transport Proteins - physiology | ATP-Binding Cassette Transporters - biosynthesis | Pregnancy | Tissue Distribution | Membrane Transport Proteins - biosynthesis | Animals | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Drug-Related Side Effects and Adverse Reactions | Multidrug Resistance-Associated Proteins - physiology | Female | ANIONS | MAMMARY GLANDS | NEOPLASMS | LUNGS | PLACENTA | CARCINOGENS | GLYCOPROTEINS | TOXINS | BLOOD-BRAIN BARRIER | TOXICITY | TUMOR CELLS | EXCRETION | 60 APPLIED LIFE SCIENCES | KIDNEYS | METABOLISM | TISSUE DISTRIBUTION | DRUGS | GENES | LIVER | BLOOD | LIPIDS
Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 216 - 241
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile... 
Multidrug resistance- associated protein | Drug-induced liver injury | ATP-binding cassette transporter | Transporter | Bile acid | Bile salt export pump | drug-induced liver injury | BSEP | MRP2 | bile acid | SALT EXPORT PUMP | multidrug resistance- associated protein | CHOLESTASIS | INDUCED LIVER-INJURY | IN-VITRO | INHIBITION | transporter | DRUG DEVELOPMENT | bile salt export pump | TOXICOLOGY | HEPATOTOXICITY | BILE-ACIDS | Humans | Drug-Related Side Effects and Adverse Reactions - metabolism | Male | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Toxicity Tests - methods | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Recombinant Proteins - metabolism | Risk Assessment | Liver - metabolism | Risk Factors | Rats | Drug-Related Side Effects and Adverse Reactions - etiology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cluster Analysis | Index Medicus
Journal Article
International journal of cancer, ISSN 0020-7136, 2014, Volume 134, Issue 6, pp. 1484 - 1494
Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase... 
brain accumulation | crizotinib | P‐glycoprotein | ALK inhibitor | elacridar | P-glycoprotein | LUNG | EML4-ALK FUSION GENE | METASTASES | PENETRATION | GF120918 | COMBINATION | ANAPLASTIC LYMPHOMA KINASE | PHARMACOKINETICS | ONCOLOGY | MULTIDRUG-RESISTANCE | PHASE-I | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pyridines - pharmacokinetics | Biological Availability | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - physiology | Brain - metabolism | Tissue Distribution | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Drug Therapy, Combination | Neoplasm Proteins - genetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Administration, Oral | Cells, Cultured | Mice, Knockout | Brain - drug effects | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Acridines - pharmacology | ATP Binding Cassette Transporter, Sub-Family B | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Plasma | Chemotherapy | Brain cancer | Rodents | Lymphomas | Glycoproteins | Metastasis
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2008, Volume 68, Issue 19, pp. 7905 - 7914
Lapatinib is active at the ATP-binding site of Lyrosine kinases that are associated with the human epidermal growth factor receptor (Her-1 or ErbB1) and Her-2.... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2013, Volume 33, Issue 7, pp. 1484 - 1493
OBJECTIVE—Transintestinal cholesterol excretion (TICE) is an alternate pathway to hepatobiliary secretion. Our study aimed at identifying molecular mechanisms... 
PCSK9 | ATP-binding cassette transporter B1 | Lipoprotein | Low-density lipoprotein receptor | Transintestinal cholesterol excretion | MULTIDRUG TRANSPORTER | low-density lipoprotein receptor | lipoprotein | DENSITY-LIPOPROTEIN RECEPTORS | KNOCKOUT MICE | COMPLETE BILE DIVERSION | P-GLYCOPROTEIN | BILIARY STEROL SECRETION | PLASMA | LIVER | CONVERTASE SUBTILISIN/KEXIN TYPE-9 | PERIPHERAL VASCULAR DISEASE | transintestinal cholesterol excretion | ABSORPTION | HEMATOLOGY | Lovastatin - pharmacology | Humans | Male | Proprotein Convertases - genetics | Jejunum - drug effects | Time Factors | Serine Endopeptidases - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Recombinant Proteins - metabolism | Receptors, LDL - genetics | Jejunum - enzymology | Serine Endopeptidases - deficiency | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Proprotein Convertases - metabolism | ATP Binding Cassette Transporter, Subfamily B - deficiency | Receptors, LDL - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - deficiency | Cholesterol - metabolism | Proprotein Convertases - deficiency | ATP Binding Cassette Transporter, Subfamily B - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Biopsy | Cholesterol, LDL - metabolism | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Life Sciences
Journal Article
Journal Article