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Biochemical Journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
Journal Article
Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN 0962-8436, 01/2009, Volume 364, Issue 1514, pp. 239 - 245
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5986, pp. 1689 - 1693
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood.... 
Myeloid cells | Leukocytosis | Transgenic animals | HDL lipoproteins | REPORTS | Atherosclerosis | Transgenes | Macrophages | Lesions | Cholesterols | Progenitor cells | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | MACROPHAGE ABCA1 | LIPID RAFTS | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | ACCUMULATION | ABCG1 | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Cell Proliferation | Lipoproteins - genetics | Lipoproteins, HDL - metabolism | Apolipoprotein A-I - genetics | Leukocytosis - metabolism | ATP-Binding Cassette Transporters - genetics | Atherosclerosis - therapy | Leukocytosis - therapy | Myeloproliferative Disorders - metabolism | Bone Marrow Transplantation | Leukocytosis - physiopathology | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Hematopoietic Stem Cells - physiology | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Multipotent Stem Cells - physiology | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Myeloproliferative Disorders - therapy | Signal Transduction | Atherosclerosis - physiopathology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Receptors, Interleukin-3 - metabolism | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Phenotype | Animals | Myeloid Progenitor Cells - physiology | Myeloproliferative Disorders - physiopathology | Mice | Hypercholesterolemia - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Cell proliferation | High density lipoproteins | Physiological aspects | Development and progression | Research | Health aspects | Hematopoietic stem cells | Adenosine triphosphate | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7981 - 7991
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 06/2019, Volume 88, Issue 1, pp. 551 - 576
Journal Article
Circulation research, ISSN 0009-7330, 2013, Volume 112, Issue 11, pp. 1456 - 1465
Rationale: Plasma high-density lipoprotein levels are inversely correlated with atherosclerosis. Although it is widely assumed that this is attributable to the... 
atherosclerosis | monocytes | macrophages | inflammation | high-density lipoprotein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | STEM-CELL PROLIFERATION | APOA-I | LESIONS | HIGH-DENSITY-LIPOPROTEIN | TANGIER-DISEASE | LIPID-ACCUMULATION | EFFLUX | GENE | REVERSE CHOLESTEROL TRANSPORT | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Cholesterol, Dietary - metabolism | Vasculitis - pathology | Monocytes - metabolism | Monocytes - immunology | Vasculitis - immunology | Vasculitis - genetics | ATP-Binding Cassette Transporters - genetics | Bone Marrow Transplantation | Lipoproteins - metabolism | Monocytes - pathology | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Spleen - pathology | Foam Cells - pathology | Neutrophils - metabolism | Foam Cells - metabolism | Macrophages - immunology | Neutrophils - pathology | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Macrophages - pathology | Neutrophils - immunology | Receptors, LDL - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Foam Cells - immunology | Mice | ATP-Binding Cassette Transporters - immunology | Lipoproteins - immunology | Animal Feed | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2004, Volume 101, Issue 26, pp. 9774 - 9779
The mechanisms responsible for the inverse relationship between plasma high-density lipoprotein (HDL) levels and atherosclerotic cardiovascular disease are... 
ATP binding cassette transporters | Biological Sciences | Transfection | Messenger RNA | HEK293 cells | HDL lipoproteins | Small interfering RNA | Lipids | Macrophages | Cholesterols | Foam cells | TANGIER-DISEASE | CELLS | B TYPE-I | ESTER TRANSFER PROTEIN | HUMAN CEREBROSPINAL-FLUID | MULTIDISCIPLINARY SCIENCES | DROSOPHILA-WHITE GENE | X-RECEPTOR | APOA-I | HDL CHOLESTEROL | PLASMA-MEMBRANE | Lipoproteins - deficiency | RNA, Small Interfering - genetics | Up-Regulation | Retinoid X Receptors | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cyclodextrins - metabolism | Lipoproteins - genetics | Humans | Lipoproteins, HDL - metabolism | ATP-Binding Cassette Transporters - genetics | Biological Transport | Gene Deletion | Liver X Receptors | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Lipoproteins, HDL - chemistry | Orphan Nuclear Receptors | ATP Binding Cassette Transporter 1 | DNA-Binding Proteins | Cell Line | Receptors, Retinoic Acid - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Cholesterol - metabolism | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Mice | ATP Binding Cassette Transporter, Sub-Family G | RNA, Small Interfering - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Influence | Research | Cardiovascular diseases | Cholesterol, HDL | Gene expression | Ribonucleic acid--RNA | Ribonucleic acid | Cholesterol | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 17, pp. 6965 - 6977
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 01/2019, Volume 88
Energy-coupling factor (ECF)–type ATP-binding cassette (ABC) transporters catalyze membrane transport of micronutrients in prokaryotes. Crystal structures and... 
Binding | Lipid composition | Prokaryotes | Lipids | Phylogeny | Cytosol | Substrates | Membrane proteins | Proteins | Micronutrients | Energy | ATP-binding protein | Coupling | Transport | Protein structure | ATP | Crystal structure
Journal Article
Arteriosclerosis thrombosis and vascular biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 7, pp. 1328 - 1337
Objective-Plasma high-density lipoproteins have several putative antiatherogenic effects, including preservation of endothelial functions. This is thought to... 
atherosclerosis | ATP-binding cassette transporters | Hypercholesterolemia | Endothelium | endothelium | ACTIVATION | NITRIC-OXIDE SYNTHASE | LINEAGE ANALYSIS | ADHESION MOLECULES | KNOCKOUT MICE | hypercholesterolemia | HIGH-DENSITY-LIPOPROTEIN | HEART-DISEASE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HDL CHOLESTEROL | HEMATOLOGY | CORONARY-ARTERY-DISEASE | Whole-Body Irradiation | ATP Binding Cassette Transporter, Subfamily G, Member 1 - deficiency | Atherosclerosis - genetics | Male | Monocytes - metabolism | Retinal Neovascularization - metabolism | Aortic Diseases - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Time Factors | Diet, High-Fat | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Retinal Neovascularization - genetics | Nitric Oxide Synthase Type III - metabolism | Aorta, Thoracic - pathology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Atherosclerosis - physiopathology | Endothelial Cells - metabolism | Tissue Culture Techniques | Aorta, Thoracic - metabolism | Aorta, Thoracic - physiopathology | Cholesterol - metabolism | Plaque, Atherosclerotic | Regional Blood Flow | Atherosclerosis - metabolism | Disease Progression | Mice, Knockout | Aortic Diseases - genetics | Macrophages - metabolism | Phenotype | Animals | ATP Binding Cassette Transporter 1 - deficiency | Endothelial Cells - pathology | Neovascularization, Physiologic | ATP Binding Cassette Transporter 1 - genetics | Index Medicus | HDL | ABC transporters | angiogenesis
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 2014, Volume 34, Issue 2, pp. 279 - 284
Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR activators (1) directly upregulate genes involved in reverse cholesterol transport and... 
atherosclerosis | ATP-binding cassette transporters | macrophages | liver X receptor | inflammation | ANTIINFLAMMATORY ACTIVITY | MYELOPROLIFERATIVE DISORDERS | LDL RECEPTOR | TERTIARY-AMINES | ACCELERATES ATHEROSCLEROSIS | KNOCKOUT MICE | NUCLEAR RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MACROPHAGE ABCA1 | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Lipoproteins - deficiency | Macrophages - transplantation | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Hydrocarbons, Fluorinated - pharmacology | Male | Aorta - metabolism | Orphan Nuclear Receptors - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver X Receptors | Myocardium - metabolism | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Female | Cytokines - genetics | Macrophages - immunology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Aorta - drug effects | Mice, Inbred C57BL | Orphan Nuclear Receptors - agonists | Gene Expression Regulation | Myocardium - pathology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | ATP Binding Cassette Transporter 1 - deficiency | Benzoates - pharmacology | Macrophages - drug effects | Mice | Benzylamines - pharmacology | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19719 - 19724
Four members of the mammalian ATP binding cassette (ABC) transporter G subfamily are thought to be involved in transmembrane (TM) transport of sterols. The... 
ATP binding cassette transporters | COS cells | Sterols | Plasmids | HDL lipoproteins | Amino acids | Cell membranes | Repression | Cholesterols | Endosomes | 27-hydroxycholesterol | 25-hydroxycholesterol | Cholesterol | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | ATHEROSCLEROSIS | MEMBRANE-PROTEIN | PLASMA-MEMBRANE | HIGH-DENSITY-LIPOPROTEIN | SENSING DOMAIN | cholesterol | SCAP | CELLULAR CHOLESTEROL EFFLUX | ENDOPLASMIC-RETICULUM | ACCUMULATION | Sterols - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Lipoproteins - genetics | Humans | Cercopithecus aethiops | Molecular Sequence Data | Macrophages, Peritoneal - cytology | Endosomes - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | HEK293 Cells | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - metabolism | Macrophages, Peritoneal - drug effects | CHO Cells | Amino Acid Sequence | Cricetinae | Cells, Cultured | Blotting, Western | Sequence Homology, Amino Acid | Animals | Intracellular Space - metabolism | Benzoates - pharmacology | Mutation | Macrophages, Peritoneal - metabolism | Benzylamines - pharmacology | COS Cells | Research | Properties | Adenosine triphosphate | Protein binding | Proteins | Membranes | ABC transporters | Cells | Steroids | Index Medicus | Biological Sciences
Journal Article
Journal Article