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1. Full Text Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
by Chen, Zhaolin and Shi, Tianlu and Zhang, Lei and Zhu, Pengli and Deng, Mingying and Huang, Cheng and Hu, Tingting and Jiang, Ling and Li, Jun
Cancer letters, ISSN 0304-3835, 2015, Volume 370, Issue 1, pp. 153 - 164
Hematology, Oncology and Palliative Medicine | ABC transporters | Inhibitors | Multidrug resistance | Cancer therapy | Life Sciences & Biomedicine | Oncology | Science & Technology | ATP-Binding Cassette Transporters - chemistry | Animals | Drug Resistance, Multiple | Epigenesis, Genetic | Humans | Drug Resistance, Neoplasm | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Epigenetic inheritance | Drug resistance in microorganisms | Index Medicus
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2. Full Text A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development
by Morgan, Ryan E and van Staden, Carlo J and Chen, Yuan and Kalyanaraman, Natarajan and Kalanzi, Jackson and Dunn II, Robert T and Afshari, Cynthia A and Hamadeh, Hisham K
Toxicological sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 216 - 241
Multidrug resistance- associated protein | Drug-induced liver injury | ATP-binding cassette transporter | Transporter | Bile acid | Bile salt export pump | Life Sciences & Biomedicine | Toxicology | Science & Technology | Humans | Drug-Related Side Effects and Adverse Reactions - metabolism | Male | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Toxicity Tests - methods | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Recombinant Proteins - metabolism | Risk Assessment | Liver - metabolism | Risk Factors | Rats | Drug-Related Side Effects and Adverse Reactions - etiology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cluster Analysis | Index Medicus
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3. Full Text HDL Particle Size Is a Critical Determinant of ABCA1-Mediated Macrophage Cellular Cholesterol Export
by Du, Xian-Ming and Kim, Mi-Jurng and Hou, Liming and Le Goff, Wilfried and Chapman, M John and Van Eck, Miranda and Curtiss, Linda K and Burnett, John R and Cartland, Sian P and Quinn, Carmel M and Kockx, Maaike and Kontush, Anatol and Rye, Kerry-Anne and Kritharides, Leonard and Jessup, Wendy
Circulation research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
foam cells | HDL | ATP-binding cassette transporters | macrophages | cholesterol, HDL | ATP binding cassette transporter 1 | Cholesterol | cholesterol-efflux regulatory protein | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Lipoproteins - deficiency | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Lipoproteins, HDL - metabolism | ATP-Binding Cassette Transporters - physiology | Recombinant Fusion Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP Binding Cassette Transporter 1 - physiology | Biological Transport | Foam Cells - metabolism | Lipoproteins, HDL2 - metabolism | CHO Cells | Cell Line | Cricetinae | Tangier Disease - enzymology | Tangier Disease - genetics | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Gene Silencing | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Lipoproteins - physiology | Mice, Knockout | Particle Size | Macrophages - metabolism | Animals | ATP Binding Cassette Transporter 1 - deficiency | ATP Binding Cassette Transporter 1 - antagonists & inhibitors | Mice | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
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4. Full Text In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a hiv integrase inhibitor
by Reese, Melinda J and Savina, Paul M and Generaux, Grant T and Tracey, Helen and Humphreys, Joan E and Kanaoka, Eri and Webster, Lindsey O and Harmon, Kelly A and Clarke, James D and Polli, Joseph W
Drug metabolism and disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology | Index Medicus
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5. Full Text Structure of the human multidrug transporter ABCG2
by Taylor, Nicholas M. I and Manolaridis, Ioannis and Jackson, Scott M and Kowal, Julia and Stahlberg, Henning and Locher, Kaspar P
Nature (London), ISSN 0028-0836, 06/2017, Volume 546, Issue 7659, pp. 504 - 509
Immunoglobulin Fab Fragments - ultrastructure | Antibodies - chemistry | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Cholesterol - chemistry | Biological Transport | Antibodies - immunology | Protein Domains | Adenosine Triphosphatases - ultrastructure | Binding Sites | Amino Acid Sequence | Neoplasm Proteins - ultrastructure | Adenosine Triphosphatases - metabolism | Antibodies - ultrastructure | Models, Molecular | Neoplasm Proteins - chemistry | Cholesterol - metabolism | Cryoelectron Microscopy | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - antagonists & inhibitors | Immunoglobulin Fab Fragments - chemistry | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - chemistry | Polymorphism, Single Nucleotide - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - ultrastructure | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Immunoglobulin Fab Fragments - immunology | Physiological aspects | Binding proteins | Observations | Drug interactions | Index Medicus
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6. Full Text Development of inhibitors of ATP-binding cassette drug transporters - present status and challenges
by Shukla, Suneet and Wu, Chung-Pu and Ambudkar, Suresh V
Expert opinion on drug metabolism & toxicology, ISSN 1742-5255, 02/2008, Volume 4, Issue 2, pp. 205 - 223
multi-drug resistance | P-glycoprotein | MRP1 | chemosensitizers | ATP hydrolysis | cancer chemotherapy | clinical trials | natural product modulators | ATP-binding cassette transporter | Natural product modulators | Multi-drug resistance | Cancer chemotherapy | Chemosensitizers | Clinical trials | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | ATP-Binding Cassette Transporters - drug effects | Drug Resistance, Multiple - drug effects | Humans | Drug Design | ATP-Binding Cassette Transporters - metabolism | Antineoplastic Agents - therapeutic use | Neoplasms - physiopathology | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Neoplasm Proteins - drug effects | Neoplasms - drug therapy | Index Medicus
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7. Full Text Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
by Mi, Yan-Jun and Liang, Yong-Ju and Huang, Hong-Bing and Zhao, Hong-Yun and Wu, Chung-Pu and Wang, Fang and Tao, Li-Yang and Zhang, Chuan-Zhao and Dai, Chun-Ling and Tiwari, Amit K and Ma, Xiao-Xu and To, Kenneth Kin Wah and Ambudkar, Suresh V and Chen, Zhe-Sheng and Fu, Li-Wu
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7981 - 7991
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Cell Survival - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - drug effects | Adenosine Triphosphatases - metabolism | Transplantation, Heterologous | Breast Neoplasms | Reverse Transcriptase Polymerase Chain Reaction | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Animals | ATP-Binding Cassette Transporters - drug effects | Mice, Nude | Cell Line, Tumor | Female | ATP Binding Cassette Transporter, Sub-Family B | Mice | Mice, Inbred BALB C | Doxorubicin - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyridines - therapeutic use | Index Medicus | Apatinib | P-glycoprotein | ATP-binding cassette transporters | Xenograft | Multidrug resistance | ABCG2
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8. Full Text IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells
by Gao, Qiang and Li, Xiu-xiu and Xu, Yi-ming and Zhang, Jin-zhao and Rong, Shi-di and Qin, Yan-qing and Fang, Jing
Cancer letters, ISSN 0304-3835, 04/2020, Volume 476, pp. 67 - 74
Colon cancer | Drug resistance | ABC transporter | IRE1α | Life Sciences & Biomedicine | Oncology | Science & Technology | Endoribonucleases - genetics | Cell Proliferation | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Drug Resistance, Multiple | Colonic Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Neoplasm Proteins - metabolism | Colonic Neoplasms - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Female | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Tumor Cells, Cultured | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B - metabolism | Xenograft Model Antitumor Assays | Animals |