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1. Full Text Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
by Chen, Zhaolin and Shi, Tianlu and Zhang, Lei and Zhu, Pengli and Deng, Mingying and Huang, Cheng and Hu, Tingting and Jiang, Ling and Li, Jun
Cancer Letters, ISSN 0304-3835, 2015, Volume 370, Issue 1, pp. 153 - 164
Highlights • Overview of ABC transporters in the role of MDR. • Inhibitors of ABC transporters will be useful tools in the modulation of MDR. • Recent... 
Hematology, Oncology and Palliative Medicine | ABC transporters | Inhibitors | Multidrug resistance | Cancer therapy | MDR1/P-GLYCOPROTEIN EXPRESSION | DOWN-REGULATION | ACUTE MYELOID-LEUKEMIA | BREAST-CANCER CELLS | PROTEIN BCRP/ABCG2 | ONCOLOGY | GASTRIC-CANCER | P-GLYCOPROTEIN INHIBITORS | IN-VIVO | TYROSINE KINASE INHIBITOR | WNT/BETA-CATENIN PATHWAY | ATP-Binding Cassette Transporters - chemistry | Animals | Drug Resistance, Multiple | Epigenesis, Genetic | Humans | Drug Resistance, Neoplasm | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Epigenetic inheritance | Drug resistance in microorganisms | Index Medicus
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2. Full Text ABC transporters in cancer: more than just drug efflux pumps
by Haber, Michelle and Henderson, Michelle J and Norris, Murray D and Fletcher, Jamie I
Nature Reviews Cancer, ISSN 1474-175X, 02/2010, Volume 10, Issue 2, pp. 147 - 156
Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs from cancer cells. However, a... 
SIDE POPULATION | ATP-DEPENDENT TRANSPORT | STEM-LIKE CELLS | BINDING-CASSETTE TRANSPORTERS | ONCOLOGY | GENE-EXPRESSION | MULTIDRUG-RESISTANCE PROTEIN | PLATELET-ACTIVATING-FACTOR | PROSTAGLANDIN E-2 TRANSPORT | CHRONIC MYELOID-LEUKEMIA | P-GLYCOPROTEIN | Neoplasms - metabolism | Drug Resistance, Multiple | Leukotrienes - physiology | Sphingosine - physiology | Humans | Clinical Trials as Topic | ATP-Binding Cassette Transporters - physiology | Disease Progression | Drug Delivery Systems | Neoplasms - drug therapy | Neoplasm Metastasis | Prostaglandins - physiology | Sphingosine - analogs & derivatives | ATP-Binding Cassette Transporters - genetics | Cell Differentiation | Lysophospholipids - physiology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Care and treatment | Drug infusion pumps | Usage | Chemotherapy | Messenger RNA | Patient outcomes | Physiological aspects | Genetic aspects | Research | Drug resistance | Cancer
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3. Full Text Nilotinib (AMN107, Tasigna ®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
by Tiwari, Amit K and Sodani, Kamlesh and Wang, Si-Rong and Kuang, Ye-Hong and Ashby, Charles R and Chen, Zhe-Sheng and Chen, Xiang
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Nilotinib, a BCR-Abl tyrosine kinase inhibitor (TKI), was developed to surmount resistance or intolerance to imatinib in patients with Philadelphia positive... 
Nilotinib | ABCB1 | Tyrosine kinase inhibitor | Multidrug resistance | BCR-Abl | ABC transporters | ABCG2 | DRUG-RESISTANCE | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | BREAST-CANCER | HIGH-AFFINITY INTERACTION | IN-VITRO | ABCG2 BCRP | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Cell Line | Cell Survival - drug effects | Drug Resistance, Multiple - drug effects | Humans | KB Cells | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Drug Resistance, Multiple - physiology | Drug Resistance, Neoplasm - physiology | Cell Survival - physiology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Tyrosine | Drug resistance in microorganisms | Hormones, Sex | Epidermal growth factor | Antineoplastic antibiotics
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4. Full Text Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
by Mi, Yan-Jun and Liang, Yong-Ju and Huang, Hong-Bing and Zhao, Hong-Yun and Wu, Chung-Pu and Wang, Fang and Tao, Li-Yang and Zhang, Chuan-Zhao and Dai, Chun-Ling and Tiwari, Amit K and Ma, Xiao-Xu and To, Kenneth Kin Wah and Ambudkar, Suresh V and Chen, Zhe-Sheng and Fu, Li-Wu
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7981 - 7991
Apatinib, a small-molecule multitargeted tyrosine kinase inhibitor, is in phase III clinical trial for the treatment of patients with non-small-cell lung... 
BREAST-CANCER CELLS | SIDE POPULATION | PROTEIN | ONCOLOGY | IN-VIVO | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | SUBFAMILY-B MEMBER-1 | ENDOTHELIAL GROWTH-FACTOR | P-GLYCOPROTEIN | ABCG2 | Cell Survival - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - drug effects | Adenosine Triphosphatases - metabolism | Transplantation, Heterologous | Breast Neoplasms | Reverse Transcriptase Polymerase Chain Reaction | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Animals | ATP-Binding Cassette Transporters - drug effects | Mice, Nude | Cell Line, Tumor | Female | ATP Binding Cassette Transporter, Sub-Family B | Mice | Mice, Inbred BALB C | Doxorubicin - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyridines - therapeutic use | Apatinib | P-glycoprotein | ATP-binding cassette transporters | Xenograft | Multidrug resistance
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5. Full Text The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade
by Kathawala, Rishil J and Gupta, Pranav and Ashby, Charles R and Chen, Zhe-Sheng
Drug Resistance Updates, ISSN 1368-7646, 2014, Volume 18, pp. 1 - 17
Abstract ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of membrane proteins in all extant phyla from prokaryotes to... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | Natural products | Multidrug resistance | Marine sponges | ABC transporters | Modulators | Tyrosine kinase inhibitors | Phosphodiesterase inhibitors | ANTICANCER DRUG-SENSITIVITY | ACUTE MYELOID-LEUKEMIA | P-GLYCOPROTEIN ABCB1 | BINDING CASSETTE TRANSPORTER | CELL LUNG-CANCER | GROWTH-FACTOR RECEPTOR | SOUTHWEST-ONCOLOGY-GROUP | PHASE-I TRIAL | ACUTE LYMPHOBLASTIC-LEUKEMIA | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | Animals | Drug Resistance, Multiple | Humans | Drug Design | ATP-Binding Cassette Transporters - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - pharmacology | Neoplasms - pathology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Neoplasms - drug therapy | Hydrolysis | Drug resistance in microorganisms | Chemotherapy | Cellular signal transduction | Cancer | Membrane proteins
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6. Full Text In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a hiv integrase inhibitor
by Reese, Melinda J and Savina, Paul M and Generaux, Grant T and Tracey, Helen and Humphreys, Joan E and Kanaoka, Eri and Webster, Lindsey O and Harmon, Kelly A and Clarke, James D and Polli, Joseph W
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require... 
SERUM CREATININE LEVELS | IMMUNODEFICIENCY-VIRUS-INFECTION | HUMAN HEPATOCYTES | HEALTHY-SUBJECTS | CYTOCHROME-P450 ENZYMES | GLOMERULAR-FILTRATION | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL PH | MULTIDRUG-RESISTANCE | BOOSTED PROTEASE INHIBITORS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology
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7. Full Text Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
by Mao, Qingcheng and Unadkat, Jashvant D
The AAPS Journal, ISSN 1550-7416, 1/2015, Volume 17, Issue 1, pp. 65 - 82
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was... 
Biochemistry, general | BCRP | Biotechnology | Biomedicine | Pharmacy | transporter | ATP-binding cassette | drug transport | Pharmacology/Toxicology | ABCG2 | INTER-SUBJECT VARIABILITY | SIDE-POPULATION PHENOTYPE | LIMITS FETAL DISTRIBUTION | CHRONIC MYELOID-LEUKEMIA | BINDING CASSETTE TRANSPORTER | TYROSINE KINASE INHIBITORS | CELL LUNG-CANCER | HIGH-AFFINITY INTERACTION | REVERSE-TRANSCRIPTASE INHIBITORS | ABCG2 MULTIDRUG TRANSPORTER | PHARMACOLOGY & PHARMACY | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Tissue Distribution | Animals | Biological Transport | Breast Neoplasms - pathology | ATP-Binding Cassette Transporters - metabolism | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neoplasms - pathology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drugs | Chemotherapy | Estrogen | Breast cancer | Uric acid | Drug resistance | Sulfates | Cancer
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