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Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5986, pp. 1689 - 1693
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood.... 
Myeloid cells | Leukocytosis | Transgenic animals | HDL lipoproteins | REPORTS | Atherosclerosis | Transgenes | Macrophages | Lesions | Cholesterols | Progenitor cells | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | MACROPHAGE ABCA1 | LIPID RAFTS | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | ACCUMULATION | ABCG1 | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Cell Proliferation | Lipoproteins - genetics | Lipoproteins, HDL - metabolism | Apolipoprotein A-I - genetics | Leukocytosis - metabolism | ATP-Binding Cassette Transporters - genetics | Atherosclerosis - therapy | Leukocytosis - therapy | Myeloproliferative Disorders - metabolism | Bone Marrow Transplantation | Leukocytosis - physiopathology | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Hematopoietic Stem Cells - physiology | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Multipotent Stem Cells - physiology | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Myeloproliferative Disorders - therapy | Signal Transduction | Atherosclerosis - physiopathology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Receptors, Interleukin-3 - metabolism | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Phenotype | Animals | Myeloid Progenitor Cells - physiology | Myeloproliferative Disorders - physiopathology | Mice | Hypercholesterolemia - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Cell proliferation | High density lipoproteins | Physiological aspects | Development and progression | Research | Health aspects | Hematopoietic stem cells | Adenosine triphosphate | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 05/2013, Volume 112, Issue 10, pp. 1345 - 1354
RATIONALE:Macrophage accumulation in adipose tissue associates with insulin resistance and increased cardiovascular disease risk. We previously have shown that... 
Apolipoprotein AI | HDL | ABC transporters | Adipocytes | Cholesterol | CARDIAC & CARDIOVASCULAR SYSTEMS | apolipoprotein AI | CELLULAR CHOLESTEROL | DEFICIENT MICE | MACROPHAGE ACCUMULATION | OBESITY | INSULIN-RESISTANCE | ADIPOSE-TISSUE INFLAMMATION | ENDOTHELIAL-CELLS | LIPID RAFTS | TOLL-LIKE RECEPTORS | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | adipocytes | TRANSGENIC MICE | Apolipoprotein A-I - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Reactive Oxygen Species - metabolism | Humans | Lipoproteins, HDL - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Lipoproteins, HDL - pharmacology | Apolipoprotein A-I - genetics | Inflammation - metabolism | Lipoproteins - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Scavenger Receptors, Class B - drug effects | Disease Models, Animal | Receptors, LDL - genetics | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Receptors, LDL - metabolism | Mice, Transgenic | Apolipoprotein A-I - metabolism | 3T3-L1 Cells | Cholesterol - metabolism | Mice, Knockout | Animals | ATP-Binding Cassette Transporters - drug effects | Membrane Microdomains - drug effects | Adipocytes - metabolism | Biological Transport - physiology | Mice | Lipoproteins - drug effects | Scavenger Receptors, Class B - metabolism | In Vitro Techniques | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19719 - 19724
Four members of the mammalian ATP binding cassette (ABC) transporter G subfamily are thought to be involved in transmembrane (TM) transport of sterols. The... 
ATP binding cassette transporters | COS cells | Sterols | Plasmids | HDL lipoproteins | Amino acids | Cell membranes | Repression | Cholesterols | Endosomes | 27-hydroxycholesterol | 25-hydroxycholesterol | Cholesterol | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | ATHEROSCLEROSIS | MEMBRANE-PROTEIN | PLASMA-MEMBRANE | HIGH-DENSITY-LIPOPROTEIN | SENSING DOMAIN | cholesterol | SCAP | CELLULAR CHOLESTEROL EFFLUX | ENDOPLASMIC-RETICULUM | ACCUMULATION | Sterols - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Lipoproteins - genetics | Humans | Cercopithecus aethiops | Molecular Sequence Data | Macrophages, Peritoneal - cytology | Endosomes - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | HEK293 Cells | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - metabolism | Macrophages, Peritoneal - drug effects | CHO Cells | Amino Acid Sequence | Cricetinae | Cells, Cultured | Blotting, Western | Sequence Homology, Amino Acid | Animals | Intracellular Space - metabolism | Benzoates - pharmacology | Mutation | Macrophages, Peritoneal - metabolism | Benzylamines - pharmacology | COS Cells | Research | Properties | Adenosine triphosphate | Protein binding | Proteins | Membranes | ABC transporters | Cells | Steroids | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9710 - 9715
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for... 
ATP binding cassette transporters | Proteins | Crystals | Adenosine triphosphatases | Lipids | Nucleotides | Exporters | Binding sites | Monomers | Crystal structure | X-ray crystallography | Nucleotide complex | Abc mitochondrial erythroid | Cardiolipin | Human membrane protein structure | COMPLEX | nucleotide complex | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | HYDROLYSIS | cardiolipin | ABC mitochondrial erythroid | P-GLYCOPROTEIN | MITOFERRIN-1 | RESISTANCE | human membrane protein structure | PROTEINS | REVEALS | Humans | Molecular Conformation | Molecular Sequence Data | Crystallography, X-Ray | Nucleotides - chemistry | ATP-Binding Cassette Transporters - chemistry | Sf9 Cells | ATP-Binding Cassette Transporters - genetics | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Adenosine Triphosphatases - metabolism | Models, Molecular | Binding Sites - genetics | Phosphatidylcholines - chemistry | Nucleotides - metabolism | Molecular Dynamics Simulation | Sequence Homology, Amino Acid | Animals | Protein Binding | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Mutation | Adenosine Triphosphate - chemistry | Phosphatidylethanolamines - chemistry | Biological transport, Active | Physiological aspects | Research | Binding proteins | Structure | Health aspects | Adenosine triphosphate | Oxidative stress | Mitochondria | ABC transporters | Index Medicus | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 216 - 241
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile... 
Multidrug resistance- associated protein | Drug-induced liver injury | ATP-binding cassette transporter | Transporter | Bile acid | Bile salt export pump | drug-induced liver injury | BSEP | MRP2 | bile acid | SALT EXPORT PUMP | multidrug resistance- associated protein | CHOLESTASIS | INDUCED LIVER-INJURY | IN-VITRO | INHIBITION | transporter | DRUG DEVELOPMENT | bile salt export pump | TOXICOLOGY | HEPATOTOXICITY | BILE-ACIDS | Humans | Drug-Related Side Effects and Adverse Reactions - metabolism | Male | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Toxicity Tests - methods | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Recombinant Proteins - metabolism | Risk Assessment | Liver - metabolism | Risk Factors | Rats | Drug-Related Side Effects and Adverse Reactions - etiology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cluster Analysis | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 2013, Volume 112, Issue 11, pp. 1456 - 1465
Rationale: Plasma high-density lipoprotein levels are inversely correlated with atherosclerosis. Although it is widely assumed that this is attributable to the... 
atherosclerosis | monocytes | macrophages | inflammation | high-density lipoprotein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | STEM-CELL PROLIFERATION | APOA-I | LESIONS | HIGH-DENSITY-LIPOPROTEIN | TANGIER-DISEASE | LIPID-ACCUMULATION | EFFLUX | GENE | REVERSE CHOLESTEROL TRANSPORT | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Atherosclerosis - genetics | Cholesterol, Dietary - metabolism | Vasculitis - pathology | Monocytes - metabolism | Monocytes - immunology | Vasculitis - immunology | Vasculitis - genetics | ATP-Binding Cassette Transporters - genetics | Bone Marrow Transplantation | Lipoproteins - metabolism | Monocytes - pathology | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter 1 | Spleen - pathology | Foam Cells - pathology | Neutrophils - metabolism | Foam Cells - metabolism | Macrophages - immunology | Neutrophils - pathology | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Macrophages - pathology | Neutrophils - immunology | Receptors, LDL - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Foam Cells - immunology | Mice | ATP-Binding Cassette Transporters - immunology | Lipoproteins - immunology | Animal Feed | Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2008, Volume 118, Issue 18, pp. 1837 - 1847
Background-Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages... 
Lipoproteins | ABC transporters | Inflammation | Cholesterol | Atherosclerosis | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | INDUCED APOPTOSIS | CELLULAR CHOLESTEROL | NECROSIS-FACTOR-ALPHA | ABCG1(-/-) BONE-MARROW | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-E | LIPID-ACCUMULATION | EFFLUX | inflammation | ABCA1-DEFICIENT MACROPHAGES | cholesterol | PERIPHERAL VASCULAR DISEASE | MICE | lipoproteins | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Membrane Microdomains - immunology | Signal Transduction - immunology | ATP-Binding Cassette Transporters - genetics | Mice, Mutant Strains | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Macrophages - immunology | Receptors, LDL - genetics | Atherosclerosis - immunology | Atherosclerosis - physiopathology | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Receptors, LDL - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Cholesterol - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | Ligands | Macrophages - drug effects | Mice | ATP-Binding Cassette Transporters - immunology | Lipoproteins - immunology | Physiological aspects | Research | Macrophages | Gene expression | Index Medicus | Abridged Index Medicus | Toll-receptors
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2011, Volume 8, Issue 4, pp. 1332 - 1341
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette... 
blood-brain barrier | quantitative LC-MS/MS | transporters | drug-metabolizing enzymes | human | PREGNANE-X RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | BARRIER | P-GLYCOPROTEIN | UDP-GLUCURONOSYLTRANSFERASE | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | GLUTATHIONE-S-TRANSFERASE | RAT-BRAIN | PROTEINS | UP-REGULATION | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glutamate Plasma Membrane Transport Proteins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Microvessels - metabolism | Glucose Transporter Type 1 - metabolism | Glutamate Plasma Membrane Transport Proteins - genetics | Excitatory Amino Acid Transporter 1 - genetics | Neoplasm Proteins - metabolism | Brain - metabolism | Brain - blood supply | Tandem Mass Spectrometry | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Chromatography, Liquid | Proteomics - methods | Neoplasm Proteins - genetics | Transcriptome - physiology | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Glutathione Transferase - metabolism | Excitatory Amino Acid Transporter 1 - metabolism | Transcriptome - genetics | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | In Vitro Techniques | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 561 - 564
Journal Article