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Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5922, pp. 1718 - 1722
Journal Article
Biochemical Journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2007, Volume 315, Issue 5811, pp. 525 - 528
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the... 
Haplotypes | Messenger RNA | Epithelial cells | Cell lines | HeLa cells | Fluorescence | Reports | Kidney cells | Codons | Immatures | Cells | SYNONYMOUS CODON USAGE | IN-VITRO | HUMAN P-GLYCOPROTEIN | MESSENGER-RNA | VIVO | PROTEIN-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | MULTIDRUG-RESISTANCE GENE | VIRUS EXPRESSION SYSTEM | Protein Biosynthesis | Cyclosporine - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cercopithecus aethiops | Substrate Specificity | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | RNA, Messenger - metabolism | Rhodamine 123 - pharmacology | Codon | Transfection | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cell Membrane - metabolism | Protein Structure, Tertiary | Cell Line | Mutagenesis, Site-Directed | Genes, MDR | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sirolimus - pharmacology | Verapamil - pharmacology | Protein Folding | Rhodamine 123 - metabolism | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Protein Conformation | Polymorphism, Single Nucleotide | HeLa Cells | Verapamil - metabolism | Research | Gene mutations | Structure | Genes | Analysis | Proteins | Genetics | Hypotheses | Protein folding | Polymorphism | Index Medicus
Journal Article
Methods in Enzymology, ISSN 0076-6879, 2009, Volume 464, Issue C, pp. 211 - 231
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile tool among model membrane systems to functionally reconstitute membrane... 
Animals | Membrane Proteins - chemistry | Models, Biological | Nanostructures - chemistry | Phospholipids - chemistry | Crystallography, X-Ray | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Lipid Bilayers - chemistry | Phosphatidylcholines - chemistry | Bacteriorhodopsins - chemistry | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 33, pp. 13386 - 13391
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2009, Volume 37, Issue 2, pp. 359 - 365
Sunitinib malate (Sutent, SU11248) is a small-molecule receptor tyrosine kinase inhibitor that inhibits cellular signaling of multiple targets such as the... 
CHRONIC MYELOGENOUS LEUKEMIA | HIGH-AFFINITY INTERACTION | MULTIDRUG TRANSPORTER | MEDIATED DRUG EFFLUX | MRP1 ABCC1 | HEMATOPOIETIC STEM-CELLS | DIFFERENTIAL IMMUNOREACTIVITY | PHARMACOLOGY & PHARMACY | ANTITUMOR-ACTIVITY | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Hydrolysis - drug effects | Humans | Protein Conformation - drug effects | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | ATP-Binding Cassette Transporters - chemistry | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Biological Transport - drug effects | Photoaffinity Labels | Adenosine Triphosphatases - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | ATP-Binding Cassette Transporters - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Benzamides | Antineoplastic Agents, Phytogenic - pharmacology | Cell Line, Transformed | ATP-Binding Cassette Transporters - antagonists & inhibitors | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2012, Volume 83, Issue 2, pp. 279 - 285
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9704 - 9709
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target... 
ATP binding cassette transporters | Molecules | Vapor phases | Micelles | Lipids | Mass spectroscopy | Ligands | Nucleotides | Detergents | Membrane proteins | Real time substrate monitoring | Mass spectrometry from native state | ABC TRANSPORTER | ATPASE ACTIVITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | COMPLEXES | mass spectrometry from native state | CONFORMATIONS | RECONSTITUTED P-GLYCOPROTEIN | GAS-PHASE | real time substrate monitoring | MACROMOLECULAR ASSEMBLIES | PROTEINS | MOLECULAR-BASIS | Detergents - chemistry | Drug Resistance, Multiple | Humans | Molecular Conformation | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pharmaceutical Preparations - classification | Nucleotides - chemistry | Lipids - chemistry | Biological Transport | Immunosuppressive Agents - metabolism | Lipids - classification | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cyclosporine - metabolism | Binding, Competitive | Detergents - metabolism | Models, Molecular | Cardiolipins - metabolism | Nucleotides - metabolism | Cardiolipins - chemistry | Pharmaceutical Preparations - metabolism | Cyclosporine - chemistry | Pharmaceutical Preparations - chemistry | Protein Binding | Protein Conformation | Kinetics | Mass Spectrometry - methods | Immunosuppressive Agents - chemistry | Cluster Analysis | Physiological aspects | Research | Drug resistance | Mass spectrometry | Methods | Binding sites (Biochemistry) | ABC transporters | Glycoproteins | Index Medicus | Biological Sciences | Physical Sciences
Journal Article