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1. Full Text Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
by Stephen G. Aller and Jodie Yu and Andrew Ward and Yue Weng and Srinivas Chittaboina and Rupeng Zhuo and Patina M. Harrell and Yenphuong T. Trinh and Qinghai Zhang and Ina L. Urbatsch and Geoffrey Chang
Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5922, pp. 1718 - 1722
P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug resistance (MDR) in the... 
Molecules | Molecular structure | Cyclic peptides | Adenosine triphosphatases | Crystals | Lipids | Reports | Biochemistry | Cell membranes | Cytoplasm | Lipid bilayers | ABC TRANSPORTER | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PURIFICATION | CASSETTE TRANSPORTER | NUCLEOTIDE-BINDING | MECHANISMS | CONFORMATION | MULTIDRUG-RESISTANCE | MICROSCOPY | Apoproteins - chemistry | Stereoisomerism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Molecular Sequence Data | Crystallography, X-Ray | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Cell Membrane - chemistry | Adenosine Triphosphate - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Binding Sites | Apoproteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Models, Molecular | Verapamil - pharmacology | Animals | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Mice | Lipid Bilayers - chemistry | Verapamil - metabolism | Drugs | Proteins | Chemical bonds | Glycoproteins | Chemical properties | Research | Structure | Pharmacology | Drug resistance | Molecular biology | Binding sites | Substrates | Index Medicus
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2. Full Text Detergent-free purification of ABC (ATP-binding-cassette) transporters
by Gulati, S and Jamshad, M and Knowles, T.J and Morrison, K.A and Downing, R and Cant, N and Collins, R and Koenderink, J.B and Ford, R.C and Overduin, M and Kerr, I.D and Dafforn, T.R and Rothnie, A.J
Biochemical Journal, ISSN 0264-6021, 2014, Volume 461, Issue 2, pp. 269 - 278
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these... 
Nanodisc | Polymer | Membrane protein | Detergent | Purification | Solubilization | polymer | TRYPTOPHAN | WILD-TYPE | TRANSLOCATION | solubilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | detergent | FLUORESCENCE | purification | nanodisc | membrane protein | MULTIDRUG-RESISTANCE PROTEIN-1 | MEMBRANE-PROTEINS | MOLECULAR-BASIS | RECONSTITUTION | RESIDUES | P-GLYCOPROTEIN REVEALS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Polystyrenes - chemistry | Recombinant Proteins - isolation & purification | ATP-Binding Cassette Transporters - chemistry | Cloning, Molecular | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Stability | Multidrug Resistance-Associated Proteins - chemistry | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Maleates - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | ATP-Binding Cassette Transporters - isolation & purification | Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification | Animals | Neoplasm Proteins - isolation & purification | Protein Binding | Ligands | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | Multidrug Resistance-Associated Proteins - isolation & purification | ATP-Binding Cassette, Sub-Family B, Member 1 - isolation & purification | Index Medicus
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3. Full Text Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin
by Xiong, Xiao-Bing and Lavasanifar, Afsaneh
ACS Nano, ISSN 1936-0851, 06/2011, Volume 5, Issue 6, pp. 5202 - 5213
In this article we report on the development of polymeric micelles that can integrate multiple functions In one system, including the capability to accommodate... 
multidrug resistance | cancer | siRNA | polymeric micelles | doxorubicin | CELLS | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | HUMAN BREAST-CANCER | CHEMISTRY, MULTIDISCIPLINARY | OVERCOME DRUG-RESISTANCE | PACLITAXEL | SMALL INTERFERING RNA | SYSTEMS | MULTIDRUG-RESISTANCE | EXPRESSION | Neoplasms - metabolism | Nanocomposites - chemistry | Drug Resistance, Multiple | Nanotechnology - methods | Humans | Drug Resistance, Neoplasm | Chemistry, Physical - methods | Hydrazones - chemistry | Drug Delivery Systems | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Micelles | Polymers - chemistry | ATP Binding Cassette Transporter, Sub-Family B | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Doxorubicin - pharmacology | Hydrogen-Ion Concentration | RNA, Small Interfering - metabolism | Index Medicus
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4. Full Text Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans
by Jin, Mi Sun and Oldham, Michael L and Zhang, Qiuju and Chen, Jue
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7421, pp. 566 - 569
P-glycoprotein (P-gp) is an ATP-binding cassette transporter that confers multidrug resistance in cancer cells(1,2). It also affects the absorption,... 
CELLS | MUTANTS | ATPASE ACTIVITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | PURIFICATION | DRUG-BINDING POCKET | ALTERNATING ACCESS | RESISTANCE | NUCLEOTIDE-BINDING | MUTATIONS | Paclitaxel - metabolism | Protein Structure, Tertiary | Caenorhabditis elegans - chemistry | Dactinomycin - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Hydrolysis | Animals | Models, Biological | Adenosine Triphosphate - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Structural Homology, Protein | Lipid Bilayers - metabolism | Binding Sites | Caenorhabditis elegans | Crystals | Genetic aspects | Glycoproteins | Research | Properties | Structure | Proteins | Nematodes | Enzymes | Genetics | Biochemistry | Adenosine triphosphatase | Index Medicus
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5. Full Text A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
by Chava Kimchi-Sarfaty and Jung Mi Oh and In-Wha Kim and Zuben E. Sauna and Anna Maria Calcagno and Suresh V. Ambudkar and Michael M. Gottesman
Science, ISSN 0036-8075, 1/2007, Volume 315, Issue 5811, pp. 525 - 528
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the... 
Haplotypes | Messenger RNA | Epithelial cells | Cell lines | HeLa cells | Fluorescence | Reports | Kidney cells | Codons | Immatures | Cells | SYNONYMOUS CODON USAGE | IN-VITRO | HUMAN P-GLYCOPROTEIN | MESSENGER-RNA | VIVO | PROTEIN-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | MULTIDRUG-RESISTANCE GENE | VIRUS EXPRESSION SYSTEM | Protein Biosynthesis | Cyclosporine - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cercopithecus aethiops | Substrate Specificity | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | RNA, Messenger - metabolism | Rhodamine 123 - pharmacology | Codon | Transfection | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cell Membrane - metabolism | Protein Structure, Tertiary | Cell Line | Mutagenesis, Site-Directed | Genes, MDR | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sirolimus - pharmacology | Verapamil - pharmacology | Protein Folding | Rhodamine 123 - metabolism | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Protein Conformation | Polymorphism, Single Nucleotide | HeLa Cells | Verapamil - metabolism | Research | Gene mutations | Structure | Genes | Analysis | Proteins | Genetics | Hypotheses | Protein folding | Polymorphism | Index Medicus
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6. Full Text Chapter 11 Reconstitution of Membrane Proteins in Phospholipid Bilayer Nanodiscs
by Ritchie, T.K and Grinkova, Y.V and Bayburt, T.H and Denisov, I.G and Zolnerciks, J.K and Atkins, W.M and Sligar, S.G
Methods in Enzymology, ISSN 0076-6879, 2009, Volume 464, Issue C, pp. 211 - 231
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile tool among model membrane systems to functionally reconstitute membrane... 
Animals | Membrane Proteins - chemistry | Models, Biological | Nanostructures - chemistry | Phospholipids - chemistry | Crystallography, X-Ray | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Lipid Bilayers - chemistry | Phosphatidylcholines - chemistry | Bacteriorhodopsins - chemistry | Index Medicus
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7. Full Text P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan
by Nienke A. de Vries and Jin Zhao and Emily Kroon and Tessa Buckle and Jos H. Beijnen and Olaf van Tellingen
Clinical Cancer Research, ISSN 1078-0432, 11/2007, Volume 13, Issue 21, pp. 6440 - 6449
Purpose: The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of P-glycoprotein (P-gp) at the... 
drug transporters | knockout mice | Blood-brain barrier | elacridar | topotecan | PHARMACOKINETICS | ONCOLOGY | IN-VIVO | BARRIER | DRUGS | PHASE-II | MICE | MULTIDRUG-RESISTANCE | INHIBITOR GF120918 | BLOOD | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Topotecan - pharmacology | Area Under Curve | Liver - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Male | ATP Binding Cassette Transporter, Sub-Family B - chemistry | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Topotecan - chemistry | Mice, Knockout | Brain - drug effects | Brain - metabolism | ATP-Binding Cassette Transporters - chemistry | Animals | Biological Transport | Brain - pathology | Female | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Blood-Brain Barrier | Index Medicus
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8. Full Text Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)
by Hodges, Laura M and Markova, Svetlana M and Chinn, Leslie W and Gow, Jason M and Kroetz, Deanna L and Klein, Teri E and Altman, Russ B
Pharmacogenetics and Genomics, ISSN 1744-6872, 03/2011, Volume 21, Issue 3, pp. 152 - 161
multidrug resistance | drug permeability | pharmacogenomics | ABC transporter | PharmGKB | TUMOR-CELL LINES | ACUTE MYELOID-LEUKEMIA | BLOOD-BRAIN-BARRIER | MULTIDRUG-RESISTANCE GENE-1 | BREAST-CANCER | INFLAMMATORY-BOWEL-DISEASE | CYCLOSPORINE-A | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSPORTER GENE | GENETICS & HEREDITY | PHARMACOLOGY & PHARMACY | SINGLE-NUCLEOTIDE POLYMORPHISMS | DRUG-DRUG INTERACTIONS | Anticonvulsants - pharmacokinetics | Pharmacogenetics | Disease - genetics | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Anticonvulsants - therapeutic use | Substrate Specificity | Antineoplastic Agents - therapeutic use | Tissue Distribution | Drug Resistance - genetics | Drug Resistance, Neoplasm - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Adenosine Triphosphate - metabolism | ATP Binding Cassette Transporter, Sub-Family B | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Antineoplastic Agents - pharmacokinetics | Mutation | Index Medicus
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9. Full Text Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
by Andrew B. Ward and Paul Szewczyk and Vinciane Grimard and Chang-Wook Lee and Lorena Martinez and Rupak Doshi and Alexandra Caya and Mark Villaluz and Els Pardon and Cristina Cregger and Douglas J. Swartz and Pierre Guy Falson and Ina L. Urbatsch and Cedric Govaerts and Jan Steyaert and Geoffrey Chang
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 33, pp. 13386 - 13391
P-glycoprotein (P-gp) is one of the best-known mediators of drug efflux-based multidrug resistance in many cancers. This validated therapeutic target is a... 
ATP binding cassette transporters | Proteins | Hydrolysis | Molecules | Crystals | Adenosine triphosphatases | Cell membranes | Biochemistry | Epitopes | Crystal structure | Nanobody-transporter complex | ABC transporter | Membrane protein structure | nanobody-transporter complex | DRUG-INTERACTIONS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | TRANSITION-STATE | membrane protein structure | CHEMOTHERAPY | SPECTROSCOPY | ABC TRANSPORTER MSBA | RESISTANCE | CASSETTE TRANSPORTER | MOLECULAR-BASIS | CYCLE | Epitope Mapping | Animals | Single-Domain Antibodies - chemistry | Models, Molecular | Protein Conformation | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Drug Delivery Systems - methods | Physiological aspects | Glycoproteins | Research | Drug resistance | Structure | Health aspects | Protein binding | Rodents | ABC transporters | Substrates | Cells | Cancer | Index Medicus | Biological Sciences
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10. Full Text Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2
by Suneet Shukla and Robert W. Robey and Susan E. Bates and Suresh V. Ambudkar
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2009, Volume 37, Issue 2, pp. 359 - 365
Sunitinib malate (Sutent, SU11248) is a small-molecule receptor tyrosine kinase inhibitor that inhibits cellular signaling of multiple targets such as the... 
CHRONIC MYELOGENOUS LEUKEMIA | HIGH-AFFINITY INTERACTION | MULTIDRUG TRANSPORTER | MEDIATED DRUG EFFLUX | MRP1 ABCC1 | HEMATOPOIETIC STEM-CELLS | DIFFERENTIAL IMMUNOREACTIVITY | PHARMACOLOGY & PHARMACY | ANTITUMOR-ACTIVITY | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Hydrolysis - drug effects | Humans | Protein Conformation - drug effects | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | ATP-Binding Cassette Transporters - chemistry | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Biological Transport - drug effects | Photoaffinity Labels | Adenosine Triphosphatases - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | ATP-Binding Cassette Transporters - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Benzamides | Antineoplastic Agents, Phytogenic - pharmacology | Cell Line, Transformed | ATP-Binding Cassette Transporters - antagonists & inhibitors | Index Medicus
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11. Full Text Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum
by Tucker, Theodora G.H.A and Milne, Alison M and Fournel-Gigleux, Sylvie and Fenner, Katherine S and Coughtrie, Michael W.H
Biochemical Pharmacology, ISSN 0006-2952, 2012, Volume 83, Issue 2, pp. 279 - 285
The ATP-binding cassette (ABC) transporters breast cancer resistance protein (BCRP), multidrug resistance-associated protein 2 (MRP2), and P-glycoprotein (Pgp)... 
BCRP | P-glycoprotein | Immunoquantification | MRP2 | Drug transporters | QUANTIFICATION | HUMAN INTESTINE | TANDEM MASS-SPECTROMETRY | SULFOTRANSFERASE | LIQUID-CHROMATOGRAPHY | GENE | EXPORT PUMP | PHARMACOLOGY & PHARMACY | CACO-2 CELLS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Predictive Value of Tests | Immunoblotting - standards | Humans | Multidrug Resistance-Associated Proteins - standards | Multidrug Resistance-Associated Proteins - biosynthesis | ATP-Binding Cassette Transporters - standards | ATP-Binding Cassette, Sub-Family B, Member 1 - standards | Immunoblotting - methods | ATP-Binding Cassette Transporters - chemistry | Duodenum - chemistry | Duodenum - metabolism | HEK293 Cells | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Reproducibility of Results | Neoplasm Proteins - biosynthesis | Liver - metabolism | Gene Expression Regulation | Multidrug Resistance-Associated Proteins - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Ribonuclease, Pancreatic - chemistry | Peptide Fragments - standards | Liver - chemistry | ATP-Binding Cassette Transporters - biosynthesis | Peptide Fragments - chemistry | Ribonuclease, Pancreatic - standards | Care and treatment | Breast cancer | Television broadcasting industry | Cancer | Index Medicus
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12. Full Text Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump
by Julien Marcoux and Sheila C. Wang and Argyris Politis and Eamonn Reading and Jerome Ma and Philip C. Biggin and Min Zhou and Houchao Tao and Qinghai Zhang and Geoffrey Chang and Nina Morgner and Carol V. Robinson
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9704 - 9709
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target... 
ATP binding cassette transporters | Molecules | Vapor phases | Micelles | Lipids | Mass spectroscopy | Ligands | Nucleotides | Detergents | Membrane proteins | Real time substrate monitoring | Mass spectrometry from native state | ABC TRANSPORTER | ATPASE ACTIVITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | COMPLEXES | mass spectrometry from native state | CONFORMATIONS | RECONSTITUTED P-GLYCOPROTEIN | GAS-PHASE | real time substrate monitoring | MACROMOLECULAR ASSEMBLIES | PROTEINS | MOLECULAR-BASIS | Detergents - chemistry | Drug Resistance, Multiple | Humans | Molecular Conformation | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pharmaceutical Preparations - classification | Nucleotides - chemistry | Lipids - chemistry | Biological Transport | Immunosuppressive Agents - metabolism | Lipids - classification | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cyclosporine - metabolism | Binding, Competitive | Detergents - metabolism | Models, Molecular | Cardiolipins - metabolism | Nucleotides - metabolism | Cardiolipins - chemistry | Pharmaceutical Preparations - metabolism | Cyclosporine - chemistry | Pharmaceutical Preparations - chemistry | Protein Binding | Protein Conformation | Kinetics | Mass Spectrometry - methods | Immunosuppressive Agents - chemistry | Cluster Analysis | Physiological aspects | Research | Drug resistance | Mass spectrometry | Methods | Binding sites (Biochemistry) | ABC transporters | Glycoproteins | Index Medicus | Biological Sciences | Physical Sciences
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13. Full Text Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1
by Johnson, Zachary Lee and Chen, Jue
Cell, ISSN 0092-8674, 03/2017, Volume 168, Issue 6, pp. 1075 - 1085.e9
The multidrug resistance protein MRP1 is an ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a role in the... 
multidrug resistance | MRP1 | ABCC1 | ABC transporter | cryo-EM | leukotriene C4 | Leukotriene C | Cryo-EM | Multidrug resistance | TRANSMEMBRANE CONDUCTANCE REGULATOR | NUCLEOTIDE-BINDING DOMAINS | CRYSTAL-STRUCTURE | MALTOSE TRANSPORTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSPORT ACTIVITY | CHARGED AMINO-ACIDS | CRYO-EM | ELECTRON-MICROSCOPY | CYSTIC-FIBROSIS | P-GLYCOPROTEIN | CELL BIOLOGY | Drug Resistance, Multiple | Humans | Multidrug Resistance-Associated Proteins - chemistry | Models, Molecular | Cryoelectron Microscopy | Hydrolysis | Sf9 Cells | Animals | Cattle | HEK293 Cells | Protein Domains | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Adenosine Triphosphate - chemistry | Multidrug Resistance-Associated Proteins - ultrastructure | Drug resistance in microorganisms | Antidepressants | Analysis | Statins | Protein binding | Antidepressants, Tricyclic | Index Medicus
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