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Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3900 - 3908
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2008, Volume 68, Issue 19, pp. 7905 - 7914
...) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABC subfamily G member 2 (ABCG2) transporters... 
BREAST-CANCER | ACQUIRED MUTATIONS | IN-VITRO | HUMAN P-GLYCOPROTEIN | ONCOLOGY | METHOTREXATE TRANSPORT | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | PHASE-I | CATALYTIC CYCLE | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasms - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Adenosine Triphosphatases - drug effects | Quinazolines - pharmacokinetics | Neoplasm Proteins - antagonists & inhibitors | Paclitaxel - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Up-Regulation - physiology | ATP-Binding Cassette Transporters - metabolism | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Paclitaxel - administration & dosage | Drug Resistance, Multiple - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Neoplasms - drug therapy | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B | Mice | Neoplasms - pathology | Quinazolines - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | BCRP | multidrug resistance | ABCB1 | P-gp | MXR | lapatinib | EGFR tyrosine kinase inhibitor
Journal Article
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 1532-6535, 2007, Volume 83, Issue 2, pp. 258 - 264
... (human organic cation transporter 1; hOCT1) and efflux transporters (ATP‐binding cassette transporters ABCB1, ABCG2, and ABCC1) using real... 
CHRONIC MYELOGENOUS LEUKEMIA | ORGANIC CATION TRANSPORTER-1 | TYROSINE KINASE INHIBITORS | INTERFERON-ALPHA | ABCG2 BCRP | BCR-ABL | BLAST CRISIS | RESISTANCE | FOLLOW-UP | PHARMACOLOGY & PHARMACY | LOW-DOSE CYTARABINE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myeloid - genetics | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | Piperazines - metabolism | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Pyrimidines - metabolism | Patient Selection | Antineoplastic Agents - metabolism | Protein-Tyrosine Kinases - genetics | Transfection | ATP-Binding Cassette Transporters - genetics | Fusion Proteins, bcr-abl | Time Factors | ATP-Binding Cassette Transporters - metabolism | Aged, 80 and over | Adult | Neoplasm Proteins - genetics | Treatment Outcome | Octamer Transcription Factor-1 - genetics | Piperazines - therapeutic use | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Disease-Free Survival | Leukemia, Myeloid - drug therapy | Regression Analysis | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Leukemia, Myeloid - metabolism | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Aged | Benzamides | Mutation | Octamer Transcription Factor-1 - metabolism | Protein Kinase Inhibitors - metabolism
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2005, Volume 204, Issue 3, pp. 216 - 237
In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease in cellular drug accumulation which is attributed to the overexpression of certain ATP-binding cassette (ABC... 
P-glycoprotein | BCRP | ATP-binding cassette transporters | Chemical toxicity | Carcinogen transport | MRP | Tissue defense | Heavy metal transport | CONJUGATE EXPORT PUMP | ORGANIC ANION TRANSPORTER | KIDNEY PROXIMAL TUBULES | FOOD-DERIVED CARCINOGEN | HUMAN LUNG-CANCER | carcinogen transport | chemical toxicity | BLOOD-BRAIN-BARRIER | AMINO-ACID RESIDUE | heavy metal transport | ATP-BINDING CASSETTE | FUNCTIONAL EXPRESSION | tissue defense | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SINGLE-NUCLEOTIDE POLYMORPHISMS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplasm Proteins - biosynthesis | Humans | Neoplasm Proteins - physiology | ATP Binding Cassette Transporter, Sub-Family B - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Multidrug Resistance-Associated Proteins - biosynthesis | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Transport Proteins - physiology | ATP-Binding Cassette Transporters - biosynthesis | Pregnancy | Tissue Distribution | Membrane Transport Proteins - biosynthesis | Animals | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Drug-Related Side Effects and Adverse Reactions | Multidrug Resistance-Associated Proteins - physiology | Female | ANIONS | MAMMARY GLANDS | NEOPLASMS | LUNGS | PLACENTA | CARCINOGENS | GLYCOPROTEINS | TOXINS | BLOOD-BRAIN BARRIER | TOXICITY | TUMOR CELLS | EXCRETION | 60 APPLIED LIFE SCIENCES | KIDNEYS | METABOLISM | TISSUE DISTRIBUTION | DRUGS | GENES | LIVER | BLOOD | LIPIDS
Journal Article
ACS chemical neuroscience, ISSN 1948-7193, 07/2017, Volume 8, Issue 7, pp. 1570 - 1576
The use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in neuroscience has rapidly expanded in rodent studies but has lagged behind in... 
blood-brain barrier | pharmacokinetics | clozapine | DREADDs | Rhesus macaque | CHEMISTRY, MEDICINAL | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | P-GLYCOPROTEIN | DESIGNER RECEPTORS | IN-VITRO | TRANSPORT | NEONATAL AMYGDALA LESIONS | PHARMACOLOGY | DRUGS | Antipsychotic Agents - blood | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Capillary Permeability - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | Macaca mulatta | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Dose-Response Relationship, Drug | Transfection | Madin Darby Canine Kidney Cells | Female | Clozapine - blood | Drug Evaluation, Preclinical | Neoplasm Proteins - genetics | Clozapine - pharmacokinetics | Clozapine - cerebrospinal fluid | Antipsychotic Agents - pharmacokinetics | Clozapine - analogs & derivatives | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - antagonists & inhibitors | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Dogs | Antipsychotic Agents - cerebrospinal fluid | blood–brain barrier
Journal Article
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 05/2016, Volume 60, Issue 5, pp. 2771 - 2781
Journal Article
International journal of cancer, ISSN 0020-7136, 11/2009, Volume 125, Issue 10, pp. 2323 - 2331
...‐resistant cells were established by exposure to serially escalated doses of gemcitabine in HPAC and CFPAC‐1 cells. Gemcitabine... 
pancreatic cancer | drug resistance | cancer stem cell | ATP‐binding cassette transporter | cell surface marker | Cancer stem cell | Cell surface marker | ATP-binding cassette transporter | Drug resistance | Pancreatic cancer | MIGRATION | TRANSPORTER | SELF-RENEWAL | IDENTIFICATION | BREAST | HUMAN COLORECTAL-CANCER | ONCOLOGY | TUMOR STEM-CELLS | GENE-EXPRESSION | CHEMORESISTANCE | CD44 | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Neoplastic Stem Cells - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Drug Resistance, Neoplasm | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | RNA, Messenger - metabolism | Immunoenzyme Techniques | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Adenocarcinoma - metabolism | Hyaluronan Receptors - metabolism | Colony-Forming Units Assay | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Blotting, Western | Xenograft Model Antitumor Assays | Antimetabolites, Antineoplastic - therapeutic use | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Mice | Mice, Inbred BALB C | Deoxycytidine - analogs & derivatives | Index Medicus
Journal Article
Journal Article