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PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0141786 - e0141786
The two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90 alpha and constitutively expressed HSP90 beta, fold, assemble and... 
ACTIVATION | COMPLEX | MECHANISM | GELDANAMYCIN | MULTIDISCIPLINARY SCIENCES | KINASE | HSF1 | ATP BINDING | HEAT-SHOCK | CHAPERONE | REVEALS | Humans | Receptor, ErbB-2 - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Isoforms - chemistry | Adenosine Triphosphate - metabolism | HEK293 Cells | HSP90 Heat-Shock Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Kelch-Like ECH-Associated Protein 1 | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Mutation | Protein Isoforms - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Protein Isoforms - genetics | Ubiquitin | Heat shock proteins | DNA binding proteins | Ligases | Protein binding | Medical research | Hsp90 protein | Transcription factors | Life assessment | Oncology | Genomes | Geldanamycin | Kinases | Clients | ErbB-2 protein | Mutants | Proteins | Inhibitors | Isoforms | Hypoxia | HSF1 protein | ATP | Binding sites | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12572 - 12577
MacB is an ABC transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the... 
X-ray crystallography | ABC transporter | Tripartite efflux pump | HEAT-STABLE ENTEROTOXIN | EFFLUX TRANSPORTER | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | HYDROLYSIS | ATP-BINDING | MEMBRANE-FUSION PROTEIN | TOLC | tripartite efflux pump | MACROLIDE TRANSPORTER | MULTIDRUG EFFLUX | INHIBITORS | Protein Multimerization | Aggregatibacter actinomycetemcomitans - metabolism | Substrate Specificity | Crystallography, X-Ray | Cell Cycle Proteins - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Biological Transport | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Protein Interaction Domains and Motifs | Binding Sites | Bacterial Outer Membrane Proteins - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Cell Cycle Proteins - metabolism | Bacterial Outer Membrane Proteins - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Recombinant Proteins - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | Bacterial Outer Membrane Proteins - metabolism | Protein Conformation, beta-Strand | Escherichia coli - genetics | Aggregatibacter actinomycetemcomitans - genetics | Escherichia coli Proteins - genetics | Protein Binding | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Adenosine Triphosphate - chemistry | Escherichia coli Proteins - chemistry | Research | Carrier proteins | Structure | Crystals | Efflux | Trafficking | Cell division | Homology | Crystallography | Substrates | Coupling (molecular) | Bellows | Signaling | Cellular biology | Antibiotics | Bacteria | ABC transporters | Dimerization | Transporter | ATP | Cytoplasm | Adenosine triphosphate | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 914 - 918
Progressive telomere attrition or uncapping of the shelterin complex elicits a DNA damage response as a result of a cell’s inability to distinguish... 
COMPLEX | REPAIR | MAMMALIAN TELOMERES | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | DYSFUNCTIONAL TELOMERES | POT1 | HOMOLOGOUS RECOMBINATION | ATM ACTIVATION | DOUBLE-STRAND BREAK | TRF2 | Telomeric Repeat Binding Protein 2 - deficiency | DNA Repair Enzymes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - deficiency | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | ATP-Binding Cassette Transporters - genetics | Nuclear Proteins - deficiency | DNA Repair Enzymes - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Fibroblasts | Telomere - metabolism | Nuclear Proteins - genetics | DNA Repair Enzymes - deficiency | Protein-Serine-Threonine Kinases - metabolism | Telomere - genetics | Cell Line | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Animals | Alleles | Chromosome Aberrations | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | DNA Damage | Tumor Suppressor p53-Binding Protein 1 | Physiological aspects | Telomeres | Research | DNA damage | Proteins | Genetics | Chromosomes | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10832 - 10836
The study of membrane proteins remains a challenging task, and approaches to unravel their dynamics are scarce. Here, yve applied hydrogen/deuterium exchange... 
ATP binding cassette transporters | Deuterium | Hydrolysis | Average linear density | Mass spectroscopy | Biochemistry | Dimers | Detergents | Exporters | Membrane proteins | ATPase cycle | Structural biology | Detergent | BMRA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MASS-SPECTROMETRY | ATP-BINDING | BINDING CASSETTE TRANSPORTER | detergent | BACILLUS-SUBTILIS | P-GLYCOPROTEINS | ALTERNATING ACCESS | structural biology | MOLECULAR-BASIS | HYDROGEN-EXCHANGE | Protein Structure, Tertiary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Multidrug Resistance-Associated Proteins - chemistry | Adenosine Triphosphatases - metabolism | Trypsin - metabolism | Bacillus subtilis - genetics | Membrane Transport Proteins - chemistry | Deuterium Exchange Measurement | Trypsin - pharmacology | Peptide Mapping | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Mass Spectrometry | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Protein Conformation | Mutagenesis - physiology | Catalysis | Multidrug Resistance-Associated Proteins - metabolism | Bacillus subtilis - metabolism | Physiological aspects | Molecular dynamics | Research | Binding proteins | Adenosine triphosphate | Proteins | Bacteria | ABC transporters | Peptides | Simulation | Mass spectrometry | Index Medicus | Bacillus subtilis | Escherichia coli | Biochemistry, Molecular Biology | Bacterial Proteins | Life Sciences | Trypsin | Mutagenesis | Adenosine Triphosphatases | Membrane Transport Proteins | Biomolecules | Multidrug Resistance-Associated Proteins | Biological Sciences
Journal Article
Structure, ISSN 0969-2126, 02/2017, Volume 25, Issue 2, pp. 287 - 294
Serine/threonine kinase 40 (STK40) was originally identified as a distant homolog of Tribbles-family proteins. Despite accumulating data attesting to the... 
X-ray crystallography | COP1 | E3 ligase | RFWD2 | Tribbles | SINK-homologous kinase | SgK495 | ATP binding | pseudokinase | STK40 | FOLD | PROTEIN | BIOPHYSICS | INTERFACE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERINE/THREONINE KINASE | CELL BIOLOGY | Humans | Substrate Specificity | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Adenosine Triphosphate - metabolism | Cloning, Molecular | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Adenosine Triphosphate - chemistry | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Structure | Ligases | Crystals | Index Medicus
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 2008, Volume 1778, Issue 9, pp. 1735 - 1756
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane. The general retion route, termed Sec-pathway, catalyzes the... 
Secretion | Tat | SecA | SecY | Twin arginine | BACILLUS-SUBTILIS SECA | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | ESCHERICHIA-COLI SECA | TWIN-ARGININE TRANSLOCASE | ATP-BINDING-SITE | twin arginine | secretion | BIOPHYSICS | EXPORT CHAPERONE SECB | AMINO-TERMINAL REGION | PROTON MOTIVE FORCE | RIESKE FE/S PROTEIN | THYLAKOID LUMEN PROTEIN | Proteins | Cell membranes
Journal Article
The Plant Cell, ISSN 1040-4651, 12/2004, Volume 16, Issue 12, pp. 3285 - 3303
Vacuoles play central roles in plant growth, development, and stress responses. To better understand vacuole function and biogenesis we have characterized the... 
Proteins | ATP binding cassette transporters | Tonoplast | Proteomics | SNARE proteins | Proteomes | Plants | Organelles | Vacuoles | Plant cells | Vacuolar Proton-Translocating ATPases - isolation & purification | Vesicular Transport Proteins - metabolism | Molecular Sequence Data | Protein Transport - physiology | Proteome - chemistry | Vacuolar Proton-Translocating ATPases - metabolism | Protein Subunits - metabolism | Arabidopsis Proteins - metabolism | Protoplasts - metabolism | Peptides - metabolism | Protein Subunits - isolation & purification | Vacuoles - chemistry | Membrane Proteins - metabolism | Proteomics - methods | Protoplasts - chemistry | Vesicular Transport Proteins - isolation & purification | Proteome - isolation & purification | SNARE Proteins | Cytoskeleton - chemistry | Plant Leaves - chemistry | Amino Acid Sequence | Membrane Proteins - isolation & purification | Arabidopsis - chemistry | Vesicular Transport Proteins - chemistry | Arabidopsis - metabolism | Arabidopsis Proteins - isolation & purification | Arabidopsis Proteins - chemistry | Membrane Proteins - chemistry | Plant Leaves - metabolism | Vacuolar Proton-Translocating ATPases - chemistry | Cytoskeleton - metabolism | Vacuoles - metabolism | Signal Transduction - physiology | Protein Subunits - chemistry | Membrane Fusion - physiology | Proteome - metabolism | Protein Structure, Tertiary - physiology | Arabidopsis thaliana | Liquid chromatography | Research | Structure | Analysis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62667 - e62667
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase... 
SIGNAL-TRANSDUCTION PATHWAYS | PPAR-ALPHA | B TYPE-I | SCAVENGER RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | APOA-I | LIVER-X-RECEPTORS | E-DEFICIENT MICE | HIGH-DENSITY-LIPOPROTEIN | Cricetinae | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ras Proteins - metabolism | ATP Binding Cassette Transporter 1 - chemistry | Cholesterol - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Gene Expression Regulation - drug effects | Proteolysis - drug effects | ATP-Binding Cassette Transporters - chemistry | Animals | MAP Kinase Signaling System - drug effects | ATP-Binding Cassette Transporters - genetics | Protein Stability - drug effects | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | ATP Binding Cassette Transporter 1 - genetics | CHO Cells | Proteolysis | DNA polymerases | Cellular signal transduction | Blood lipids | Macrophages | Mitogens | Protein kinases | Cholesterol | Protein binding | Phosphorylation | H-Ras protein | RNA-directed DNA polymerase | Transcription | Syngeneic grafts | Liver | Gene regulation | Kinases | Cell surface | Protein turnover | K-Ras protein | Degradation | ABCA1 protein | Proteins | Signal transduction | Pathways | Rodents | Atherosclerosis | Cell cycle | Inhibition | Lipoproteins (high density) | Efflux | Liver X receptors | Extracellular signal-regulated kinase | MAP kinase | Ras protein | Gene expression | Apolipoproteins | Polymerase chain reaction | Signaling | Lipoproteins | Inhibitors | Protein kinase | Pharmacy | Cell lines | ATP-binding protein | Transduction | ATP | Transporter | ABC transporter | Kidney transplantation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2007, Volume 447, Issue 7141, pp. 218 - 221
The MRE11 complex (MRE11, RAD50 and NBS1) and the ataxia-telangiectasia mutated (ATM) kinase function in the same DNA damage response pathway to effect cell... 
RECRUITMENT | PROTEIN | METABOLISM | NIJMEGEN BREAKAGE SYNDROME | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | CHECKPOINT | MICE | ATM ACTIVATION | ATAXIA-TELANGIECTASIA | CELLULAR-RESPONSE | BH3 Interacting Domain Death Agonist Protein - deficiency | Protein-Serine-Threonine Kinases - deficiency | Phosphorylation | Humans | Molecular Sequence Data | BH3 Interacting Domain Death Agonist Protein - genetics | DNA-Binding Proteins - deficiency | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Phenotype | Animals | Alleles | Checkpoint Kinase 2 | Mice | Apoptosis | Sequence Deletion - genetics | Molecular biology | DNA damage | Rodents | Index Medicus
Journal Article