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Drug Discovery Today, ISSN 1359-6446, 02/2016, Volume 21, Issue 2, pp. 369 - 375
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 03/2015, Volume 185, Issue 3, pp. 786 - 797
Periostin actively contributes to tissue injury, fibrosis, atherosclerosis, and inflammatory diseases; however, its role in hepatic fibrosis is unclear.... 
NICHE COMPONENT | CELLS | ATTENUATES LIVER FIBROSIS | OSTEOPONTIN | GROWTH | MATRICELLULAR PROTEINS | EXTRACELLULAR-MATRIX | PATHOLOGY | CANCER | PROGRESSION | TENASCIN-C
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 11/2015, Volume 60, Issue 11, pp. 3329 - 3339
Wogonoside (WO), a flavonoid extracted from Huangqin, plays multiple physiological roles. However, it has remained elusive how WO regulates hepatic... 
Biochemistry, general | Hepatic fibrosis | Medicine & Public Health | Hepatology | Carbon tetrachloride | Gastroenterology | Oncology | TGF-β | HSC-T6 | Wogonoside | PI3K/Akt/mTOR | Transplant Surgery | ATTENUATES LIVER FIBROSIS | SIGNALING PATHWAYS | RAT | STELLATE CELLS | INJURY | ALPHA | PROLIFERATION | TGF-beta | MICE | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | PI3K/AKT/MTOR PATHWAY | Liver - pathology | Rats, Wistar | Carbon Tetrachloride | Male | Intracellular Signaling Peptides and Proteins - metabolism | Dose-Response Relationship, Drug | Liver Cirrhosis, Experimental - prevention & control | Liver - drug effects | Time Factors | Protective Agents - pharmacology | Liver Cirrhosis, Experimental - pathology | Chemical and Drug Induced Liver Injury - blood | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Cytoprotection | Chemical and Drug Induced Liver Injury - prevention & control | Glucosides - pharmacology | Flavanones - pharmacology | Liver - metabolism | Inflammation Mediators - blood | Biomarkers - blood | Liver Cirrhosis, Experimental - blood | Collagen - blood | Animals | Signal Transduction - drug effects | Liver Cirrhosis, Experimental - chemically induced | Oxidative Stress - drug effects | Liver diseases | Collagen | Liver | Fibrosis | Stem cells | Physiological aspects | Bone morphogenetic proteins | Models | Superoxide | Transforming growth factors | Muscle proteins
Journal Article
by Wu, LW and Zhang, QH and Mo, WH and Feng, J and Li, SN and Li, JJ and Liu, T and Xu, SZ and Wang, WW and Lu, XY and Yu, Q and Chen, K and Xia, YJ and Lu, J and Xu, L and Zhou, YQ and Fan, XM and Guo, CY
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2017, Volume 7
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were... 
GROWTH-FACTOR-BETA | ATTENUATES LIVER FIBROSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RATS | EXTRACELLULAR-MATRIX | MECHANISMS | MICE | EXPRESSION | CANCER | MODULATION
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 05/2017, Volume 41, Issue 3, pp. 1156 - 1166
Background/Aims: Astragaloside (AGS) extracted from radix astragalin (Huangqi) has been considered to be beneficial to liver diseases. In this study, we... 
PKC | Hepatic fbrosis | Diabetes | PAK | PAR2 | Astragaloside | Hepatic fibrosis | PROTEINASE-ACTIVATED RECEPTOR-2 | ATTENUATES LIVER FIBROSIS | PHYSIOLOGY | STELLATE CELLS | INJURY | MECHANISMS | CELL BIOLOGY | INHIBITION | INFLAMMATION | ANTIOXIDANT | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Diabetes Mellitus, Experimental - drug therapy | Triterpenes - pharmacology | Streptozocin | Carbon Tetrachloride | Receptor, PAR-2 - metabolism | Transforming Growth Factor beta1 - metabolism | Tumor Necrosis Factor-alpha - genetics | Diabetes Mellitus, Experimental - genetics | Male | Interleukin-1beta - genetics | Liver Cirrhosis - chemically induced | Receptor, PAR-2 - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - genetics | Interleukin-1beta - metabolism | Diabetes Mellitus, Experimental - chemically induced | Interleukin-6 - metabolism | Liver Cirrhosis - genetics | Receptor, PAR-2 - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Liver Cirrhosis - drug therapy | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Protein Kinase C-epsilon - genetics | Rats | Transforming Growth Factor beta1 - genetics | Rats, Sprague-Dawley | Aspartate Aminotransferases - metabolism | Animals | Protein Kinase C-epsilon - metabolism | Diabetes Mellitus, Experimental - pathology | Liver Cirrhosis - pathology | Alanine Transaminase - metabolism | Saponins - pharmacology | Proteins | Diabetic retinopathy | Membranes | Liver diseases | Pathogenesis | Collagen | Rodents | Extracellular matrix | Alcohol | Gene expression | Carbon
Journal Article
American Journal of Physiology-Gastrointestinal and Liver Physiology, ISSN 0193-1857, 10/2016, Volume 311, Issue 4, pp. G724 - G733
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 2013, Volume 4, p. 195
Background: Progression of liver fibrosis is characterized by synthesis and degradation of extracellular matrix (ECM). Matrix-metalloproteinases (MMP) cleave... 
Antifibrotic | ECM (extracellular matrix) | remodeling | Statins | Fibrosis | Markers | PHYSIOLOGY | LIVER FIBROSIS | STELLATE CELLS | FIBROGENESIS | ATTENUATES HEPATIC-FIBROSIS | TRANSIENT ELASTOGRAPHY | PRESSURE | CIRRHOTIC RATS | STIFFNESS | statins | fibrosis | markers | antifibrotic | remodelling
Journal Article
by Peng, Y and Li, L and Zhang, X and Xie, MY and Yang, CY and Tu, S and Shen, H and Hu, GY and Tao, LJ and Yang, HX
EXPERIMENTAL AND THERAPEUTIC MEDICINE, ISSN 1792-0981, 07/2019, Volume 18, Issue 1, pp. 41 - 48
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 513, Issue 3, pp. 657 - 662
The objective of this study was to evaluate whether fucoxanthin (FCX) have anti-fibrogenic properties in hepatic stellate cells (HSCs). FCX significantly... 
Hepatic stellate cells | Fucoxanthin | SMAD3 | Fibrogenesis | Pro-fibrogenic genes | APOPTOSIS | ATTENUATES LIVER FIBROSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID EXTRACT | REVERSES | INHIBITION | BIOPHYSICS | PATHWAY | BLUE-GREEN-ALGA | ASTAXANTHIN | EXPRESSION | Oxidases | Anopheles | RNA | Transforming growth factors | Gene expression | Genes
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2018, Volume 233, Issue 3, pp. 2067 - 2074
Fibrosis of the subsynovial connective tissue (SSCT) in carpal tunnel syndrome (CTS) patients is increasingly recognized as an important aspect of CTS... 
carpal tunnel syndrome | fibrosis | subsynovial connective tissue | transforming growth factor β | CANCER-CELLS | SUBSYNOVIAL CONNECTIVE-TISSUE | ATTENUATES LIVER FIBROSIS | PHYSIOLOGY | TGF-BETA | transforming growth factor beta | SYSTEMIC-SCLEROSIS | PDGF RECEPTOR | CELL BIOLOGY | RENAL FIBROSIS | GROWTH-FACTOR-BETA | RECEPTOR TYROSINE KINASES | LUNG-DISEASE | Fibrosis - drug therapy | ErbB Receptors - antagonists & inhibitors | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Collagen Type III - biosynthesis | Connective Tissue - pathology | Humans | Cells, Cultured | Synovial Membrane - pathology | Collagen Type III - genetics | Connective Tissue Growth Factor - biosynthesis | Plasminogen Activator Inhibitor 1 - biosynthesis | Carpal Tunnel Syndrome - pathology | Collagen Type I - biosynthesis | Collagen Type I - genetics | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Connective Tissue Growth Factor - genetics | Fibrosis - pathology | Plasminogen Activator Inhibitor 1 - genetics | Carpal Tunnel Syndrome - drug therapy | Transforming Growth Factor beta - metabolism | Synovial Membrane - cytology | Connective Tissue Cells - cytology | Fibroblasts - metabolism | Carpal tunnel syndrome | Collagen | Analysis | Genes | Gene expression | Vascular endothelial growth factor | Growth factors | Smad protein | Collagen (type I) | Platelet-derived growth factor | Epidermal growth factor receptors | Gene regulation | Overuse injuries | Collagen (type III) | Connective tissue growth factor | Patients | Vascular endothelial growth factor receptors | Polymerase chain reaction | Connective tissues | Signal transduction | Signaling | Epidermal growth factor | Down-regulation | Fibrosis | Fibroblasts | Inhibition | Subsynovial connective tissue
Journal Article