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Nature reviews. Drug discovery, ISSN 1474-1776, 06/2019, Volume 18, Issue 6, pp. 408 - 410
Despite industry’s past setbacks with autophagy inhibitors, preclinical and clinical findings are starting to revitalize a once written-off strategy. 
Autophagy
Journal Article
eJournal
Nature, ISSN 0028-0836, 01/2019, Volume 565, Issue 7737, pp. E3 - E3
Journal Article
eLife, ISSN 2050-084X, 11/2016, Volume 5, Issue 2016
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are... 
MOLECULAR-DYNAMICS | ATG12-ATG5 CONJUGATE | SWISS-MODEL WORKSPACE | STRUCTURAL BASIS | MEMBRANE | IN-VIVO | BIOLOGY | SCAFFOLD PROTEIN | UBIQUITIN-LIKE PROTEINS | SACCHAROMYCES-CEREVISIAE | LIPIDATION | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | Humans | Transcription Factor TFIIIA - genetics | Autophagy-Related Protein 5 - chemistry | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein 8 Family - metabolism | Transcription Factor TFIIIA - metabolism | Autophagy-Related Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Biological Transport | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Autophagy - genetics | Autophagy-Related Protein 8 Family - genetics | Nuclear Proteins - genetics | Autophagy-Related Proteins - genetics | Binding Sites | Sequestosome-1 Protein - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Autophagy-Related Protein 12 - genetics | Protein Structure, Secondary | Signal Transduction | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Receptors, Cell Surface - metabolism | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Autophagy-Related Protein 8 Family - chemistry | Saccharomyces cerevisiae Proteins - genetics | Autophagy-Related Protein 12 - metabolism | Sequestosome-1 Protein - genetics | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Autophagy-Related Protein 5 - metabolism | Protein Binding | Molecular Docking Simulation | HeLa Cells | Autophagy-Related Proteins - metabolism | Receptors, Cell Surface - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Observations | Autophagy (Cytology) | Ubiquitin | Proteins | Enzymes | Membranes | Peptides | Laboratories | Kinases | Autophagy | Phagocytosis | Binding sites | Recruitment | Index Medicus
Journal Article
Pancreatology, ISSN 1424-3903, 09/2017, Volume 17, Issue 4, pp. S56 - S56
Autophagy, evaluated by LC3, was detected in response to the Cae treatment. [...]a clear LC3 redistribution was observed with Cae treatment. [...]in response... 
Autophagy
Journal Article
Pancreatology, ISSN 1424-3903, 09/2017, Volume 17, Issue 4, pp. S36 - S36
VMP1 is an autophagy-related protein which is able to induce autophagy even in non-starved condition. [...]VMP1 is induced by acute pancreatitis and mediates... 
Autophagy
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173676 - e0173676
Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPAR alpha may be... 
INSULIN SIGNALING TRANSDUCTION | GLUCOSE-HOMEOSTASIS | FIBROBLAST-GROWTH-FACTOR-21 | DEACETYLATION | METABOLISM | PATHWAY | STEATOSIS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | RECEPTORS | FOXO1 | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes | Index Medicus
Journal Article
Folia Neuropathologica, ISSN 1641-4640, 2018, Volume 56, Issue 2, pp. 133 - 140
Autophagy is an intracellular degradation process that is involved in α-synuclein (α-syn) homeostasis and Parkinson’s disease (PD). The purpose of this study... 
Autophagy
Journal Article
Methods in Enzymology, ISSN 0076-6879, 2017, Volume 587, pp. 377 - 390
Macroautophagy, hereafter autophagy, is a major degradation pathway in eukaryotic systems that allows the removal of large intracellular structures such as... 
Phosphatidylethanolamine | Atg8 lipidation | Isolation membrane | SUVs | GUVs | Reconstitution | Autophagy | Ubiquitin-like system | TARGET | GATE-16 | PROTEIN LIPIDATION | MEMBRANE-BINDING | BIOGENESIS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | AUTOPHAGOSOME FORMATION | SELECTIVE AUTOPHAGY | LC3 | CELL BIOLOGY | Autophagy-Related Proteins - isolation & purification | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Multiprotein Complexes | Unilamellar Liposomes - chemistry | Green Fluorescent Proteins - genetics | Autophagy-Related Protein 8 Family - metabolism | Ubiquitin-Conjugating Enzymes - isolation & purification | Recombinant Proteins - isolation & purification | Autophagy-Related Protein 7 - isolation & purification | Saccharomyces cerevisiae Proteins - isolation & purification | Microtubule-Associated Proteins - isolation & purification | Autophagy-Related Protein 8 Family - genetics | Autophagy-Related Proteins - genetics | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Recombinant Proteins - genetics | Autophagy-Related Protein 8 Family - chemistry | Saccharomyces cerevisiae Proteins - genetics | Autophagy-Related Protein 12 - metabolism | Autophagy-Related Protein 7 - genetics | Unilamellar Liposomes - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Autophagy-Related Protein 5 - metabolism | Luminescent Proteins - genetics | Phosphatidylethanolamines - metabolism | Autophagy-Related Proteins - metabolism | Luminescent Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 04/2015, Volume 11, Issue 4, pp. 670 - 684
Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and proteins. Impaired autophagic activity is involved in... 
CASP3, caspase 3, apoptosis-related cysteine peptidase | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | TUBB4, tubulin, β 4, class IV | DRAM2, DNA-damage regulated autophagy modulator 2 | IL13, interleukin 13 | CAV1, caveolin 1, caveolae protein, 22kDa | CCL3, chemokine (C-C motif) ligand 3 | ATG9B, autophagy-related 9B | RELA, v-rel reticuloendotheliosis viral oncogene homolog A | TGFB1, transforming growth factor, β 1 | ATG4B, autophagy-related 4B | epithelial cell | ATG3, autophagy-related 3 | CXCR2, chemokine (C-X-C motif) receptor 2 | lung fibrosis | IFNG, interferon, gamma | ATG7, autophagy-related 7 | ATG5, autophagy-related 5 | CXCL1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity α) | autophagin-1 | GFP-LC3B, green fluorescent protein-LC3B | TGFBR2, transforming growth factor, β receptor II (70/80kDa) | autophagy | TNF, tumor necrosis factor | IL12B, interleukin 12B | WT, wild type | idiopathic pulmonary fibrosis | IPF, idiopathic pulmonary fibrosis | SQSTM1, sequestosome 1 | ACTA2, actin, α 2, smooth muscle, aorta | BAX, BCL2-associated X protein | ATG4B | cysteine peptidase | Epithelial cell | Autophagin-1 | Autophagy | Idiopathic pulmonary fibrosis | Lung fibrosis | APOPTOSIS | LUNG INJURY | RECEPTOR | CELL BIOLOGY | DISEASES | EPITHELIAL-CELLS | IL-17A PROMOTES | INFLAMMATION | MICE | EXPRESSION | CAVEOLIN-1 | Autophagy-Related Proteins | Cytokines - metabolism | Gene Expression - drug effects | Epithelial Cells - drug effects | Apoptosis - genetics | Autophagy - physiology | Idiopathic Pulmonary Fibrosis - chemically induced | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Mice, Knockout | Animals | Cysteine Endopeptidases - metabolism | Cysteine Endopeptidases - genetics | Bleomycin - pharmacology | Homeostasis - drug effects | Epithelial Cells - cytology | Cytokines - genetics | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 741 - 750
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2010, Volume 190, Issue 4, pp. 523 - 531
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 1, pp. 182 - 187
Journal Article