X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (43) 43
autoproteolytic activation (38) 38
biochemistry & molecular biology (32) 32
amino acid sequence (22) 22
molecular sequence data (20) 20
animals (15) 15
humans (15) 15
crystallography, x-ray (13) 13
catalysis (12) 12
cell biology (11) 11
models, molecular (11) 11
mutagenesis, site-directed (10) 10
cephalosporin acylase (9) 9
enzyme activation (9) 9
recombinant proteins - metabolism (9) 9
binding sites (8) 8
biophysics (8) 8
enzymes (8) 8
mutation (8) 8
penicillin amidase - chemistry (8) 8
protein structure, tertiary (8) 8
7-aminocephalosporanic acid acylase (7) 7
amidohydrolases - metabolism (7) 7
catalytic domain (7) 7
escherichia-coli (7) 7
microbiology (7) 7
n-terminal nucleophile (7) 7
penicillin amidase - genetics (7) 7
penicillin amidase - metabolism (7) 7
protein conformation (7) 7
protein structure, secondary (7) 7
proteins (7) 7
substrate specificity (7) 7
bacterial proteins - chemistry (6) 6
biotechnology & applied microbiology (6) 6
escherichia coli - genetics (6) 6
gene expression (6) 6
mice (6) 6
protein (6) 6
protein processing, post-translational (6) 6
proteolysis (6) 6
recombinant proteins - chemistry (6) 6
amidohydrolases - chemistry (5) 5
amino acids (5) 5
autoproteolytic cleavage (5) 5
catalytic mechanism (5) 5
crystal-structure (5) 5
crystal-structures (5) 5
enzyme precursors - metabolism (5) 5
escherichia coli - enzymology (5) 5
gamma-glutamyltransferase - genetics (5) 5
glycosylasparaginase (5) 5
hydrogen-ion concentration (5) 5
intramolecular proteolysis (5) 5
kinetics (5) 5
penicillin acylase (5) 5
progelatinase-a (5) 5
protein engineering (5) 5
recombinant proteins - genetics (5) 5
sequence homology, amino acid (5) 5
site-directed mutagenesis (5) 5
7-aminocephalosporanic acid (4) 4
amino acids - metabolism (4) 4
antibiotics (4) 4
bacterial proteins - genetics (4) 4
bacterial proteins - metabolism (4) 4
biotechnology (4) 4
cephalosporins - metabolism (4) 4
crystal structure (4) 4
extracellular-matrix (4) 4
gamma-glutamyltransferase - chemistry (4) 4
gamma-glutamyltransferase - metabolism (4) 4
glutaryl-7-aminocephalosporanic acid (4) 4
hydrolases (4) 4
iv collagenase (4) 4
metalloendopeptidases - metabolism (4) 4
peptides (4) 4
protein binding (4) 4
structure-activity relationship (4) 4
20s proteasome (3) 3
amidohydrolases - genetics (3) 3
amino-acids (3) 3
analysis (3) 3
angstrom crystal-structure (3) 3
autocatalytic processing (3) 3
autoproteolytic processing (3) 3
bacteria (3) 3
c-terminal domain (3) 3
cells, cultured (3) 3
cloning (3) 3
cloning, molecular (3) 3
enzyme precursors - chemistry (3) 3
enzyme precursors - genetics (3) 3
erythroid-potentiating activity (3) 3
escherichia coli proteins - metabolism (3) 3
furin (3) 3
gamma-glutamyltranspeptidase (3) 3
gelatinases - metabolism (3) 3
human lysosomal aspartylglucosaminidase (3) 3
incremental binding energy (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 43, pp. E10032 - E10040
Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in animal models and in humans. Its signaling activity is terminated... 
Endocannabinoid | Palmitoylethanolamide | N-terminal nucleophile hydrolase | N-acylethanolamine acid amidase interfacial activation | endocannabinoid | N-TERMINAL HYDROLASE | palmitoylethanolamide | MONOACYLGLYCEROL LIPASE | MULTIDISCIPLINARY SCIENCES | PROTEOLYTIC ACTIVATION | SUPPRESSES INFLAMMATION | INHIBITORS SYNTHESIS | N-acylethanolamine acid amidase | RAT MODEL | HYDROLYZING ACID AMIDASE | ACTIVITY-RELATIONSHIP SAR | BIOLOGICAL EVALUATION | interfacial activation | AUTOPROTEOLYTIC ACTIVATION | Amidohydrolases - metabolism | Catalytic Domain - drug effects | Analgesics - pharmacology | Cell Line | Rabbits | Humans | Enzyme Inhibitors - pharmacology | Drug Discovery - methods | Structure-Activity Relationship | Pain - metabolism | Inflammation - metabolism | Sf9 Cells | Animals | Ethanolamines - metabolism | Pain - drug therapy | Ligands | Mice | Palmitic Acids - metabolism | Health aspects | Cannabinoids | Drugs | Membranes | Animal models | Amidase | Lipids | Activation | Helices | Hydrophobicity | Proteins | Lipid membranes | Pain | Analgesics | Proteolysis | N-Acylethanolamine | Nonsteroidal anti-inflammatory drugs | Catalysis | Coordination compounds | Crystal structure | Enzymes | Hydrolase | Immunoregulation | Substrate inhibition | Pharmacology | Immune systems | Inhibitors | Drug discovery | Binding sites | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 45, pp. 37949 - 37963
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2007, Volume 403, Issue 3, pp. 553 - 563
We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for... 
Proteoglycan | Matrix metalloproteinase (MMP) | Chondroitin sulfate | Membrane-type 3 MMP (MT3-MMP) | Tissue inhibitor of metalloproteinases-2 (TIMP-2) | Sulfation | membrane-type 3 MMP (MT3-MMP) | TUMOR PROGRESSION | chondroitin sulfate | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMOPEXIN-LIKE DOMAIN | MEMBRANE-TYPE-1 MATRIX-METALLOPROTEINASE | NG2 PROTEOGLYCAN | proteoglycan | PROGELATINASE-A | tissue inhibitor of metalloproteinases-2 (TIMP-2) | matrix metalloproteinase (MMP) | CDNA LIBRARY | sulfation | EXTRACELLULAR-MATRIX | MT-MMPS | EXPRESSION | AUTOPROTEOLYTIC ACTIVATION | Melanoma - metabolism | Protein Structure, Tertiary | Humans | Chondroitin Sulfate Proteoglycans - metabolism | Metalloendopeptidases - metabolism | Chondroitin Sulfates - physiology | Enzyme Precursors - metabolism | Matrix Metalloproteinase 16 - physiology | Gelatinases - metabolism | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Matrix Metalloproteinase Inhibitors | Membrane Proteins - metabolism | Tumor Cells, Cultured | Index Medicus | βDX, p-nitro-β-D-xylopyranoside | MCSP, melanoma-specific CS proteoglycan | ECM, extracellular matrix | GAG, glycosaminoglycan | APMA, 4-aminophenylmercuric acetate | MT-MMP, membrane-type MMP | TIMP-2, tissue inhibitor of metalloproteinases-2 | CDMMP-2, C-terminal domain of MMP-2 | BAP, Escherichia coli bacterial alkaline phosphatase | HRP, horseradish peroxidase | ECL, enhanced chemiluminescence | HA, hyaluronan | IDV, individual values | IPTG, isopropyl β-D-thiogalactoside | C4S, chondroitin 4-sulfate | ConA, concanavalin A | MMP, matrix metalloproteinase | CS, chondroitin sulfate
Journal Article
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/1997, Volume 16, Issue 7, pp. 1508 - 1518
Journal Article
Journal Article
Journal Article
Journal Article