NeuroImage, ISSN 1053-8119, 07/2016, Volume 135, pp. 333 - 344
We report the development of a double diffusion encoding (DDE) MRI method to estimate and map the axon diameter distribution (ADD) within an imaging volume. A...
Nonparametric | Axon diameter distribution | Double diffusion encoding | Average axon diameter | MRI | Pore size distribution | Double pulsed field gradient | Empirical | MICROSCOPIC DIFFUSION ANISOTROPY | SPINAL-CORD | PORE-SIZE DISTRIBUTION | NEUROSCIENCES | NEUROIMAGING | RESTRICTED DIFFUSION | PFG | NMR | MULTIPLE-SCLEROSIS | CORPUS-CALLOSUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PLASTICITY | Data Interpretation, Statistical | Reproducibility of Results | Image Interpretation, Computer-Assisted - methods | Male | Ferrets | Diffusion Tensor Imaging - methods | White Matter - diagnostic imaging | Algorithms | Animals | Sensitivity and Specificity | Statistical Distributions | Axons - ultrastructure | Image Enhancement - methods | In Vitro Techniques | Pattern Recognition, Automated - methods | White Matter - cytology | Pore size | Traumatic brain injury | Ischemia | Microscopy | Anisotropy | Morphology | Nervous system | Histology | Experiments | Methods
Nonparametric | Axon diameter distribution | Double diffusion encoding | Average axon diameter | MRI | Pore size distribution | Double pulsed field gradient | Empirical | MICROSCOPIC DIFFUSION ANISOTROPY | SPINAL-CORD | PORE-SIZE DISTRIBUTION | NEUROSCIENCES | NEUROIMAGING | RESTRICTED DIFFUSION | PFG | NMR | MULTIPLE-SCLEROSIS | CORPUS-CALLOSUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PLASTICITY | Data Interpretation, Statistical | Reproducibility of Results | Image Interpretation, Computer-Assisted - methods | Male | Ferrets | Diffusion Tensor Imaging - methods | White Matter - diagnostic imaging | Algorithms | Animals | Sensitivity and Specificity | Statistical Distributions | Axons - ultrastructure | Image Enhancement - methods | In Vitro Techniques | Pattern Recognition, Automated - methods | White Matter - cytology | Pore size | Traumatic brain injury | Ischemia | Microscopy | Anisotropy | Morphology | Nervous system | Histology | Experiments | Methods
Journal Article
Magnetic Resonance in Medicine, ISSN 0740-3194, 06/2008, Volume 59, Issue 6, pp. 1347 - 1354
The diameter of a myelinated nerve axon is directly proportional to its conduction velocity, so the axon diameter distribution helps determine the channel...
diffusion | MRI | axon diameter | q‐space | nerve | Nerve | Q-space | Diffusion | Axon diameter | FIELD GRADIENT | WEIGHTED MRI | HUMAN BRAIN | WHITE-MATTER | ANISOTROPIC WATER DIFFUSION | DROPLET SIZE DISTRIBUTIONS | CONDUCTION-VELOCITY | MYELINATED NERVE-FIBERS | PFG-NMR | MAGNETIC-RESONANCE | q-space | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Animals | Magnetic Resonance Spectroscopy - methods | Swine | Staining and Labeling | Axons - ultrastructure | Diffusion Magnetic Resonance Imaging | Sciatic Nerve - ultrastructure | Image Processing, Computer-Assisted - methods | Optic Nerve - ultrastructure | Spinal Cord - ultrastructure
diffusion | MRI | axon diameter | q‐space | nerve | Nerve | Q-space | Diffusion | Axon diameter | FIELD GRADIENT | WEIGHTED MRI | HUMAN BRAIN | WHITE-MATTER | ANISOTROPIC WATER DIFFUSION | DROPLET SIZE DISTRIBUTIONS | CONDUCTION-VELOCITY | MYELINATED NERVE-FIBERS | PFG-NMR | MAGNETIC-RESONANCE | q-space | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Animals | Magnetic Resonance Spectroscopy - methods | Swine | Staining and Labeling | Axons - ultrastructure | Diffusion Magnetic Resonance Imaging | Sciatic Nerve - ultrastructure | Image Processing, Computer-Assisted - methods | Optic Nerve - ultrastructure | Spinal Cord - ultrastructure
Journal Article
Brain, ISSN 0006-8950, 5/2009, Volume 132, Issue 5, pp. 1210 - 1220
Here, we present the first in vivo non-invasive measurement of the axon diameter distribution in the rat corpus callosum. Previously, this measurement was only...
Brain | Axon diameter distribution | Diffusion | MRI | Corpus callosum | diffusion | WHITE-MATTER | CONDUCTION-VELOCITY | HUMANS | brain | MYELINATED NERVE-FIBERS | NEUROSCIENCES | RESTRICTED DIFFUSION | CLINICAL NEUROLOGY | DEMYELINATION | SPECTROSCOPY | axon diameter distribution | DIFFUSION-TENSOR | corpus callosum | MORPHOLOGY | Animals | Image Processing, Computer-Assisted | Rats, Wistar | Axons - ultrastructure | Rats | Male | Corpus Callosum - ultrastructure | Diffusion Magnetic Resonance Imaging - methods | Microscopy, Electron | Cluster Analysis | Original
Brain | Axon diameter distribution | Diffusion | MRI | Corpus callosum | diffusion | WHITE-MATTER | CONDUCTION-VELOCITY | HUMANS | brain | MYELINATED NERVE-FIBERS | NEUROSCIENCES | RESTRICTED DIFFUSION | CLINICAL NEUROLOGY | DEMYELINATION | SPECTROSCOPY | axon diameter distribution | DIFFUSION-TENSOR | corpus callosum | MORPHOLOGY | Animals | Image Processing, Computer-Assisted | Rats, Wistar | Axons - ultrastructure | Rats | Male | Corpus Callosum - ultrastructure | Diffusion Magnetic Resonance Imaging - methods | Microscopy, Electron | Cluster Analysis | Original
Journal Article
NMR in Biomedicine, ISSN 0952-3480, 12/2019, Volume 32, Issue 12, p. n/a
Mapping average axon diameter (AAD) and axon diameter distribution (ADD) in neuronal tissues non‐invasively is a challenging task that may have a tremendous...
diffusion MRI | double diffusion encoding (DDE)‐MRI | microstructure | spinal cord | axon diameter | Magnetic resonance spectroscopy | Spinal cord | Magnetic resonance imaging | DDE | Central nervous system | Histology | Mapping | Nitrous oxide | Tissues | Diffusion | Substantia alba | Microstructure
diffusion MRI | double diffusion encoding (DDE)‐MRI | microstructure | spinal cord | axon diameter | Magnetic resonance spectroscopy | Spinal cord | Magnetic resonance imaging | DDE | Central nervous system | Histology | Mapping | Nitrous oxide | Tissues | Diffusion | Substantia alba | Microstructure
Journal Article
NeuroImage, ISSN 1053-8119, 07/2012, Volume 61, Issue 4, pp. 1000 - 1016
This paper introduces neurite orientation dispersion and density imaging (NODDI), a practical diffusion MRI technique for estimating the microstructural...
Neurite density | Diffusion MRI | Microstructure imaging | Orientation dispersion | Gray matter microstructure | White matter microstructure | DIFFUSION-WEIGHTED MRI | WHITE-MATTER | MODEL | NEUROSCIENCES | NEUROIMAGING | CEREBRAL-CORTEX | DEGENERATION | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | TENSOR MRI | MULTIPLE FIBER ORIENTATIONS | UNCERTAINTY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuroimaging - methods | Brain - cytology | Neurites - ultrastructure | Humans | Image Interpretation, Computer-Assisted | Adult | Male | Brain Mapping - methods | Diffusion Magnetic Resonance Imaging - methods | Brain | Diagnostic imaging | Anisotropy | Specific gravity | Aging | Protocol
Neurite density | Diffusion MRI | Microstructure imaging | Orientation dispersion | Gray matter microstructure | White matter microstructure | DIFFUSION-WEIGHTED MRI | WHITE-MATTER | MODEL | NEUROSCIENCES | NEUROIMAGING | CEREBRAL-CORTEX | DEGENERATION | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | TENSOR MRI | MULTIPLE FIBER ORIENTATIONS | UNCERTAINTY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuroimaging - methods | Brain - cytology | Neurites - ultrastructure | Humans | Image Interpretation, Computer-Assisted | Adult | Male | Brain Mapping - methods | Diffusion Magnetic Resonance Imaging - methods | Brain | Diagnostic imaging | Anisotropy | Specific gravity | Aging | Protocol
Journal Article
BRAIN STRUCTURE & FUNCTION, ISSN 1863-2653, 05/2019, Volume 224, Issue 4, pp. 1469 - 1488
Tissue microstructure modeling of diffusion MRI signal is an active research area striving to bridge the gap between macroscopic MRI resolution and...
Fiber orientation distribution | QUANTIFICATION | ANATOMY & MORPHOLOGY | 3d electron microscopy | Axonal diameter distribution | MODEL | 3d axon segmentation | QUANTITATIVE-ANALYSIS | ANISOTROPY | NEUROSCIENCES | Corpus callosum | Axonal diameter variation | DENSITY | DISTRIBUTIONS | SPACE | Diffusion coarse-graining | CONNECTIVITY | CORPUS-CALLOSUM | g-Ratio | Diffusion time-dependence | Axons | Scanning electron microscopy | Learning algorithms | Image processing | Magnetic resonance imaging | Segmentation | Microscopy | Myelin | Histology | Variation | Substantia alba
Fiber orientation distribution | QUANTIFICATION | ANATOMY & MORPHOLOGY | 3d electron microscopy | Axonal diameter distribution | MODEL | 3d axon segmentation | QUANTITATIVE-ANALYSIS | ANISOTROPY | NEUROSCIENCES | Corpus callosum | Axonal diameter variation | DENSITY | DISTRIBUTIONS | SPACE | Diffusion coarse-graining | CONNECTIVITY | CORPUS-CALLOSUM | g-Ratio | Diffusion time-dependence | Axons | Scanning electron microscopy | Learning algorithms | Image processing | Magnetic resonance imaging | Segmentation | Microscopy | Myelin | Histology | Variation | Substantia alba
Journal Article
NeuroImage, ISSN 1053-8119, 02/2012, Volume 59, Issue 4, pp. 3976 - 3994
This article proposes a new measure called Apparent Fibre Density (AFD) for the analysis of high angular resolution diffusion-weighted images using...
Motor Neurone Disease | Diffusion MRI | Fibre orientation distribution | Amyotrophic Lateral Sclerosis | Spherical deconvolution | Apparent Fibre Density | Amyotrophic lateral sclerosis | Motor neurone disease | Apparent fibre density | RAT SPINAL-CORD | WALLERIAN DEGENERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | ORIENTATION DISTRIBUTIONS | MYELINATED NERVE-FIBERS | NEUROSCIENCES | NEUROIMAGING | VOXEL-BASED MORPHOMETRY | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | TENSOR MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Female | Male | Image Processing, Computer-Assisted | Humans | Diffusion Magnetic Resonance Imaging | Motor Neuron Disease - pathology | Magnetic resonance imaging | Monte Carlo method | Attention deficit disorder | Studies | Software | Diffusion | Anisotropy | Registration
Motor Neurone Disease | Diffusion MRI | Fibre orientation distribution | Amyotrophic Lateral Sclerosis | Spherical deconvolution | Apparent Fibre Density | Amyotrophic lateral sclerosis | Motor neurone disease | Apparent fibre density | RAT SPINAL-CORD | WALLERIAN DEGENERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | ORIENTATION DISTRIBUTIONS | MYELINATED NERVE-FIBERS | NEUROSCIENCES | NEUROIMAGING | VOXEL-BASED MORPHOMETRY | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | TENSOR MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Female | Male | Image Processing, Computer-Assisted | Humans | Diffusion Magnetic Resonance Imaging | Motor Neuron Disease - pathology | Magnetic resonance imaging | Monte Carlo method | Attention deficit disorder | Studies | Software | Diffusion | Anisotropy | Registration
Journal Article
Frontiers in Neuroanatomy, ISSN 1662-5129, 2016, Volume 10, Issue MAY, p. 59
Axon diameter is an important neuroanatomical characteristic of the nervous system that alters in the course of neurological disorders such as multiple...
Gamma distribution | Probability distribution function | Axon diameter distribution | Electron microscopy | Generalized extreme value distribution | Corpus callosum | probability distribution function | generalized extreme value distribution | gamma distribution | WHITE-MATTER | axon diameter distribution | ANATOMY & MORPHOLOGY | DIFFUSION MRI | electron microscopy | corpus callosum | NEUROSCIENCES | BRAIN | Multiple sclerosis | Analysis | Distribution (Probability theory) | Performance evaluation | Subpopulations | Nervous system | Mathematical functions | Probability distribution | Anatomy | Neurological diseases | Autism | Axons | Magnetic resonance imaging | Microscopy | Corpus Callosum
Gamma distribution | Probability distribution function | Axon diameter distribution | Electron microscopy | Generalized extreme value distribution | Corpus callosum | probability distribution function | generalized extreme value distribution | gamma distribution | WHITE-MATTER | axon diameter distribution | ANATOMY & MORPHOLOGY | DIFFUSION MRI | electron microscopy | corpus callosum | NEUROSCIENCES | BRAIN | Multiple sclerosis | Analysis | Distribution (Probability theory) | Performance evaluation | Subpopulations | Nervous system | Mathematical functions | Probability distribution | Anatomy | Neurological diseases | Autism | Axons | Magnetic resonance imaging | Microscopy | Corpus Callosum
Journal Article
NEUROIMAGE, ISSN 1053-8119, 10/2013, Volume 80, pp. 234 - 245
The engineering of a 3 T human MRI scanner equipped with 300 mT/m gradients - the strongest gradients ever built for an in vivo human MRI scanner - was a major...
Human connectome | HEAD-INJURY | Consciousness | Tractography | Traumatic coma | Postmortem | AMYOTROPHIC-LATERAL-SCLEROSIS | THALAMIC INTRALAMINAR NUCLEI | NEUROSCIENCES | NEUROIMAGING | Corpus callosum | RETICULAR-FORMATION | In vivo | AXON DIAMETER DISTRIBUTION | TRAUMATIC BRAIN-INJURY | CORPUS-CALLOSUM | Diffusion MRI | ASCENDING AROUSAL SYSTEM | PLACEBO-CONTROLLED TRIAL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Axon diameter | Brain - cytology | Humans | Male | Brain - physiology | Nerve Net - physiology | Nerve Net - cytology | Diffusion Tensor Imaging - methods | Young Adult | Pilot Projects | Animals | Connectome - methods | Adult | Female | Image Enhancement - methods | Models, Neurological | Models, Anatomic | traumatic coma | tractography | consciousness | postmortem | diffusion MRI | in vivo | corpus callosum | human connectome | axon diameter
Human connectome | HEAD-INJURY | Consciousness | Tractography | Traumatic coma | Postmortem | AMYOTROPHIC-LATERAL-SCLEROSIS | THALAMIC INTRALAMINAR NUCLEI | NEUROSCIENCES | NEUROIMAGING | Corpus callosum | RETICULAR-FORMATION | In vivo | AXON DIAMETER DISTRIBUTION | TRAUMATIC BRAIN-INJURY | CORPUS-CALLOSUM | Diffusion MRI | ASCENDING AROUSAL SYSTEM | PLACEBO-CONTROLLED TRIAL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Axon diameter | Brain - cytology | Humans | Male | Brain - physiology | Nerve Net - physiology | Nerve Net - cytology | Diffusion Tensor Imaging - methods | Young Adult | Pilot Projects | Animals | Connectome - methods | Adult | Female | Image Enhancement - methods | Models, Neurological | Models, Anatomic | traumatic coma | tractography | consciousness | postmortem | diffusion MRI | in vivo | corpus callosum | human connectome | axon diameter
Journal Article
NeuroImage, ISSN 1053-8119, 02/2012, Volume 59, Issue 3, pp. 2241 - 2254
This paper aims to identify the minimum requirements for an accurate model of the diffusion MR signal in white matter of the brain. We construct a taxonomy of...
Diffusion MRI | Microstructure imaging | Compartment models | White matter | Axon diameter | DESIGN | PARAMETERS | NEUROSCIENCES | NEUROIMAGING | DENSITY | NMR | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | FRAMEWORK | SPIN-ECHO | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - cytology | Brain - anatomy & histology | Rats | Terminology as Topic | Male | Axons - physiology | Models, Statistical | Rats, Sprague-Dawley | Diffusion Tensor Imaging - methods | Algorithms | Animals | Image Processing, Computer-Assisted | Axons - ultrastructure | Bayes Theorem | Classification | Water - chemistry | Brain Chemistry | Tissue Fixation | Models, Anatomic | Brain | Models | Medical research | Nuclear magnetic resonance--NMR | Diffusion
Diffusion MRI | Microstructure imaging | Compartment models | White matter | Axon diameter | DESIGN | PARAMETERS | NEUROSCIENCES | NEUROIMAGING | DENSITY | NMR | AXON DIAMETER DISTRIBUTION | WATER DIFFUSION | FRAMEWORK | SPIN-ECHO | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - cytology | Brain - anatomy & histology | Rats | Terminology as Topic | Male | Axons - physiology | Models, Statistical | Rats, Sprague-Dawley | Diffusion Tensor Imaging - methods | Algorithms | Animals | Image Processing, Computer-Assisted | Axons - ultrastructure | Bayes Theorem | Classification | Water - chemistry | Brain Chemistry | Tissue Fixation | Models, Anatomic | Brain | Models | Medical research | Nuclear magnetic resonance--NMR | Diffusion
Journal Article
Neuroimage, ISSN 1053-8119, 2011, Volume 58, Issue 1, pp. 177 - 188
Diffusional kurtosis imaging (DKI) is a clinically feasible extension of diffusion tensor imaging that probes restricted water diffusion in biological tissues...
Axonal density | Kurtosis | Diffusion | Microstructure | MRI | White matter | NERVOUS-SYSTEM | MYELIN WATER | HUMAN BRAIN | SELF-DIFFUSION | NEUROSCIENCES | NEUROIMAGING | TENSOR | AXON DIAMETER DISTRIBUTION | IN-VIVO | MAGNETIC-RESONANCE | RAT-BRAIN | GAUSSIAN WATER DIFFUSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - cytology | Data Interpretation, Statistical | Body Water - physiology | Brain - anatomy & histology | Humans | Male | Axons - physiology | Image Processing, Computer-Assisted - methods | Normal Distribution | Diffusion Tensor Imaging - methods | Algorithms | Nerve Fibers - physiology | Axons - ultrastructure | Adult | Female | Models, Neurological | Anisotropy | Diagnostic imaging | Attention deficit disorder | Brain | Permeability | White Matter | microstructure | kurtosis | axonal density
Axonal density | Kurtosis | Diffusion | Microstructure | MRI | White matter | NERVOUS-SYSTEM | MYELIN WATER | HUMAN BRAIN | SELF-DIFFUSION | NEUROSCIENCES | NEUROIMAGING | TENSOR | AXON DIAMETER DISTRIBUTION | IN-VIVO | MAGNETIC-RESONANCE | RAT-BRAIN | GAUSSIAN WATER DIFFUSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - cytology | Data Interpretation, Statistical | Body Water - physiology | Brain - anatomy & histology | Humans | Male | Axons - physiology | Image Processing, Computer-Assisted - methods | Normal Distribution | Diffusion Tensor Imaging - methods | Algorithms | Nerve Fibers - physiology | Axons - ultrastructure | Adult | Female | Models, Neurological | Anisotropy | Diagnostic imaging | Attention deficit disorder | Brain | Permeability | White Matter | microstructure | kurtosis | axonal density
Journal Article