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Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 9/2017, Volume 23, Issue 18, pp. 5366 - 5373
Journal Article
Reproductive Sciences, ISSN 1933-7191, 7/2019, Volume 26, Issue 7, pp. 979 - 987
Several features exist that distinguish endometriotic cells from eutopic endometrial cells. Progesterone resistance is one of the main distinguishing features,... 
AZD4547 | endometriosis | FGF | HAND2 | PROGESTERONE | MECHANISMS | PATHOPHYSIOLOGY | OBSTETRICS & GYNECOLOGY | WOMEN | INHIBITOR AZD4547 | REPRODUCTIVE BIOLOGY | GENES | STROMAL CELLS
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 20, pp. 9085 - 9104
Fibroblast growth factor receptors (FGFR1–4) are promising therapeutic targets in many cancers. With the resurgence of interest in irreversible inhibitors,... 
CH5183284/DEBIO 1347 | AZD4547 | SELECTIVE INHIBITOR | DESIGN | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | JNJ-42756493 | OVERCOME RESISTANCE | DERIVATIVES | EGFR | STRATEGIES
Journal Article
ONCOGENESIS, ISSN 2157-9024, 07/2016, Volume 5, Issue 7, pp. e241 - e241
Aberrant fibroblast growth factor receptor (FGFR) activation/expression is a common feature in lung cancer (LC). In this study, we evaluated the antitumor... 
AZD4547 | AMPLIFICATION | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | SENSITIVITY | INHIBITOR | GEFITINIB RESISTANCE | EXPRESSION | RECEPTOR TYROSINE KINASE | Original
Journal Article
MedChemComm, ISSN 2040-2503, 2017, Volume 8, Issue 8, pp. 1604 - 1613
A diverse range of selective FGFR4 inhibitor hit series were identified using unbiased screening approaches and by the modification of known kinase inhibitor... 
MEDICINAL CHEMISTRY | AZD4547 | POTENT | CHEMISTRY, MEDICINAL | PATHWAY | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FGFR4 INHIBITORS | THERAPIES | CANCER | DISCOVERY | FAMILY
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 09/2018, Volume 102, pp. 128 - 137
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 610 - 621
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 43, pp. 74539 - 74553
Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to FGFR inhibitors. The aim of this study was to investigate... 
Clinical stage | Disease free survival time | FGFR1 high amplification | ESCC | Prognostic marker | SURVIVAL | PROTEIN | LANDSCAPE | disease free survival time | clinical stage | CANCER | CELL BIOLOGY | AZD4547 | prognostic marker | SQUAMOUS-CELL CARCINOMA | EXPRESSION
Journal Article
by Shan, LP and Liu, W and Zhan, YH
AGING-US, ISSN 1945-4589, 09/2019, Volume 11, Issue 18, pp. 7780 - 7795
Rapid appearance of resistance to fibroblast growth factor receptor (FGFR) inhibitors hampers targeted regimens in bladder cancer. In the present study, we... 
MIGRATION | SIGNALING PATHWAYS | COMPREHENSIVE MOLECULAR CHARACTERIZATION | SENSITIVITY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | AZD4547 | INVASION | xenograft | bladder cancer | GROWTH | sulfated polysaccharide of Sepiella maindroni ink | CARCINOMA | EXPRESSION | FGFR therapy resistance
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 4/2019, Volume 26, Issue 4, pp. 1093 - 1102
The prognosis of scirrhous gastric carcinoma (SGC), which is characterized by rapid infiltration and proliferation of cancer cells accompanied by extensive... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | AZD4547 | SURGERY | FACTOR RECEPTOR INHIBITOR | SELECTIVE INHIBITOR | KERATINOCYTE GROWTH-FACTOR | ONCOLOGY | SAFETY | GENE AMPLIFICATION | MYOFIBROBLASTS | K-SAM | PHASE-I | CARCINOMA | Fibroblast growth factors | Epidermal growth factor | Stomach cancer | Analysis | Cancer
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2013, Volume 32, Issue 4, pp. 763 - 767
Angiogenesis is a process of neovascular formation from pre-existing blood vessels, which consists of sequential steps for vascular destabilization, angiogenic... 
Dovitinib | Lung cancer | Colorectal cancer | Breast cancer | Ponatinib | Vascular medicine | Bevacizumab | AZD4547 | Sunitinib | Sorafenib | Chitosan | Gastric cancer | Field cancerization | Poly(lactic-co-glycolic acid) | sunitinib | VASCULAR DEVELOPMENT | MEDICINE, RESEARCH & EXPERIMENTAL | chitosan | CELLS | vascular medicine | ANTI-VEGF | colorectal cancer | sorafenib | gastric cancer | breast cancer | dovitinib | OVARIAN-CANCER | DELIVERY | lung cancer | BREAST-CANCER | field cancerization | THERAPY | DISEASE | bevacizumab | ponatinib | poly(lactic-co-glycolic acid) | ENDOTHELIAL GROWTH-FACTOR | Cell Proliferation | Epigenesis, Genetic | Humans | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - genetics | Antibodies, Monoclonal, Humanized - genetics | Fibroblast Growth Factor 4 - genetics | Neoplasms - therapy | Neoplasms - genetics | Angiogenesis Inhibitors - therapeutic use | Fibroblast Growth Factor 2 - metabolism | Fibroblast Growth Factor 4 - metabolism | Neovascularization, Pathologic - therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Signal Transduction | Endothelial Cells - metabolism | Vascular Endothelial Growth Factor A - therapeutic use | Genotype | Fibroblast Growth Factor 2 - genetics | Macular Degeneration - genetics | Macular Degeneration - therapy | Neovascularization, Pathologic - genetics | MicroRNAs - genetics | Neoplasms - pathology | Macular Degeneration - pathology
Journal Article
Journal Article