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Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 3, pp. 1577 - 1592
In the present study, a series of novel dual-target histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors were designed and... 
IN-VITRO | POTENT | AZD8055 | CHEMISTRY, MEDICINAL | MECHANISM | ANTITUMOR-ACTIVITY | MTOR KINASE INHIBITOR
Journal Article
FASEB Journal, ISSN 0892-6638, 11/2018, Volume 32, Issue 11, pp. 5824 - 5834
We investigated whether rapamycin-insensitive mechanistic target of rapamycin (mTOR) signaling plays a role in regulating resistance exercise-induced muscle... 
AZD8055 | Translation | Metabolism | Contraction | Skeletal muscle | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SKELETAL-MUSCLE | MTOR | CELL BIOLOGY | HYPERTROPHY | INSULIN-RESISTANCE | PRAS40 | IN-VIVO | GROWTH | BIOLOGY | translation | contraction | AMPK | metabolism | skeletal muscle
Journal Article
Experimental Cell Research, ISSN 0014-4827, 04/2018, Volume 365, Issue 2, pp. 177 - 184
Neuroblastoma (NB) is one of the most common solid tumors in children. High-risk NB remains lethal in about 50% of patients despite comprehensive and intensive... 
mTOR kinase | AZD8055 | Neuroblastoma | Autophagy | Apoptosis | MAMMALIAN TARGET | RATIONALE | CANCER | CELL BIOLOGY | POTENT | TARGETING MTOR | THERAPY | ONCOLOGY | GROWTH | INHIBITOR | PI3K/AKT/MTOR PATHWAY | Index Medicus
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 09/2015, Volume 6, Issue september, p. 677
Target of rapamycin (TOR) acts as a master regulator to control cell growth by integrating nutrient, energy, and growth factors in all eukaryotic species. TOR... 
AsTORis | TOR signaling | AZD8055 | Phytohormone | Photosynthesis | Gene expression profile | RAPAMYCIN | TARGET | CELLS | KINASE | HOMOLOG | TRANSLATION | phytohormone | YEAST TOR | PLANT SCIENCES | asTORis | METABOLISM | photosynthesis | gene expression profile | MTOR INHIBITORS | PLANT-GROWTH | Physiological aspects | Cellular signal transduction | Genetic aspects | Plant hormones
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 03/2019, Volume 25, Issue 5, pp. 1574 - 1587
Purpose: To determine whether inhibition of mTORkinase-mediated signaling represents a valid therapeutic approach for chronic lymphocytic leukemia (CLL).... 
MAMMALIAN TARGET | IN-VITRO | AZD8055 | BRUTON TYROSINE KINASE | EVEROLIMUS | ONCOLOGY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | AKT | COMBINATION | EXPRESSION | mTOR inhibition | CLL | BCR signaling | FOXO1
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8736 - 8747
Journal Article
Cancer Research, ISSN 0008-5472, 12/2014, Volume 74, Issue 23, pp. 7037 - 7047
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 7/2014, Volume 13, Issue 7, pp. 1848 - 1859
Aberrant activation of multiple signaling pathways is common in acute myeloid leukemia (AML) cells, which can be linked to a poor prognosis for patients with... 
ABT-737 | apoptosis | AZD8055 | acute myeloid leukemia | selumetinib
Journal Article
Leukemia, ISSN 0887-6924, 06/2012, Volume 26, Issue 6, pp. 1195 - 1202
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2015, Volume 14, Issue 11, pp. 2508 - 2518
Journal Article