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azd9291 (64) 64
science & technology (53) 53
life sciences & biomedicine (52) 52
oncology (37) 37
humans (34) 34
mutation (31) 31
lung neoplasms - drug therapy (27) 27
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carcinoma, non-small-cell lung - drug therapy (24) 24
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epidermal growth factor (19) 19
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respiratory tract diseases (17) 17
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carcinoma, non-small-cell lung - genetics (16) 16
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erbb receptors - antagonists & inhibitors (16) 16
t790m (16) 16
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lung neoplasms - pathology (15) 15
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tyrosine (15) 15
animals (14) 14
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egfr (14) 14
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epidermal growth factor receptor (8) 8
neoplasms. tumors. oncology. including cancer and carcinogens (8) 8
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respiratory system (8) 8
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acrylamides - therapeutic use (7) 7
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protein kinase inhibitors - administration & dosage (7) 7
protein-tyrosine kinase (7) 7
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chemistry (6) 6
gene amplification (6) 6
lung neoplasms - metabolism (6) 6
piperazines - pharmacology (6) 6
acrylamides - administration & dosage (5) 5
aniline compounds - administration & dosage (5) 5
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binding sites (5) 5
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xenograft model antitumor assays (5) 5
acrylamides - chemistry (4) 4
afatinib (4) 4
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carcinoma, non-small-cell lung - enzymology (4) 4
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Reviews on recent clinical trials, ISSN 1574-8871, 06/2016, Volume 11, Issue 2, pp. 99 - 105
Journal Article
Cancer discovery, ISSN 2159-8290, 09/2014, Volume 4, Issue 9, pp. 1046 - 1061
Journal Article
Lung cancer (Amsterdam, Netherlands), ISSN 0169-5002, 12/2015, Volume 90, Issue 3, pp. 509 - 515
Highlights • Multiple platforms were compared for detection of EGFR mutations in plasma ctDNA. • Digital and traditional PCR assays were assessed using plasma... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Epidermal growth factor receptor mutation | T790M | Circulating tumor DNA | AZD9291 | Non-small cell lung cancer | Respiratory System | Oncology | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - drug therapy | DNA Mutational Analysis - standards | Humans | ErbB Receptors - genetics | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | DNA Mutational Analysis - methods | Biomarkers, Tumor | Polymerase Chain Reaction - methods | DNA, Neoplasm - blood | Sensitivity and Specificity | Female | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Lung Neoplasms - genetics | Reproducibility of Results | Aniline Compounds - pharmacology | ErbB Receptors - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Protein Kinase Inhibitors - therapeutic use | Polymerase Chain Reaction - standards | Carcinoma, Non-Small-Cell Lung - blood | Acrylamides - therapeutic use | Lung Neoplasms - blood | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung Neoplasms - diagnosis | Genetic research | Lung cancer, Non-small cell | Comparative analysis | Epidermal growth factor | Index Medicus
Journal Article
Journal Article
Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2018, Volume 18, Issue 4, pp. 550 - 555
Journal Article
Journal Article
Cancer letters, ISSN 0304-3835, 04/2018, Volume 420, pp. 242 - 246
Given the successful identification of epidermal growth factor receptor EGFR T790M, the third-generation EGFR tyrosine kinase inhibitor (TKI), osimertinib... 
Osimertinib | EGFR TKI | Resistant mechanisms | AZD9291 | Therapeutic strategies | Life Sciences & Biomedicine | Oncology | Science & Technology | Tyrosine | Epidermal growth factor | Analysis | Immunotherapy | Lung cancer, Small cell | Lung cancer, Non-small cell | Health aspects | Index Medicus
Journal Article
Journal Article
Cancer, ISSN 1097-0142, 12/2018, Volume 125, Issue 6, pp. 892 - 901
Journal Article
Journal Article
Cancer letters, ISSN 0304-3835, 10/2016, Volume 380, Issue 2, pp. 494 - 504
Highlights • Met amplification and protein hyperactivation is a resistance mechanism to both 1st and 3rd generation EGFR inhibitors • Met inhibition... 
Hematology, Oncology and Palliative Medicine | Resistance | Erlotinib | Met | EGFR | AZD9291 | Bim | Life Sciences & Biomedicine | Oncology | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Female | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Pyrazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Lung Neoplasms - genetics | Aniline Compounds - pharmacology | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Pyrimidines - pharmacology | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Gene Amplification | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Erlotinib Hydrochloride - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | G1 Phase Cell Cycle Checkpoints - drug effects | Drug Resistance, Neoplasm - drug effects | Respiratory agents | Care and treatment | Drug therapy | Lung cancer | Cancer | Index Medicus
Journal Article