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Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0121980
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF)... 
COLON CANCERS | HNPCC | EVOLUTION | HEREDITARY | NONPOLYPOSIS COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | RISK | FRAMESHIFT MUTATIONS | TUMORS | GENETIC ALTERATIONS | MutL Protein Homolog 1 | Microsatellite Instability | Age Factors | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | MutS Homolog 2 Protein - genetics | Aberrant Crypt Foci - pathology | DNA-Binding Proteins - genetics | Aberrant Crypt Foci - genetics | Proteins - genetics | Young Adult | Adaptor Proteins, Signal Transducing - genetics | Adult | Aged | Nuclear Proteins - genetics | bcl-2-Associated X Protein - genetics | Intestinal Mucosa - pathology | Immunohistochemistry | Gene mutations | Colorectal cancer | Transformation | Bax protein | Endometrial cancer | Genes | Mucosa | Colorectal carcinoma | Biology | Microsatellite instability | Inactivation | DNA repair | Proteins | Alterations | Intestine | Mismatch repair | Cooperation | Gastroenterology | Tumorigenesis | Lesions | Repair | Deoxyribonucleic acid--DNA | Medical research | Microsatellites | Stability | Deactivation | MLH1 protein | MSH2 protein | Patients | Molecular chains | Pathology | Crypts | Protein expression | Mutation | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 6, pp. 598 - 606
Journal Article
Anticancer Research, ISSN 0250-7005, 06/2016, Volume 36, Issue 6, pp. 2745 - 2750
Flat aberrant crypt foci (flat ACF) and mucin-depleted foci (MDF) have previously been described as preneoplastic colonic lesions. We used the novel A/J Min/+... 
A/J Min/+ mouse | Flat ACF | MDF | Colorectal cancer | Aberrant Crypt Foci - diagnosis | Animals | Mucins - analysis | Mice | Aberrant Crypt Foci - pathology | Colorectal Neoplasms - pathology | Colorectal Neoplasms - diagnosis
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56020
Background: Colon carcinogenesis is a multistep process and it emanates from a series of molecular and histopathological alterations. Glycyrrhizic acid (GA) is... 
K-RAS MUTATIONS | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | MAST-CELLS | PROLIFERATIVE ACTIVITY | PRENEOPLASTIC LESIONS | NF-KAPPA-B | ABERRANT CRYPT FOCI | MUCIN-DEPLETED FOCI | PROMYELOTIC LEUKEMIA | Rats, Wistar | Apoptosis - drug effects | Colon - drug effects | Colon - immunology | Male | Aberrant Crypt Foci - immunology | Mucins - analysis | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Sialomucins - analysis | Aberrant Crypt Foci - prevention & control | Anticarcinogenic Agents - therapeutic use | Connexin 43 - analysis | Aberrant Crypt Foci - chemically induced | Mast Cells - immunology | Colon - pathology | Colorectal Neoplasms - prevention & control | Rats | Aberrant Crypt Foci - pathology | Connexin 43 - immunology | Colorectal Neoplasms - chemically induced | Mast Cells - drug effects | Tumor Necrosis Factor-alpha - analysis | Dimethylhydrazines | Glycyrrhizic Acid - therapeutic use | Animals | Colorectal Neoplasms - immunology | Mast Cells - pathology | Cell Proliferation - drug effects | Colorectal Neoplasms - pathology | Prevention | Antiviral agents | Colon cancer | Oncology, Experimental | Inflammation | Research | Tumor proteins | Vascular endothelial growth factor | Cancer | Apoptosis | Biological properties | p53 Protein | Colorectal cancer | Connexin 43 | Caspase-3 | Carcinogenesis | Angiogenesis | Carcinogens | Toxicology | Rodents | Tumor necrosis factor-TNF | Colon | Supplementation | Lesions | NF-κB protein | Cytokines | Cyclin-dependent kinases | Caspase | Pharmacology | Tumor necrosis factor-α | Nitric-oxide synthase | Mucin | Acids | Natural products | Caspase-9 | Mast cells | Infiltration | Mutation | Cyclooxygenase-2 | Aberration | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122288
Annona muricata has been used in folk medicine for the treatment of cancer and tumors. This study evaluated the chemopreventive properties of an ethyl acetate... 
CANCER-CELLS | OXIDATIVE STRESS | LIPID-PEROXIDATION | MEDIATED PATHWAY | ANTIOXIDANT STATUS | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | NUCLEAR ANTIGEN PCNA | EXPRESSION | EXTRACT | FAMILY | Caspase 7 - metabolism | Immunohistochemistry | Plant Extracts - chemistry | Caspase 9 - metabolism | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Caspase 3 - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Azoxymethane - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Furans - chemistry | Lipid Peroxidation - drug effects | Furans - toxicity | bcl-2-Associated X Protein - genetics | Lactones - chemistry | Aberrant Crypt Foci - drug therapy | Malondialdehyde - metabolism | Plant Leaves - chemistry | Aberrant Crypt Foci - chemically induced | Colon - pathology | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Aberrant Crypt Foci - pathology | Down-Regulation - drug effects | Rats, Sprague-Dawley | Colon - metabolism | Lactones - toxicity | HT29 Cells | Up-Regulation - drug effects | Animals | Plant Leaves - metabolism | Annona - chemistry | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Proliferating Cell Nuclear Antigen - metabolism | Plant Extracts - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - genetics | Annona - metabolism | Animal experimentation | Care and treatment | Analysis | Medicine, Botanic | Colorectal cancer | Mitochondrial DNA | Medicine, Herbal | Research | Cytochrome | Bcl-2 protein | 5-Fluorouracil | Lipid peroxidation | Cytotoxicity | Biochemistry | Cancer therapies | Caspase-3 | Anticancer properties | Antioxidants | Proteins | Time dependence | Mitochondria | Energy dissipation | Membrane potential | Peroxidation | Ethyl acetate | Malondialdehyde | Methylene blue | Cytochrome c | Caspase-9 | Cytochromes | Acetic acid | Drugs | Bax protein | Science | Lipids | mRNA | Leaves | Control | Colon cancer | Azoxymethane | Rodents | Cell cycle | Down-regulation | Colon | Bioassay | Bioassays | Caspase | Biological assays | Chromatography | Natural products | Antitumor activity | Pharmaceuticals | Apoptosis | Tumors | Cancer
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 07/2014, Volume 468, Issue 1-2, pp. 178 - 186
coating of 5-fluorouracil pellets by ethylcellulose and pectin powder mixture (8:3 weight ratio) in capsule at simulated gastrointestinal media provides... 
Colon-specific drug delivery | Colon cancer | 5-Fluorouracil | In vivo pellet coating | RATS | PREVENTION | PHARMACOLOGY & PHARMACY | Adenocarcinoma - pathology | Antimetabolites, Antineoplastic - pharmacokinetics | Adenocarcinoma - chemically induced | Colonic Neoplasms - drug therapy | Biological Availability | Colonic Neoplasms - chemically induced | Colonic Neoplasms - metabolism | Adenoma - metabolism | Antimetabolites, Antineoplastic - administration & dosage | Drug Delivery Systems | Feasibility Studies | Cellulose - chemistry | Adenocarcinoma - metabolism | Antimetabolites, Antineoplastic - blood | Fluorouracil - administration & dosage | Fluorouracil - blood | Adenoma - drug therapy | Female | Cellulose - analogs & derivatives | Aberrant Crypt Foci - drug therapy | Aberrant Crypt Foci - chemically induced | Powders | Administration, Oral | Solubility | Technology, Pharmaceutical - methods | Aberrant Crypt Foci - pathology | Antimetabolites, Antineoplastic - chemistry | Adenocarcinoma - drug therapy | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Pectins - chemistry | Aberrant Crypt Foci - metabolism | Dimethylhydrazines | Animals | Tumor Burden - drug effects | Fluorouracil - chemistry | Colonic Neoplasms - pathology | Adenoma - pathology | Fluorouracil - pharmacokinetics | Tablets, Enteric-Coated | Adenoma - chemically induced | Coatings | Fluorouracil | Index Medicus
Journal Article
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2016, Volume 138, Issue 6, pp. 1482 - 1493
The sonic hedgehog (Shh) signaling has been known to contribute to carcinogenesis in organ, where hedgehog exerted organogenesis and in cancers, which are... 
sonic hedgehog | cancer prevention | ACF | colitis‐associated cancer | Shh inhibitor | 15‐PGDH | 15-PGDH | colitis-associated cancer | SUPPRESSOR | COLON-CANCER | PATHOGENESIS | CARCINOGENESIS | EPITHELIAL-CELLS | ONCOLOGY | SIGNALING PATHWAY | INFLAMMATION | HELICOBACTER-PYLORI | TUMOR-GROWTH | TUMORIGENESIS | Cell Cycle - genetics | Apoptosis - drug effects | Colonic Neoplasms - prevention & control | Humans | Colitis - complications | Apoptosis - genetics | Colitis - pathology | NF-kappa B - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Colonic Neoplasms - metabolism | Cell Nucleus - metabolism | Time Factors | Cyclooxygenase 2 - genetics | Colitis - chemically induced | Inflammation Mediators - metabolism | Colonic Neoplasms - etiology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Aberrant Crypt Foci - prevention & control | Disease Models, Animal | Gene Expression | Aberrant Crypt Foci - pathology | Hedgehog Proteins - antagonists & inhibitors | beta Catenin - metabolism | Protein Transport | Aberrant Crypt Foci - metabolism | Animals | NF-kappa B - genetics | Colonic Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Biomarkers | Mice | Cell Cycle - drug effects | Prevention | Dextran | Developmental biology | Analysis | Development and progression | Colitis | Sulfates | Cancer | Itraconazole | Inflammatory bowel disease | Inflammation | Dehydrogenases | Rodents | Apoptosis | Index Medicus
Journal Article
Journal Article