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Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111664
As an important source of drugs, natural products play an important role in the discovery and development of new drugs. More than 60% of anti-tumor drugs are... 
Natural products | JAK-STAT | VEGFR | PDGFR | Bcr-Abl | HER-2/neu | c-Met(HGFR) | IGF-1R | FGFR | Tyrosine kinase inhibitors | EGFR
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2006, Volume 75, Issue 1, pp. 93 - 109
The development of tyrosine phosphorylation inhibitors has transformed the approach to cancer therapy and is likely to affect other fields of medicine. In... 
Signal transduction | Tyrphostin | Tyrosine phosphorylation | Cancer therapy | IRREVERSIBLE INHIBITORS | SIGNAL-TRANSDUCTION THERAPY | GROWTH-FACTOR-RECEPTOR | signal transduction | ANTIPROLIFERATIVE AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCR-ABL | CHRONIC MYELOID-LEUKEMIA | CELL LUNG-CANCER | cancer therapy | SELECTIVE INHIBITOR | IN-VITRO | tyrphostin | tyrosine phosphorylation | TUMOR-GROWTH | Erlotinib Hydrochloride | Protein-Tyrosine Kinases - metabolism | Humans | Graft Occlusion, Vascular - prevention & control | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Piperazines - metabolism | Antineoplastic Agents - therapeutic use | Piperazines - chemistry | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Fusion Proteins, bcr-abl | Quinazolines - metabolism | Adenosine Triphosphate - metabolism | Janus Kinase 2 - metabolism | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Molecular Structure | Janus Kinase 3 - metabolism | Tyrphostins - chemistry | Quinazolines - chemistry | Janus Kinase 2 - antagonists & inhibitors | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Piperazines - therapeutic use | Antineoplastic Agents - chemistry | Imatinib Mesylate | Tyrphostins - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Quinazolines - therapeutic use | Receptors, Platelet-Derived Growth Factor - metabolism | Tyrphostins - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Signal Transduction - physiology | Benzamides | Adenosine Triphosphate - chemistry | Protein Kinase Inhibitors - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article